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Protein

Proteasome subunit beta type

Gene

pbs-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5632684. Hedgehog 'on' state.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta typeUniRule annotation (EC:3.4.25.1UniRule annotation)
Gene namesi
Name:pbs-1Imported
ORF Names:CELE_K08D12.1Imported, K08D12.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiK08D12.1; CE25941; WBGene00003947; pbs-1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotationSAAS annotation, ProteasomeUniRule annotationImported

PTM / Processingi

Proteomic databases

EPDiQ966I8.
PaxDbiQ966I8.
PeptideAtlasiQ966I8.

Expressioni

Gene expression databases

BgeeiWBGene00003947.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.UniRule annotation

Protein-protein interaction databases

STRINGi6239.K08D12.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ966I8.
SMRiQ966I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0174. Eukaryota.
ENOG410XS23. LUCA.
GeneTreeiENSGT00510000046484.
HOGENOMiHOG000091079.
InParanoidiQ966I8.
KOiK02738.
OMAiHDRIYCC.
OrthoDBiEOG091G0GUI.
PhylomeDBiQ966I8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR035140. Proteasome_beta6.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PANTHERiPTHR11599:SF82. PTHR11599:SF82. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q966I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDEKRKAIP AIGFYPQEEI STGTTLIAME YNGGVVVGTD SRTSAGSFIT
60 70 80 90 100
SRATNKITPI TDNMVVCRSG SAADTQAIAD IAKYHIDVYT MTENKPVTIY
110 120 130 140 150
RSSQIFRQFL YNYREQLSAS VLVAGWDEEL GGQVYAIPIG GFVSRQRSTA
160 170 180 190 200
SGSGSTFVQG FLDSQWRPNL TLEECKAIVK QAVGLATFRD GSSGGVVRLA
210 220 230
VINKAGSQFE LFRPDKPGFP FVQTPTPHLS FPPHIEQVL
Length:239
Mass (Da):26,096
Last modified:December 1, 2001 - v1
Checksum:iA2E13D7741964138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CCD72799.1.
RefSeqiNP_500125.1. NM_067724.6.
UniGeneiCel.12539.

Genome annotation databases

EnsemblMetazoaiK08D12.1; K08D12.1; WBGene00003947.
GeneIDi176978.
KEGGicel:CELE_K08D12.1.
UCSCiK08D12.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ966I8_CAEEL
AccessioniPrimary (citable) accession number: Q966I8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported