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Q967M2

- Q967M2_GIAIN

UniProt

Q967M2 - Q967M2_GIAIN

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Protein
Submitted name: Adenine phosphoribosyltransferase
Gene
DHA2_112885
Organism
Giardia intestinalis (Giardia lamblia)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei63 – 631Transition state stabilizerImported
Active sitei100 – 1001Proton donor/acceptorImported

GO - Molecular functioni

  1. transferase activity, transferring glycosyl groups Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseImported, Transferase

Enzyme and pathway databases

BRENDAi2.4.2.7. 322.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenine phosphoribosyltransferaseImported
Gene namesi
ORF Names:DHA2_112885Imported
OrganismiGiardia intestinalis (Giardia lamblia)Imported
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia
ProteomesiUP000018320: Unassembled WGS sequence

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L1QX-ray1.85A1-180[»]
1L1RX-ray1.95A1-180[»]

Miscellaneous databases

EvolutionaryTraceiQ967M2.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q967M2-1 [UniParc]FASTAAdd to Basket

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MTMSVADAHA LIKTIPDFPT KGIAFKDLSD ILSTPAALDA VRKEVTAHYK    50
DVPITKVVGI ESRGFILGGI VANSLGVGFV ALRKAGKLPG DVCKCTFDME 100
YQKGVTIEVQ KRQLGPHDVV LLHDDVLATG GTLLAAIELC ETAGVKPENI 150
YINVLYEIEA LKGREKVGQK CTRLFSVIRE 180
Length:180
Mass (Da):19,436
Last modified:December 1, 2001 - v1
Checksum:iE9426D7975C0CE5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378363 mRNA. Translation: AAK56310.1.
AHGT01000011 Genomic DNA. Translation: ESU38582.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF378363 mRNA. Translation: AAK56310.1 .
AHGT01000011 Genomic DNA. Translation: ESU38582.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1L1Q X-ray 1.85 A 1-180 [» ]
1L1R X-ray 1.95 A 1-180 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.4.2.7. 322.

Miscellaneous databases

EvolutionaryTracei Q967M2.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The adenine phosphoribosyltransferase from Giardia lamblia has a unique reaction mechanism and unusual substrate binding properties."
    Sarver A.E., Wang C.C.
    J. Biol. Chem. 277:39973-39980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration."
    Shi W., Sarver A.E., Wang C.C., Tanaka K.S., Almo S.C., Schramm V.L.
    J. Biol. Chem. 277:39981-39988(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), ACTIVE SITE.
  3. "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and Pig)."
    Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F., Nash T.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DHImported.

Entry informationi

Entry nameiQ967M2_GIAIN
AccessioniPrimary (citable) accession number: Q967M2
Secondary accession number(s): A8BXA3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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