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Q969F8

- KISSR_HUMAN

UniProt

Q969F8 - KISSR_HUMAN

Protein

KiSS-1 receptor

Gene

KISS1R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.1 Publication

    GO - Molecular functioni

    1. neuropeptide binding Source: Ensembl
    2. neuropeptide receptor activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: Ensembl
    2. arachidonic acid secretion Source: Ensembl
    3. calcium-mediated signaling Source: Ensembl
    4. G-protein coupled receptor signaling pathway Source: UniProtKB
    5. negative regulation of cell proliferation Source: Ensembl
    6. neuropeptide signaling pathway Source: GOC
    7. positive regulation of hormone secretion Source: Ensembl
    8. positive regulation of stress fiber assembly Source: Ensembl
    9. positive regulation of synaptic transmission Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Protein family/group databases

    TCDBi9.A.14.18.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KiSS-1 receptor
    Short name:
    KiSS-1R
    Alternative name(s):
    G-protein coupled receptor 54
    G-protein coupled receptor OT7T175
    Short name:
    hOT7T175
    Hypogonadotropin-1
    Kisspeptins receptor
    Metastin receptor
    Gene namesi
    Name:KISS1R
    Synonyms:AXOR12, GPR54
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4510. KISS1R.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hypogonadotropic hypogonadism 8 with or without anosmia (HH8) [MIM:614837]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).5 Publications
    Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in KISS1R as well as in other HH-associated genes including FGFR1 and IL17RD (PubMed:23643382).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. 1 Publication
    VAR_043906
    Natural varianti148 – 1481L → S in HH8; 65% reduction of inositol phosphate production. 1 Publication
    Corresponds to variant rs28939719 [ dbSNP | Ensembl ].
    VAR_021392
    Natural varianti189 – 1891A → T in HH8; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in FGFR1. 1 Publication
    VAR_069961
    Natural varianti194 – 1941A → D in HH8; phenotype consistent with Kallmann syndrome; the patient also carries a mutation in IL17RD. 1 Publication
    VAR_069962
    Natural varianti223 – 2231C → R in HH8; exhibit profoundly impaired signaling. 1 Publication
    VAR_021393
    Natural varianti297 – 2971R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. 1 Publication
    VAR_021394
    Precocious puberty, central 1 (CPPB1) [MIM:176400]: A condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti386 – 3861R → P in CPPB1; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. 1 Publication
    VAR_043907

    Keywords - Diseasei

    Disease mutation, Hypogonadotropic hypogonadism

    Organism-specific databases

    MIMi176400. phenotype.
    614837. phenotype.
    Orphaneti478. Kallmann syndrome.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    PharmGKBiPA28899.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398KiSS-1 receptorPRO_0000069695Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ969F8.
    PRIDEiQ969F8.

    Expressioni

    Tissue specificityi

    Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.6 Publications

    Inductioni

    Expressed at higher levels in first trimester trophoblasts than at term of gestation.

    Gene expression databases

    ArrayExpressiQ969F8.
    BgeeiQ969F8.
    CleanExiHS_KISS1R.
    GenevestigatoriQ969F8.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PPP2CAP677753EBI-8481408,EBI-712311

    Protein-protein interaction databases

    BioGridi124162. 1 interaction.
    IntActiQ969F8. 1 interaction.
    STRINGi9606.ENSP00000234371.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969F8.
    SMRiQ969F8. Positions 48-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 7811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini102 – 12019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini139 – 15719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 20224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 26340CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini285 – 30521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini329 – 39870CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei79 – 10123Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei121 – 13818Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei306 – 32823Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296869.
    HOGENOMiHOG000230487.
    HOVERGENiHBG106952.
    InParanoidiQ969F8.
    KOiK08374.
    OMAiSWHPRSY.
    PhylomeDBiQ969F8.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008103. KiSS_1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01728. KISS1RECEPTR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA    50
    ALMLLGLVGN SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA 100
    LLYPLPGWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA 150
    LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRAY CSEAFPSRAL 200
    ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP ADSALQGQVL 250
    AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA 300
    AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR 350
    PGPSDPAAPH AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL 398
    Length:398
    Mass (Da):42,586
    Last modified:February 6, 2007 - v2
    Checksum:iECAE2208848F5B06
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. 1 Publication
    VAR_043906
    Natural varianti148 – 1481L → S in HH8; 65% reduction of inositol phosphate production. 1 Publication
    Corresponds to variant rs28939719 [ dbSNP | Ensembl ].
    VAR_021392
    Natural varianti189 – 1891A → T in HH8; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in FGFR1. 1 Publication
    VAR_069961
    Natural varianti194 – 1941A → D in HH8; phenotype consistent with Kallmann syndrome; the patient also carries a mutation in IL17RD. 1 Publication
    VAR_069962
    Natural varianti223 – 2231C → R in HH8; exhibit profoundly impaired signaling. 1 Publication
    VAR_021393
    Natural varianti297 – 2971R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. 1 Publication
    VAR_021394
    Natural varianti364 – 3641L → H.7 Publications
    Corresponds to variant rs350132 [ dbSNP | Ensembl ].
    VAR_021395
    Natural varianti386 – 3861R → P in CPPB1; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. 1 Publication
    VAR_043907

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051065 mRNA. Translation: BAB55446.1.
    AF343725 mRNA. Translation: AAK83235.1.
    AJ309020 mRNA. Translation: CAC40817.1.
    AY029541 mRNA. Translation: AAK33126.1.
    AY253981 mRNA. Translation: AAP82929.1.
    AY253982 mRNA. Translation: AAP82930.1.
    EU883577 mRNA. Translation: ACG60651.1.
    AC005379 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69583.1.
    BC140825 mRNA. Translation: AAI40826.1.
    BC141812 mRNA. Translation: AAI41813.1.
    CCDSiCCDS12049.1.
    RefSeqiNP_115940.2. NM_032551.4.
    UniGeneiHs.208229.

    Genome annotation databases

    EnsembliENST00000234371; ENSP00000234371; ENSG00000116014.
    GeneIDi84634.
    KEGGihsa:84634.
    UCSCiuc002lqk.4. human.

    Polymorphism databases

    DMDMi125987836.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Tintin's blight - Issue 58 of May 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051065 mRNA. Translation: BAB55446.1 .
    AF343725 mRNA. Translation: AAK83235.1 .
    AJ309020 mRNA. Translation: CAC40817.1 .
    AY029541 mRNA. Translation: AAK33126.1 .
    AY253981 mRNA. Translation: AAP82929.1 .
    AY253982 mRNA. Translation: AAP82930.1 .
    EU883577 mRNA. Translation: ACG60651.1 .
    AC005379 Genomic DNA. No translation available.
    CH471139 Genomic DNA. Translation: EAW69583.1 .
    BC140825 mRNA. Translation: AAI40826.1 .
    BC141812 mRNA. Translation: AAI41813.1 .
    CCDSi CCDS12049.1.
    RefSeqi NP_115940.2. NM_032551.4.
    UniGenei Hs.208229.

    3D structure databases

    ProteinModelPortali Q969F8.
    SMRi Q969F8. Positions 48-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124162. 1 interaction.
    IntActi Q969F8. 1 interaction.
    STRINGi 9606.ENSP00000234371.

    Chemistry

    BindingDBi Q969F8.
    ChEMBLi CHEMBL5413.
    GuidetoPHARMACOLOGYi 266.

    Protein family/group databases

    TCDBi 9.A.14.18.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 125987836.

    Proteomic databases

    PaxDbi Q969F8.
    PRIDEi Q969F8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000234371 ; ENSP00000234371 ; ENSG00000116014 .
    GeneIDi 84634.
    KEGGi hsa:84634.
    UCSCi uc002lqk.4. human.

    Organism-specific databases

    CTDi 84634.
    GeneCardsi GC19P000917.
    GeneReviewsi KISS1R.
    HGNCi HGNC:4510. KISS1R.
    MIMi 176400. phenotype.
    604161. gene.
    614837. phenotype.
    neXtProti NX_Q969F8.
    Orphaneti 478. Kallmann syndrome.
    432. Normosmic congenital hypogonadotropic hypogonadism.
    PharmGKBi PA28899.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296869.
    HOGENOMi HOG000230487.
    HOVERGENi HBG106952.
    InParanoidi Q969F8.
    KOi K08374.
    OMAi SWHPRSY.
    PhylomeDBi Q969F8.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii KiSS1-derived_peptide_receptor.
    GenomeRNAii 84634.
    NextBioi 74561.
    PROi Q969F8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969F8.
    Bgeei Q969F8.
    CleanExi HS_KISS1R.
    Genevestigatori Q969F8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008103. KiSS_1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01728. KISS1RECEPTR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
    2. "FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54."
      Clements M.K., McDonald T.P., Wang R., Xie G., O'Dowd B.F., George S.R., Austin C.P., Liu Q.
      Biochem. Biophys. Res. Commun. 284:1189-1193(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    4. "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
      Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M.
      J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, POSSIBLE FUNCTION, TISSUE SPECIFICITY.
      Tissue: Hypothalamus.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HH8 SER-148, VARIANT HIS-364.
    6. "Isolation of cDNA coding for human KISS1 receptor (KISS1R)."
      Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    7. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-364.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-364.
    10. Cited for: REVIEW.
    11. Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
    12. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
      Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
      J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
    13. "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
      Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M.
      J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN THYROID CANCER.
    14. "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54."
      de Roux N., Genin E., Carel J.-C., Matsuda F., Chaussain J.-L., Milgrom E.
      Proc. Natl. Acad. Sci. U.S.A. 100:10972-10976(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN HH8.
    15. "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
      Ikeguchi M., Hirooka Y., Kaibara N.
      J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
    16. "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
      Ikeguchi M., Yamaguchi K., Kaibara N.
      Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA.
    17. "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
      Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G.
      J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ROLE IN THROPHOBLAST MIGRATION AND INVASION.
    18. "Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
      Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F.
      Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
    19. "Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
      Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A.
      J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HH8 ARG-223 AND LEU-297, VARIANT HIS-364, CHARACTERIZATION OF VARIANTS HH8 ARG-223 AND LEU-297.
    20. "Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54."
      Tenenbaum-Rakover Y., Commenges-Ducos M., Iovane A., Aumas C., Admoni O., de Roux N.
      J. Clin. Endocrinol. Metab. 92:1137-1144(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HH8 PRO-102.
    21. Cited for: VARIANT CPPB1 PRO-386, CHARACTERIZATION OF VARIANT CPPB1 PRO-386.
    22. Cited for: VARIANTS HH8 THR-189 AND ASP-194.

    Entry informationi

    Entry nameiKISSR_HUMAN
    AccessioniPrimary (citable) accession number: Q969F8
    Secondary accession number(s): A5D8U2, B2RTV1, Q96QG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

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