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Q967M2

- Q967M2_GIAIN

UniProt

Q967M2 - Q967M2_GIAIN

Protein
Submitted name:

Adenine phosphoribosyltransferase

Gene

DHA2_112885

Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei63 – 631Transition state stabilizerImported
    Active sitei100 – 1001Proton donor/acceptorImported

    GO - Molecular functioni

    1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosyltransferaseImported, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.2.7. 322.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adenine phosphoribosyltransferaseImported
    Gene namesi
    ORF Names:DHA2_112885Imported
    OrganismiGiardia intestinalis (Giardia lamblia)Imported
    Taxonomic identifieri5741 [NCBI]
    Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
    ProteomesiUP000018320: Unassembled WGS sequence

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1L1QX-ray1.85A1-180[»]
    1L1RX-ray1.95A1-180[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ967M2.

    Family & Domainsi

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q967M2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMSVADAHA LIKTIPDFPT KGIAFKDLSD ILSTPAALDA VRKEVTAHYK    50
    DVPITKVVGI ESRGFILGGI VANSLGVGFV ALRKAGKLPG DVCKCTFDME 100
    YQKGVTIEVQ KRQLGPHDVV LLHDDVLATG GTLLAAIELC ETAGVKPENI 150
    YINVLYEIEA LKGREKVGQK CTRLFSVIRE 180
    Length:180
    Mass (Da):19,436
    Last modified:December 1, 2001 - v1
    Checksum:iE9426D7975C0CE5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378363 mRNA. Translation: AAK56310.1.
    AHGT01000011 Genomic DNA. Translation: ESU38582.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF378363 mRNA. Translation: AAK56310.1 .
    AHGT01000011 Genomic DNA. Translation: ESU38582.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1L1Q X-ray 1.85 A 1-180 [» ]
    1L1R X-ray 1.95 A 1-180 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.4.2.7. 322.

    Miscellaneous databases

    EvolutionaryTracei Q967M2.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties."
      Sarver A.E., Wang C.C.
      J. Biol. Chem. 277:39973-39980(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration."
      Shi W., Sarver A.E., Wang C.C., Tanaka K.S., Almo S.C., Schramm V.L.
      J. Biol. Chem. 277:39981-39988(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), ACTIVE SITE.
    3. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
      Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DHImported.

    Entry informationi

    Entry nameiQ967M2_GIAIN
    AccessioniPrimary (citable) accession number: Q967M2
    Secondary accession number(s): A8BXA3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3