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Protein

Thymic stromal lymphopoietin

Gene

TSLP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.3 Publications
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.1 Publication

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145777-MONOMER.
SignaLinkiQ969D9.
SIGNORiQ969D9.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Gene namesi
Name:TSLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30743. TSLP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi85480.
OpenTargetsiENSG00000145777.
PharmGKBiPA162407159.

Polymorphism and mutation databases

BioMutaiTSLP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000030087329 – 159Thymic stromal lymphopoietinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 110By similarity
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi69 ↔ 75By similarity
Disulfide bondi90 ↔ 137By similarity
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ969D9.
PeptideAtlasiQ969D9.
PRIDEiQ969D9.

PTM databases

PhosphoSitePlusiQ969D9.

Expressioni

Tissue specificityi

Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva.2 Publications

Inductioni

Released by primary epithelial cells in response to certain microbial products, physical injury, or inflammatory cytokines.1 Publication

Gene expression databases

BgeeiENSG00000145777.
CleanExiHS_TSLP.
ExpressionAtlasiQ969D9. baseline and differential.
GenevisibleiQ969D9. HS.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.By similarity

Protein-protein interaction databases

BioGridi124555. 3 interactors.
IntActiQ969D9. 2 interactors.
STRINGi9606.ENSP00000339804.

Structurei

3D structure databases

ProteinModelPortaliQ969D9.
SMRiQ969D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J13Z. Eukaryota.
ENOG4111BHG. LUCA.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ969D9.
KOiK05436.
OrthoDBiEOG091G12VL.
PhylomeDBiQ969D9.
TreeFamiTF338216.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q969D9-1) [UniParc]FASTAAdd to basket
Also known as: lfTSLP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPFALLYVL SVSFRKIFIL QLVGLVLTYD FTNCDFEKIK AAYLSTISKD
60 70 80 90 100
LITYMSGTKS TEFNNTVSCS NRPHCLTEIQ SLTFNPTAGC ASLAKEMFAM
110 120 130 140 150
KTKAALAIWC PGYSETQINA TQAMKKRRKR KVTTNKCLEQ VSQLQGLWRR

FNRPLLKQQ
Length:159
Mass (Da):18,141
Last modified:December 1, 2001 - v1
Checksum:iFE158129406E3963
GO
Isoform 2 (identifier: Q969D9-2) [UniParc]FASTAAdd to basket
Also known as: sfTSLP

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:63
Mass (Da):7,426
Checksum:iF9B3AD49846E71B2
GO

Sequence cautioni

The sequence AAH16720 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH22894 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 11MFPFALLYVLS → MKCLGQSKKEE in AAH40592 (PubMed:15372022).CuratedAdd BLAST11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574621 – 96Missing in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037115 mRNA. Translation: AAK67490.1.
AF338732 mRNA. Translation: AAK60617.1.
AC008572 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49038.1.
BC016720 mRNA. Translation: AAH16720.1. Different initiation.
BC022894 mRNA. Translation: AAH22894.1. Different initiation.
BC040592 mRNA. Translation: AAH40592.1.
CCDSiCCDS4101.1. [Q969D9-1]
RefSeqiNP_149024.1. NM_033035.4. [Q969D9-1]
NP_612561.2. NM_138551.4. [Q969D9-2]
XP_011542000.1. XM_011543698.1. [Q969D9-2]
UniGeneiHs.389874.

Genome annotation databases

EnsembliENST00000344895; ENSP00000339804; ENSG00000145777. [Q969D9-1]
ENST00000379706; ENSP00000427827; ENSG00000145777. [Q969D9-2]
GeneIDi85480.
KEGGihsa:85480.
UCSCiuc003kpb.3. human. [Q969D9-1]
uc031skq.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037115 mRNA. Translation: AAK67490.1.
AF338732 mRNA. Translation: AAK60617.1.
AC008572 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW49038.1.
BC016720 mRNA. Translation: AAH16720.1. Different initiation.
BC022894 mRNA. Translation: AAH22894.1. Different initiation.
BC040592 mRNA. Translation: AAH40592.1.
CCDSiCCDS4101.1. [Q969D9-1]
RefSeqiNP_149024.1. NM_033035.4. [Q969D9-1]
NP_612561.2. NM_138551.4. [Q969D9-2]
XP_011542000.1. XM_011543698.1. [Q969D9-2]
UniGeneiHs.389874.

3D structure databases

ProteinModelPortaliQ969D9.
SMRiQ969D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124555. 3 interactors.
IntActiQ969D9. 2 interactors.
STRINGi9606.ENSP00000339804.

PTM databases

PhosphoSitePlusiQ969D9.

Polymorphism and mutation databases

BioMutaiTSLP.

Proteomic databases

PaxDbiQ969D9.
PeptideAtlasiQ969D9.
PRIDEiQ969D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344895; ENSP00000339804; ENSG00000145777. [Q969D9-1]
ENST00000379706; ENSP00000427827; ENSG00000145777. [Q969D9-2]
GeneIDi85480.
KEGGihsa:85480.
UCSCiuc003kpb.3. human. [Q969D9-1]
uc031skq.1. human.

Organism-specific databases

CTDi85480.
DisGeNETi85480.
GeneCardsiTSLP.
H-InvDBHIX0200750.
HGNCiHGNC:30743. TSLP.
MIMi607003. gene.
neXtProtiNX_Q969D9.
OpenTargetsiENSG00000145777.
PharmGKBiPA162407159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J13Z. Eukaryota.
ENOG4111BHG. LUCA.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ969D9.
KOiK05436.
OrthoDBiEOG091G12VL.
PhylomeDBiQ969D9.
TreeFamiTF338216.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145777-MONOMER.
SignaLinkiQ969D9.
SIGNORiQ969D9.

Miscellaneous databases

GeneWikiiThymic_stromal_lymphopoietin.
GenomeRNAii85480.
PROiQ969D9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145777.
CleanExiHS_TSLP.
ExpressionAtlasiQ969D9. baseline and differential.
GenevisibleiQ969D9. HS.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSLP_HUMAN
AccessioniPrimary (citable) accession number: Q969D9
Secondary accession number(s): G3XAM8, Q8IW99, Q96AU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.