ID   FATE1_HUMAN             Reviewed;         183 AA.
AC   Q969F0;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 161.
DE   RecName: Full=Fetal and adult testis-expressed transcript protein;
DE   AltName: Full=Cancer/testis antigen 43;
DE            Short=CT43;
DE   AltName: Full=Tumor antigen BJ-HCC-2;
GN   Name=FATE1; Synonyms=FATE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Testis;
RX   PubMed=11694338; DOI=10.1016/s0303-7207(01)00666-9;
RA   Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.;
RT   "Human FATE is a novel X-linked gene expressed in fetal and adult testis.";
RL   Mol. Cell. Endocrinol. 184:25-32(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12865919; DOI=10.1038/sj.bjc.6601062;
RA   Dong X.Y., Su Y.R., Qian X.P., Yang X.A., Pang X.W., Wu H.Y., Chen W.F.;
RT   "Identification of two novel CT antigens and their capacity to elicit
RT   antibody response in hepatocellular carcinoma patients.";
RL   Br. J. Cancer 89:291-297(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, INTERACTION WITH BIK AND RNF183, SUBCELLULAR LOCATION, AND
RP   MUTAGENESIS OF LEU-151.
RX   PubMed=26567849; DOI=10.1038/ncomms9840;
RA   Maxfield K.E., Taus P.J., Corcoran K., Wooten J., Macion J., Zhou Y.,
RA   Borromeo M., Kollipara R.K., Yan J., Xie Y., Xie X.J., Whitehurst A.W.;
RT   "Comprehensive functional characterization of cancer-testis antigens
RT   defines obligate participation in multiple hallmarks of cancer.";
RL   Nat. Commun. 6:8840-8840(2015).
RN   [6]
RP   SUBCELLULAR LOCATION, AND INTERACTION WITH IMMT AND EMD.
RX   PubMed=27402544; DOI=10.15252/embr.201541504;
RA   Doghman-Bouguerra M., Granatiero V., Sbiera S., Sbiera I.,
RA   Lacas-Gervais S., Brau F., Fassnacht M., Rizzuto R., Lalli E.;
RT   "FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and
RT   mitochondria.";
RL   EMBO Rep. 17:1264-1280(2016).
RN   [7]
RP   VARIANTS VAL-10; THR-34 AND ARG-125.
RX   PubMed=12811541; DOI=10.1007/s00439-003-0974-9;
RA   Olesen C., Silber J., Eiberg H., Ernst E., Petersen K., Lindenberg S.,
RA   Tommerup N.;
RT   "Mutational analysis of the human FATE gene in 144 infertile men.";
RL   Hum. Genet. 113:195-201(2003).
CC   -!- FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-
CC       mitochondria coupling. Negatively regulates the ER-mitochondria
CC       distance and Ca(2+) transfer from ER to mitochondria possibly
CC       implicating it in the regulation of apoptosis (PubMed:27402544). May
CC       collaborate with RNF183 to restrain BIK protein levels thus regulating
CC       apoptotic signaling (PubMed:26567849). {ECO:0000269|PubMed:27402544,
CC       ECO:0000305|PubMed:26567849}.
CC   -!- SUBUNIT: Interacts with BIK and RNF183 (PubMed:26567849). Interacts
CC       with IMMT/MIC60and EMD (PubMed:27402544). {ECO:0000269|PubMed:26567849,
CC       ECO:0000269|PubMed:27402544}.
CC   -!- INTERACTION:
CC       Q969F0; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-743099, EBI-741181;
CC       Q969F0; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-743099, EBI-11522760;
CC       Q969F0; O95236-2: APOL3; NbExp=3; IntAct=EBI-743099, EBI-11976321;
CC       Q969F0; Q6FGT0: AQP9; NbExp=3; IntAct=EBI-743099, EBI-10249621;
CC       Q969F0; P07307-3: ASGR2; NbExp=3; IntAct=EBI-743099, EBI-12808270;
CC       Q969F0; A0A0S2Z5Y8: ATCAY; NbExp=3; IntAct=EBI-743099, EBI-16432496;
CC       Q969F0; Q92843: BCL2L2; NbExp=6; IntAct=EBI-743099, EBI-707714;
CC       Q969F0; Q13323: BIK; NbExp=8; IntAct=EBI-743099, EBI-700794;
CC       Q969F0; Q12982: BNIP2; NbExp=6; IntAct=EBI-743099, EBI-752094;
CC       Q969F0; Q12983: BNIP3; NbExp=6; IntAct=EBI-743099, EBI-749464;
CC       Q969F0; O60238: BNIP3L; NbExp=3; IntAct=EBI-743099, EBI-849893;
CC       Q969F0; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-743099, EBI-8648738;
CC       Q969F0; Q86Z23: C1QL4; NbExp=3; IntAct=EBI-743099, EBI-12062109;
CC       Q969F0; Q9BXU9: CALN1; NbExp=3; IntAct=EBI-743099, EBI-12187137;
CC       Q969F0; Q6NSX1: CCDC70; NbExp=7; IntAct=EBI-743099, EBI-6873045;
CC       Q969F0; P11912: CD79A; NbExp=6; IntAct=EBI-743099, EBI-7797864;
CC       Q969F0; Q01151: CD83; NbExp=3; IntAct=EBI-743099, EBI-2873723;
CC       Q969F0; Q16543: CDC37; NbExp=3; IntAct=EBI-743099, EBI-295634;
CC       Q969F0; Q9HA82: CERS4; NbExp=3; IntAct=EBI-743099, EBI-2622997;
CC       Q969F0; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-743099, EBI-852194;
CC       Q969F0; P15509: CSF2RA; NbExp=3; IntAct=EBI-743099, EBI-1763264;
CC       Q969F0; P40313: CTRL; NbExp=3; IntAct=EBI-743099, EBI-7883667;
CC       Q969F0; P25024: CXCR1; NbExp=3; IntAct=EBI-743099, EBI-3905522;
CC       Q969F0; P49682-3: CXCR3; NbExp=3; IntAct=EBI-743099, EBI-16432539;
CC       Q969F0; Q9BTE1: DCTN5; NbExp=3; IntAct=EBI-743099, EBI-747324;
CC       Q969F0; Q96LL9: DNAJC30; NbExp=3; IntAct=EBI-743099, EBI-8639143;
CC       Q969F0; P50402: EMD; NbExp=10; IntAct=EBI-743099, EBI-489887;
CC       Q969F0; Q8N128-2: FAM177A1; NbExp=3; IntAct=EBI-743099, EBI-12201693;
CC       Q969F0; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-743099, EBI-18304435;
CC       Q969F0; Q969F0: FATE1; NbExp=3; IntAct=EBI-743099, EBI-743099;
CC       Q969F0; Q9BZ67: FRMD8; NbExp=3; IntAct=EBI-743099, EBI-5773072;
CC       Q969F0; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-743099, EBI-6166686;
CC       Q969F0; Q9NU53: GINM1; NbExp=3; IntAct=EBI-743099, EBI-12204961;
CC       Q969F0; O14653: GOSR2; NbExp=3; IntAct=EBI-743099, EBI-4401517;
CC       Q969F0; O00155: GPR25; NbExp=5; IntAct=EBI-743099, EBI-10178951;
CC       Q969F0; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-743099, EBI-18053395;
CC       Q969F0; Q9BT40: INPP5K; NbExp=7; IntAct=EBI-743099, EBI-749162;
CC       Q969F0; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-743099, EBI-749265;
CC       Q969F0; Q9ULS6: KCNS2; NbExp=6; IntAct=EBI-743099, EBI-10323864;
CC       Q969F0; Q9UIQ6: LNPEP; NbExp=3; IntAct=EBI-743099, EBI-2805360;
CC       Q969F0; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-743099, EBI-12133176;
CC       Q969F0; Q8N386: LRRC25; NbExp=3; IntAct=EBI-743099, EBI-11304917;
CC       Q969F0; O60449-3: LY75; NbExp=3; IntAct=EBI-743099, EBI-10186753;
CC       Q969F0; Q9P0N8: MARCHF2; NbExp=6; IntAct=EBI-743099, EBI-10317612;
CC       Q969F0; Q86UD3: MARCHF3; NbExp=3; IntAct=EBI-743099, EBI-2341065;
CC       Q969F0; Q9NX47: MARCHF5; NbExp=4; IntAct=EBI-743099, EBI-2341610;
CC       Q969F0; Q8N4S9: MARVELD2; NbExp=3; IntAct=EBI-743099, EBI-6875061;
CC       Q969F0; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-743099, EBI-11956541;
CC       Q969F0; O75425: MOSPD3; NbExp=3; IntAct=EBI-743099, EBI-12179105;
CC       Q969F0; Q95460: MR1; NbExp=3; IntAct=EBI-743099, EBI-10280401;
CC       Q969F0; Q95460-2: MR1; NbExp=3; IntAct=EBI-743099, EBI-12201447;
CC       Q969F0; Q9NX14: NDUFB11; NbExp=6; IntAct=EBI-743099, EBI-1246182;
CC       Q969F0; Q8WWG1: NRG4; NbExp=7; IntAct=EBI-743099, EBI-8637292;
CC       Q969F0; Q8IZ57: NRSN1; NbExp=3; IntAct=EBI-743099, EBI-10264528;
CC       Q969F0; Q7RTS6: OTOP2; NbExp=4; IntAct=EBI-743099, EBI-7642372;
CC       Q969F0; Q9Y237: PIN4; NbExp=3; IntAct=EBI-743099, EBI-714599;
CC       Q969F0; Q99640-2: PKMYT1; NbExp=3; IntAct=EBI-743099, EBI-12257782;
CC       Q969F0; Q04941: PLP2; NbExp=3; IntAct=EBI-743099, EBI-608347;
CC       Q969F0; Q8TAS3: PRRG2; NbExp=6; IntAct=EBI-743099, EBI-10272071;
CC       Q969F0; Q8N0V3: RBFA; NbExp=3; IntAct=EBI-743099, EBI-3232108;
CC       Q969F0; Q7Z5B4-5: RIC3; NbExp=3; IntAct=EBI-743099, EBI-12375429;
CC       Q969F0; Q96D59: RNF183; NbExp=4; IntAct=EBI-743099, EBI-743938;
CC       Q969F0; Q9NS64: RPRM; NbExp=6; IntAct=EBI-743099, EBI-1052363;
CC       Q969F0; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-743099, EBI-10244780;
CC       Q969F0; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-743099, EBI-2695784;
CC       Q969F0; Q96IW7: SEC22A; NbExp=6; IntAct=EBI-743099, EBI-8652744;
CC       Q969F0; Q9BRL7: SEC22C; NbExp=6; IntAct=EBI-743099, EBI-10297029;
CC       Q969F0; Q15436: SEC23A; NbExp=3; IntAct=EBI-743099, EBI-81088;
CC       Q969F0; Q15437: SEC23B; NbExp=3; IntAct=EBI-743099, EBI-742673;
CC       Q969F0; Q9H2H9: SLC38A1; NbExp=6; IntAct=EBI-743099, EBI-9978441;
CC       Q969F0; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-743099, EBI-10290130;
CC       Q969F0; P30825: SLC7A1; NbExp=6; IntAct=EBI-743099, EBI-4289564;
CC       Q969F0; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-743099, EBI-5235586;
CC       Q969F0; Q96QK8: SMIM14; NbExp=4; IntAct=EBI-743099, EBI-373430;
CC       Q969F0; Q5SQN1: SNAP47; NbExp=3; IntAct=EBI-743099, EBI-10244848;
CC       Q969F0; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-743099, EBI-17280858;
CC       Q969F0; Q9H7V2: SYNDIG1; NbExp=6; IntAct=EBI-743099, EBI-726331;
CC       Q969F0; Q8N205: SYNE4; NbExp=5; IntAct=EBI-743099, EBI-7131783;
CC       Q969F0; O43759: SYNGR1; NbExp=3; IntAct=EBI-743099, EBI-6269521;
CC       Q969F0; O43759-2: SYNGR1; NbExp=6; IntAct=EBI-743099, EBI-12187159;
CC       Q969F0; Q8TBG9: SYNPR; NbExp=3; IntAct=EBI-743099, EBI-10273251;
CC       Q969F0; Q9NPL8: TIMMDC1; NbExp=4; IntAct=EBI-743099, EBI-6268651;
CC       Q969F0; P48230: TM4SF4; NbExp=3; IntAct=EBI-743099, EBI-8650934;
CC       Q969F0; P17152: TMEM11; NbExp=4; IntAct=EBI-743099, EBI-723946;
CC       Q969F0; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-743099, EBI-11724423;
CC       Q969F0; Q5SNT2-2: TMEM201; NbExp=3; IntAct=EBI-743099, EBI-11994282;
CC       Q969F0; Q96NL1: TMEM74; NbExp=3; IntAct=EBI-743099, EBI-10292091;
CC       Q969F0; Q9Y228: TRAF3IP3; NbExp=6; IntAct=EBI-743099, EBI-765817;
CC       Q969F0; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-743099, EBI-10180829;
CC       Q969F0; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-743099, EBI-4401271;
CC       Q969F0; A0A024R8A9: USP20; NbExp=3; IntAct=EBI-743099, EBI-14096082;
CC       Q969F0; Q9Y2K6: USP20; NbExp=3; IntAct=EBI-743099, EBI-2511991;
CC       Q969F0; Q9Y279: VSIG4; NbExp=3; IntAct=EBI-743099, EBI-903131;
CC       Q969F0; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-743099, EBI-12190699;
CC       Q969F0; Q9BSR8: YIPF4; NbExp=6; IntAct=EBI-743099, EBI-751253;
CC       Q969F0; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-743099, EBI-748373;
CC       Q969F0; O95159: ZFPL1; NbExp=3; IntAct=EBI-743099, EBI-718439;
CC       Q969F0; P14079: tax; Xeno; NbExp=3; IntAct=EBI-743099, EBI-9675698;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26567849,
CC       ECO:0000269|PubMed:27402544}. Mitochondrion outer membrane
CC       {ECO:0000269|PubMed:27402544}. Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:27402544}; Single-pass membrane protein
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:27402544}.
CC       Note=Localized to specific membrane structures termed mitochondria-
CC       associated membranes (MAMs) which connect the endoplasmic reticulum
CC       (ER) and the mitochondria. Also associated with the outer surface of
CC       mitochondria at sites that are not in close contact with the ER.
CC       {ECO:0000269|PubMed:27402544}.
CC   -!- TISSUE SPECIFICITY: Testis-specific in fetus (aged from 6 to 11 weeks).
CC       In adult, expressed predominantly in testis, with some expression in
CC       lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338).
CC       Highly expressed in certain types of cancer tissues such as
CC       hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in
CC       normal pancreas (PubMed:12865919). {ECO:0000269|PubMed:11694338,
CC       ECO:0000269|PubMed:12865919}.
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DR   EMBL; AF249872; AAK69024.1; -; mRNA.
DR   EMBL; AY101182; AAM48744.1; -; mRNA.
DR   EMBL; AK057369; BAB71454.1; -; mRNA.
DR   EMBL; BC022064; AAH22064.1; -; mRNA.
DR   CCDS; CCDS14700.1; -.
DR   RefSeq; NP_149076.1; NM_033085.2.
DR   AlphaFoldDB; Q969F0; -.
DR   SMR; Q969F0; -.
DR   BioGRID; 124636; 112.
DR   IntAct; Q969F0; 101.
DR   MINT; Q969F0; -.
DR   STRING; 9606.ENSP00000359375; -.
DR   BioMuta; FATE1; -.
DR   DMDM; 37078481; -.
DR   MassIVE; Q969F0; -.
DR   PaxDb; 9606-ENSP00000359375; -.
DR   PeptideAtlas; Q969F0; -.
DR   ProteomicsDB; 75746; -.
DR   Antibodypedia; 30697; 354 antibodies from 22 providers.
DR   DNASU; 89885; -.
DR   Ensembl; ENST00000370350.7; ENSP00000359375.3; ENSG00000147378.11.
DR   GeneID; 89885; -.
DR   KEGG; hsa:89885; -.
DR   MANE-Select; ENST00000370350.7; ENSP00000359375.3; NM_033085.3; NP_149076.1.
DR   UCSC; uc004fex.4; human.
DR   AGR; HGNC:24683; -.
DR   CTD; 89885; -.
DR   DisGeNET; 89885; -.
DR   GeneCards; FATE1; -.
DR   HGNC; HGNC:24683; FATE1.
DR   HPA; ENSG00000147378; Tissue enriched (testis).
DR   MIM; 300450; gene.
DR   neXtProt; NX_Q969F0; -.
DR   OpenTargets; ENSG00000147378; -.
DR   PharmGKB; PA134875203; -.
DR   VEuPathDB; HostDB:ENSG00000147378; -.
DR   eggNOG; ENOG502SRT6; Eukaryota.
DR   GeneTree; ENSGT00390000006832; -.
DR   HOGENOM; CLU_129363_0_0_1; -.
DR   InParanoid; Q969F0; -.
DR   OMA; MEHGSQS; -.
DR   OrthoDB; 4268839at2759; -.
DR   PhylomeDB; Q969F0; -.
DR   TreeFam; TF338514; -.
DR   PathwayCommons; Q969F0; -.
DR   SignaLink; Q969F0; -.
DR   BioGRID-ORCS; 89885; 9 hits in 771 CRISPR screens.
DR   ChiTaRS; FATE1; human.
DR   GeneWiki; FATE1; -.
DR   GenomeRNAi; 89885; -.
DR   Pharos; Q969F0; Tbio.
DR   PRO; PR:Q969F0; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q969F0; Protein.
DR   Bgee; ENSG00000147378; Expressed in right testis and 105 other cell types or tissues.
DR   ExpressionAtlas; Q969F0; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; IDA:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IDA:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
DR   GO; GO:0051562; P:negative regulation of mitochondrial calcium ion concentration; IDA:UniProtKB.
DR   InterPro; IPR039153; FATE1.
DR   InterPro; IPR039433; Mff-like_dom.
DR   PANTHER; PTHR21128; FETAL AND ADULT TESTIS-EXPRESSED TRANSCRIPT PROTEIN; 1.
DR   PANTHER; PTHR21128:SF0; FETAL AND ADULT TESTIS-EXPRESSED TRANSCRIPT PROTEIN; 1.
DR   Pfam; PF05644; Miff; 1.
DR   Genevisible; Q969F0; HS.
PE   1: Evidence at protein level;
KW   Apoptosis; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..183
FT                   /note="Fetal and adult testis-expressed transcript protein"
FT                   /id="PRO_0000087200"
FT   TRANSMEM        163..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          42..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         10
FT                   /note="A -> V (16% of the population; infertile and fertile
FT                   individuals; dbSNP:rs3810715)"
FT                   /evidence="ECO:0000269|PubMed:12811541"
FT                   /id="VAR_016917"
FT   VARIANT         34
FT                   /note="I -> T (in fertile and infertile individuals)"
FT                   /evidence="ECO:0000269|PubMed:12811541"
FT                   /id="VAR_016918"
FT   VARIANT         125
FT                   /note="S -> R (in fertile and infertile individuals;
FT                   dbSNP:rs141497002)"
FT                   /evidence="ECO:0000269|PubMed:12811541"
FT                   /id="VAR_016919"
FT   MUTAGEN         151
FT                   /note="L->D: Impairs association with mitochondria."
FT                   /evidence="ECO:0000269|PubMed:27402544"
SQ   SEQUENCE   183 AA;  20712 MW;  F3448EDCBCD148CB CRC64;
     MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK KQKLEQKAAG
     SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE YAGNFQGIRF HYDRNPGTDA
     VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA LEEQGATWRH RETLIIAVLV SASIANLWLW
     MNQ
//