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Protein

Urocortin-3

Gene

UCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Urocortin-3
Alternative name(s):
Stresscopin
Urocortin III
Short name:
Ucn III
Gene namesi
Name:UCN3
Synonyms:SPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17781. UCN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA130413153.

Polymorphism and mutation databases

BioMutaiUCN3.
DMDMi296452853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 11897PRO_0000006245Add
BLAST
Chaini120 – 15738Urocortin-3PRO_0000006246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei157 – 1571Isoleucine amideSequence analysis

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiQ969E3.
PeptideAtlasiQ969E3.
PRIDEiQ969E3.

PTM databases

iPTMnetiQ969E3.
PhosphoSiteiQ969E3.

Expressioni

Gene expression databases

BgeeiENSG00000178473.
CleanExiHS_UCN3.
GenevisibleiQ969E3. HS.

Organism-specific databases

HPAiHPA038281.

Interactioni

Subunit structurei

Binds with high affinity to CRF receptors 2-alpha and 2-beta.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125284. 2 interactions.
STRINGi9606.ENSP00000369798.

Structurei

Secondary structure

1
161
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi121 – 1233Combined sources
Helixi143 – 15614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMHNMR-A120-157[»]
3N93X-ray2.50C142-157[»]
ProteinModelPortaliQ969E3.
SMRiQ969E3. Positions 120-157.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969E3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ00. Eukaryota.
ENOG410YJR9. LUCA.
GeneTreeiENSGT00390000001251.
HOGENOMiHOG000230495.
HOVERGENiHBG036243.
InParanoidiQ969E3.
KOiK05257.
OMAiQRTKFTL.
OrthoDBiEOG091G10Y0.
PhylomeDBiQ969E3.
TreeFamiTF330723.

Family and domain databases

InterProiIPR000187. CRF.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMPVHFLLL LLLLLGGPRT GLPHKFYKAK PIFSCLNTAL SEAEKGQWED
60 70 80 90 100
ASLLSKRSFH YLRSRDASSG EEEEGKEKKT FPISGARGGA RGTRYRYVSQ
110 120 130 140 150
AQPRGKPRQD TAKSPHRTKF TLSLDVPTNI MNLLFNIAKA KNLRAQAAAN
160
AHLMAQIGRK K
Length:161
Mass (Da):17,961
Last modified:May 18, 2010 - v2
Checksum:iB83B3D8D30879911
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771E → K.
Corresponds to variant rs12768730 [ dbSNP | Ensembl ].
VAR_060410
Natural varianti91 – 911R → G.3 Publications
Corresponds to variant rs10904481 [ dbSNP | Ensembl ].
VAR_060411

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361943 Genomic DNA. Translation: AAK67317.1.
AY026949 mRNA. Translation: AAK11729.1.
AL683826 Genomic DNA. Translation: CAI23624.1.
BC069530 mRNA. Translation: AAH69530.1.
BC100867 mRNA. Translation: AAI00868.1.
BC100868 mRNA. Translation: AAI00869.1.
BC100869 mRNA. Translation: AAI00870.1.
BC100870 mRNA. Translation: AAI00871.1.
CCDSiCCDS7065.1.
RefSeqiNP_444277.2. NM_053049.3.
UniGeneiHs.511775.
Hs.680475.

Genome annotation databases

EnsembliENST00000380433; ENSP00000369798; ENSG00000178473.
GeneIDi114131.
KEGGihsa:114131.
UCSCiuc001ihx.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361943 Genomic DNA. Translation: AAK67317.1.
AY026949 mRNA. Translation: AAK11729.1.
AL683826 Genomic DNA. Translation: CAI23624.1.
BC069530 mRNA. Translation: AAH69530.1.
BC100867 mRNA. Translation: AAI00868.1.
BC100868 mRNA. Translation: AAI00869.1.
BC100869 mRNA. Translation: AAI00870.1.
BC100870 mRNA. Translation: AAI00871.1.
CCDSiCCDS7065.1.
RefSeqiNP_444277.2. NM_053049.3.
UniGeneiHs.511775.
Hs.680475.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RMHNMR-A120-157[»]
3N93X-ray2.50C142-157[»]
ProteinModelPortaliQ969E3.
SMRiQ969E3. Positions 120-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125284. 2 interactions.
STRINGi9606.ENSP00000369798.

PTM databases

iPTMnetiQ969E3.
PhosphoSiteiQ969E3.

Polymorphism and mutation databases

BioMutaiUCN3.
DMDMi296452853.

Proteomic databases

PaxDbiQ969E3.
PeptideAtlasiQ969E3.
PRIDEiQ969E3.

Protocols and materials databases

DNASUi114131.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380433; ENSP00000369798; ENSG00000178473.
GeneIDi114131.
KEGGihsa:114131.
UCSCiuc001ihx.2. human.

Organism-specific databases

CTDi114131.
GeneCardsiUCN3.
H-InvDBHIX0035360.
HGNCiHGNC:17781. UCN3.
HPAiHPA038281.
MIMi605901. gene.
neXtProtiNX_Q969E3.
PharmGKBiPA130413153.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ00. Eukaryota.
ENOG410YJR9. LUCA.
GeneTreeiENSGT00390000001251.
HOGENOMiHOG000230495.
HOVERGENiHBG036243.
InParanoidiQ969E3.
KOiK05257.
OMAiQRTKFTL.
OrthoDBiEOG091G10Y0.
PhylomeDBiQ969E3.
TreeFamiTF330723.

Miscellaneous databases

EvolutionaryTraceiQ969E3.
GeneWikiiUCN3.
GenomeRNAii114131.
PROiQ969E3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178473.
CleanExiHS_UCN3.
GenevisibleiQ969E3. HS.

Family and domain databases

InterProiIPR000187. CRF.
IPR024270. Urocortin_II/III.
[Graphical view]
PANTHERiPTHR17575. PTHR17575. 1 hit.
PfamiPF00473. CRF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUCN3_HUMAN
AccessioniPrimary (citable) accession number: Q969E3
Secondary accession number(s): Q496H2, Q5SR91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.