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Protein

UDP-glucose 6-dehydrogenase 1

Gene

UGD1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NADBy similarity
Binding sitei38 – 381NADBy similarity
Binding sitei161 – 1611NADBy similarity
Active sitei272 – 2721NucleophileBy similarity
Binding sitei342 – 3421NADBy similarity
Binding sitei447 – 4471SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NADBy similarity
Nucleotide bindingi86 – 905NADBy similarity
Nucleotide bindingi127 – 1282NADBy similarity
Nucleotide bindingi272 – 2754NADBy similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase 1
Short name:
UDP-GlcDH 1
Short name:
UDPGDH 1
Alternative name(s):
Gm-UGD1
Gene namesi
Name:UGD1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827 Componenti: Chromosome 8

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480UDP-glucose 6-dehydrogenase 1PRO_0000074065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei393 – 3931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ96558.
ProMEXiQ96558.

Expressioni

Gene expression databases

GenevestigatoriQ96558.

Structurei

3D structure databases

ProteinModelPortaliQ96558.
SMRiQ96558. Positions 3-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 1615Substrate bindingBy similarity
Regioni216 – 2238Substrate bindingBy similarity
Regioni256 – 26914Substrate bindingBy similarityAdd
BLAST
Regioni334 – 3352Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ96558.
KOiK00012.
OMAiETERHGF.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY
60 70 80 90 100
EPGLDGVVKQ CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA
110 120 130 140 150
ADLTYWESAA RMIADVSKSD KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF
160 170 180 190 200
QILSNPEFLA EGTAIKDLFN PDRVLIGGRE TPEGQKAIQT LKDVYAQWVP
210 220 230 240 250
EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GANVQQVSYS
260 270 280 290 300
VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI
310 320 330 340 350
KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC
360 370 380 390 400
QGLLGDKANL SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV
410 420 430 440 450
SVVWDAYEAT KDAHGLCILT EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV
460 470 480
DADKLREIGF IVYSIGKPLD PWLKDMPAVA
Length:480
Mass (Da):52,942
Last modified:February 1, 1997 - v1
Checksum:iAFCADA0F5951FD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53418 mRNA. Translation: AAB58398.1.
PIRiT08818.
RefSeqiNP_001238410.1. NM_001251481.1.
XP_006584641.1. XM_006584578.1.
UniGeneiGma.6350.

Genome annotation databases

EnsemblPlantsiGLYMA08G26520.1; GLYMA08G26520.1; GLYMA08G26520.
GeneIDi548074.
KEGGigmx:548074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53418 mRNA. Translation: AAB58398.1.
PIRiT08818.
RefSeqiNP_001238410.1. NM_001251481.1.
XP_006584641.1. XM_006584578.1.
UniGeneiGma.6350.

3D structure databases

ProteinModelPortaliQ96558.
SMRiQ96558. Positions 3-467.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ96558.
ProMEXiQ96558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiGLYMA08G26520.1; GLYMA08G26520.1; GLYMA08G26520.
GeneIDi548074.
KEGGigmx:548074.

Phylogenomic databases

InParanoidiQ96558.
KOiK00012.
OMAiETERHGF.

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.

Gene expression databases

GenevestigatoriQ96558.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of an enzyme that synthesizes a key nucleotide-sugar precursor of hemicellulose biosynthesis from soybean: UDP-glucose dehydrogenase."
    Tenhaken R., Thulke O.
    Plant Physiol. 112:1127-1134(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Williams 82.
  2. "Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls."
    Klinghammer M., Tenhaken R.
    J. Exp. Bot. 58:3609-3621(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiUGDH1_SOYBN
AccessioniPrimary (citable) accession number: Q96558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.