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Protein

Eukaryotic translation initiation factor 3 subunit I

Gene

eif-3.I

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-CEL-72689 Formation of a pool of free 40S subunits
R-CEL-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-CEL-72702 Ribosomal scanning and start codon recognition
SignaLinkiQ965S8

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit IUniRule annotation
Short name:
eIF3iUniRule annotation
Gene namesi
Name:eif-3.IUniRule annotation
ORF Names:Y74C10AR.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiY74C10AR.1a ; CE30325 ; WBGene00001232 ; eif-3.I

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003653371 – 327Eukaryotic translation initiation factor 3 subunit IAdd BLAST327

Proteomic databases

EPDiQ965S8
PaxDbiQ965S8
PeptideAtlasiQ965S8
PRIDEiQ965S8

Expressioni

Gene expression databases

BgeeiWBGene00001232
ExpressionAtlasiQ965S8 baseline and differential

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

STRINGi6239.Y74C10AR.1

Structurei

3D structure databases

ProteinModelPortaliQ965S8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 49WD 1Add BLAST42
Repeati51 – 89WD 2Add BLAST39
Repeati188 – 227WD 3Add BLAST40
Repeati229 – 268WD 4Add BLAST40
Repeati285 – 324WD 5Add BLAST40

Sequence similaritiesi

Belongs to the eIF-3 subunit I family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0643 Eukaryota
ENOG410XQ3E LUCA
GeneTreeiENSGT00630000089849
HOGENOMiHOG000231322
InParanoidiQ965S8
KOiK03246
OMAiFETRFWH
OrthoDBiEOG091G0AIZ
PhylomeDBiQ965S8

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03008 eIF3i, 1 hit
InterProiView protein in InterPro
IPR027525 eIF3i
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19877 PTHR19877, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

Sequencei

Sequence statusi: Complete.

Q965S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLSLKGHE RALTRVRFNR EGDLTFSCAK DKKPCVWYTE NGERIGSYDG
60 70 80 90 100
HNGAVWDIDV SWDTTKCVTA SGDLTVKIWD AELGNCLYTI NHQTPMKSCG
110 120 130 140 150
FSYSGNLVCF TTQKMTKNLS TFQVRDLRDS SQMVEGGESF FYSQFDVNAT
160 170 180 190 200
TALFTQMDDL VTIGFESGLL QQYDLRNPDT PIHTNESVHR YSVQDLQLSP
210 220 230 240 250
RGDFLISASR DKTAALLDVN DLKKLKQYKS ERPVNSACIS PNRDHICLGG
260 270 280 290 300
GEDAMQVTQT SVSAGHFEAK IYHMVFEEEF ARFKGHFGPI NTMAWHPSGT
310 320
IIATGGEDGY IRIQEFDEDY LGFTYDF
Length:327
Mass (Da):36,873
Last modified:June 1, 2002 - v2
Checksum:iBC30C4C154FD224C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081786 Genomic DNA Translation: CCD73538.1
RefSeqiNP_490988.2, NM_058587.4
UniGeneiCel.20302

Genome annotation databases

EnsemblMetazoaiY74C10AR.1a; Y74C10AR.1a; WBGene00001232
GeneIDi171809
KEGGicel:CELE_Y74C10AR.1
UCSCiY74C10AR.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiEIF3I_CAEEL
AccessioniPrimary (citable) accession number: Q965S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health