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Q967Z0

- MYSP_DERFA

UniProt

Q967Z0 - MYSP_DERFA

Protein

Paramyosin

Gene
N/A
Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.

    GO - Molecular functioni

    1. motor activity Source: InterPro

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paramyosin
    Alternative name(s):
    Antigen Df642
    Allergen: Der f 11
    OrganismiDermatophagoides farinae (American house dust mite)
    Taxonomic identifieri6954 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

    Subcellular locationi

    Cytoplasmmyofibril
    Note: Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. myofibril Source: UniProtKB-SubCell
    2. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Binds to IgE.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei297. Der f 11.
    3249. Der f 11.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›692›692ParamyosinPRO_0000211247Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ967Z0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1515Nonhelical regionSequence AnalysisAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili16 – ›692›677Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paramyosin family.Curated

    Keywords - Domaini

    Coiled coil

    Family and domain databases

    InterProiIPR002928. Myosin_tail.
    [Graphical view]
    PfamiPF01576. Myosin_tail_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q967Z0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK    50
    AKNKSDKEKQ KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK 100
    IEEINRTVIE LTSHKQRLSQ ENTELIKEVH EVKLQLDNAN HLKTQIAQQL 150
    EDTRHRLEEE ERKRASLENH AHTLEVELES LKVQLDEESE ARLELERQLT 200
    KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE QLEALLNKCS 250
    SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE 300
    VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA 350
    KSQLNDAHRR IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI 400
    AELAQVRHDY EKRLAQKDEE IEALRKQYQI EIEQLNMRLA EAEAKLKTEI 450
    ARLKKKYQAQ ITELELSLDA ANKANIDLQK TIKKQALQIT ELQAHYDEVH 500
    RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ AEQLHEEAVV 550
    RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE 600
    LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV 650
    IAKLESRIRD VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ 692
    Length:692
    Mass (Da):81,372
    Last modified:December 1, 2001 - v1
    Checksum:i61FC6380C9D7C9E2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei692 – 6921

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352244 mRNA. Translation: AAK39511.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF352244 mRNA. Translation: AAK39511.1 .

    3D structure databases

    ProteinModelPortali Q967Z0.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 297. Der f 11.
    3249. Der f 11.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002928. Myosin_tail.
    [Graphical view ]
    Pfami PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae."
      Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S., Chua K.-Y.
      Clin. Exp. Allergy 29:1606-1613(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen."
      Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N., Hung M.W., Lee B.L., Chua K.-Y.
      J. Allergy Clin. Immunol. 102:295-303(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

    Entry informationi

    Entry nameiMYSP_DERFA
    AccessioniPrimary (citable) accession number: Q967Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3