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Protein

Nuclear shuttle protein

Gene

BR1

Organism
Cabbage leaf curl virus (isolate Jamaica) (CaLCuV)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the genomic viral ssDNA, shuttles it into and out of the cell nucleus. Begomoviruses use 2 proteins to transport their DNA from cell to cell. The nuclear shuttle protein (NSP) shuttles it between nucleus and cytoplasm and the movement protein (MP) probably transports the DNA-NSP complex to the cell periphery and facilitates movement across the cell wall (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear shuttle protein
Short name:
NSP
Alternative name(s):
Protein BR1
Protein BV1
Gene namesi
ORF Names:BR1, BV1
OrganismiCabbage leaf curl virus (isolate Jamaica) (CaLCuV)
Taxonomic identifieri345184 [NCBI]
Taxonomic lineageiVirusesssDNA virusesGeminiviridaeBegomovirus
Virus hostiBrassica oleracea (Wild cabbage) [TaxID: 3712]
Proteomesi
  • UP000007622 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host cytoplasm, Host membrane, Host nucleus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150E → G: Complete loss of interaction with Arabidopsis thaliana NSI protein. Reduced level of infectivity. 1 Publication1
Mutagenesisi164I → T: Complete loss of interaction with Arabidopsis thaliana NSI protein. Reduced level of infectivity. 1 Publication1
Mutagenesisi187D → G: Complete loss of interaction with Arabidopsis thaliana NSI protein. Reduced level of infectivity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236981 – 256Nuclear shuttle proteinAdd BLAST256

Proteomic databases

PRIDEiQ96706

Interactioni

Subunit structurei

Binds to single-stranded and double-stranded viral DNA. Interacts with the host nuclear shuttle interacting (NSI) protein. This interaction may allow NSP to recruit NSI monomers to the viral genome and thus regulate nuclear export of viral genome by NSP.3 Publications

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 187Interaction with Arabidopsis thaliana NSI proteinAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 42Bipartite nuclear localization signalBy similarityAdd BLAST22
Motifi81 – 96Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000LH

Family and domain databases

InterProiView protein in InterPro
IPR001530 Gemini_BR1
IPR000263 GV_A/BR1_coat
PfamiView protein in Pfam
PF00844 Gemini_coat, 1 hit
PRINTSiPR00223 GEMCOATARBR1
PR00225 GEMCOATBR1

Sequencei

Sequence statusi: Complete.

Q96706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPTKFRRGV SYSQRRFVSR NQSSKRGTFV RRTDGKRRKG PSSKAHDEPK
60 70 80 90 100
MKLQRIHENQ YGPEFVMTHN SALSTFINFP VLGKIEPNRS RSYIKLNRLS
110 120 130 140 150
FKGTVKIERV HADVNMDGVI SKIEGVFSLV IVVDRKPHLS STGGLHTFDE
160 170 180 190 200
IFGARIHSHG NLAITPGLKD RYYVLHVLKR VLSVEKDTLM VDLEGSTTIS
210 220 230 240 250
NRRYNCWASF NDLEHDLCNG VYANISKNAI LVYYCWMSDA MSKASTFVSY

DLDYLG
Length:256
Mass (Da):29,278
Last modified:February 1, 1997 - v1
Checksum:i0C2E8E0DB4D2B748
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65530 Genomic DNA Translation: AAB17965.1

Similar proteinsi

Entry informationi

Entry nameiNSP_CALCV
AccessioniPrimary (citable) accession number: Q96706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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