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Q967M2 (Q967M2_GIAIN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
ORF Names:DHA2_112885 EMBL ESU38582.1
OrganismGiardia intestinalis (Giardia lamblia) [Complete proteome] EMBL AAK56310.1
Taxonomic identifier5741 [NCBI]
Taxonomic lineageEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region83 – 842Sulfate 2 binding PDB 1L1Q
Region128 – 1325Sulfate 3 binding PDB 1L1Q

Sites

Active site1001Proton donor/acceptor PDB 1L1R
Binding site91Sulfate 1 PDB 1L1Q
Binding site261Sulfate 1 PDB 1L1Q
Binding site621Sulfate 2; via amide nitrogen PDB 1L1Q
Binding site631Sulfate 3 PDB 1L1Q
Binding site1001Sulfate 3; via amide nitrogen PDB 1L1Q
Binding site1561Sulfate 1 PDB 1L1Q
Site631Transition state stabilizer PDB 1L1R

Sequences

Sequence LengthMass (Da)Tools
Q967M2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E9426D7975C0CE5C

FASTA18019,436
        10         20         30         40         50         60 
MTMSVADAHA LIKTIPDFPT KGIAFKDLSD ILSTPAALDA VRKEVTAHYK DVPITKVVGI 

        70         80         90        100        110        120 
ESRGFILGGI VANSLGVGFV ALRKAGKLPG DVCKCTFDME YQKGVTIEVQ KRQLGPHDVV 

       130        140        150        160        170        180 
LLHDDVLATG GTLLAAIELC ETAGVKPENI YINVLYEIEA LKGREKVGQK CTRLFSVIRE 

« Hide

References

[1]"The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties."
Sarver A.E., Wang C.C.
J. Biol. Chem. 277:39973-39980(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration."
Shi W., Sarver A.E., Wang C.C., Tanaka K.S., Almo S.C., Schramm V.L.
J. Biol. Chem. 277:39981-39988(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH SULFATE, ACTIVE SITE.
[3]"Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DH EMBL ESU38582.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378363 mRNA. Translation: AAK56310.1.
AHGT01000011 Genomic DNA. Translation: ESU38582.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1L1QX-ray1.85A1-180[»]
1L1RX-ray1.95A1-180[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.4.2.7. 322.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ967M2.

Entry information

Entry nameQ967M2_GIAIN
AccessionPrimary (citable) accession number: Q967M2
Secondary accession number(s): A8BXA3
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)