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Q969F8

- KISSR_HUMAN

UniProt

Q969F8 - KISSR_HUMAN

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Protein

KiSS-1 receptor

Gene
KISS1R, AXOR12, GPR54
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.2 Publications

GO - Molecular functioni

  1. neuropeptide binding Source: Ensembl
  2. neuropeptide receptor activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. activation of MAPKK activity Source: Ensembl
  2. arachidonic acid secretion Source: Ensembl
  3. calcium-mediated signaling Source: Ensembl
  4. G-protein coupled receptor signaling pathway Source: UniProtKB
  5. negative regulation of cell proliferation Source: Ensembl
  6. neuropeptide signaling pathway Source: GOC
  7. positive regulation of hormone secretion Source: Ensembl
  8. positive regulation of stress fiber assembly Source: Ensembl
  9. positive regulation of synaptic transmission Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Protein family/group databases

TCDBi9.A.14.18.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
KiSS-1 receptor
Short name:
KiSS-1R
Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name:
hOT7T175
Hypogonadotropin-1
Kisspeptins receptor
Metastin receptor
Gene namesi
Name:KISS1R
Synonyms:AXOR12, GPR54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4510. KISS1R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Extracellular Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 7811Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei79 – 10123Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini102 – 12019Extracellular Reviewed predictionAdd
BLAST
Transmembranei121 – 13818Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini139 – 15719Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini179 – 20224Extracellular Reviewed predictionAdd
BLAST
Transmembranei203 – 22321Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini224 – 26340Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei264 – 28421Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini285 – 30521Extracellular Reviewed predictionAdd
BLAST
Transmembranei306 – 32823Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini329 – 39870Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 8 with or without anosmia (HH8) [MIM:614837]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Note: The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in KISS1R as well as in other HH-associated genes including FGFR1 and IL17RD (1 Publication).5 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. 1 Publication
VAR_043906
Natural varianti148 – 1481L → S in HH8; 65% reduction of inositol phosphate production. 1 Publication
Corresponds to variant rs28939719 [ dbSNP | Ensembl ].
VAR_021392
Natural varianti189 – 1891A → T in HH8; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in FGFR1. 1 Publication
VAR_069961
Natural varianti194 – 1941A → D in HH8; phenotype consistent with Kallmann syndrome; the patient also carries a mutation in IL17RD. 1 Publication
VAR_069962
Natural varianti223 – 2231C → R in HH8; exhibit profoundly impaired signaling. 1 Publication
VAR_021393
Natural varianti297 – 2971R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. 1 Publication
VAR_021394
Precocious puberty, central 1 (CPPB1) [MIM:176400]: A condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti386 – 3861R → P in CPPB1; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. 1 Publication
VAR_043907

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism

Organism-specific databases

MIMi176400. phenotype.
614837. phenotype.
Orphaneti478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBiPA28899.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398KiSS-1 receptorPRO_0000069695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi18 – 181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi115 ↔ 191 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969F8.
PRIDEiQ969F8.

Expressioni

Tissue specificityi

Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism.6 Publications

Inductioni

Expressed at higher levels in first trimester trophoblasts than at term of gestation.

Gene expression databases

ArrayExpressiQ969F8.
BgeeiQ969F8.
CleanExiHS_KISS1R.
GenevestigatoriQ969F8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2CAP677753EBI-8481408,EBI-712311

Protein-protein interaction databases

BioGridi124162. 1 interaction.
IntActiQ969F8. 1 interaction.
STRINGi9606.ENSP00000234371.

Structurei

3D structure databases

ProteinModelPortaliQ969F8.
SMRiQ969F8. Positions 48-338.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296869.
HOGENOMiHOG000230487.
HOVERGENiHBG106952.
InParanoidiQ969F8.
KOiK08374.
OMAiSWHPRSY.
PhylomeDBiQ969F8.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969F8-1 [UniParc]FASTAAdd to Basket

« Hide

MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA    50
ALMLLGLVGN SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA 100
LLYPLPGWVL GDFMCKFVNY IQQVSVQATC ATLTAMSVDR WYVTVFPLRA 150
LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL HRLSPGPRAY CSEAFPSRAL 200
ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP ADSALQGQVL 250
AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA 300
AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR 350
PGPSDPAAPH AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL 398
Length:398
Mass (Da):42,586
Last modified:February 6, 2007 - v2
Checksum:iECAE2208848F5B06
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. 1 Publication
VAR_043906
Natural varianti148 – 1481L → S in HH8; 65% reduction of inositol phosphate production. 1 Publication
Corresponds to variant rs28939719 [ dbSNP | Ensembl ].
VAR_021392
Natural varianti189 – 1891A → T in HH8; phenotype consistent with normosmic idiopathic hypogonadotropic hypogonadism; the patient also carries a mutation in FGFR1. 1 Publication
VAR_069961
Natural varianti194 – 1941A → D in HH8; phenotype consistent with Kallmann syndrome; the patient also carries a mutation in IL17RD. 1 Publication
VAR_069962
Natural varianti223 – 2231C → R in HH8; exhibit profoundly impaired signaling. 1 Publication
VAR_021393
Natural varianti297 – 2971R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. 1 Publication
VAR_021394
Natural varianti364 – 3641L → H.7 Publications
Corresponds to variant rs350132 [ dbSNP | Ensembl ].
VAR_021395
Natural varianti386 – 3861R → P in CPPB1; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. 1 Publication
VAR_043907

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051065 mRNA. Translation: BAB55446.1.
AF343725 mRNA. Translation: AAK83235.1.
AJ309020 mRNA. Translation: CAC40817.1.
AY029541 mRNA. Translation: AAK33126.1.
AY253981 mRNA. Translation: AAP82929.1.
AY253982 mRNA. Translation: AAP82930.1.
EU883577 mRNA. Translation: ACG60651.1.
AC005379 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69583.1.
BC140825 mRNA. Translation: AAI40826.1.
BC141812 mRNA. Translation: AAI41813.1.
CCDSiCCDS12049.1.
RefSeqiNP_115940.2. NM_032551.4.
UniGeneiHs.208229.

Genome annotation databases

EnsembliENST00000234371; ENSP00000234371; ENSG00000116014.
GeneIDi84634.
KEGGihsa:84634.
UCSCiuc002lqk.4. human.

Polymorphism databases

DMDMi125987836.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051065 mRNA. Translation: BAB55446.1 .
AF343725 mRNA. Translation: AAK83235.1 .
AJ309020 mRNA. Translation: CAC40817.1 .
AY029541 mRNA. Translation: AAK33126.1 .
AY253981 mRNA. Translation: AAP82929.1 .
AY253982 mRNA. Translation: AAP82930.1 .
EU883577 mRNA. Translation: ACG60651.1 .
AC005379 Genomic DNA. No translation available.
CH471139 Genomic DNA. Translation: EAW69583.1 .
BC140825 mRNA. Translation: AAI40826.1 .
BC141812 mRNA. Translation: AAI41813.1 .
CCDSi CCDS12049.1.
RefSeqi NP_115940.2. NM_032551.4.
UniGenei Hs.208229.

3D structure databases

ProteinModelPortali Q969F8.
SMRi Q969F8. Positions 48-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124162. 1 interaction.
IntActi Q969F8. 1 interaction.
STRINGi 9606.ENSP00000234371.

Chemistry

BindingDBi Q969F8.
ChEMBLi CHEMBL5413.
GuidetoPHARMACOLOGYi 266.

Protein family/group databases

TCDBi 9.A.14.18.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

Polymorphism databases

DMDMi 125987836.

Proteomic databases

PaxDbi Q969F8.
PRIDEi Q969F8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234371 ; ENSP00000234371 ; ENSG00000116014 .
GeneIDi 84634.
KEGGi hsa:84634.
UCSCi uc002lqk.4. human.

Organism-specific databases

CTDi 84634.
GeneCardsi GC19P000917.
GeneReviewsi KISS1R.
HGNCi HGNC:4510. KISS1R.
MIMi 176400. phenotype.
604161. gene.
614837. phenotype.
neXtProti NX_Q969F8.
Orphaneti 478. Kallmann syndrome.
432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKBi PA28899.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296869.
HOGENOMi HOG000230487.
HOVERGENi HBG106952.
InParanoidi Q969F8.
KOi K08374.
OMAi SWHPRSY.
PhylomeDBi Q969F8.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii KiSS1-derived_peptide_receptor.
GenomeRNAii 84634.
NextBioi 74561.
PROi Q969F8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969F8.
Bgeei Q969F8.
CleanExi HS_KISS1R.
Genevestigatori Q969F8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008103. KiSS_1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01728. KISS1RECEPTR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
  2. "FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54."
    Clements M.K., McDonald T.P., Wang R., Xie G., O'Dowd B.F., George S.R., Austin C.P., Liu Q.
    Biochem. Biophys. Res. Commun. 284:1189-1193(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  4. "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
    Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M.
    J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, POSSIBLE FUNCTION, TISSUE SPECIFICITY.
    Tissue: Hypothalamus.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HH8 SER-148, VARIANT HIS-364.
  6. "Isolation of cDNA coding for human KISS1 receptor (KISS1R)."
    Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-364.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-364.
  10. Cited for: REVIEW.
  11. Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
  12. "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
    Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D.
    J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
  13. "Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
    Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M.
    J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN THYROID CANCER.
  14. "Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54."
    de Roux N., Genin E., Carel J.-C., Matsuda F., Chaussain J.-L., Milgrom E.
    Proc. Natl. Acad. Sci. U.S.A. 100:10972-10976(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN HH8.
  15. "Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
    Ikeguchi M., Hirooka Y., Kaibara N.
    J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
  16. "Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
    Ikeguchi M., Yamaguchi K., Kaibara N.
    Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA.
  17. "Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
    Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G.
    J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ROLE IN THROPHOBLAST MIGRATION AND INVASION.
  18. "Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
    Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F.
    Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
  19. "Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
    Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A.
    J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HH8 ARG-223 AND LEU-297, VARIANT HIS-364, CHARACTERIZATION OF VARIANTS HH8 ARG-223 AND LEU-297.
  20. "Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54."
    Tenenbaum-Rakover Y., Commenges-Ducos M., Iovane A., Aumas C., Admoni O., de Roux N.
    J. Clin. Endocrinol. Metab. 92:1137-1144(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HH8 PRO-102.
  21. Cited for: VARIANT CPPB1 PRO-386, CHARACTERIZATION OF VARIANT CPPB1 PRO-386.
  22. Cited for: VARIANTS HH8 THR-189 AND ASP-194.

Entry informationi

Entry nameiKISSR_HUMAN
AccessioniPrimary (citable) accession number: Q969F8
Secondary accession number(s): A5D8U2, B2RTV1, Q96QG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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