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Protein

Chagasin

Gene

cha

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tight-binding and reversible inhibitor of papain-like cysteine proteases.1 Publication

GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity Source: CACAO

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI42.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Chagasin
Gene namesi
Name:cha
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

  • Flagellar pocket 1 Publication
  • Cytoplasmic vesicle 1 Publication
  • Cell surface 1 Publication

  • Note: Flagellar pocket and cytoplasmic vesicles of trypomastigotes and to the cell surface of amastigotes.

GO - Cellular componenti

  • cell surface Source: CACAO
  • ciliary pocket Source: CACAO
  • cytoplasmic vesicle Source: CACAO

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182911 – 110ChagasinAdd BLAST110

Proteomic databases

PaxDbiQ966X9.

Interactioni

Protein-protein interaction databases

DIPiDIP-29312N.
STRINGi353153.XP_813685.1.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Helixi7 – 9Combined sources3
Beta strandi13 – 17Combined sources5
Beta strandi21 – 28Combined sources8
Helixi30 – 32Combined sources3
Beta strandi35 – 38Combined sources4
Turni39 – 41Combined sources3
Beta strandi42 – 44Combined sources3
Turni48 – 50Combined sources3
Beta strandi51 – 58Combined sources8
Beta strandi63 – 66Combined sources4
Beta strandi69 – 77Combined sources9
Beta strandi79 – 90Combined sources12
Turni92 – 94Combined sources3
Turni97 – 99Combined sources3
Beta strandi101 – 110Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO8NMR-A2-110[»]
2H7WX-ray1.70A/B1-110[»]
2NNRX-ray1.70A/B1-110[»]
2NQDX-ray1.75A2-110[»]
2OULX-ray2.20B1-110[»]
3CBJX-ray1.80B1-110[»]
3CBKX-ray2.67B1-110[»]
3E1ZX-ray1.86A1-110[»]
ProteinModelPortaliQ966X9.
SMRiQ966X9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ966X9.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi29 – 33NPTTG motif5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410K32U. Eukaryota.
ENOG410Y4IS. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR018990. Prot_inh_I42_chagasin.
PfamiView protein in Pfam
PF09394. Inhibitor_I42. 1 hit.
SUPFAMiSSF141066. SSF141066. 1 hit.

Sequencei

Sequence statusi: Complete.

Q966X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKVTKAHN GATLTVAVGE LVEIQLPSNP TTGFAWYFEG GTKESPNESM
60 70 80 90 100
FTVENKYFPP DSKLLGAGGT EHFHVTVKAA GTHAVNLTYM RPWTGPSHDS
110
ERFTVYLKAN
Length:110
Mass (Da):12,040
Last modified:December 1, 2001 - v1
Checksum:i717F8448EAA38242
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299433 mRNA. Translation: CAC39242.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ299433 mRNA. Translation: CAC39242.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FO8NMR-A2-110[»]
2H7WX-ray1.70A/B1-110[»]
2NNRX-ray1.70A/B1-110[»]
2NQDX-ray1.75A2-110[»]
2OULX-ray2.20B1-110[»]
3CBJX-ray1.80B1-110[»]
3CBKX-ray2.67B1-110[»]
3E1ZX-ray1.86A1-110[»]
ProteinModelPortaliQ966X9.
SMRiQ966X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29312N.
STRINGi353153.XP_813685.1.

Protein family/group databases

MEROPSiI42.001.

Proteomic databases

PaxDbiQ966X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410K32U. Eukaryota.
ENOG410Y4IS. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ966X9.

Family and domain databases

InterProiView protein in InterPro
IPR018990. Prot_inh_I42_chagasin.
PfamiView protein in Pfam
PF09394. Inhibitor_I42. 1 hit.
SUPFAMiSSF141066. SSF141066. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHAG_TRYCR
AccessioniPrimary (citable) accession number: Q966X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: December 1, 2001
Last modified: January 18, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.