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Q967M2

- Q967M2_GIAIN

UniProt

Q967M2 - Q967M2_GIAIN

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Protein
Submitted name:

Adenine phosphoribosyltransferase

Gene

DHA2_112885

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei63 – 631Transition state stabilizerImported
Active sitei100 – 1001Proton donor/acceptorImported

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BRENDAi2.4.2.7. 322.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenine phosphoribosyltransferaseImported
Gene namesi
ORF Names:DHA2_112885Imported
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
ProteomesiUP000018320: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L1QX-ray1.85A1-180[»]
1L1RX-ray1.95A1-180[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ967M2.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q967M2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMSVADAHA LIKTIPDFPT KGIAFKDLSD ILSTPAALDA VRKEVTAHYK
60 70 80 90 100
DVPITKVVGI ESRGFILGGI VANSLGVGFV ALRKAGKLPG DVCKCTFDME
110 120 130 140 150
YQKGVTIEVQ KRQLGPHDVV LLHDDVLATG GTLLAAIELC ETAGVKPENI
160 170 180
YINVLYEIEA LKGREKVGQK CTRLFSVIRE
Length:180
Mass (Da):19,436
Last modified:December 1, 2001 - v1
Checksum:iE9426D7975C0CE5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378363 mRNA. Translation: AAK56310.1.
AHGT01000011 Genomic DNA. Translation: ESU38582.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378363 mRNA. Translation: AAK56310.1 .
AHGT01000011 Genomic DNA. Translation: ESU38582.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1L1Q X-ray 1.85 A 1-180 [» ]
1L1R X-ray 1.95 A 1-180 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.4.2.7. 322.

Miscellaneous databases

EvolutionaryTracei Q967M2.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties."
    Sarver A.E., Wang C.C.
    J. Biol. Chem. 277:39973-39980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration."
    Shi W., Sarver A.E., Wang C.C., Tanaka K.S., Almo S.C., Schramm V.L.
    J. Biol. Chem. 277:39981-39988(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), ACTIVE SITE.
  3. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
    Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DHImported.

Entry informationi

Entry nameiQ967M2_GIAIN
AccessioniPrimary (citable) accession number: Q967M2
Secondary accession number(s): A8BXA3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3