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Protein
Submitted name:

Adenine phosphoribosyltransferase

Gene

DHA2_112885

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei63 – 631Transition state stabilizerCombined sources
Active sitei100 – 1001Proton donor/acceptorCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BRENDAi2.4.2.7. 2401.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenine phosphoribosyltransferaseImported
Gene namesi
ORF Names:DHA2_112885Imported
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
ProteomesiUP000018320 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L1QX-ray1.85A1-180[»]
1L1RX-ray1.95A1-180[»]
ProteinModelPortaliQ967M2.
SMRiQ967M2. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ967M2.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q967M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMSVADAHA LIKTIPDFPT KGIAFKDLSD ILSTPAALDA VRKEVTAHYK
60 70 80 90 100
DVPITKVVGI ESRGFILGGI VANSLGVGFV ALRKAGKLPG DVCKCTFDME
110 120 130 140 150
YQKGVTIEVQ KRQLGPHDVV LLHDDVLATG GTLLAAIELC ETAGVKPENI
160 170 180
YINVLYEIEA LKGREKVGQK CTRLFSVIRE
Length:180
Mass (Da):19,436
Last modified:December 1, 2001 - v1
Checksum:iE9426D7975C0CE5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378363 mRNA. Translation: AAK56310.1.
AHGT01000011 Genomic DNA. Translation: ESU38582.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378363 mRNA. Translation: AAK56310.1.
AHGT01000011 Genomic DNA. Translation: ESU38582.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L1QX-ray1.85A1-180[»]
1L1RX-ray1.95A1-180[»]
ProteinModelPortaliQ967M2.
SMRiQ967M2. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.4.2.7. 2401.

Miscellaneous databases

EvolutionaryTraceiQ967M2.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties."
    Sarver A.E., Wang C.C.
    J. Biol. Chem. 277:39973-39980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration."
    Shi W., Sarver A.E., Wang C.C., Tanaka K.S., Almo S.C., Schramm V.L.
    J. Biol. Chem. 277:39981-39988(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), ACTIVE SITE.
  3. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
    Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DHImported.

Entry informationi

Entry nameiQ967M2_GIAIN
AccessioniPrimary (citable) accession number: Q967M2
Secondary accession number(s): A8BXA3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.