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Q969F0

- FATE1_HUMAN

UniProt

Q969F0 - FATE1_HUMAN

Protein

Fetal and adult testis-expressed transcript protein

Gene

FATE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fetal and adult testis-expressed transcript protein
    Alternative name(s):
    Cancer/testis antigen 43
    Short name:
    CT43
    Tumor antigen BJ-HCC-2
    Gene namesi
    Name:FATE1
    Synonyms:FATE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:24683. FATE1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: LIFEdb
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134875203.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Fetal and adult testis-expressed transcript proteinPRO_0000087200Add
    BLAST

    Proteomic databases

    PaxDbiQ969F0.
    PRIDEiQ969F0.

    Expressioni

    Tissue specificityi

    Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain.

    Gene expression databases

    ArrayExpressiQ969F0.
    BgeeiQ969F0.
    CleanExiHS_FATE1.
    GenevestigatoriQ969F0.

    Organism-specific databases

    HPAiHPA034604.

    Interactioni

    Protein-protein interaction databases

    BioGridi124636. 5 interactions.
    IntActiQ969F0. 11 interactions.
    MINTiMINT-1474102.
    STRINGi9606.ENSP00000359375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969F0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18119HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45167.
    HOGENOMiHOG000293282.
    HOVERGENiHBG051556.
    InParanoidiQ969F0.
    OMAiWNMTATR.
    OrthoDBiEOG7XM308.
    PhylomeDBiQ969F0.
    TreeFamiTF338514.

    Family and domain databases

    InterProiIPR008518. FATE/Miff/Tango-11.
    [Graphical view]
    PfamiPF05644. Miff. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q969F0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK    50
    KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE 100
    YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA 150
    LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ 183
    Length:183
    Mass (Da):20,712
    Last modified:December 1, 2001 - v1
    Checksum:iF3448EDCBCD148CB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 Publication
    Corresponds to variant rs3810715 [ dbSNP | Ensembl ].
    VAR_016917
    Natural varianti34 – 341I → T in fertile and infertile individuals. 1 Publication
    VAR_016918
    Natural varianti125 – 1251S → R in fertile and infertile individuals. 1 Publication
    VAR_016919

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249872 mRNA. Translation: AAK69024.1.
    AY101182 mRNA. Translation: AAM48744.1.
    AK057369 mRNA. Translation: BAB71454.1.
    BC022064 mRNA. Translation: AAH22064.1.
    CCDSiCCDS14700.1.
    RefSeqiNP_149076.1. NM_033085.2.
    UniGeneiHs.301960.

    Genome annotation databases

    EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
    GeneIDi89885.
    KEGGihsa:89885.
    UCSCiuc004fex.3. human.

    Polymorphism databases

    DMDMi37078481.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF249872 mRNA. Translation: AAK69024.1 .
    AY101182 mRNA. Translation: AAM48744.1 .
    AK057369 mRNA. Translation: BAB71454.1 .
    BC022064 mRNA. Translation: AAH22064.1 .
    CCDSi CCDS14700.1.
    RefSeqi NP_149076.1. NM_033085.2.
    UniGenei Hs.301960.

    3D structure databases

    ProteinModelPortali Q969F0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124636. 5 interactions.
    IntActi Q969F0. 11 interactions.
    MINTi MINT-1474102.
    STRINGi 9606.ENSP00000359375.

    Polymorphism databases

    DMDMi 37078481.

    Proteomic databases

    PaxDbi Q969F0.
    PRIDEi Q969F0.

    Protocols and materials databases

    DNASUi 89885.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370350 ; ENSP00000359375 ; ENSG00000147378 .
    GeneIDi 89885.
    KEGGi hsa:89885.
    UCSCi uc004fex.3. human.

    Organism-specific databases

    CTDi 89885.
    GeneCardsi GC0XP150884.
    HGNCi HGNC:24683. FATE1.
    HPAi HPA034604.
    MIMi 300450. gene.
    neXtProti NX_Q969F0.
    PharmGKBi PA134875203.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45167.
    HOGENOMi HOG000293282.
    HOVERGENi HBG051556.
    InParanoidi Q969F0.
    OMAi WNMTATR.
    OrthoDBi EOG7XM308.
    PhylomeDBi Q969F0.
    TreeFami TF338514.

    Miscellaneous databases

    ChiTaRSi FATE1. human.
    GeneWikii FATE1.
    GenomeRNAii 89885.
    NextBioi 76405.
    PROi Q969F0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969F0.
    Bgeei Q969F0.
    CleanExi HS_FATE1.
    Genevestigatori Q969F0.

    Family and domain databases

    InterProi IPR008518. FATE/Miff/Tango-11.
    [Graphical view ]
    Pfami PF05644. Miff. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human FATE is a novel X-linked gene expressed in fetal and adult testis."
      Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.
      Mol. Cell. Endocrinol. 184:25-32(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "BJ-HCC-2, a tumor-associated gene which is expressed only in the normal pancreas and testis."
      Dong X.-Y., Chen W.-F.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Mutational analysis of the human FATE gene in 144 infertile men."
      Olesen C., Silber J., Eiberg H., Ernst E., Petersen K., Lindenberg S., Tommerup N.
      Hum. Genet. 113:195-201(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-10; THR-34 AND ARG-125.

    Entry informationi

    Entry nameiFATE1_HUMAN
    AccessioniPrimary (citable) accession number: Q969F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3