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Q969D9

- TSLP_HUMAN

UniProt

Q969D9 - TSLP_HUMAN

Protein

Thymic stromal lymphopoietin

Gene

TSLP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.3 Publications

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiQ969D9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymic stromal lymphopoietin
    Gene namesi
    Name:TSLP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30743. TSLP.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162407159.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 159131Thymic stromal lymphopoietinPRO_0000300873Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ969D9.
    PRIDEiQ969D9.

    PTM databases

    PhosphoSiteiQ969D9.

    Expressioni

    Tissue specificityi

    Expressed in a number of tissues including heart, liver and prostate.1 Publication

    Inductioni

    Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.1 Publication

    Gene expression databases

    ArrayExpressiQ969D9.
    BgeeiQ969D9.
    CleanExiHS_TSLP.
    GenevestigatoriQ969D9.

    Interactioni

    Subunit structurei

    Interacts with a receptor composed of CRLF2 and IL7R.

    Protein-protein interaction databases

    BioGridi124555. 3 interactions.
    IntActiQ969D9. 2 interactions.
    STRINGi9606.ENSP00000339804.

    Structurei

    3D structure databases

    ProteinModelPortaliQ969D9.
    SMRiQ969D9. Positions 29-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42670.
    HOGENOMiHOG000154693.
    HOVERGENiHBG094875.
    KOiK05436.
    OrthoDBiEOG7R56W9.
    PhylomeDBiQ969D9.
    TreeFamiTF338216.

    Family and domain databases

    InterProiIPR029189. TSLP.
    [Graphical view]
    PfamiPF15216. TSLP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q969D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD    50
    LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM 100
    KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR 150
    FNRPLLKQQ 159
    Length:159
    Mass (Da):18,141
    Last modified:December 1, 2001 - v1
    Checksum:iFE158129406E3963
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 1111MFPFALLYVLS → MKCLGQSKKEE in AAH40592. (PubMed:15489334)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037115 mRNA. Translation: AAK67490.1.
    AF338732 mRNA. Translation: AAK60617.1.
    BC040592 mRNA. Translation: AAH40592.1.
    CCDSiCCDS4101.1.
    RefSeqiNP_149024.1. NM_033035.4.
    UniGeneiHs.389874.

    Genome annotation databases

    EnsembliENST00000344895; ENSP00000339804; ENSG00000145777.
    ENST00000420978; ENSP00000399099; ENSG00000145777.
    GeneIDi85480.
    KEGGihsa:85480.
    UCSCiuc003kpb.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037115 mRNA. Translation: AAK67490.1 .
    AF338732 mRNA. Translation: AAK60617.1 .
    BC040592 mRNA. Translation: AAH40592.1 .
    CCDSi CCDS4101.1.
    RefSeqi NP_149024.1. NM_033035.4.
    UniGenei Hs.389874.

    3D structure databases

    ProteinModelPortali Q969D9.
    SMRi Q969D9. Positions 29-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124555. 3 interactions.
    IntActi Q969D9. 2 interactions.
    STRINGi 9606.ENSP00000339804.

    PTM databases

    PhosphoSitei Q969D9.

    Proteomic databases

    PaxDbi Q969D9.
    PRIDEi Q969D9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344895 ; ENSP00000339804 ; ENSG00000145777 .
    ENST00000420978 ; ENSP00000399099 ; ENSG00000145777 .
    GeneIDi 85480.
    KEGGi hsa:85480.
    UCSCi uc003kpb.2. human.

    Organism-specific databases

    CTDi 85480.
    GeneCardsi GC05P110405.
    H-InvDB HIX0200750.
    HGNCi HGNC:30743. TSLP.
    MIMi 607003. gene.
    neXtProti NX_Q969D9.
    PharmGKBi PA162407159.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42670.
    HOGENOMi HOG000154693.
    HOVERGENi HBG094875.
    KOi K05436.
    OrthoDBi EOG7R56W9.
    PhylomeDBi Q969D9.
    TreeFami TF338216.

    Enzyme and pathway databases

    SignaLinki Q969D9.

    Miscellaneous databases

    GeneWikii Thymic_stromal_lymphopoietin.
    GenomeRNAii 85480.
    NextBioi 76148.
    PROi Q969D9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q969D9.
    Bgeei Q969D9.
    CleanExi HS_TSLP.
    Genevestigatori Q969D9.

    Family and domain databases

    InterProi IPR029189. TSLP.
    [Graphical view ]
    Pfami PF15216. TSLP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
    2. "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
      Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
      Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
      Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
      J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ALLERGIC INFLAMMATION, INDUCTION.

    Entry informationi

    Entry nameiTSLP_HUMAN
    AccessioniPrimary (citable) accession number: Q969D9
    Secondary accession number(s): Q8IW99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3