SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q969D9

- TSLP_HUMAN

UniProt

Q969D9 - TSLP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymic stromal lymphopoietin

Gene
TSLP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.3 Publications

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ969D9.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Gene namesi
Name:TSLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:30743. TSLP.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 159131Thymic stromal lymphopoietinPRO_0000300873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi64 – 641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ969D9.
PRIDEiQ969D9.

PTM databases

PhosphoSiteiQ969D9.

Expressioni

Tissue specificityi

Expressed in a number of tissues including heart, liver and prostate.1 Publication

Inductioni

Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.1 Publication

Gene expression databases

ArrayExpressiQ969D9.
BgeeiQ969D9.
CleanExiHS_TSLP.
GenevestigatoriQ969D9.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R.

Protein-protein interaction databases

BioGridi124555. 3 interactions.
IntActiQ969D9. 2 interactions.
STRINGi9606.ENSP00000339804.

Structurei

3D structure databases

ProteinModelPortaliQ969D9.
SMRiQ969D9. Positions 29-151.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42670.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
KOiK05436.
OrthoDBiEOG7R56W9.
PhylomeDBiQ969D9.
TreeFamiTF338216.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q969D9-1 [UniParc]FASTAAdd to Basket

« Hide

MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD    50
LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM 100
KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR 150
FNRPLLKQQ 159
Length:159
Mass (Da):18,141
Last modified:December 1, 2001 - v1
Checksum:iFE158129406E3963
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 1111MFPFALLYVLS → MKCLGQSKKEE in AAH40592. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY037115 mRNA. Translation: AAK67490.1.
AF338732 mRNA. Translation: AAK60617.1.
BC040592 mRNA. Translation: AAH40592.1.
CCDSiCCDS4101.1.
RefSeqiNP_149024.1. NM_033035.4.
UniGeneiHs.389874.

Genome annotation databases

EnsembliENST00000344895; ENSP00000339804; ENSG00000145777.
ENST00000420978; ENSP00000399099; ENSG00000145777.
GeneIDi85480.
KEGGihsa:85480.
UCSCiuc003kpb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY037115 mRNA. Translation: AAK67490.1 .
AF338732 mRNA. Translation: AAK60617.1 .
BC040592 mRNA. Translation: AAH40592.1 .
CCDSi CCDS4101.1.
RefSeqi NP_149024.1. NM_033035.4.
UniGenei Hs.389874.

3D structure databases

ProteinModelPortali Q969D9.
SMRi Q969D9. Positions 29-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124555. 3 interactions.
IntActi Q969D9. 2 interactions.
STRINGi 9606.ENSP00000339804.

PTM databases

PhosphoSitei Q969D9.

Proteomic databases

PaxDbi Q969D9.
PRIDEi Q969D9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344895 ; ENSP00000339804 ; ENSG00000145777 .
ENST00000420978 ; ENSP00000399099 ; ENSG00000145777 .
GeneIDi 85480.
KEGGi hsa:85480.
UCSCi uc003kpb.2. human.

Organism-specific databases

CTDi 85480.
GeneCardsi GC05P110405.
H-InvDB HIX0200750.
HGNCi HGNC:30743. TSLP.
MIMi 607003. gene.
neXtProti NX_Q969D9.
PharmGKBi PA162407159.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42670.
HOGENOMi HOG000154693.
HOVERGENi HBG094875.
KOi K05436.
OrthoDBi EOG7R56W9.
PhylomeDBi Q969D9.
TreeFami TF338216.

Enzyme and pathway databases

SignaLinki Q969D9.

Miscellaneous databases

GeneWikii Thymic_stromal_lymphopoietin.
GenomeRNAii 85480.
NextBioi 76148.
PROi Q969D9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q969D9.
Bgeei Q969D9.
CleanExi HS_TSLP.
Genevestigatori Q969D9.

Family and domain databases

InterProi IPR029189. TSLP.
[Graphical view ]
Pfami PF15216. TSLP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
  2. "Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation."
    Quentmeier H., Drexler H.G., Fleckenstein D., Zaborski M., Armstrong A., Sims J.E., Lyman S.D.
    Leukemia 15:1286-1292(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells."
    Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G.
    J. Exp. Med. 204:253-258(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ALLERGIC INFLAMMATION, INDUCTION.

Entry informationi

Entry nameiTSLP_HUMAN
AccessioniPrimary (citable) accession number: Q969D9
Secondary accession number(s): Q8IW99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi