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Q969D9 (TSLP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymic stromal lymphopoietin
Gene names
Name:TSLP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells. Ref.1 Ref.2 Ref.4

Subunit structure

Interacts with a receptor composed of CRLF2 and IL7R.

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed in a number of tissues including heart, liver and prostate. Ref.2

Induction

Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines. Ref.4

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 159131Thymic stromal lymphopoietin
PRO_0000300873

Amino acid modifications

Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1 – 1111MFPFALLYVLS → MKCLGQSKKEE in AAH40592. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q969D9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FE158129406E3963

FASTA15918,141
        10         20         30         40         50         60 
MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD LITYMSGTKS 

        70         80         90        100        110        120 
TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM KTKAALAIWC PGYSETQINA 

       130        140        150 
TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR FNRPLLKQQ 

« Hide

References

« Hide 'large scale' references
[1]"Human thymic stromal lymphopoietin preferentially stimulates myeloid cells."
Reche P.A., Soumelis V., Gorman D.M., Clifford T., Liu M.-R., Travis M., Zurawski S.M., Johnston J., Liu Y.-J., Spits H., de Waal Malefyt R., Kastelein R.A., Bazan J.F.
J. Immunol. 167:336-343(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
[2]"Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN ALLERGIC INFLAMMATION, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY037115 mRNA. Translation: AAK67490.1.
AF338732 mRNA. Translation: AAK60617.1.
BC040592 mRNA. Translation: AAH40592.1.
CCDSCCDS4101.1.
RefSeqNP_149024.1. NM_033035.4.
UniGeneHs.389874.

3D structure databases

ProteinModelPortalQ969D9.
SMRQ969D9. Positions 29-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124555. 3 interactions.
IntActQ969D9. 2 interactions.
STRING9606.ENSP00000339804.

PTM databases

PhosphoSiteQ969D9.

Proteomic databases

PaxDbQ969D9.
PRIDEQ969D9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344895; ENSP00000339804; ENSG00000145777.
ENST00000420978; ENSP00000399099; ENSG00000145777.
GeneID85480.
KEGGhsa:85480.
UCSCuc003kpb.2. human.

Organism-specific databases

CTD85480.
GeneCardsGC05P110405.
H-InvDBHIX0200750.
HGNCHGNC:30743. TSLP.
MIM607003. gene.
neXtProtNX_Q969D9.
PharmGKBPA162407159.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42670.
HOGENOMHOG000154693.
HOVERGENHBG094875.
KOK05436.
OrthoDBEOG7R56W9.
PhylomeDBQ969D9.
TreeFamTF338216.

Enzyme and pathway databases

SignaLinkQ969D9.

Gene expression databases

ArrayExpressQ969D9.
BgeeQ969D9.
CleanExHS_TSLP.
GenevestigatorQ969D9.

Family and domain databases

InterProIPR029189. TSLP.
[Graphical view]
PfamPF15216. TSLP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiThymic_stromal_lymphopoietin.
GenomeRNAi85480.
NextBio76148.
PROQ969D9.
SOURCESearch...

Entry information

Entry nameTSLP_HUMAN
AccessionPrimary (citable) accession number: Q969D9
Secondary accession number(s): Q8IW99
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM