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Q96558

- UGDH1_SOYBN

UniProt

Q96558 - UGDH1_SOYBN

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Protein

UDP-glucose 6-dehydrogenase 1

Gene
UGD1
Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NAD By similarity
Binding sitei38 – 381NAD By similarity
Binding sitei161 – 1611NAD By similarity
Active sitei272 – 2721Nucleophile By similarity
Binding sitei342 – 3421NAD By similarity
Binding sitei447 – 4471Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NAD By similarity
Nucleotide bindingi86 – 905NAD By similarity
Nucleotide bindingi127 – 1282NAD By similarity
Nucleotide bindingi272 – 2754NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase 1
Short name:
UDP-GlcDH 1
Short name:
UDPGDH 1
Alternative name(s):
Gm-UGD1
Gene namesi
Name:UGD1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Chromosome 8

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480UDP-glucose 6-dehydrogenase 1PRO_0000074065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei393 – 3931Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ96558.
ProMEXiQ96558.

Expressioni

Gene expression databases

GenevestigatoriQ96558.

Structurei

3D structure databases

ProteinModelPortaliQ96558.
SMRiQ96558. Positions 3-467.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1615Substrate binding By similarity
Regioni216 – 2238Substrate binding By similarity
Regioni256 – 26914Substrate binding By similarityAdd
BLAST
Regioni334 – 3352Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00012.
OMAiVELNTWQ.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96558-1 [UniParc]FASTAAdd to Basket

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MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY    50
EPGLDGVVKQ CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA 100
ADLTYWESAA RMIADVSKSD KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF 150
QILSNPEFLA EGTAIKDLFN PDRVLIGGRE TPEGQKAIQT LKDVYAQWVP 200
EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GANVQQVSYS 250
VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI 300
KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC 350
QGLLGDKANL SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV 400
SVVWDAYEAT KDAHGLCILT EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV 450
DADKLREIGF IVYSIGKPLD PWLKDMPAVA 480
Length:480
Mass (Da):52,942
Last modified:February 1, 1997 - v1
Checksum:iAFCADA0F5951FD11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53418 mRNA. Translation: AAB58398.1.
PIRiT08818.
RefSeqiNP_001238410.1. NM_001251481.1.
XP_006584641.1. XM_006584578.1.
UniGeneiGma.6350.

Genome annotation databases

EnsemblPlantsiGLYMA08G26520.1; GLYMA08G26520.1; GLYMA08G26520.
GeneIDi548074.
KEGGigmx:548074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U53418 mRNA. Translation: AAB58398.1 .
PIRi T08818.
RefSeqi NP_001238410.1. NM_001251481.1.
XP_006584641.1. XM_006584578.1.
UniGenei Gma.6350.

3D structure databases

ProteinModelPortali Q96558.
SMRi Q96558. Positions 3-467.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q96558.
ProMEXi Q96558.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi GLYMA08G26520.1 ; GLYMA08G26520.1 ; GLYMA08G26520 .
GeneIDi 548074.
KEGGi gmx:548074.

Phylogenomic databases

KOi K00012.
OMAi VELNTWQ.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .

Gene expression databases

Genevestigatori Q96558.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning of an enzyme that synthesizes a key nucleotide-sugar precursor of hemicellulose biosynthesis from soybean: UDP-glucose dehydrogenase."
    Tenhaken R., Thulke O.
    Plant Physiol. 112:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Williams 82.
  2. "Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls."
    Klinghammer M., Tenhaken R.
    J. Exp. Bot. 58:3609-3621(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiUGDH1_SOYBN
AccessioniPrimary (citable) accession number: Q96558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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