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Protein

Fetal and adult testis-expressed transcript protein

Gene

FATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fetal and adult testis-expressed transcript protein
Alternative name(s):
Cancer/testis antigen 43
Short name:
CT43
Tumor antigen BJ-HCC-2
Gene namesi
Name:FATE1
Synonyms:FATE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:24683. FATE1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei163 – 18119HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Fetal and adult testis-expressed transcript proteinPRO_0000087200Add
BLAST

Proteomic databases

PaxDbiQ969F0.
PRIDEiQ969F0.

Expressioni

Tissue specificityi

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain.

Gene expression databases

BgeeiQ969F0.
CleanExiHS_FATE1.
ExpressionAtlasiQ969F0. baseline.
GenevestigatoriQ969F0.

Organism-specific databases

HPAiHPA034604.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
taxP140793EBI-743099,EBI-9675698From a different organism.

Protein-protein interaction databases

BioGridi124636. 49 interactions.
IntActiQ969F0. 13 interactions.
MINTiMINT-1474102.
STRINGi9606.ENSP00000359375.

Structurei

3D structure databases

ProteinModelPortaliQ969F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45167.
GeneTreeiENSGT00390000006832.
HOGENOMiHOG000293282.
HOVERGENiHBG051556.
InParanoidiQ969F0.
OMAiWNMTATR.
OrthoDBiEOG7XM308.
PhylomeDBiQ969F0.
TreeFamiTF338514.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PfamiPF05644. Miff. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK
60 70 80 90 100
KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE
110 120 130 140 150
YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA
160 170 180
LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Length:183
Mass (Da):20,712
Last modified:December 1, 2001 - v1
Checksum:iF3448EDCBCD148CB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 Publication
Corresponds to variant rs3810715 [ dbSNP | Ensembl ].
VAR_016917
Natural varianti34 – 341I → T in fertile and infertile individuals. 1 Publication
VAR_016918
Natural varianti125 – 1251S → R in fertile and infertile individuals. 1 Publication
VAR_016919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSiCCDS14700.1.
RefSeqiNP_149076.1. NM_033085.2.
UniGeneiHs.301960.

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
GeneIDi89885.
KEGGihsa:89885.
UCSCiuc004fex.3. human.

Polymorphism databases

DMDMi37078481.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSiCCDS14700.1.
RefSeqiNP_149076.1. NM_033085.2.
UniGeneiHs.301960.

3D structure databases

ProteinModelPortaliQ969F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124636. 49 interactions.
IntActiQ969F0. 13 interactions.
MINTiMINT-1474102.
STRINGi9606.ENSP00000359375.

Polymorphism databases

DMDMi37078481.

Proteomic databases

PaxDbiQ969F0.
PRIDEiQ969F0.

Protocols and materials databases

DNASUi89885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
GeneIDi89885.
KEGGihsa:89885.
UCSCiuc004fex.3. human.

Organism-specific databases

CTDi89885.
GeneCardsiGC0XP150884.
HGNCiHGNC:24683. FATE1.
HPAiHPA034604.
MIMi300450. gene.
neXtProtiNX_Q969F0.
PharmGKBiPA134875203.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45167.
GeneTreeiENSGT00390000006832.
HOGENOMiHOG000293282.
HOVERGENiHBG051556.
InParanoidiQ969F0.
OMAiWNMTATR.
OrthoDBiEOG7XM308.
PhylomeDBiQ969F0.
TreeFamiTF338514.

Miscellaneous databases

ChiTaRSiFATE1. human.
GeneWikiiFATE1.
GenomeRNAii89885.
NextBioi76405.
PROiQ969F0.
SOURCEiSearch...

Gene expression databases

BgeeiQ969F0.
CleanExiHS_FATE1.
ExpressionAtlasiQ969F0. baseline.
GenevestigatoriQ969F0.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PfamiPF05644. Miff. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human FATE is a novel X-linked gene expressed in fetal and adult testis."
    Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.
    Mol. Cell. Endocrinol. 184:25-32(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "BJ-HCC-2, a tumor-associated gene which is expressed only in the normal pancreas and testis."
    Dong X.-Y., Chen W.-F.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Mutational analysis of the human FATE gene in 144 infertile men."
    Olesen C., Silber J., Eiberg H., Ernst E., Petersen K., Lindenberg S., Tommerup N.
    Hum. Genet. 113:195-201(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-10; THR-34 AND ARG-125.

Entry informationi

Entry nameiFATE1_HUMAN
AccessioniPrimary (citable) accession number: Q969F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.