Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Liver-expressed antimicrobial peptide 2

Gene

LEAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has an antimicrobial activity.1 Publication

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • antimicrobial humoral response Source: Reactome
  • defense response to bacterium Source: UniProtKB-KW
  • defense response to fungus Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

ReactomeiR-HSA-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:LEAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164406.7.
HGNCiHGNC:29571. LEAP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi116842.
OpenTargetsiENSG00000164406.
PharmGKBiPA162393840.

Polymorphism and mutation databases

BioMutaiLEAP2.
DMDMi20138667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000001735523 – 37Add BLAST15
ChainiPRO_000001735638 – 77Liver-expressed antimicrobial peptide 2Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 65
Disulfide bondi60 ↔ 70

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ969E1.
PeptideAtlasiQ969E1.
PRIDEiQ969E1.

Expressioni

Gene expression databases

BgeeiENSG00000164406.
CleanExiHS_LEAP2.
GenevisibleiQ969E1. HS.

Organism-specific databases

HPAiHPA035750.

Interactioni

Protein-protein interaction databases

BioGridi125535. 5 interactors.

Structurei

Secondary structure

177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi46 – 48Combined sources3
Helixi57 – 59Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L1QNMR-A38-77[»]
ProteinModelPortaliQ969E1.
SMRiQ969E1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969E1.

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ969E1.
OMAiTMLRSME.
OrthoDBiEOG091G13A9.
PhylomeDBiQ969E1.
TreeFamiTF336274.

Family and domain databases

InterProiView protein in InterPro
IPR009955. LEAP-2.
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiView protein in Pfam
PF07359. LEAP-2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Length:77
Mass (Da):8,814
Last modified:December 1, 2001 - v1
Checksum:iFD1C300B0F42E4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306405 mRNA. Translation: CAC51306.1.
AJ409064 Genomic DNA. Translation: CAC51515.1.
AJ409065 mRNA. Translation: CAC51516.1.
CH471062 Genomic DNA. Translation: EAW62306.1.
CH471062 Genomic DNA. Translation: EAW62307.1.
BC070199 mRNA. Translation: AAH70199.1.
CCDSiCCDS4163.1.
RefSeqiNP_443203.1. NM_052971.2.
UniGeneiHs.337588.

Genome annotation databases

EnsembliENST00000296877; ENSP00000296877; ENSG00000164406.
GeneIDi116842.
KEGGihsa:116842.
UCSCiuc003kyc.4. human.

Similar proteinsi

Entry informationi

Entry nameiLEAP2_HUMAN
AccessioniPrimary (citable) accession number: Q969E1
Secondary accession number(s): D3DQ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families