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Protein

Thymic stromal lymphopoietin

Gene

TSLP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.3 Publications
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • interleukin-7 receptor binding Source: UniProtKB

GO - Biological processi

  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • defense response to fungus Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • interleukin-7-mediated signaling pathway Source: Reactome
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of growth of symbiont on or near host surface Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of chemokine (C-C motif) ligand 1 production Source: UniProtKB
  • positive regulation of chemokine production Source: UniProtKB
  • positive regulation of cytokine-mediated signaling pathway Source: UniProtKB
  • positive regulation of granulocyte colony-stimulating factor production Source: UniProtKB
  • positive regulation of inflammatory response Source: UniProtKB
  • positive regulation of interleukin-10 production Source: UniProtKB
  • positive regulation of interleukin-13 production Source: UniProtKB
  • positive regulation of interleukin-5 production Source: UniProtKB
  • positive regulation of interleukin-5 secretion Source: UniProtKB
  • positive regulation of interleukin-6 production Source: UniProtKB
  • positive regulation of mast cell activation Source: UniProtKB
  • positive regulation of STAT cascade Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-1266695 Interleukin-7 signaling
SignaLinkiQ969D9
SIGNORiQ969D9

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Gene namesi
Name:TSLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145777.14
HGNCiHGNC:30743 TSLP
MIMi607003 gene
neXtProtiNX_Q969D9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi85480
OpenTargetsiENSG00000145777
PharmGKBiPA162407159

Polymorphism and mutation databases

BioMutaiTSLP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000030087329 – 159Thymic stromal lymphopoietinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 110By similarity
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi69 ↔ 75By similarity
Disulfide bondi90 ↔ 137By similarity
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969D9
PeptideAtlasiQ969D9
PRIDEiQ969D9

PTM databases

PhosphoSitePlusiQ969D9

Expressioni

Tissue specificityi

Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.2 Publications

Inductioni

Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.1 Publication

Gene expression databases

BgeeiENSG00000145777
CleanExiHS_TSLP
ExpressionAtlasiQ969D9 baseline and differential
GenevisibleiQ969D9 HS

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB
  • interleukin-7 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124555, 3 interactors
IntActiQ969D9, 2 interactors
STRINGi9606.ENSP00000339804

Structurei

Secondary structure

1159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi31 – 33Combined sources3
Helixi36 – 45Combined sources10
Helixi47 – 54Combined sources8
Helixi60 – 62Combined sources3
Helixi72 – 84Combined sources13
Helixi97 – 109Combined sources13
Helixi135 – 151Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J11X-ray2.56A36-159[»]
5J12X-ray3.55A1-159[»]
5J13X-ray2.30A29-159[»]
ProteinModelPortaliQ969D9
SMRiQ969D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J13Z Eukaryota
ENOG4111BHG LUCA
GeneTreeiENSGT00390000012541
HOGENOMiHOG000154693
HOVERGENiHBG094875
InParanoidiQ969D9
KOiK05436
OrthoDBiEOG091G12VL
PhylomeDBiQ969D9
TreeFamiTF338216

Family and domain databases

Gene3Di1.20.1250.90, 1 hit
InterProiView protein in InterPro
IPR029189 TSLP
IPR038329 TSLP_sf
PANTHERiPTHR38003 PTHR38003, 1 hit
PfamiView protein in Pfam
PF15216 TSLP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969D9-1) [UniParc]FASTAAdd to basket
Also known as: lfTSLP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD
60 70 80 90 100
LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM
110 120 130 140 150
KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR

FNRPLLKQQ
Length:159
Mass (Da):18,141
Last modified:December 1, 2001 - v1
Checksum:iFE158129406E3963
GO
Isoform 2 (identifier: Q969D9-2) [UniParc]FASTAAdd to basket
Also known as: sfTSLP

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:63
Mass (Da):7,426
Checksum:iF9B3AD49846E71B2
GO

Sequence cautioni

The sequence AAH16720 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH22894 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 11MFPFALLYVLS → MKCLGQSKKEE in AAH40592 (PubMed:15372022).CuratedAdd BLAST11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574621 – 96Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037115 mRNA Translation: AAK67490.1
AF338732 mRNA Translation: AAK60617.1
AC008572 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49038.1
BC016720 mRNA Translation: AAH16720.1 Different initiation.
BC022894 mRNA Translation: AAH22894.1 Different initiation.
BC040592 mRNA Translation: AAH40592.1
CCDSiCCDS4101.1 [Q969D9-1]
RefSeqiNP_149024.1, NM_033035.4 [Q969D9-1]
NP_612561.2, NM_138551.4 [Q969D9-2]
XP_011542000.1, XM_011543698.1 [Q969D9-2]
UniGeneiHs.389874

Genome annotation databases

EnsembliENST00000344895; ENSP00000339804; ENSG00000145777 [Q969D9-1]
ENST00000379706; ENSP00000427827; ENSG00000145777 [Q969D9-2]
GeneIDi85480
KEGGihsa:85480
UCSCiuc003kpb.3 human [Q969D9-1]
uc031skq.1 human

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTSLP_HUMAN
AccessioniPrimary (citable) accession number: Q969D9
Secondary accession number(s): G3XAM8, Q8IW99, Q96AU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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