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Q967Z0

- MYSP_DERFA

UniProt

Q967Z0 - MYSP_DERFA

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Protein
Paramyosin
Gene
N/A
Organism
Dermatophagoides farinae (American house dust mite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.

GO - Molecular functioni

  1. motor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Paramyosin
Alternative name(s):
Antigen Df642
Allergen: Der f 11
OrganismiDermatophagoides farinae (American house dust mite)
Taxonomic identifieri6954 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariAcariformesSarcoptiformesAstigmataPsoroptidiaAnalgoideaPyroglyphidaeDermatophagoidinaeDermatophagoides

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. myofibril Source: UniProtKB-SubCell
  2. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei297. Der f 11.
3249. Der f 11.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›692›692Paramyosin
PRO_0000211247Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ967Z0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1515Nonhelical region Reviewed prediction
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – ›692›677 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the paramyosin family.

Keywords - Domaini

Coiled coil

Family and domain databases

InterProiIPR002928. Myosin_tail.
[Graphical view]
PfamiPF01576. Myosin_tail_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q967Z0-1 [UniParc]FASTAAdd to Basket

« Hide

MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK    50
AKNKSDKEKQ KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK 100
IEEINRTVIE LTSHKQRLSQ ENTELIKEVH EVKLQLDNAN HLKTQIAQQL 150
EDTRHRLEEE ERKRASLENH AHTLEVELES LKVQLDEESE ARLELERQLT 200
KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE QLEALLNKCS 250
SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE 300
VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA 350
KSQLNDAHRR IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI 400
AELAQVRHDY EKRLAQKDEE IEALRKQYQI EIEQLNMRLA EAEAKLKTEI 450
ARLKKKYQAQ ITELELSLDA ANKANIDLQK TIKKQALQIT ELQAHYDEVH 500
RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ AEQLHEEAVV 550
RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE 600
LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV 650
IAKLESRIRD VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ 692
Length:692
Mass (Da):81,372
Last modified:December 1, 2001 - v1
Checksum:i61FC6380C9D7C9E2
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei692 – 6921

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352244 mRNA. Translation: AAK39511.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF352244 mRNA. Translation: AAK39511.1 .

3D structure databases

ProteinModelPortali Q967Z0.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 297. Der f 11.
3249. Der f 11.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002928. Myosin_tail.
[Graphical view ]
Pfami PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae."
    Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S., Chua K.-Y.
    Clin. Exp. Allergy 29:1606-1613(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of a novel 98-kd Dermatophagoides farinae mite allergen."
    Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N., Hung M.W., Lee B.L., Chua K.-Y.
    J. Allergy Clin. Immunol. 102:295-303(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.

Entry informationi

Entry nameiMYSP_DERFA
AccessioniPrimary (citable) accession number: Q967Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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