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Q96558 (UGDH1_SOYBN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucose 6-dehydrogenase 1

Short name=UDP-Glc dehydrogenase 1
Short name=UDP-GlcDH 1
Short name=UDPGDH 1
EC=1.1.1.22
Alternative name(s):
Gm-UGD1
Gene names
Name:UGD1
OrganismGlycine max (Soybean) (Glycine hispida) [Reference proteome]
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. Ref.1

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processUDP-glucuronate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480UDP-glucose 6-dehydrogenase 1
PRO_0000074065

Regions

Nucleotide binding8 – 136NAD By similarity
Nucleotide binding86 – 905NAD By similarity
Nucleotide binding127 – 1282NAD By similarity
Nucleotide binding272 – 2754NAD By similarity
Region157 – 1615Substrate binding By similarity
Region216 – 2238Substrate binding By similarity
Region256 – 26914Substrate binding By similarity
Region334 – 3352Substrate binding By similarity

Sites

Active site2721Nucleophile By similarity
Binding site331NAD By similarity
Binding site381NAD By similarity
Binding site1611NAD By similarity
Binding site3421NAD By similarity
Binding site4471Substrate By similarity

Amino acid modifications

Modified residue3931Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96558 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AFCADA0F5951FD11

FASTA48052,942
        10         20         30         40         50         60 
MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY EPGLDGVVKQ 

        70         80         90        100        110        120 
CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA ADLTYWESAA RMIADVSKSD 

       130        140        150        160        170        180 
KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF QILSNPEFLA EGTAIKDLFN PDRVLIGGRE 

       190        200        210        220        230        240 
TPEGQKAIQT LKDVYAQWVP EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT 

       250        260        270        280        290        300 
GANVQQVSYS VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI 

       310        320        330        340        350        360 
KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC QGLLGDKANL 

       370        380        390        400        410        420 
SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV SVVWDAYEAT KDAHGLCILT 

       430        440        450        460        470        480 
EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV DADKLREIGF IVYSIGKPLD PWLKDMPAVA 

« Hide

References

[1]"Cloning of an enzyme that synthesizes a key nucleotide-sugar precursor of hemicellulose biosynthesis from soybean: UDP-glucose dehydrogenase."
Tenhaken R., Thulke O.
Plant Physiol. 112:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: cv. Williams 82.
[2]"Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls."
Klinghammer M., Tenhaken R.
J. Exp. Bot. 58:3609-3621(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53418 mRNA. Translation: AAB58398.1.
PIRT08818.
RefSeqNP_001238410.1. NM_001251481.1.
XP_006584641.1. XM_006584578.1.
UniGeneGma.6350.

3D structure databases

ProteinModelPortalQ96558.
SMRQ96558. Positions 3-467.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ96558.
ProMEXQ96558.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsGLYMA08G26520.1; GLYMA08G26520.1; GLYMA08G26520.
GeneID548074.
KEGGgmx:548074.

Phylogenomic databases

KOK00012.
OMAVELNTWQ.

Enzyme and pathway databases

UniPathwayUPA00038; UER00491.

Gene expression databases

GenevestigatorQ96558.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUGDH1_SOYBN
AccessionPrimary (citable) accession number: Q96558
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways