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Q966Y3

- JNK_SUBDO

UniProt

Q966Y3 - JNK_SUBDO

Protein

Stress-activated protein kinase JNK

Gene

JNK

Organism
Suberites domuncula (Sponge)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511ATPPROSITE-ProRule annotation
    Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 346ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. JNK cascade Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stress-activated protein kinase JNK (EC:2.7.11.24)
    Gene namesi
    Name:JNK
    OrganismiSuberites domuncula (Sponge)Imported
    Taxonomic identifieri55567 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHadromeridaSuberitidaeSuberites

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Stress-activated protein kinase JNKPRO_0000186272Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei179 – 1791PhosphothreonineBy similarity
    Modified residuei181 – 1811PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-179 and Tyr-181, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ966Y3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ966Y3.
    SMRiQ966Y3. Positions 4-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 317296Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi179 – 1813TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01772. JNKMAPKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q966Y3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSDYYSQR VGDTVFTVQK RYTNLTNIGS GAQGVVCSAF DTVTQEKIAI    50
    KKLVKPFQNE TYAKRAFREL RLMKMVDHKN IIGLKNLFTP AKSLDDFQDV 100
    YIVMELMDAN LCRVIGIELD HDRMSYLLYQ LLCGIKHLHS AGIIHRDLKP 150
    SNIVVKEDCS LKILDFGLAR TADQTFNMTP YVVTRYYRAP EVIVGMKYKE 200
    NVDIWSVGCI FAEMIRGDIL LPGKDYIDQW NKVTQVLGTP PSVFFKQLSS 250
    SVRLYCESQP RYAGKSWKDL FPDDVFPNDT PEDKAKTRHG RDLLSKMLQI 300
    DPQNRITVEQ ALAHPYVSIW YDPAEVHAPP PKRYDHALDE QSIPLDQWKT 350
    RIYEEVKTYN S 361
    Length:361
    Mass (Da):41,566
    Last modified:December 1, 2001 - v1
    Checksum:i5CAA9A360CDAA744
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291511 mRNA. Translation: CAC38785.1.
    AJ307673 Genomic DNA. Translation: CAC85496.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291511 mRNA. Translation: CAC38785.1 .
    AJ307673 Genomic DNA. Translation: CAC85496.1 .

    3D structure databases

    ProteinModelPortali Q966Y3.
    SMRi Q966Y3. Positions 4-356.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q966Y3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008351. MAPK_JNK.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01772. JNKMAPKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular response of the sponge Suberites domuncula to bacterial infection."
      Boehm M., Hentschel U., Friedrich A., Steffen R., Pahler S., Gamulin V., Mueller I.M., Mueller W.E.G.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Conservation of the positions of metazoan introns from sponges to humans."
      Mueller W.E.G., Boehm M., Grebenjuk V.A., Skorokhod A., Mueller I.M., Gamulin V.
      Gene 295:299-309(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiJNK_SUBDO
    AccessioniPrimary (citable) accession number: Q966Y3
    Secondary accession number(s): Q8I1N5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3