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Protein

Liver-expressed antimicrobial peptide 2

Gene

LEAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has an antimicrobial activity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Liver-expressed antimicrobial peptide 2
Short name:
LEAP-2
Gene namesi
Name:LEAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29571. LEAP2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393840.

Polymorphism and mutation databases

BioMutaiLEAP2.
DMDMi20138667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 3715PRO_0000017355Add
BLAST
Chaini38 – 7740Liver-expressed antimicrobial peptide 2PRO_0000017356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 65
Disulfide bondi60 ↔ 70

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ969E1.
PRIDEiQ969E1.

Expressioni

Gene expression databases

BgeeiQ969E1.
CleanExiHS_LEAP2.
GenevisibleiQ969E1. HS.

Organism-specific databases

HPAiHPA035750.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296877.

Structurei

Secondary structure

1
77
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi46 – 483Combined sources
Helixi57 – 593Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L1QNMR-A38-77[»]
ProteinModelPortaliQ969E1.
SMRiQ969E1. Positions 38-77.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ969E1.

Family & Domainsi

Sequence similaritiesi

Belongs to the LEAP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ969E1.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
PhylomeDBiQ969E1.
TreeFamiTF336274.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWHLKLCAVL MIFLLLLGQI DGSPIPEVSS AKRRPRRMTP FWRGVSLRPI
60 70
GASCRDDSEC ITRLCRKRRC SLSVAQE
Length:77
Mass (Da):8,814
Last modified:December 1, 2001 - v1
Checksum:iFD1C300B0F42E4C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306405 mRNA. Translation: CAC51306.1.
AJ409064 Genomic DNA. Translation: CAC51515.1.
AJ409065 mRNA. Translation: CAC51516.1.
CH471062 Genomic DNA. Translation: EAW62306.1.
CH471062 Genomic DNA. Translation: EAW62307.1.
BC070199 mRNA. Translation: AAH70199.1.
CCDSiCCDS4163.1.
RefSeqiNP_443203.1. NM_052971.2.
UniGeneiHs.337588.

Genome annotation databases

EnsembliENST00000296877; ENSP00000296877; ENSG00000164406.
GeneIDi116842.
KEGGihsa:116842.
UCSCiuc003kyc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306405 mRNA. Translation: CAC51306.1.
AJ409064 Genomic DNA. Translation: CAC51515.1.
AJ409065 mRNA. Translation: CAC51516.1.
CH471062 Genomic DNA. Translation: EAW62306.1.
CH471062 Genomic DNA. Translation: EAW62307.1.
BC070199 mRNA. Translation: AAH70199.1.
CCDSiCCDS4163.1.
RefSeqiNP_443203.1. NM_052971.2.
UniGeneiHs.337588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L1QNMR-A38-77[»]
ProteinModelPortaliQ969E1.
SMRiQ969E1. Positions 38-77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296877.

Polymorphism and mutation databases

BioMutaiLEAP2.
DMDMi20138667.

Proteomic databases

PaxDbiQ969E1.
PRIDEiQ969E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296877; ENSP00000296877; ENSG00000164406.
GeneIDi116842.
KEGGihsa:116842.
UCSCiuc003kyc.4. human.

Organism-specific databases

CTDi116842.
GeneCardsiLEAP2.
HGNCiHGNC:29571. LEAP2.
HPAiHPA035750.
MIMi611373. gene.
neXtProtiNX_Q969E1.
PharmGKBiPA162393840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J7PZ. Eukaryota.
ENOG410Y6EA. LUCA.
GeneTreeiENSGT00390000013467.
HOGENOMiHOG000037938.
HOVERGENiHBG052319.
InParanoidiQ969E1.
OMAiMWHLKLL.
OrthoDBiEOG7673F2.
PhylomeDBiQ969E1.
TreeFamiTF336274.

Miscellaneous databases

EvolutionaryTraceiQ969E1.
GenomeRNAii116842.
PROiQ969E1.
SOURCEiSearch...

Gene expression databases

BgeeiQ969E1.
CleanExiHS_LEAP2.
GenevisibleiQ969E1. HS.

Family and domain databases

InterProiIPR009955. LEAP-2.
[Graphical view]
PANTHERiPTHR21007. PTHR21007. 1 hit.
PfamiPF07359. LEAP-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver."
    Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E., Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C., Wattler F., Wattler S., Adermann K.
    Protein Sci. 12:143-152(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DISULFIDE BONDS.
    Tissue: Liver and Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Structural and functional analysis of human liver-expressed antimicrobial peptide 2."
    Henriques S.T., Tan C.C., Craik D.J., Clark R.J.
    ChemBioChem 11:2148-2157(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 38-77, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiLEAP2_HUMAN
AccessioniPrimary (citable) accession number: Q969E1
Secondary accession number(s): D3DQ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.