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Protein

General transcription factor 3C polypeptide 6

Gene

GTF3C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.1 Publication

GO - Molecular functioni

GO - Biological processi

  • 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
  • transcription, DNA-templated Source: HGNC
  • transcription from RNA polymerase III promoter Source: HGNC
  • tRNA transcription from RNA polymerase III promoter Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155115-MONOMER.
ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 6
Alternative name(s):
Transcription factor IIIC 35 kDa subunit
Short name:
TFIIIC 35 kDa subunit
Short name:
TFIIIC35
Transcription factor IIIC subunit 6
Gene namesi
Name:GTF3C6
Synonyms:C6orf51
ORF Names:CDA020, NPD020
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20872. GTF3C6.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • transcription factor TFIIIC complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155115.
PharmGKBiPA162390481.

Polymorphism and mutation databases

BioMutaiGTF3C6.
DMDMi30580360.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000895072 – 213General transcription factor 3C polypeptide 6Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ969F1.
MaxQBiQ969F1.
PaxDbiQ969F1.
PeptideAtlasiQ969F1.
PRIDEiQ969F1.

PTM databases

iPTMnetiQ969F1.
PhosphoSitePlusiQ969F1.

Expressioni

Gene expression databases

BgeeiENSG00000155115.
CleanExiHS_GTF3C6.
GenevisibleiQ969F1. HS.

Organism-specific databases

HPAiHPA056179.
HPA061345.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with GTF3C4 and GTF3C5.1 Publication

Protein-protein interaction databases

BioGridi125192. 12 interactors.
IntActiQ969F1. 1 interactor.
STRINGi9606.ENSP00000357863.

Structurei

3D structure databases

ProteinModelPortaliQ969F1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIIC subunit 6 family.Curated

Phylogenomic databases

eggNOGiENOG410IFFM. Eukaryota.
ENOG4111V4R. LUCA.
GeneTreeiENSGT00390000000510.
HOGENOMiHOG000037444.
HOVERGENiHBG050905.
InParanoidiQ969F1.
KOiK15203.
OMAiCVFAGEY.
OrthoDBiEOG091G10KF.
PhylomeDBiQ969F1.
TreeFamiTF329713.

Family and domain databases

InterProiIPR019481. TFIIIC_tau55-rel.
[Graphical view]
PfamiPF10419. TFIIIC_sub6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAADERSP EDGEDEEEEE QLVLVELSGI IDSDFLSKCE NKCKVLGIDT
60 70 80 90 100
ERPILQVDSC VFAGEYEDTL GTCVIFEENV EHADTEGNNK TVLKYKCHTM
110 120 130 140 150
KKLSMTRTLL TEKKEGEENI GGVEWLQIKD NDFSYRPNMI CNFLHENEDE
160 170 180 190 200
EVVASAPDKS LELEEEEIQM NDSSNLSCEQ EKPMHLEIED SGPLIDIPSE
210
TEGSVFMETQ MLP
Length:213
Mass (Da):24,049
Last modified:December 1, 2001 - v1
Checksum:iF2EC5E97B42B6FB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF137904 mRNA. Translation: ABO33431.1.
AF361492 mRNA. Translation: AAL57217.1.
AF361496 mRNA. Translation: AAL57221.1.
AK057977 mRNA. Translation: BAB71624.1.
AL357515 Genomic DNA. Translation: CAH73393.1.
CH471051 Genomic DNA. Translation: EAW48305.1.
BC011593 mRNA. Translation: AAH11593.1.
CCDSiCCDS5087.1.
RefSeqiNP_612417.1. NM_138408.3.
UniGeneiHs.418520.

Genome annotation databases

EnsembliENST00000329970; ENSP00000357863; ENSG00000155115.
GeneIDi112495.
KEGGihsa:112495.
UCSCiuc003pum.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF137904 mRNA. Translation: ABO33431.1.
AF361492 mRNA. Translation: AAL57217.1.
AF361496 mRNA. Translation: AAL57221.1.
AK057977 mRNA. Translation: BAB71624.1.
AL357515 Genomic DNA. Translation: CAH73393.1.
CH471051 Genomic DNA. Translation: EAW48305.1.
BC011593 mRNA. Translation: AAH11593.1.
CCDSiCCDS5087.1.
RefSeqiNP_612417.1. NM_138408.3.
UniGeneiHs.418520.

3D structure databases

ProteinModelPortaliQ969F1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125192. 12 interactors.
IntActiQ969F1. 1 interactor.
STRINGi9606.ENSP00000357863.

PTM databases

iPTMnetiQ969F1.
PhosphoSitePlusiQ969F1.

Polymorphism and mutation databases

BioMutaiGTF3C6.
DMDMi30580360.

Proteomic databases

EPDiQ969F1.
MaxQBiQ969F1.
PaxDbiQ969F1.
PeptideAtlasiQ969F1.
PRIDEiQ969F1.

Protocols and materials databases

DNASUi112495.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329970; ENSP00000357863; ENSG00000155115.
GeneIDi112495.
KEGGihsa:112495.
UCSCiuc003pum.4. human.

Organism-specific databases

CTDi112495.
GeneCardsiGTF3C6.
HGNCiHGNC:20872. GTF3C6.
HPAiHPA056179.
HPA061345.
MIMi611784. gene.
neXtProtiNX_Q969F1.
OpenTargetsiENSG00000155115.
PharmGKBiPA162390481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFM. Eukaryota.
ENOG4111V4R. LUCA.
GeneTreeiENSGT00390000000510.
HOGENOMiHOG000037444.
HOVERGENiHBG050905.
InParanoidiQ969F1.
KOiK15203.
OMAiCVFAGEY.
OrthoDBiEOG091G10KF.
PhylomeDBiQ969F1.
TreeFamiTF329713.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155115-MONOMER.
ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSiGTF3C6. human.
GenomeRNAii112495.
PROiQ969F1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155115.
CleanExiHS_GTF3C6.
GenevisibleiQ969F1. HS.

Family and domain databases

InterProiIPR019481. TFIIIC_tau55-rel.
[Graphical view]
PfamiPF10419. TFIIIC_sub6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C6_HUMAN
AccessioniPrimary (citable) accession number: Q969F1
Secondary accession number(s): Q5VXN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.