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Q967Z0 (MYSP_DERFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paramyosin
Alternative name(s):
Antigen Df642
Allergen=Der f 11
OrganismDermatophagoides farinae (American house dust mite)
Taxonomic identifier6954 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Protein attributes

Sequence length692 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Allergenic properties

Causes an allergic reaction in human. Binds to IgE.

Sequence similarities

Belongs to the paramyosin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Thick filament
   DiseaseAllergen
   DomainCoiled coil
   Molecular functionMotor protein
Muscle protein
Myosin
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentmyofibril

Inferred from electronic annotation. Source: UniProtKB-SubCell

myosin filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionmotor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›692›692Paramyosin
PRO_0000211247

Regions

Region1 – 1515Nonhelical region Potential
Coiled coil16 – ›692›677 Potential

Experimental info

Non-terminal residue6921

Sequences

Sequence LengthMass (Da)Tools
Q967Z0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 61FC6380C9D7C9E2

FASTA69281,372
        10         20         30         40         50         60 
MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK AKNKSDKEKQ 

        70         80         90        100        110        120 
KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK IEEINRTVIE LTSHKQRLSQ 

       130        140        150        160        170        180 
ENTELIKEVH EVKLQLDNAN HLKTQIAQQL EDTRHRLEEE ERKRASLENH AHTLEVELES 

       190        200        210        220        230        240 
LKVQLDEESE ARLELERQLT KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE 

       250        260        270        280        290        300 
QLEALLNKCS SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE 

       310        320        330        340        350        360 
VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA KSQLNDAHRR 

       370        380        390        400        410        420 
IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI AELAQVRHDY EKRLAQKDEE 

       430        440        450        460        470        480 
IEALRKQYQI EIEQLNMRLA EAEAKLKTEI ARLKKKYQAQ ITELELSLDA ANKANIDLQK 

       490        500        510        520        530        540 
TIKKQALQIT ELQAHYDEVH RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ 

       550        560        570        580        590        600 
AEQLHEEAVV RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE 

       610        620        630        640        650        660 
LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV IAKLESRIRD 

       670        680        690 
VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ 

« Hide

References

[1]"Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae."
Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S., Chua K.-Y.
Clin. Exp. Allergy 29:1606-1613(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen."
Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N., Hung M.W., Lee B.L., Chua K.-Y.
J. Allergy Clin. Immunol. 102:295-303(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF352244 mRNA. Translation: AAK39511.1.

3D structure databases

ProteinModelPortalQ967Z0.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome297. Der f 11.
3249. Der f 11.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002928. Myosin_tail.
[Graphical view]
PfamPF01576. Myosin_tail_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYSP_DERFA
AccessionPrimary (citable) accession number: Q967Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries