Q969F8 (KISSR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
KiSS-1 receptor
Short name=KiSS-1R

Alternative name(s):
G-protein coupled receptor 54
G-protein coupled receptor OT7T175
Short name=hOT7T175
Hypogonadotropin-1
Kisspeptins receptor
Metastin receptor

Gene names

Name:	KISS1R
Synonyms:	AXOR12, GPR54

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins. Ref.4 Ref.17
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Most highly expressed in the pancreas, placenta and spinal cord, with lower-level of expression in peripheral blood leukocytes, kidney, lung, fetal liver, stomach, small intestine, testes, spleen, thymus, adrenal glands and lymph nodes. In the adult brain, expressed in the superior frontal gyrus, putamen, caudate nucleus, cingulate gyrus, nucleus accumbens, hippocampus, pons and amygdala, as well as the hypothalamus and pituitary. Expression levels are higher in early (7-9 weeks) than term placentas. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation. Also found in the extravillous trophoblast suggesting endocrine/paracrine activation mechanism. Ref.1 Ref.2 Ref.3 Ref.4 Ref.12 Ref.17
Induction	Expressed at higher levels in first trimester trophoblasts than at term of gestation.
Involvement in disease	Hypogonadotropic hypogonadism 8 with or without anosmia (HH8) [MIM:614837]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.14 Ref.19 Ref.20 Central precocious puberty (CEPREPU) [MIM:176400]: A condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis. Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Disease	Disease mutation Hypogonadotropic hypogonadism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of MAPKK activity Inferred from electronic annotation. Source: Compara arachidonic acid secretion Inferred from electronic annotation. Source: Compara behavior Non-traceable author statement Ref.3. Source: UniProtKB calcium-mediated signaling Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of hormone secretion Inferred from electronic annotation. Source: Compara positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara integral to membrane Inferred from direct assay Ref.3. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	neuropeptide binding Inferred from electronic annotation. Source: Compara neuropeptide receptor activity Inferred from direct assay Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	KiSS-1 receptor		PRO_0000069695
Regions
	Topological domain	1 – 46	46	Extracellular Potential
	Transmembrane	47 – 67	21	Helical; Name=1; Potential
	Topological domain	68 – 78	11	Cytoplasmic Potential
	Transmembrane	79 – 101	23	Helical; Name=2; Potential
	Topological domain	102 – 120	19	Extracellular Potential
	Transmembrane	121 – 138	18	Helical; Name=3; Potential
	Topological domain	139 – 157	19	Cytoplasmic Potential
	Transmembrane	158 – 178	21	Helical; Name=4; Potential
	Topological domain	179 – 202	24	Extracellular Potential
	Transmembrane	203 – 223	21	Helical; Name=5; Potential
	Topological domain	224 – 263	40	Cytoplasmic Potential
	Transmembrane	264 – 284	21	Helical; Name=6; Potential
	Topological domain	285 – 305	21	Extracellular Potential
	Transmembrane	306 – 328	23	Helical; Name=7; Potential
	Topological domain	329 – 398	70	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Disulfide bond	115 ↔ 191		By similarity
Natural variations
	Natural variant	102	1	L → P in HH8; absence of inositol phosphate accumulation under kisspeptin challenge; normal affinity for kisspeptin. Ref.20		VAR_043906
	Natural variant	148	1	L → S in HH8; 65% reduction of inositol phosphate production. Ref.5 Corresponds to variant rs28939719 [ dbSNP | Ensembl ].		VAR_021392
	Natural variant	223	1	C → R in HH8; exhibit profoundly impaired signaling. Ref.19		VAR_021393
	Natural variant	297	1	R → L in HH8; mild reduction in ligand-stimulated activity across the ligand dose range. Ref.19		VAR_021394
	Natural variant	364	1	L → H. Ref.1 Ref.2 Ref.4 Ref.5 Ref.8 Ref.9 Ref.19 Corresponds to variant rs350132 [ dbSNP | Ensembl ].		VAR_021395
	Natural variant	386	1	R → P in central precocious puberty; reduced rate of decline in inositol phosphate accumulation after kisspeptin stimulation; prolonged phosphorylation of ERK. Ref.21		VAR_043907

Sequences

	Sequence		Length	Mass (Da)
	Q969F8 [UniParc]. Last modified February 6, 2007. Version 2. Checksum: ECAE2208848F5B06	FASTA	398	42,586
	10 20 30 40 50 60 MHTVATSGPN ASWGAPANAS GCPGCGANAS DGPVPSPRAV DAWLVPLFFA ALMLLGLVGN 70 80 90 100 110 120 SLVIYVICRH KPMRTVTNFY IANLAATDVT FLLCCVPFTA LLYPLPGWVL GDFMCKFVNY 130 140 150 160 170 180 IQQVSVQATC ATLTAMSVDR WYVTVFPLRA LHRRTPRLAL AVSLSIWVGS AAVSAPVLAL 190 200 210 220 230 240 HRLSPGPRAY CSEAFPSRAL ERAFALYNLL ALYLLPLLAT CACYAAMLRH LGRVAVRPAP 250 260 270 280 290 300 ADSALQGQVL AERAGAVRAK VSRLVAAVVL LFAACWGPIQ LFLVLQALGP AGSWHPRSYA 310 320 330 340 350 360 AYALKTWAHC MSYSNSALNP LLYAFLGSHF RQAFRRVCPC APRRPRRPRR PGPSDPAAPH 370 380 390 AELLRLGSHP APARAQKPGS SGLAARGLCV LGEDNAPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor." Ohtaki T., Shintani Y., Honda S., Matsumoto H., Hori A., Kanehashi K., Terao Y., Kumano S., Takatsu Y., Masuda Y., Ishibashi Y., Watanabe T., Asada M., Yamada T., Suenaga M., Kitada C., Usuki S., Kurokawa T. , Onda H., Nishimura O., Fujino M. Nature 411:613-617(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
[2]	"FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54." Clements M.K., McDonald T.P., Wang R., Xie G., O'Dowd B.F., George S.R., Austin C.P., Liu Q. Biochem. Biophys. Res. Commun. 284:1189-1193(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, TISSUE SPECIFICITY.
[3]	"AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1." Muir A.I., Chamberlain L., Elshourbagy N.A., Michalovich D., Moore D.J., Calamari A., Szekeres P.G., Sarau H.M., Chambers J.K., Murdock P., Steplewski K., Shabon U., Miller J.E., Middleton S.E., Darker J.G., Larminie C.G.C., Wilson S., Bergsma D.J. , Emson P., Faull R., Philpott K.L., Harrison D.C. J. Biol. Chem. 276:28969-28975(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[4]	"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54." Kotani M., Detheux M., Vandenbogaerde A., Communi D., Vanderwinden J.-M., Le Poul E., Brezillon S., Tyldesley R., Suarez-Huerta N., Vandeput F., Blanpain C., Schiffmann S.N., Vassart G., Parmentier M. J. Biol. Chem. 276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-364, POSSIBLE FUNCTION, TISSUE SPECIFICITY. Tissue: Hypothalamus.
[5]	"The GPR54 gene as a regulator of puberty." Seminara S.B., Messager S., Chatzidaki E.E., Thresher R.R., Acierno J.S. Jr., Shagoury J.K., Bo-Abbas Y., Kuohung W., Schwinof K.M., Hendrick A.G., Zahn D., Dixon J., Kaiser U.B., Slaugenhaupt S.A., Gusella J.F., O'Rahilly S., Carlton M.B.L., Crowley W.F. Jr., Aparicio S.A.J.R., Colledge W.H. N. Engl. J. Med. 349:1614-1627(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HH8 SER-148, VARIANT HIS-364.
[6]	"Isolation of cDNA coding for human KISS1 receptor (KISS1R)." Kaighin V.A., Martin A.L., Aronstam R.S. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[7]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-364.
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-364.
[10]	"GPR54 and puberty." Colledge W.H. Trends Endocrinol. Metab. 15:448-453(2004) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[11]	"Metastin suppresses the motility and growth of CHO cells transfected with its receptor." Hori A., Honda S., Asada M., Ohtaki T., Oda K., Watanabe T., Shintani Y., Yamada T., Suenaga M., Kitada C., Onda H., Kurokawa T., Nishimura O., Fujino M. Biochem. Biophys. Res. Commun. 286:958-963(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION.
[12]	"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells." Janneau J.-L., Maldonado-Estrada J., Tachdjian G., Miran I., Motte N., Saulnier P., Sabourin J.-C., Cote J.-F., Simon B., Frydman R., Chaouat G., Bellet D. J. Clin. Endocrinol. Metab. 87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS.
[13]	"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells." Ringel M.D., Hardy E., Bernet V.J., Burch H.B., Schuppert F., Burman K.D., Saji M. J. Clin. Endocrinol. Metab. 87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN THYROID CANCER.
[14]	"Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54." de Roux N., Genin E., Carel J.-C., Matsuda F., Chaussain J.-L., Milgrom E. Proc. Natl. Acad. Sci. U.S.A. 100:10972-10976(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN HH8.
[15]	"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma." Ikeguchi M., Hirooka Y., Kaibara N. J. Cancer Res. Clin. Oncol. 129:531-535(2003) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA.
[16]	"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma." Ikeguchi M., Yamaguchi K., Kaibara N. Clin. Cancer Res. 10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA.
[17]	"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts." Bilban M., Ghaffari-Tabrizi N., Hintermann E., Bauer S., Molzer S., Zoratti C., Malli R., Sharabi A., Hiden U., Graier W., Knoefler M., Andreae F., Wagner O., Quaranta V., Desoye G. J. Cell Sci. 117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, ROLE IN THROPHOBLAST MIGRATION AND INVASION.
[18]	"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors." Becker J.A.J., Mirjolet J.-F., Bernard J., Burgeon E., Simons M.-J., Vassart G., Parmentier M., Libert F. Biochem. Biophys. Res. Commun. 326:677-686(2005) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES.
[19]	"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism." Semple R.K., Achermann J.C., Ellery J., Farooqi I.S., Karet F.E., Stanhope R.G., O'rahilly S., Aparicio S.A. J. Clin. Endocrinol. Metab. 90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS HH8 ARG-223 AND LEU-297, VARIANT HIS-364, CHARACTERIZATION OF VARIANTS HH8 ARG-223 AND LEU-297.
[20]	"Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54." Tenenbaum-Rakover Y., Commenges-Ducos M., Iovane A., Aumas C., Admoni O., de Roux N. J. Clin. Endocrinol. Metab. 92:1137-1144(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT HH8 PRO-102.
[21]	"A GPR54-activating mutation in a patient with central precocious puberty." Teles M.G., Bianco S.D.C., Brito V.N., Trarbach E.B., Kuohung W., Xu S., Seminara S.B., Mendonca B.B., Kaiser U.B., Latronico A.C. N. Engl. J. Med. 358:709-715(2008) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CENTRAL PRECOCIOUS PUBERTY PRO-386, CHARACTERIZATION OF VARIANT CENTRAL PRECOCIOUS PUBERTY PRO-386.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Tintin's blight - Issue 58 of May 2005

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051065 mRNA. Translation: BAB55446.1. AF343725 mRNA. Translation: AAK83235.1. AJ309020 mRNA. Translation: CAC40817.1. AY029541 mRNA. Translation: AAK33126.1. AY253981 mRNA. Translation: AAP82929.1. AY253982 mRNA. Translation: AAP82930.1. EU883577 mRNA. Translation: ACG60651.1. AC005379 Genomic DNA. No translation available. CH471139 Genomic DNA. Translation: EAW69583.1. BC140825 mRNA. Translation: AAI40826.1. BC141812 mRNA. Translation: AAI41813.1.
IPI	IPI00099988.
RefSeq	NP_115940.2. NM_032551.4.
UniGene	Hs.208229.
3D structure databases
ProteinModelPortal	Q969F8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000234371.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	125987836.
Proteomic databases
PaxDb	Q969F8.
PRIDE	Q969F8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000234371; ENSP00000234371; ENSG00000116014.
GeneID	84634.
KEGG	hsa:84634.
UCSC	uc002lqk.4. human.
Organism-specific databases
CTD	84634.
GeneCards	GC19P000917.
HGNC	HGNC:4510. KISS1R.
MIM	176400. phenotype. 604161. gene. 614837. phenotype.
neXtProt	NX_Q969F8.
Orphanet	432. Normosmic congenital hypogonadotropic hypogonadism.
PharmGKB	PA28899.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG296869.
HOGENOM	HOG000230487.
HOVERGEN	HBG106952.
InParanoid	Q969F8.
KO	K08374.
OMA	GSWHPRS.
OrthoDB	EOG483D51.
PhylomeDB	Q969F8.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q969F8.
CleanEx	HS_KISS1R.
Genevestigator	Q969F8.
GermOnline	ENSG00000116014. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008103. KiSS_1_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01728. KISS1RECEPTR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q969F8.
ChEMBL	CHEMBL5413.
GenomeRNAi	84634.
NextBio	74561.
SOURCE	Search...

Entry information

Entry name

KISSR_HUMAN

Accession

Primary (citable) accession number: Q969F8
Secondary accession number(s): A5D8U2, B2RTV1, Q96QG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.