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Protein

Transcription elongation factor A protein-like 3

Gene

TCEAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 3
Short name:
TCEA-like protein 3
Alternative name(s):
Transcription elongation factor S-II protein-like 3
Gene namesi
Name:TCEAL3
ORF Names:MSTP072
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28247. TCEAL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394737.

Polymorphism and mutation databases

BioMutaiTCEAL3.
DMDMi74762641.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Transcription elongation factor A protein-like 3PRO_0000239207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ969E4.
MaxQBiQ969E4.
PaxDbiQ969E4.
PeptideAtlasiQ969E4.
PRIDEiQ969E4.

PTM databases

iPTMnetiQ969E4.
PhosphoSiteiQ969E4.

Expressioni

Gene expression databases

BgeeiENSG00000196507.
CleanExiHS_TCEAL3.
GenevisibleiQ969E4. HS.

Organism-specific databases

HPAiHPA045564.
HPA058982.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ969E4. 1 interaction.
STRINGi9606.ENSP00000243286.

Structurei

3D structure databases

ProteinModelPortaliQ969E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 7567Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

eggNOGiENOG410JBBY. Eukaryota.
ENOG41113V2. LUCA.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ969E4.
OMAiERQPTHE.
OrthoDBiEOG091G0HD3.
PhylomeDBiQ969E4.
TreeFamiTF336871.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q969E4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDVEG KTECEGKRED
60 70 80 90 100
EGEPGDEGQL EDEGSQEKQG RSEGEGKPQG EGKPASQAKP ESQPRAAEKR
110 120 130 140 150
PAEDYVPRKA KRKTDRGTDD SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ
160 170 180 190 200
EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG VRGVRGGGRG QRGLHDIPYL
Length:200
Mass (Da):22,502
Last modified:December 1, 2001 - v1
Checksum:iF8F18B86A1A8F484
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871Q → E.
Corresponds to variant rs12009847 [ dbSNP | Ensembl ].
VAR_059829

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163263 mRNA. Translation: AAQ13592.1.
AK098494 mRNA. Translation: BAC05318.1.
Z73965 Genomic DNA. Translation: CAI42029.1.
CH471190 Genomic DNA. Translation: EAW54703.1.
CH471190 Genomic DNA. Translation: EAW54704.1.
BC007622 mRNA. Translation: AAH07622.1.
BC008703 mRNA. Translation: AAH08703.1.
CCDSiCCDS14511.1.
RefSeqiNP_001006934.1. NM_001006933.1.
NP_116315.1. NM_032926.2.
UniGeneiHs.311776.

Genome annotation databases

EnsembliENST00000243286; ENSP00000243286; ENSG00000196507.
ENST00000372627; ENSP00000361710; ENSG00000196507.
ENST00000372628; ENSP00000361711; ENSG00000196507.
GeneIDi85012.
KEGGihsa:85012.
UCSCiuc004ekq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163263 mRNA. Translation: AAQ13592.1.
AK098494 mRNA. Translation: BAC05318.1.
Z73965 Genomic DNA. Translation: CAI42029.1.
CH471190 Genomic DNA. Translation: EAW54703.1.
CH471190 Genomic DNA. Translation: EAW54704.1.
BC007622 mRNA. Translation: AAH07622.1.
BC008703 mRNA. Translation: AAH08703.1.
CCDSiCCDS14511.1.
RefSeqiNP_001006934.1. NM_001006933.1.
NP_116315.1. NM_032926.2.
UniGeneiHs.311776.

3D structure databases

ProteinModelPortaliQ969E4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ969E4. 1 interaction.
STRINGi9606.ENSP00000243286.

PTM databases

iPTMnetiQ969E4.
PhosphoSiteiQ969E4.

Polymorphism and mutation databases

BioMutaiTCEAL3.
DMDMi74762641.

Proteomic databases

EPDiQ969E4.
MaxQBiQ969E4.
PaxDbiQ969E4.
PeptideAtlasiQ969E4.
PRIDEiQ969E4.

Protocols and materials databases

DNASUi85012.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243286; ENSP00000243286; ENSG00000196507.
ENST00000372627; ENSP00000361710; ENSG00000196507.
ENST00000372628; ENSP00000361711; ENSG00000196507.
GeneIDi85012.
KEGGihsa:85012.
UCSCiuc004ekq.4. human.

Organism-specific databases

CTDi85012.
GeneCardsiTCEAL3.
H-InvDBHIX0203314.
HGNCiHGNC:28247. TCEAL3.
HPAiHPA045564.
HPA058982.
neXtProtiNX_Q969E4.
PharmGKBiPA128394737.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JBBY. Eukaryota.
ENOG41113V2. LUCA.
GeneTreeiENSGT00510000046867.
HOGENOMiHOG000231342.
HOVERGENiHBG055896.
InParanoidiQ969E4.
OMAiERQPTHE.
OrthoDBiEOG091G0HD3.
PhylomeDBiQ969E4.
TreeFamiTF336871.

Miscellaneous databases

ChiTaRSiTCEAL3. human.
GenomeRNAii85012.
PROiQ969E4.

Gene expression databases

BgeeiENSG00000196507.
CleanExiHS_TCEAL3.
GenevisibleiQ969E4. HS.

Family and domain databases

InterProiIPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCAL3_HUMAN
AccessioniPrimary (citable) accession number: Q969E4
Secondary accession number(s): D3DXA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.