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Q96562

- CHS2_HORVU

UniProt

Q96562 - CHS2_HORVU

Protein

Chalcone synthase 2

Gene

CHS2

Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. Substrate preference is feruloyl-CoA = caffeoyl-CoA >> cinnamoyl-CoA.

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei166 – 1661PROSITE-ProRule annotation

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 2 (EC:2.3.1.74)
    Alternative name(s):
    Naringenin-chalcone synthase 2
    Gene namesi
    Name:CHS2
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiQ96562.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Chalcone synthase 2PRO_0000215980Add
    BLAST

    Expressioni

    Inductioni

    Strong in response to inoculation with fungi.

    Gene expression databases

    GenevestigatoriQ96562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96562.
    SMRiQ96562. Positions 6-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96562-1 [UniParc]FASTAAdd to Basket

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    MAAVRLKEVR MAQRAEGLAT VLAIGTAVPA NCVYQATYPD YYFRVTKSEH    50
    LADLKEKFQR MCDKSMIRKR HMHLTEEILI KNPKICAHME TSLDARHAIA 100
    LVEVPKLGQG AAEKAIKEWG QPLSKITHLV FCTTSGVDMP GADYQLTKLL 150
    GLSPTVKRLM MYQQGCFGGA TVLRLAKDIA ENNRGARVLV VCSEITAMAF 200
    RGPCKSHLDS LVGHALFGDG AAAAIIGADP DQLDEQPVFQ LVSASQTILP 250
    ESEGAIDGHL TEAGLTIHLL KDVPGLISEN IEQALEDAFE PLGIHNWNSI 300
    FWIAHPGGPA ILDRVEDRVG LDKKRMRASR EVLSEYGNMS SASVLFVLDV 350
    MRKSSAKDGL ATTGEGKDWG VLFGFGPGLT VETLVLHSVP VPVPTAASA 399
    Length:399
    Mass (Da):43,189
    Last modified:February 1, 1997 - v1
    Checksum:iB41F54CD647FF22D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09233 mRNA. Translation: CAA70435.1.
    PIRiT04485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09233 mRNA. Translation: CAA70435.1 .
    PIRi T04485.

    3D structure databases

    ProteinModelPortali Q96562.
    SMRi Q96562. Positions 6-391.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q96562.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Gene expression databases

    Genevestigatori Q96562.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A chalcone synthase with an unusual substrate preference is expressed in barley leaves in response to UV light and pathogen attack."
      Christensen A.B., Gregersen P.L., Schroeder J., Collinge D.B.
      Plant Mol. Biol. 37:849-857(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Pallas / P-02.
      Tissue: Leaf.

    Entry informationi

    Entry nameiCHS2_HORVU
    AccessioniPrimary (citable) accession number: Q96562
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3