Q967Z0 (MYSP_DERFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Paramyosin Alternative name(s): Antigen Df642 Allergen=Der f 11
Organism	Dermatophagoides farinae (American house dust mite)
Taxonomic identifier	6954 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Acari › Acariformes › Sarcoptiformes › Astigmata › Psoroptidia › Analgoidea › Pyroglyphidae › Dermatophagoidinae › Dermatophagoides

Protein attributes

Sequence length	692 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm › myofibril. Note: Thick filaments of the myofibrils.
Allergenic properties	Causes an allergic reaction in human. Binds to IgE.
Sequence similarities	Belongs to the paramyosin family.

Ontologies

Keywords
Cellular component	Cytoplasm Thick filament
Disease	Allergen
Domain	Coiled coil
Molecular function	Motor protein Muscle protein Myosin
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	myofibril Inferred from electronic annotation. Source: UniProtKB-SubCell myosin filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›692	›692	Paramyosin		PRO_0000211247
Regions
	Region	1 – 15	15	Nonhelical region Potential
	Coiled coil	16 – ›692	›677	Potential
Experimental info
	Non-terminal residue	692	1

Sequences

	Sequence		Length	Mass (Da)
	Q967Z0 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 61FC6380C9D7C9E2	FASTA	692	81,372
	10 20 30 40 50 60 MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK AKNKSDKEKQ 70 80 90 100 110 120 KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK IEEINRTVIE LTSHKQRLSQ 130 140 150 160 170 180 ENTELIKEVH EVKLQLDNAN HLKTQIAQQL EDTRHRLEEE ERKRASLENH AHTLEVELES 190 200 210 220 230 240 LKVQLDEESE ARLELERQLT KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE 250 260 270 280 290 300 QLEALLNKCS SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE 310 320 330 340 350 360 VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA KSQLNDAHRR 370 380 390 400 410 420 IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI AELAQVRHDY EKRLAQKDEE 430 440 450 460 470 480 IEALRKQYQI EIEQLNMRLA EAEAKLKTEI ARLKKKYQAQ ITELELSLDA ANKANIDLQK 490 500 510 520 530 540 TIKKQALQIT ELQAHYDEVH RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ 550 560 570 580 590 600 AEQLHEEAVV RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE 610 620 630 640 650 660 LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV IAKLESRIRD 670 680 690 VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ

References

[1]	"Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae." Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S., Chua K.-Y. Clin. Exp. Allergy 29:1606-1613(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen." Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N., Hung M.W., Lee B.L., Chua K.-Y. J. Allergy Clin. Immunol. 102:295-303(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF352244 mRNA. Translation: AAK39511.1.
3D structure databases
ProteinModelPortal	Q967Z0.
ModBase	Search...
Protein family/group databases
Allergome	297. Der f 11. 3249. Der f 11.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002928. Myosin_tail. [Graphical view]
Pfam	PF01576. Myosin_tail_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYSP_DERFA

Accession

Primary (citable) accession number: Q967Z0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)