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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Gene

SMARCE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by Swi/Snf complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi66 – 134HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • chromatin binding Source: ProtInc
  • DNA binding Source: UniProtKB-KW
  • ligand-dependent nuclear receptor binding Source: BHF-UCL
  • N-acetyltransferase activity Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • RNA binding Source: Ensembl
  • transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: UniProtKB
  • chromatin modification Source: UniProtKB-KW
  • chromatin remodeling Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neurogenesis Source: Ensembl
  • nucleosome disassembly Source: BHF-UCL
  • regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Neurogenesis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ969G3.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Alternative name(s):
BRG1-associated factor 57
Short name:
BAF57
Gene namesi
Name:SMARCE1
Synonyms:BAF57
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11109. SMARCE1.

Subcellular locationi

GO - Cellular componenti

  • nBAF complex Source: UniProtKB
  • npBAF complex Source: UniProtKB
  • nuclear chromatin Source: UniProtKB
  • nuclear chromosome Source: ProtInc
  • nucleoplasm Source: HPA
  • nucleus Source: LIFEdb
  • protein complex Source: UniProtKB
  • SWI/SNF complex Source: UniProtKB
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Meningioma (MNGMA)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common neoplasm of the central nervous system derived from arachnoidal cells. The majority of meningiomas are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Most cases are sporadic. Familial occurrence of meningioma is rare.
See also OMIM:607174
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071873125 – 132EYNESMKA → GLHRFIVL in MNGMA; found in a case of childhood clear cell meningioma; associated with disease susceptibility. 1 Publication8
Coffin-Siris syndrome 5 (CSS5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported.
See also OMIM:616938
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06821573Y → C in CSS5. 1 PublicationCorresponds to variant rs387906857dbSNPEnsembl.1
Natural variantiVAR_07693273Y → S in CSS5. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi6605.
MalaCardsiSMARCE1.
MIMi607174. phenotype.
616938. phenotype.
OpenTargetsiENSG00000073584.
Orphaneti1465. Coffin-Siris syndrome.
263662. Familial multiple meningioma.
PharmGKBiPA35959.

Polymorphism and mutation databases

BioMutaiSMARCE1.
DMDMi61247587.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485771 – 411SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Omega-N-methylarginineCombined sources1
Modified residuei40Omega-N-methylarginineCombined sources1
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki92Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei265PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ969G3.
MaxQBiQ969G3.
PaxDbiQ969G3.
PeptideAtlasiQ969G3.
PRIDEiQ969G3.

PTM databases

iPTMnetiQ969G3.
PhosphoSitePlusiQ969G3.

Expressioni

Gene expression databases

BgeeiENSG00000073584.
CleanExiHS_SMARCE1.
ExpressionAtlasiQ969G3. baseline and differential.
GenevisibleiQ969G3. HS.

Organism-specific databases

HPAiCAB037318.
HPA003916.

Interactioni

Subunit structurei

Component of a number of multiprotein chromatin-remodeling complexes: Swi/Snf-A (BAF), Swi/Snf-B (PBAF), Brm, Brg1(I) and Brg1(II). Each of the complexes contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1 (SNF5/INI1). Other subunits specific to each of the complexes may also be present. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Also binds to the SRC/p160 family of histone acetyltransferases (HATs) composed of NCOA1, NCOA2, and NCOA3. Interacts with RCOR1/CoREST, NR3C1 and ZMIM2/ZIMP7. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with BRDT (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-455078,EBI-10187270
ARID2Q68CP94EBI-455078,EBI-637818
BRMS1Q9HCU93EBI-455078,EBI-714781
CCDC136Q96JN2-23EBI-455078,EBI-10171416
CCDC172P0C7W63EBI-455078,EBI-2548868
CDR2Q018505EBI-455078,EBI-1181367
CEP170P1Q96L145EBI-455078,EBI-743488
CEP63Q96MT84EBI-455078,EBI-741977
CEP70Q8NHQ15EBI-455078,EBI-739624
EPS8Q129293EBI-455078,EBI-375576
EXOC7Q9UPT55EBI-455078,EBI-720048
GOLGA2Q083793EBI-455078,EBI-618309
ING5Q8WYH83EBI-455078,EBI-488533
JAKMIP2Q96AA83EBI-455078,EBI-752007
KIFC3Q9BVG84EBI-455078,EBI-2125614
KRT15P190123EBI-455078,EBI-739566
KRT31Q153235EBI-455078,EBI-948001
KRT40Q6A1625EBI-455078,EBI-10171697
KRTAP10-9P604113EBI-455078,EBI-10172052
MED4Q9NPJ63EBI-455078,EBI-394607
MEOX2A4D1275EBI-455078,EBI-10172134
MIPOL1Q8TD105EBI-455078,EBI-2548751
MRFAP1L1Q96HT83EBI-455078,EBI-748896
MTUS2Q5JR593EBI-455078,EBI-742948
NOTCH2NLQ7Z3S93EBI-455078,EBI-945833
NUP62P371983EBI-455078,EBI-347978
RALBP1Q153115EBI-455078,EBI-749285
RCOR1Q9UKL04EBI-455096,EBI-926563
RINT1Q6NUQ13EBI-455078,EBI-726876
SPAG5Q96R063EBI-455078,EBI-413317
STX11O755583EBI-455078,EBI-714135
SYCE1Q8N0S23EBI-455078,EBI-6872807
TFIP11Q9UBB95EBI-455078,EBI-1105213
TRIM54Q9BYV25EBI-455078,EBI-2130429
TRIP10Q156423EBI-455078,EBI-739936
TRIP10Q15642-24EBI-455078,EBI-6550597
TXLNAP402223EBI-455078,EBI-359793
USHBP1Q8N6Y03EBI-455078,EBI-739895

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: BHF-UCL
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112489. 124 interactors.
DIPiDIP-27614N.
DIP-33041N.
IntActiQ969G3. 87 interactors.
MINTiMINT-1137973.
STRINGi9606.ENSP00000323967.

Structurei

3D structure databases

ProteinModelPortaliQ969G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili220 – 319Sequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 65Pro-richAdd BLAST61
Compositional biasi320 – 411Glu-richAdd BLAST92

Domaini

The HMG domain is essential for CD4 silencing and CD8 activation; mutation of this domain blocks thymus development.By similarity

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4715. Eukaryota.
ENOG410Y9B3. LUCA.
GeneTreeiENSGT00390000003628.
HOGENOMiHOG000230965.
HOVERGENiHBG054558.
InParanoidiQ969G3.
KOiK11651.
OMAiCISIEPA.
OrthoDBiEOG091G0ER1.
PhylomeDBiQ969G3.
TreeFamiTF321146.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR030089. BAF57.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR13711:SF206. PTHR13711:SF206. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969G3-1) [UniParc]FASTAAdd to basket
Also known as: BAF57

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR
60 70 80 90 100
VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII
110 120 130 140 150
GGMWRDLTDE EKQEYLNEYE AEKIEYNESM KAYHNSPAYL AYINAKSRAE
160 170 180 190 200
AALEEESRQR QSRMEKGEPY MSIQPAEDPD DYDDGFSMKH TATARFQRNH
210 220 230 240 250
RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK LEAELLQIEE
260 270 280 290 300
RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIAAEIA QAEEQARKRQ
310 320 330 340 350
EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET
360 370 380 390 400
TESQQNGEEG TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP
410
TDPIPEDEKK E
Length:411
Mass (Da):46,649
Last modified:October 25, 2004 - v2
Checksum:i6F1C1B7917BAD506
GO
Isoform 2 (identifier: Q969G3-2) [UniParc]FASTAAdd to basket
Also known as: BAF57v

The sequence of this isoform differs from the canonical sequence as follows:
     344-363: ETHLEETTESQQNGEEGTST → KNCQLCPRKTLTSRYTDFPD
     364-411: Missing.

Show »
Length:363
Mass (Da):41,780
Checksum:iCAADA4121B64578D
GO
Isoform 3 (identifier: Q969G3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:341
Mass (Da):39,260
Checksum:i8E5D2873CC92A598
GO
Isoform 4 (identifier: Q969G3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-51: Missing.

Show »
Length:376
Mass (Da):42,836
Checksum:i945FCF2B107F5429
GO
Isoform 5 (identifier: Q969G3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-51: Missing.
     344-411: ETHLEETTES...DPIPEDEKKE → KNCQLCPRKTLTSRYTDFPD

Show »
Length:328
Mass (Da):37,967
Checksum:iB87AE458E82C27A5
GO
Isoform 6 (identifier: Q969G3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.
     344-411: ETHLEETTES...DPIPEDEKKE → KNCQLCPRKTLTSRYTDFPD

Show »
Length:293
Mass (Da):34,390
Checksum:iFD0A8E38AD0ADC91
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46G → S in AAP35840 (Ref. 3) Curated1
Sequence conflicti46G → S in AAH07082 (PubMed:15489334).Curated1
Sequence conflicti46G → S in AAH11017 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06821573Y → C in CSS5. 1 PublicationCorresponds to variant rs387906857dbSNPEnsembl.1
Natural variantiVAR_07693273Y → S in CSS5. 1 Publication1
Natural variantiVAR_071873125 – 132EYNESMKA → GLHRFIVL in MNGMA; found in a case of childhood clear cell meningioma; associated with disease susceptibility. 1 Publication8

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0476041 – 70Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_04782517 – 51Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_047826344 – 411ETHLE…DEKKE → KNCQLCPRKTLTSRYTDFPD in isoform 5 and isoform 6. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_011801344 – 363ETHLE…EGTST → KNCQLCPRKTLTSRYTDFPD in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_011802364 – 411Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035262 Genomic DNA. Translation: AAC04509.1.
EU327017 mRNA. Translation: ACA81391.1.
EU327018 mRNA. Translation: ACA81392.1.
EU327019 mRNA. Translation: ACA81393.1.
EU327020 mRNA. Translation: ACA81394.1.
BT007176 mRNA. Translation: AAP35840.1.
AK001532 mRNA. Translation: BAG50933.1.
AK095047 mRNA. Translation: BAG52975.1.
AK294218 mRNA. Translation: BAG57525.1.
AC004585 Genomic DNA. No translation available.
AC073508 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60670.1.
BC007082 mRNA. Translation: AAH07082.1.
BC011017 mRNA. Translation: AAH11017.1.
BC063700 mRNA. Translation: AAH63700.1.
CCDSiCCDS11370.1. [Q969G3-1]
RefSeqiNP_003070.3. NM_003079.4. [Q969G3-1]
UniGeneiHs.743978.

Genome annotation databases

EnsembliENST00000348513; ENSP00000323967; ENSG00000073584. [Q969G3-1]
ENST00000377808; ENSP00000367039; ENSG00000073584. [Q969G3-5]
ENST00000400122; ENSP00000411607; ENSG00000073584. [Q969G3-6]
ENST00000578044; ENSP00000464511; ENSG00000073584. [Q969G3-3]
ENST00000580419; ENSP00000462475; ENSG00000073584. [Q969G3-4]
GeneIDi6605.
KEGGihsa:6605.
UCSCiuc002hux.4. human. [Q969G3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035262 Genomic DNA. Translation: AAC04509.1.
EU327017 mRNA. Translation: ACA81391.1.
EU327018 mRNA. Translation: ACA81392.1.
EU327019 mRNA. Translation: ACA81393.1.
EU327020 mRNA. Translation: ACA81394.1.
BT007176 mRNA. Translation: AAP35840.1.
AK001532 mRNA. Translation: BAG50933.1.
AK095047 mRNA. Translation: BAG52975.1.
AK294218 mRNA. Translation: BAG57525.1.
AC004585 Genomic DNA. No translation available.
AC073508 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60670.1.
BC007082 mRNA. Translation: AAH07082.1.
BC011017 mRNA. Translation: AAH11017.1.
BC063700 mRNA. Translation: AAH63700.1.
CCDSiCCDS11370.1. [Q969G3-1]
RefSeqiNP_003070.3. NM_003079.4. [Q969G3-1]
UniGeneiHs.743978.

3D structure databases

ProteinModelPortaliQ969G3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112489. 124 interactors.
DIPiDIP-27614N.
DIP-33041N.
IntActiQ969G3. 87 interactors.
MINTiMINT-1137973.
STRINGi9606.ENSP00000323967.

PTM databases

iPTMnetiQ969G3.
PhosphoSitePlusiQ969G3.

Polymorphism and mutation databases

BioMutaiSMARCE1.
DMDMi61247587.

Proteomic databases

EPDiQ969G3.
MaxQBiQ969G3.
PaxDbiQ969G3.
PeptideAtlasiQ969G3.
PRIDEiQ969G3.

Protocols and materials databases

DNASUi6605.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348513; ENSP00000323967; ENSG00000073584. [Q969G3-1]
ENST00000377808; ENSP00000367039; ENSG00000073584. [Q969G3-5]
ENST00000400122; ENSP00000411607; ENSG00000073584. [Q969G3-6]
ENST00000578044; ENSP00000464511; ENSG00000073584. [Q969G3-3]
ENST00000580419; ENSP00000462475; ENSG00000073584. [Q969G3-4]
GeneIDi6605.
KEGGihsa:6605.
UCSCiuc002hux.4. human. [Q969G3-1]

Organism-specific databases

CTDi6605.
DisGeNETi6605.
GeneCardsiSMARCE1.
GeneReviewsiSMARCE1.
HGNCiHGNC:11109. SMARCE1.
HPAiCAB037318.
HPA003916.
MalaCardsiSMARCE1.
MIMi603111. gene.
607174. phenotype.
616938. phenotype.
neXtProtiNX_Q969G3.
OpenTargetsiENSG00000073584.
Orphaneti1465. Coffin-Siris syndrome.
263662. Familial multiple meningioma.
PharmGKBiPA35959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4715. Eukaryota.
ENOG410Y9B3. LUCA.
GeneTreeiENSGT00390000003628.
HOGENOMiHOG000230965.
HOVERGENiHBG054558.
InParanoidiQ969G3.
KOiK11651.
OMAiCISIEPA.
OrthoDBiEOG091G0ER1.
PhylomeDBiQ969G3.
TreeFamiTF321146.

Enzyme and pathway databases

ReactomeiR-HSA-3214858. RMTs methylate histone arginines.
SIGNORiQ969G3.

Miscellaneous databases

GeneWikiiSMARCE1.
GenomeRNAii6605.
PROiQ969G3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073584.
CleanExiHS_SMARCE1.
ExpressionAtlasiQ969G3. baseline and differential.
GenevisibleiQ969G3. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR030089. BAF57.
IPR009071. HMG_box_dom.
[Graphical view]
PANTHERiPTHR13711:SF206. PTHR13711:SF206. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMCE1_HUMAN
AccessioniPrimary (citable) accession number: Q969G3
Secondary accession number(s): B3KMC1
, B4DFR4, C0IMW4, C0IMW5, C0IMW7, H7C3F6, O43539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 25, 2004
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.