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Q966Y3

- JNK_SUBDO

UniProt

Q966Y3 - JNK_SUBDO

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Protein

Stress-activated protein kinase JNK

Gene

JNK

Organism
Suberites domuncula (Sponge)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium.By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511ATPPROSITE-ProRule annotation
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 346ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. JNK cascade Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-activated protein kinase JNK (EC:2.7.11.24)
Gene namesi
Name:JNK
OrganismiSuberites domuncula (Sponge)Imported
Taxonomic identifieri55567 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHadromeridaSuberitidaeSuberites

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Stress-activated protein kinase JNKPRO_0000186272Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791PhosphothreonineBy similarity
Modified residuei181 – 1811PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-179 and Tyr-181, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ966Y3.

Structurei

3D structure databases

ProteinModelPortaliQ966Y3.
SMRiQ966Y3. Positions 4-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 317296Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi179 – 1813TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q966Y3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSSDYYSQR VGDTVFTVQK RYTNLTNIGS GAQGVVCSAF DTVTQEKIAI
60 70 80 90 100
KKLVKPFQNE TYAKRAFREL RLMKMVDHKN IIGLKNLFTP AKSLDDFQDV
110 120 130 140 150
YIVMELMDAN LCRVIGIELD HDRMSYLLYQ LLCGIKHLHS AGIIHRDLKP
160 170 180 190 200
SNIVVKEDCS LKILDFGLAR TADQTFNMTP YVVTRYYRAP EVIVGMKYKE
210 220 230 240 250
NVDIWSVGCI FAEMIRGDIL LPGKDYIDQW NKVTQVLGTP PSVFFKQLSS
260 270 280 290 300
SVRLYCESQP RYAGKSWKDL FPDDVFPNDT PEDKAKTRHG RDLLSKMLQI
310 320 330 340 350
DPQNRITVEQ ALAHPYVSIW YDPAEVHAPP PKRYDHALDE QSIPLDQWKT
360
RIYEEVKTYN S
Length:361
Mass (Da):41,566
Last modified:December 1, 2001 - v1
Checksum:i5CAA9A360CDAA744
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291511 mRNA. Translation: CAC38785.1.
AJ307673 Genomic DNA. Translation: CAC85496.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291511 mRNA. Translation: CAC38785.1 .
AJ307673 Genomic DNA. Translation: CAC85496.1 .

3D structure databases

ProteinModelPortali Q966Y3.
SMRi Q966Y3. Positions 4-356.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q966Y3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01772. JNKMAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular response of the sponge Suberites domuncula to bacterial infection."
    Boehm M., Hentschel U., Friedrich A., Steffen R., Pahler S., Gamulin V., Mueller I.M., Mueller W.E.G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Conservation of the positions of metazoan introns from sponges to humans."
    Mueller W.E.G., Boehm M., Grebenjuk V.A., Skorokhod A., Mueller I.M., Gamulin V.
    Gene 295:299-309(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiJNK_SUBDO
AccessioniPrimary (citable) accession number: Q966Y3
Secondary accession number(s): Q8I1N5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3