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Protein

Paramyosin

Gene
N/A
Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.

GO - Molecular functioni

  1. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Paramyosin
Alternative name(s):
Antigen Df642
Allergen: Der f 11
OrganismiDermatophagoides farinae (American house dust mite)
Taxonomic identifieri6954 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. myofibril Source: UniProtKB-SubCell
  2. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei297. Der f 11.
3249. Der f 11.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›692›692ParamyosinPRO_0000211247Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ967Z0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1515Nonhelical regionSequence AnalysisAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – ›692›677Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the paramyosin family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q967Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK
60 70 80 90 100
AKNKSDKEKQ KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK
110 120 130 140 150
IEEINRTVIE LTSHKQRLSQ ENTELIKEVH EVKLQLDNAN HLKTQIAQQL
160 170 180 190 200
EDTRHRLEEE ERKRASLENH AHTLEVELES LKVQLDEESE ARLELERQLT
210 220 230 240 250
KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE QLEALLNKCS
260 270 280 290 300
SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE
310 320 330 340 350
VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA
360 370 380 390 400
KSQLNDAHRR IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI
410 420 430 440 450
AELAQVRHDY EKRLAQKDEE IEALRKQYQI EIEQLNMRLA EAEAKLKTEI
460 470 480 490 500
ARLKKKYQAQ ITELELSLDA ANKANIDLQK TIKKQALQIT ELQAHYDEVH
510 520 530 540 550
RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ AEQLHEEAVV
560 570 580 590 600
RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE
610 620 630 640 650
LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV
660 670 680 690
IAKLESRIRD VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ
Length:692
Mass (Da):81,372
Last modified:December 1, 2001 - v1
Checksum:i61FC6380C9D7C9E2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei692 – 6921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352244 mRNA. Translation: AAK39511.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF352244 mRNA. Translation: AAK39511.1.

3D structure databases

ProteinModelPortaliQ967Z0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei297. Der f 11.
3249. Der f 11.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae."
    Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S., Chua K.-Y.
    Clin. Exp. Allergy 29:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen."
    Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N., Hung M.W., Lee B.L., Chua K.-Y.
    J. Allergy Clin. Immunol. 102:295-303(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Entry informationi

Entry nameiMYSP_DERFA
AccessioniPrimary (citable) accession number: Q967Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.