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Protein

Fetal and adult testis-expressed transcript protein

Gene

FATE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fetal and adult testis-expressed transcript protein
Alternative name(s):
Cancer/testis antigen 43
Short name:
CT43
Tumor antigen BJ-HCC-2
Gene namesi
Name:FATE1
Synonyms:FATE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:24683. FATE1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei163 – 18119HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875203.

Polymorphism and mutation databases

BioMutaiFATE1.
DMDMi37078481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Fetal and adult testis-expressed transcript proteinPRO_0000087200Add
BLAST

Proteomic databases

PaxDbiQ969F0.
PRIDEiQ969F0.

Expressioni

Tissue specificityi

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain.

Gene expression databases

BgeeiQ969F0.
CleanExiHS_FATE1.
ExpressionAtlasiQ969F0. baseline.
GenevisibleiQ969F0. HS.

Organism-specific databases

HPAiHPA034604.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-743099,EBI-741181
AQP9Q6FGT03EBI-743099,EBI-10249621
BCL2L2Q928433EBI-743099,EBI-707714
BIKQ133234EBI-743099,EBI-700794
BNIP2Q129823EBI-743099,EBI-752094
BNIP3Q129833EBI-743099,EBI-749464
BNIP3LO602383EBI-743099,EBI-849893
BTN2A2Q8WVV53EBI-743099,EBI-8648738
CCDC155Q8N6L03EBI-743099,EBI-749265
CCDC70Q6NSX13EBI-743099,EBI-6873045
CD79AP119123EBI-743099,EBI-7797864
CSF2RAP155093EBI-743099,EBI-1763264
DCTN5Q9BTE13EBI-743099,EBI-747324
EMDP504024EBI-743099,EBI-489887
INPP5KQ9BT403EBI-743099,EBI-749162
KCNS2Q9ULS63EBI-743099,EBI-10323864
LNPEPQ9UIQ63EBI-743099,EBI-2805360
LY75O60449-33EBI-743099,EBI-10186753
MARCH2Q9P0N83EBI-743099,EBI-10317612
MARCH5Q9NX473EBI-743099,EBI-2341610
MR1Q954603EBI-743099,EBI-10280401
NDUFB11Q9NX143EBI-743099,EBI-1246182
NRG4Q8WWG14EBI-743099,EBI-8637292
NRSN1Q8IZ573EBI-743099,EBI-10264528
PIN4Q9Y2373EBI-743099,EBI-714599
PRRG2Q8TAS33EBI-743099,EBI-10272071
RPRMQ9NS643EBI-743099,EBI-1052363
SEC22AQ96IW73EBI-743099,EBI-8652744
SEC22CQ9BRL73EBI-743099,EBI-10297029
SEC23BQ154373EBI-743099,EBI-742673
SLC38A1Q9H2H93EBI-743099,EBI-9978441
SLC7A1P308253EBI-743099,EBI-4289564
SNAP47Q5SQN13EBI-743099,EBI-10244848
SYNDIG1Q9H7V23EBI-743099,EBI-726331
SYNE4Q8N2055EBI-743099,EBI-7131783
SYNGR1O437593EBI-743099,EBI-6269521
SYNPRQ8TBG93EBI-743099,EBI-10273251
taxP140793EBI-743099,EBI-9675698From a different organism.
TIMMDC1Q9NPL83EBI-743099,EBI-6268651
TM4SF4P482303EBI-743099,EBI-8650934
TMEM74Q96NL13EBI-743099,EBI-10292091
TRAF3IP3Q9Y2283EBI-743099,EBI-765817
USP20Q9Y2K63EBI-743099,EBI-2511991
YIPF4Q9BSR83EBI-743099,EBI-751253

Protein-protein interaction databases

BioGridi124636. 49 interactions.
IntActiQ969F0. 54 interactions.
MINTiMINT-1474102.
STRINGi9606.ENSP00000359375.

Structurei

3D structure databases

ProteinModelPortaliQ969F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45167.
GeneTreeiENSGT00390000006832.
HOGENOMiHOG000293282.
HOVERGENiHBG051556.
InParanoidiQ969F0.
OMAiWNMTATR.
OrthoDBiEOG7XM308.
PhylomeDBiQ969F0.
TreeFamiTF338514.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PfamiPF05644. Miff. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPPNTKA EMEMSLAEEL NHGRQGENQE HLVIAEMMEL GSRSRGASQK
60 70 80 90 100
KQKLEQKAAG SASAKRVWNM TATRPKKMGS QLPKPRMLRE SGHGDAHLQE
110 120 130 140 150
YAGNFQGIRF HYDRNPGTDA VAQTSLEEFN VLEMEVMRRQ LYAVNRRLRA
160 170 180
LEEQGATWRH RETLIIAVLV SASIANLWLW MNQ
Length:183
Mass (Da):20,712
Last modified:December 1, 2001 - v1
Checksum:iF3448EDCBCD148CB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101A → V Common polymorphism; 16% of the population; infertile and fertile individuals. 1 Publication
Corresponds to variant rs3810715 [ dbSNP | Ensembl ].
VAR_016917
Natural varianti34 – 341I → T in fertile and infertile individuals. 1 Publication
VAR_016918
Natural varianti125 – 1251S → R in fertile and infertile individuals. 1 Publication
VAR_016919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSiCCDS14700.1.
RefSeqiNP_149076.1. NM_033085.2.
UniGeneiHs.301960.

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
GeneIDi89885.
KEGGihsa:89885.
UCSCiuc004fex.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF249872 mRNA. Translation: AAK69024.1.
AY101182 mRNA. Translation: AAM48744.1.
AK057369 mRNA. Translation: BAB71454.1.
BC022064 mRNA. Translation: AAH22064.1.
CCDSiCCDS14700.1.
RefSeqiNP_149076.1. NM_033085.2.
UniGeneiHs.301960.

3D structure databases

ProteinModelPortaliQ969F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124636. 49 interactions.
IntActiQ969F0. 54 interactions.
MINTiMINT-1474102.
STRINGi9606.ENSP00000359375.

Polymorphism and mutation databases

BioMutaiFATE1.
DMDMi37078481.

Proteomic databases

PaxDbiQ969F0.
PRIDEiQ969F0.

Protocols and materials databases

DNASUi89885.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370350; ENSP00000359375; ENSG00000147378.
GeneIDi89885.
KEGGihsa:89885.
UCSCiuc004fex.3. human.

Organism-specific databases

CTDi89885.
GeneCardsiGC0XP150884.
HGNCiHGNC:24683. FATE1.
HPAiHPA034604.
MIMi300450. gene.
neXtProtiNX_Q969F0.
PharmGKBiPA134875203.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45167.
GeneTreeiENSGT00390000006832.
HOGENOMiHOG000293282.
HOVERGENiHBG051556.
InParanoidiQ969F0.
OMAiWNMTATR.
OrthoDBiEOG7XM308.
PhylomeDBiQ969F0.
TreeFamiTF338514.

Miscellaneous databases

ChiTaRSiFATE1. human.
GeneWikiiFATE1.
GenomeRNAii89885.
NextBioi76405.
PROiQ969F0.
SOURCEiSearch...

Gene expression databases

BgeeiQ969F0.
CleanExiHS_FATE1.
ExpressionAtlasiQ969F0. baseline.
GenevisibleiQ969F0. HS.

Family and domain databases

InterProiIPR008518. FATE/Miff/Tango-11.
[Graphical view]
PfamiPF05644. Miff. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human FATE is a novel X-linked gene expressed in fetal and adult testis."
    Olesen C., Larsen N.J., Byskov A.G., Harboe T.L., Tommerup N.
    Mol. Cell. Endocrinol. 184:25-32(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "BJ-HCC-2, a tumor-associated gene which is expressed only in the normal pancreas and testis."
    Dong X.-Y., Chen W.-F.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Mutational analysis of the human FATE gene in 144 infertile men."
    Olesen C., Silber J., Eiberg H., Ernst E., Petersen K., Lindenberg S., Tommerup N.
    Hum. Genet. 113:195-201(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-10; THR-34 AND ARG-125.

Entry informationi

Entry nameiFATE1_HUMAN
AccessioniPrimary (citable) accession number: Q969F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.