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Q969F0 (FATE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fetal and adult testis-expressed transcript protein
Alternative name(s):
Cancer/testis antigen 43
Short name=CT43
Tumor antigen BJ-HCC-2
Gene names
Name:FATE1
Synonyms:FATE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Fetal and adult testis-expressed transcript protein
PRO_0000087200

Regions

Transmembrane163 – 18119Helical; Potential

Natural variations

Natural variant101A → V Common polymorphism; 16% of the population; infertile and fertile individuals. Ref.5
Corresponds to variant rs3810715 [ dbSNP | Ensembl ].
VAR_016917
Natural variant341I → T in fertile and infertile individuals. Ref.5
VAR_016918
Natural variant1251S → R in fertile and infertile individuals. Ref.5
VAR_016919

Sequences

Sequence LengthMass (Da)Tools
Q969F0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: F3448EDCBCD148CB

FASTA18320,712
        10         20         30         40         50         60 
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK KQKLEQKAAG 

        70         80         90        100        110        120 
SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE YAGNFQGIRF HYDRNPGTDA 

       130        140        150        160        170        180 
VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA LEEQGATWRH RETLIIAVLV SASIANLWLW 


MNQ 

« Hide

References

« Hide 'large scale' references
[1]"Human FATE is a novel X-linked gene expressed in fetal and adult testis."
Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.
Mol. Cell. Endocrinol. 184:25-32(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"BJ-HCC-2, a tumor-associated gene which is expressed only in the normal pancreas and testis."
Dong X.-Y., Chen W.-F.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[5]"Mutational analysis of the human FATE gene in 144 infertile men."
Olesen C., Silber J., Eiberg H., Ernst E., Petersen K., Lindenberg S., Tommerup N.
Hum. Genet. 113:195-201(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS VAL-10; THR-34 AND ARG-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSCCDS14700.1.
RefSeqNP_149076.1. NM_033085.2.
UniGeneHs.301960.

3D structure databases

ProteinModelPortalQ969F0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124636. 5 interactions.
IntActQ969F0. 11 interactions.
MINTMINT-1474102.
STRING9606.ENSP00000359375.

Polymorphism databases

DMDM37078481.

Proteomic databases

PaxDbQ969F0.
PRIDEQ969F0.

Protocols and materials databases

DNASU89885.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370350; ENSP00000359375; ENSG00000147378.
GeneID89885.
KEGGhsa:89885.
UCSCuc004fex.3. human.

Organism-specific databases

CTD89885.
GeneCardsGC0XP150884.
HGNCHGNC:24683. FATE1.
HPAHPA034604.
MIM300450. gene.
neXtProtNX_Q969F0.
PharmGKBPA134875203.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45167.
HOGENOMHOG000293282.
HOVERGENHBG051556.
InParanoidQ969F0.
OMAWNMTATR.
OrthoDBEOG7XM308.
PhylomeDBQ969F0.
TreeFamTF338514.

Gene expression databases

ArrayExpressQ969F0.
BgeeQ969F0.
CleanExHS_FATE1.
GenevestigatorQ969F0.

Family and domain databases

InterProIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PfamPF05644. Miff. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFATE1. human.
GeneWikiFATE1.
GenomeRNAi89885.
NextBio76405.
PROQ969F0.
SOURCESearch...

Entry information

Entry nameFATE1_HUMAN
AccessionPrimary (citable) accession number: Q969F0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM