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Protein

Eukaryotic translation initiation factor 3 subunit I

Gene

eif-3.I

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.
SignaLinkiQ965S8.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit IUniRule annotation
Short name:
eIF3iUniRule annotation
Gene namesi
Name:eif-3.IUniRule annotation
ORF Names:Y74C10AR.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY74C10AR.1; CE30325; WBGene00001232; eif-3.I.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Eukaryotic translation initiation factor 3 subunit IPRO_0000365337Add
BLAST

Proteomic databases

EPDiQ965S8.
PaxDbiQ965S8.
PRIDEiQ965S8.

Expressioni

Gene expression databases

ExpressionAtlasiQ965S8. baseline.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi6239.Y74C10AR.1.

Structurei

3D structure databases

ProteinModelPortaliQ965S8.
SMRiQ965S8. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 4942WD 1Add
BLAST
Repeati51 – 8939WD 2Add
BLAST
Repeati188 – 22740WD 3Add
BLAST
Repeati229 – 26840WD 4Add
BLAST
Repeati285 – 32440WD 5Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.UniRule annotation
Contains 5 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0643. Eukaryota.
ENOG410XQ3E. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000231322.
InParanoidiQ965S8.
KOiK03246.
OMAiKATVCAF.
OrthoDBiEOG7PVWPK.
PhylomeDBiQ965S8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03008. eIF3i.
InterProiIPR027525. eIF3i.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q965S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLSLKGHE RALTRVRFNR EGDLTFSCAK DKKPCVWYTE NGERIGSYDG
60 70 80 90 100
HNGAVWDIDV SWDTTKCVTA SGDLTVKIWD AELGNCLYTI NHQTPMKSCG
110 120 130 140 150
FSYSGNLVCF TTQKMTKNLS TFQVRDLRDS SQMVEGGESF FYSQFDVNAT
160 170 180 190 200
TALFTQMDDL VTIGFESGLL QQYDLRNPDT PIHTNESVHR YSVQDLQLSP
210 220 230 240 250
RGDFLISASR DKTAALLDVN DLKKLKQYKS ERPVNSACIS PNRDHICLGG
260 270 280 290 300
GEDAMQVTQT SVSAGHFEAK IYHMVFEEEF ARFKGHFGPI NTMAWHPSGT
310 320
IIATGGEDGY IRIQEFDEDY LGFTYDF
Length:327
Mass (Da):36,873
Last modified:June 1, 2002 - v2
Checksum:iBC30C4C154FD224C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081786 Genomic DNA. Translation: CCD73538.1.
RefSeqiNP_490988.2. NM_058587.4.
UniGeneiCel.20302.

Genome annotation databases

EnsemblMetazoaiY74C10AR.1a; Y74C10AR.1a; WBGene00001232.
GeneIDi171809.
KEGGicel:CELE_Y74C10AR.1.
UCSCiY74C10AR.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081786 Genomic DNA. Translation: CCD73538.1.
RefSeqiNP_490988.2. NM_058587.4.
UniGeneiCel.20302.

3D structure databases

ProteinModelPortaliQ965S8.
SMRiQ965S8. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y74C10AR.1.

Proteomic databases

EPDiQ965S8.
PaxDbiQ965S8.
PRIDEiQ965S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY74C10AR.1a; Y74C10AR.1a; WBGene00001232.
GeneIDi171809.
KEGGicel:CELE_Y74C10AR.1.
UCSCiY74C10AR.1. c. elegans.

Organism-specific databases

CTDi171809.
WormBaseiY74C10AR.1; CE30325; WBGene00001232; eif-3.I.

Phylogenomic databases

eggNOGiKOG0643. Eukaryota.
ENOG410XQ3E. LUCA.
GeneTreeiENSGT00630000089849.
HOGENOMiHOG000231322.
InParanoidiQ965S8.
KOiK03246.
OMAiKATVCAF.
OrthoDBiEOG7PVWPK.
PhylomeDBiQ965S8.

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.
SignaLinkiQ965S8.

Miscellaneous databases

PROiQ965S8.

Gene expression databases

ExpressionAtlasiQ965S8. baseline.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03008. eIF3i.
InterProiIPR027525. eIF3i.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiEIF3I_CAEEL
AccessioniPrimary (citable) accession number: Q965S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2002
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.