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Protein

Chagasin

Gene

cha

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tight-binding and reversible inhibitor of papain-like cysteine proteases.1 Publication

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI42.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Chagasin
Gene namesi
Name:cha
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

  • Flagellar pocket 1 Publication
  • Cytoplasmic vesicle 1 Publication
  • Cell surface 1 Publication

  • Note: Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.

GO - Cellular componenti

  • cell surface Source: CACAO
  • ciliary pocket Source: CACAO
  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182911 – 110ChagasinAdd BLAST110

Proteomic databases

PaxDbiQ966X9.

Interactioni

Protein-protein interaction databases

DIPiDIP-29312N.
STRINGi353153.XP_813685.1.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi7 – 9Combined sources3
Beta strandi13 – 17Combined sources5
Beta strandi21 – 28Combined sources8
Helixi30 – 32Combined sources3
Beta strandi35 – 38Combined sources4
Turni39 – 41Combined sources3
Beta strandi42 – 44Combined sources3
Turni48 – 50Combined sources3
Beta strandi51 – 58Combined sources8
Beta strandi63 – 66Combined sources4
Beta strandi69 – 77Combined sources9
Beta strandi79 – 90Combined sources12
Turni92 – 94Combined sources3
Turni97 – 99Combined sources3
Beta strandi101 – 110Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO8NMR-A2-110[»]
2H7WX-ray1.70A/B1-110[»]
2NNRX-ray1.70A/B1-110[»]
2NQDX-ray1.75A2-110[»]
2OULX-ray2.20B1-110[»]
3CBJX-ray1.80B1-110[»]
3CBKX-ray2.67B1-110[»]
3E1ZX-ray1.86A1-110[»]
ProteinModelPortaliQ966X9.
SMRiQ966X9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ966X9.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi29 – 33NPTTG motif5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410K32U. Eukaryota.
ENOG410Y4IS. LUCA.

Family and domain databases

InterProiIPR018990. Prot_inh_I42_chagasin.
[Graphical view]
PfamiPF09394. Inhibitor_I42. 1 hit.
[Graphical view]
SUPFAMiSSF141066. SSF141066. 1 hit.

Sequencei

Sequence statusi: Complete.

Q966X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKVTKAHN GATLTVAVGE LVEIQLPSNP TTGFAWYFEG GTKESPNESM
60 70 80 90 100
FTVENKYFPP DSKLLGAGGT EHFHVTVKAA GTHAVNLTYM RPWTGPSHDS
110
ERFTVYLKAN
Length:110
Mass (Da):12,040
Last modified:December 1, 2001 - v1
Checksum:i717F8448EAA38242
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299433 mRNA. Translation: CAC39242.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299433 mRNA. Translation: CAC39242.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO8NMR-A2-110[»]
2H7WX-ray1.70A/B1-110[»]
2NNRX-ray1.70A/B1-110[»]
2NQDX-ray1.75A2-110[»]
2OULX-ray2.20B1-110[»]
3CBJX-ray1.80B1-110[»]
3CBKX-ray2.67B1-110[»]
3E1ZX-ray1.86A1-110[»]
ProteinModelPortaliQ966X9.
SMRiQ966X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29312N.
STRINGi353153.XP_813685.1.

Protein family/group databases

MEROPSiI42.001.

Proteomic databases

PaxDbiQ966X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410K32U. Eukaryota.
ENOG410Y4IS. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ966X9.

Family and domain databases

InterProiIPR018990. Prot_inh_I42_chagasin.
[Graphical view]
PfamiPF09394. Inhibitor_I42. 1 hit.
[Graphical view]
SUPFAMiSSF141066. SSF141066. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHAG_TRYCR
AccessioniPrimary (citable) accession number: Q966X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.