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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh), L-lactate dehydrogenase (101263923), L-lactate dehydrogenase (ldh2), L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:ldhImported
Synonyms:101252012Imported, ldh1Imported
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Chromosome 8

Subcellular locationi

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc08g078850.2.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 177Ldh_1_NInterPro annotationAdd BLAST140
Domaini180 – 343Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
KOiK00016.
OMAiMDLMQTA.
OrthoDBiEOG09360DKP.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSSSSSSL GPGGLDLTQA FFKSISNAAP PSPTKRHTKI SVIGVGNVGM
60 70 80 90 100
AIAQTILTQD LVDELALVDA KSDKLRGEML DLQHAAAFLP RTKIHASIDY
110 120 130 140 150
SVTAGSDLCI VTAGARQNPG ESRLNLLQRN MALFRSIIPP LVKYSPETTL
160 170 180 190 200
LVVSNPVDVL TYVAWKLSGF PANRVIGSGT NLDSSRFRFL IADHLDVNAQ
210 220 230 240 250
DVQAYIVGEH GDSSVALWSG ISVGGVPVLS FLERQQIALE KETLEKIHQE
260 270 280 290 300
VVHSAYEVIS LKGYTSWAIG YSVANLARTI LRDQRRIHPV SVLAKGFYGI
310 320 330 340 350
DGGDVFLSLP AQLGRSGVLG VTNVHLTDEE IEQLRNSAKT ILEVQSQLGI
Length:350
Mass (Da):37,708
Last modified:February 1, 1997 - v1
Checksum:i3957C1D4FB04D70F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08887 mRNA. Translation: CAA70100.1.
Y10602 Genomic DNA. Translation: CAA71611.1.
PIRiT07061.
RefSeqiNP_001266265.1. NM_001279336.1.
UniGeneiLes.97.

Genome annotation databases

EnsemblPlantsiSolyc08g078850.2.1; Solyc08g078850.2.1; Solyc08g078850.2.
GeneIDi101252012.
GrameneiSolyc08g078850.2.1; Solyc08g078850.2.1; Solyc08g078850.2.
KEGGisly:101252012.

Similar proteinsi

Entry informationi

Entry nameiQ96569_SOLLC
AccessioniPrimary (citable) accession number: Q96569
Entry historyiIntegrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported