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Q969F8 (KISSR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KiSS-1 receptor

Short name=KiSS-1R
Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name=hOT7T175
Hypogonadotropin-1
Kisspeptins receptor
Metastin receptor
Gene names
Name:KISS1R
Synonyms:AXOR12, GPR54
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Ref.4 Ref.17

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. Ref.1 Ref.2 Ref.3 Ref.4 Ref.12 Ref.17

Induction

Expressed at higher levels in first trimester trophoblasts than at term of gestation.

Involvement in disease

Hypogonadotropic hypogonadism 8 with or without anosmia (HH8) [MIM:614837]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in KISS1R as well as in other HH-associated genes including FGFR1 and IL17RD (Ref.22). Ref.5 Ref.14 Ref.19 Ref.20 Ref.22

Precocious puberty, central 1 (CPPB1) [MIM:176400]: A condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.21

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DiseaseDisease mutation
Hypogonadotropic hypogonadism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Non-traceable author statement Ref.3. Source: UniProtKB

activation of MAPKK activity

Inferred from electronic annotation. Source: Ensembl

arachidonic acid secretion

Inferred from electronic annotation. Source: Ensembl

behavior

Non-traceable author statement Ref.3. Source: UniProtKB

calcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from direct assay Ref.3. Source: GOC

positive regulation of hormone secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of stress fiber assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell surface

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from direct assay Ref.3. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionneuropeptide binding

Inferred from electronic annotation. Source: Ensembl

neuropeptide receptor activity

Inferred from direct assay Ref.3. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP2CAP677753EBI-8481408,EBI-712311

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 398398KiSS-1 receptor
PRO_0000069695

Regions

Topological domain1 – 4646Extracellular Potential
Transmembrane47 – 6721Helical; Name=1; Potential
Topological domain68 – 7811Cytoplasmic Potential
Transmembrane79 – 10123Helical; Name=2; Potential
Topological domain102 – 12019Extracellular Potential
Transmembrane121 – 13818Helical; Name=3; Potential
Topological domain139 – 15719Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 20224Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 26340Cytoplasmic Potential
Transmembrane264 – 28421Helical; Name=6; Potential
Topological domain285 – 30521Extracellular Potential
Transmembrane306 – 32823Helical; Name=7; Potential
Topological domain329 – 39870Cytoplasmic Potential

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Glycosylation281N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 191 By similarity

Natural variations

Natural variant1021L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. Ref.20
VAR_043906
Natural variant1481L → S in HH8; 65% reduction of inositol phosphate production. Ref.5
Corresponds to variant rs28939719 [ dbSNP | Ensembl ].
VAR_021392
Natural variant1891A → T in HH8; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in FGFR1. Ref.22
VAR_069961
Natural variant1941A → D in HH8; phenotype consistent with Kallmann syndrome; the patient also carries a mutation in IL17RD. Ref.22
VAR_069962
Natural variant2231C → R in HH8; exhibit profoundly impaired signaling. Ref.19
VAR_021393
Natural variant2971R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. Ref.19
VAR_021394
Natural variant3641L → H. Ref.1 Ref.2 Ref.4 Ref.5 Ref.8 Ref.9 Ref.19
Corresponds to variant rs350132 [ dbSNP | Ensembl ].
VAR_021395
Natural variant3861R → P in CPPB1; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. Ref.21
VAR_043907

Sequences

Sequence LengthMass (Da)Tools
Q969F8 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: ECAE2208848F5B06

FASTA39842,586
        10         20         30         40         50         60 
MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA ALMLLGLVGN 

        70         80         90        100        110        120 
SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPGWVL GDFMCKFVNY 

       130        140        150        160        170        180 
IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL 

       190        200        210        220        230        240 
HRLSPGPRAY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP 

       250        260        270        280        290        300 
ADSALQGQVL AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA 

       310        320        330        340        350        360 
AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR PGPSDPAAPH 

       370        380        390 
AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL 

« Hide

References

« Hide 'large scale' references
[1]"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor."
Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., Ishibashi Y., Watanabe T., Asada M., Yamada T., Suenaga M., Kitada C., Usuki S., Kurokawa T. expand/collapse author list , Onda H., Nishimura O., Fujino M.
Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
[2]"FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54."
Clements M.K., McDonald T.P., Wang R., Xie G., O'Dowd B.F., George S.R., Austin C.P., Liu Q.
Biochem. Biophys. Res. Commun. 284:1189-1193(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
[3]"AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1."
Muir A.I., Chamberlain L., Elshourbagy N.A., Michalovich D., Moore D.J., Calamari A., Szekeres P.G., Sarau H.M., Chambers J.K., Murdock P., Steplewski K., Shabon U., Miller J.E., Middleton S.E., Darker J.G., Larminie C.G.C., Wilson S., Bergsma D.J. expand/collapse author list , Emson P., Faull R., Philpott K.L., Harrison D.C.
J. Biol. Chem. 276:28969-28975(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[4]"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M.
J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, POSSIBLE FUNCTION, TISSUE SPECIFICITY.
Tissue: Hypothalamus.
[5]"The GPR54 gene as a regulator of puberty."
Seminara S.B., Messager S., Chatzidaki E.E., Thresher R.R., Acierno J.S. Jr., Shagoury J.K., Bo-Abbas Y., Kuohung W., Schwinof K.M., Hendrick A.G., Zahn D., Dixon J., Kaiser U.B., Slaugenhaupt S.A., Gusella J.F., O'Rahilly S., Carlton M.B.L., Crowley W.F. Jr., Aparicio S.A.J.R., Colledge W.H.
N. Engl. J. Med. 349:1614-1627(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HH8 SER-148, VARIANT HIS-364.
[6]"Isolation of cDNA coding for human KISS1 receptor (KISS1R)."
Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[7]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-364.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-364.
[10]"GPR54 and puberty."
Colledge W.H.
Trends Endocrinol. Metab. 15:448-453(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[11]"Metastin suppresses the motility and growth of CHO cells transfected with its receptor."
Hori A., Honda S., Asada M., Ohtaki T., Oda K., Watanabe T., Shintani Y., Yamada T., Suenaga M., Kitada C., Onda H., Kurokawa T., Nishimura O., Fujino M.
Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
[12]"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
[13]"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M.
J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN THYROID CANCER.
[14]"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54."
de Roux N., Genin E., Carel J.-C., Matsuda F., Chaussain J.-L., Milgrom E.
Proc. Natl. Acad. Sci. U.S.A. 100:10972-10976(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN HH8.
[15]"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
Ikeguchi M., Hirooka Y., Kaibara N.
J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
[16]"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
Ikeguchi M., Yamaguchi K., Kaibara N.
Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA.
[17]"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G.
J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, ROLE IN THROPHOBLAST MIGRATION AND INVASION.
[18]"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F.
Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
[19]"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A.
J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HH8 ARG-223 AND LEU-297, VARIANT HIS-364, CHARACTERIZATION OF VARIANTS HH8 ARG-223 AND LEU-297.
[20]"Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54."
Tenenbaum-Rakover Y., Commenges-Ducos M., Iovane A., Aumas C., Admoni O., de Roux N.
J. Clin. Endocrinol. Metab. 92:1137-1144(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT HH8 PRO-102.
[21]"A GPR54-activating mutation in a patient with central precocious puberty."
Teles M.G., Bianco S.D.C., Brito V.N., Trarbach E.B., Kuohung W., Xu S., Seminara S.B., Mendonca B.B., Kaiser U.B., Latronico A.C.
N. Engl. J. Med. 358:709-715(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CPPB1 PRO-386, CHARACTERIZATION OF VARIANT CPPB1 PRO-386.
[22]"Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism."
Miraoui H., Dwyer A.A., Sykiotis G.P., Plummer L., Chung W., Feng B., Beenken A., Clarke J., Pers T.H., Dworzynski P., Keefe K., Niedziela M., Raivio T., Crowley W.F. Jr., Seminara S.B., Quinton R., Hughes V.A., Kumanov P. expand/collapse author list , Young J., Yialamas M.A., Hall J.E., Van Vliet G., Chanoine J.P., Rubenstein J., Mohammadi M., Tsai P.S., Sidis Y., Lage K., Pitteloud N.
Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS HH8 THR-189 AND ASP-194.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051065 mRNA. Translation: BAB55446.1.
AF343725 mRNA. Translation: AAK83235.1.
AJ309020 mRNA. Translation: CAC40817.1.
AY029541 mRNA. Translation: AAK33126.1.
AY253981 mRNA. Translation: AAP82929.1.
AY253982 mRNA. Translation: AAP82930.1.
EU883577 mRNA. Translation: ACG60651.1.
AC005379 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69583.1.
BC140825 mRNA. Translation: AAI40826.1.
BC141812 mRNA. Translation: AAI41813.1.
RefSeqNP_115940.2. NM_032551.4.
UniGeneHs.208229.

3D structure databases

ProteinModelPortalQ969F8.
SMRQ969F8. Positions 48-338.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124162. 1 interaction.
IntActQ969F8. 1 interaction.
STRING9606.ENSP00000234371.

Chemistry

BindingDBQ969F8.
ChEMBLCHEMBL5413.
GuidetoPHARMACOLOGY266.

Protein family/group databases

TCDB9.A.14.18.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

Polymorphism databases

DMDM125987836.

Proteomic databases

PaxDbQ969F8.
PRIDEQ969F8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000234371; ENSP00000234371; ENSG00000116014.
GeneID84634.
KEGGhsa:84634.
UCSCuc002lqk.4. human.

Organism-specific databases

CTD84634.
GeneCardsGC19P000917.
HGNCHGNC:4510. KISS1R.
MIM176400. phenotype.
604161. gene.
614837. phenotype.
neXtProtNX_Q969F8.
Orphanet478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBPA28899.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296869.
HOGENOMHOG000230487.
HOVERGENHBG106952.
InParanoidQ969F8.
KOK08374.
OMASWHPRSY.
PhylomeDBQ969F8.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ969F8.
BgeeQ969F8.
CleanExHS_KISS1R.
GenevestigatorQ969F8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKiSS1-derived_peptide_receptor.
GenomeRNAi84634.
NextBio74561.
PROQ969F8.
SOURCESearch...

Entry information

Entry nameKISSR_HUMAN
AccessionPrimary (citable) accession number: Q969F8
Secondary accession number(s): A5D8U2, B2RTV1, Q96QG0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 6, 2007
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries