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Q966Y3 (JNK_SUBDO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Stress-activated protein kinase JNK

EC=2.7.11.24
Gene names
Name:JNK
OrganismSuberites domuncula (Sponge)
Taxonomic identifier55567 [NCBI]
Taxonomic lineageEukaryotaMetazoaPoriferaDemospongiaeTetractinomorphaHadromeridaSuberitidaeSuberites

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity By similarity. UniProtKB P45983

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB P45983

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity. UniProtKB P45983

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-179 and Tyr-181, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Stress-activated protein kinase JNK
PRO_0000186272

Regions

Domain22 – 317296Protein kinase UniProtKB P53779
Nucleotide binding29 – 346ATP By similarity UniProtKB P53779
Motif179 – 1813TXY

Sites

Active site1471Proton acceptor By similarity UniProtKB P53779
Binding site511ATP By similarity UniProtKB P53779

Amino acid modifications

Modified residue1791Phosphothreonine By similarity UniProtKB P53779
Modified residue1811Phosphotyrosine By similarity UniProtKB P53779

Sequences

Sequence LengthMass (Da)Tools
Q966Y3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5CAA9A360CDAA744

FASTA36141,566
        10         20         30         40         50         60 
MSSSDYYSQR VGDTVFTVQK RYTNLTNIGS GAQGVVCSAF DTVTQEKIAI KKLVKPFQNE 

        70         80         90        100        110        120 
TYAKRAFREL RLMKMVDHKN IIGLKNLFTP AKSLDDFQDV YIVMELMDAN LCRVIGIELD 

       130        140        150        160        170        180 
HDRMSYLLYQ LLCGIKHLHS AGIIHRDLKP SNIVVKEDCS LKILDFGLAR TADQTFNMTP 

       190        200        210        220        230        240 
YVVTRYYRAP EVIVGMKYKE NVDIWSVGCI FAEMIRGDIL LPGKDYIDQW NKVTQVLGTP 

       250        260        270        280        290        300 
PSVFFKQLSS SVRLYCESQP RYAGKSWKDL FPDDVFPNDT PEDKAKTRHG RDLLSKMLQI 

       310        320        330        340        350        360 
DPQNRITVEQ ALAHPYVSIW YDPAEVHAPP PKRYDHALDE QSIPLDQWKT RIYEEVKTYN 


S 

« Hide

References

[1]"Molecular response of the sponge Suberites domuncula to bacterial infection."
Boehm M., Hentschel U., Friedrich A., Steffen R., Pahler S., Gamulin V., Mueller I.M., Mueller W.E.G.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Conservation of the positions of metazoan introns from sponges to humans."
Mueller W.E.G., Boehm M., Grebenjuk V.A., Skorokhod A., Mueller I.M., Gamulin V.
Gene 295:299-309(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ291511 mRNA. Translation: CAC38785.1.
AJ307673 Genomic DNA. Translation: CAC85496.1.

3D structure databases

ProteinModelPortalQ966Y3.
SMRQ966Y3. Positions 4-356.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ966Y3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01772. JNKMAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJNK_SUBDO
AccessionPrimary (citable) accession number: Q966Y3
Secondary accession number(s): Q8I1N5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families