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Q96558

- UGDH1_SOYBN

UniProt

Q96558 - UGDH1_SOYBN

Protein

UDP-glucose 6-dehydrogenase 1

Gene

UGD1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331NADBy similarity
    Binding sitei38 – 381NADBy similarity
    Binding sitei161 – 1611NADBy similarity
    Active sitei272 – 2721NucleophileBy similarity
    Binding sitei342 – 3421NADBy similarity
    Binding sitei447 – 4471SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NADBy similarity
    Nucleotide bindingi86 – 905NADBy similarity
    Nucleotide bindingi127 – 1282NADBy similarity
    Nucleotide bindingi272 – 2754NADBy similarity

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase 1
    Short name:
    UDP-GlcDH 1
    Short name:
    UDPGDH 1
    Alternative name(s):
    Gm-UGD1
    Gene namesi
    Name:UGD1
    OrganismiGlycine max (Soybean) (Glycine hispida)
    Taxonomic identifieri3847 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
    ProteomesiUP000008827: Chromosome 8

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480UDP-glucose 6-dehydrogenase 1PRO_0000074065Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei393 – 3931PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ96558.
    ProMEXiQ96558.

    Expressioni

    Gene expression databases

    GenevestigatoriQ96558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96558.
    SMRiQ96558. Positions 3-467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni157 – 1615Substrate bindingBy similarity
    Regioni216 – 2238Substrate bindingBy similarity
    Regioni256 – 26914Substrate bindingBy similarityAdd
    BLAST
    Regioni334 – 3352Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK00012.
    OMAiVELNTWQ.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96558-1 [UniParc]FASTAAdd to Basket

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    MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY    50
    EPGLDGVVKQ CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA 100
    ADLTYWESAA RMIADVSKSD KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF 150
    QILSNPEFLA EGTAIKDLFN PDRVLIGGRE TPEGQKAIQT LKDVYAQWVP 200
    EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GANVQQVSYS 250
    VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI 300
    KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC 350
    QGLLGDKANL SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV 400
    SVVWDAYEAT KDAHGLCILT EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV 450
    DADKLREIGF IVYSIGKPLD PWLKDMPAVA 480
    Length:480
    Mass (Da):52,942
    Last modified:February 1, 1997 - v1
    Checksum:iAFCADA0F5951FD11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53418 mRNA. Translation: AAB58398.1.
    PIRiT08818.
    RefSeqiNP_001238410.1. NM_001251481.1.
    XP_006584641.1. XM_006584578.1.
    UniGeneiGma.6350.

    Genome annotation databases

    EnsemblPlantsiGLYMA08G26520.1; GLYMA08G26520.1; GLYMA08G26520.
    GeneIDi548074.
    KEGGigmx:548074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53418 mRNA. Translation: AAB58398.1 .
    PIRi T08818.
    RefSeqi NP_001238410.1. NM_001251481.1.
    XP_006584641.1. XM_006584578.1.
    UniGenei Gma.6350.

    3D structure databases

    ProteinModelPortali Q96558.
    SMRi Q96558. Positions 3-467.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q96558.
    ProMEXi Q96558.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi GLYMA08G26520.1 ; GLYMA08G26520.1 ; GLYMA08G26520 .
    GeneIDi 548074.
    KEGGi gmx:548074.

    Phylogenomic databases

    KOi K00012.
    OMAi VELNTWQ.

    Enzyme and pathway databases

    UniPathwayi UPA00038 ; UER00491 .

    Gene expression databases

    Genevestigatori Q96558.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of an enzyme that synthesizes a key nucleotide-sugar precursor of hemicellulose biosynthesis from soybean: UDP-glucose dehydrogenase."
      Tenhaken R., Thulke O.
      Plant Physiol. 112:1127-1134(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: cv. Williams 82.
    2. "Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls."
      Klinghammer M., Tenhaken R.
      J. Exp. Bot. 58:3609-3621(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiUGDH1_SOYBN
    AccessioniPrimary (citable) accession number: Q96558
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3