Q969A8 (HXK_TOXGO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase
EC=2.7.1.1

Gene names

Name:

HXK

Organism

Toxoplasma gondii

Taxonomic identifier

5811 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Coccidia › Eucoccidiorida › Eimeriorina › Sarcocystidae › Toxoplasma

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Hexokinase		PRO_0000197600
Regions
	Nucleotide binding	85 – 90	6	ATP Potential
	Region	163 – 189	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q969A8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 4758C4D97F253D68	FASTA	468	51,468
	10 20 30 40 50 60 MQPRQPGDEA KQLAELEVVR QMMTPTREVL LELHESFLKE LQRGLEMHKR HGITWVPEEC 70 80 90 100 110 120 SMKMLDSCVS NLPTGAEVGE AYAIDFGGST CRAVRCSLLG KGKMEIIQDK ICLRSAEHRC 130 140 150 160 170 180 AKGFMDKKAG GKELFDQFAM CIRGLMDRSG DLKKAEETNT PVPVGFTFSF PCAQAALNSS 190 200 210 220 230 240 FLIEWTKGFE TGRENPDRVE GKDVAVLLAD ALQRHNVPAV CKAIVNDTVG TLVSCAYQRV 250 260 270 280 290 300 PGTPECRVGL IIGTGFNACY VEPEASNYGY TGTVVNMEAG NFHKDLPRNE IDVEVDEKTH 310 320 330 340 350 360 NRGKQQFEKL VSGYYIGEIV RVAAVRVFGA RAPEKASVRH SIHGETASTI RDDHSQDKAA 370 380 390 400 410 420 SIQAIKECWG VTMDLDDIKC IWEICRLVFD RSAAFAATLA VALCYRTGRL DTGSTVGIDG 430 440 450 460 ALYVKNQWYR EAVEYYTKLV AGDAAKNIHY CIADDGSGKG AALIADVN

References

[1]	"Hexokinase." Saito T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049736 mRNA. Translation: BAB55664.1.
3D structure databases
ProteinModelPortal	Q969A8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.7.1.1. 6411.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK_TOXGO

Accession

Primary (citable) accession number: Q969A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	December 1, 2001
Last modified:	September 21, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)