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Protein

Fetal and adult testis-expressed transcript protein

Gene

FATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).1 Publication1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of mitochondrial calcium ion concentration Source: UniProtKB

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Fetal and adult testis-expressed transcript protein
Alternative name(s):
Cancer/testis antigen 43
Short name:
CT43
Tumor antigen BJ-HCC-2
Gene namesi
Name:FATE1
Synonyms:FATE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147378.11.
HGNCiHGNC:24683. FATE1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei163 – 181HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi151L → D: Impairs association with mitochondria. 1 Publication1

Organism-specific databases

DisGeNETi89885.
OpenTargetsiENSG00000147378.
PharmGKBiPA134875203.

Polymorphism and mutation databases

BioMutaiFATE1.
DMDMi37078481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000872001 – 183Fetal and adult testis-expressed transcript proteinAdd BLAST183

Proteomic databases

PaxDbiQ969F0.
PeptideAtlasiQ969F0.
PRIDEiQ969F0.

Expressioni

Tissue specificityi

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).2 Publications

Gene expression databases

BgeeiENSG00000147378.
CleanExiHS_FATE1.
ExpressionAtlasiQ969F0. baseline and differential.
GenevisibleiQ969F0. HS.

Organism-specific databases

HPAiHPA034604.

Interactioni

Subunit structurei

Interacts with BIK and RNF183 (PubMed:26567849). Interacts with IMMT/MIC60and EMD (PubMed:27402544).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-743099,EBI-741181
AQP9Q6FGT03EBI-743099,EBI-10249621
BCL2L2Q928435EBI-743099,EBI-707714
BIKQ133238EBI-743099,EBI-700794
BNIP2Q129825EBI-743099,EBI-752094
BNIP3Q129837EBI-743099,EBI-749464
BNIP3LO602383EBI-743099,EBI-849893
BTN2A2Q8WVV53EBI-743099,EBI-8648738
CCDC155Q8N6L05EBI-743099,EBI-749265
CCDC70Q6NSX17EBI-743099,EBI-6873045
CD79AP119127EBI-743099,EBI-7797864
CSF2RAP155093EBI-743099,EBI-1763264
DCTN5Q9BTE13EBI-743099,EBI-747324
EMDP504029EBI-743099,EBI-489887
GPR25O001556EBI-743099,EBI-10178951
INPP5KQ9BT405EBI-743099,EBI-749162
KCNS2Q9ULS65EBI-743099,EBI-10323864
LNPEPQ9UIQ63EBI-743099,EBI-2805360
LY75O60449-33EBI-743099,EBI-10186753
MARCH2Q9P0N85EBI-743099,EBI-10317612
MARCH5Q9NX473EBI-743099,EBI-2341610
MFFQ9GZY8-54EBI-743099,EBI-11956541
MR1Q954603EBI-743099,EBI-10280401
NDUFB11Q9NX145EBI-743099,EBI-1246182
NRG4Q8WWG16EBI-743099,EBI-8637292
NRSN1Q8IZ573EBI-743099,EBI-10264528
PIN4Q9Y2373EBI-743099,EBI-714599
PRRG2Q8TAS35EBI-743099,EBI-10272071
RNF183Q96D593EBI-743099,EBI-743938
RPRMQ9NS645EBI-743099,EBI-1052363
SEC22AQ96IW75EBI-743099,EBI-8652744
SEC22CQ9BRL73EBI-743099,EBI-10297029
SEC23BQ154373EBI-743099,EBI-742673
SLC38A1Q9H2H95EBI-743099,EBI-9978441
SLC7A1P308255EBI-743099,EBI-4289564
SMIM14Q96QK83EBI-743099,EBI-373430
SNAP47Q5SQN13EBI-743099,EBI-10244848
SYNDIG1Q9H7V25EBI-743099,EBI-726331
SYNE4Q8N2055EBI-743099,EBI-7131783
SYNGR1O437593EBI-743099,EBI-6269521
SYNGR1O43759-25EBI-743099,EBI-12187159
SYNPRQ8TBG93EBI-743099,EBI-10273251
taxP140793EBI-743099,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
TIMMDC1Q9NPL83EBI-743099,EBI-6268651
TM4SF4P482303EBI-743099,EBI-8650934
TMEM11P171523EBI-743099,EBI-723946
TMEM179BQ7Z7N94EBI-743099,EBI-11724423
TMEM74Q96NL13EBI-743099,EBI-10292091
TRAF3IP3Q9Y2285EBI-743099,EBI-765817
USP20Q9Y2K63EBI-743099,EBI-2511991
YIPF4Q9BSR85EBI-743099,EBI-751253

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124636. 54 interactors.
IntActiQ969F0. 93 interactors.
MINTiMINT-1474102.
STRINGi9606.ENSP00000359375.

Structurei

3D structure databases

ProteinModelPortaliQ969F0.
SMRiQ969F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J190. Eukaryota.
ENOG410YXUY. LUCA.
GeneTreeiENSGT00390000006832.
HOGENOMiHOG000293282.
HOVERGENiHBG051556.
InParanoidiQ969F0.
OMAiEQGATWR.
OrthoDBiEOG091G0QVT.
PhylomeDBiQ969F0.
TreeFamiTF338514.

Sequencei

Sequence statusi: Complete.

Q969F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK
60 70 80 90 100
KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE
110 120 130 140 150
YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA
160 170 180
LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Length:183
Mass (Da):20,712
Last modified:December 1, 2001 - v1
Checksum:iF3448EDCBCD148CB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01691710A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 PublicationCorresponds to variant dbSNP:rs3810715Ensembl.1
Natural variantiVAR_01691834I → T in fertile and infertile individuals. 1 Publication1
Natural variantiVAR_016919125S → R in fertile and infertile individuals. 1 PublicationCorresponds to variant dbSNP:rs141497002Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSiCCDS14700.1.
RefSeqiNP_149076.1. NM_033085.2.
UniGeneiHs.301960.

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
GeneIDi89885.
KEGGihsa:89885.
UCSCiuc004fex.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFATE1_HUMAN
AccessioniPrimary (citable) accession number: Q969F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot