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Reviewed, UniProtKB/Swiss-Prot Q96558 (UGDH_SOYBN)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    UDP-glucose 6-dehydrogenase
      Short name=UDP-Glc dehydrogenase
      Short name=UDP-GlcDH
      Short name=UDPGDH
    EC=1.1.1.22
OrganismGlycine max (Soybean)
Taxonomic identifier3847 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Phaseoleae › Glycine

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Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Provides UDP-glucuronic acid for hemicellulose precursors.

Catalytic activity

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathway

Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.

Sequence similarities

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

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Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNAD or NADH binding

Inferred from electronic annotation. Source: InterPro

UDP-glucose 6-dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 480480UDP-glucose 6-dehydrogenase
PRO_0000074065

Regions

Nucleotide binding3 – 2018NAD By similarity
Region158 – 1614Substrate binding By similarity

Sites

Active site2721Nucleophile By similarity
Binding site331NAD By similarity
Binding site381NAD By similarity
Binding site901NAD By similarity
Binding site1281NAD; via amide nitrogen By similarity
Binding site1611NAD By similarity
Binding site2161Substrate By similarity
Binding site2691Substrate; via amide nitrogen By similarity
Binding site2751NAD By similarity
Binding site3351Substrate By similarity
Binding site3421NAD By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q96558-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AFCADA0F5951FD11

FASTA48052,942
        10         20         30         40         50         60 
MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY EPGLDGVVKQ 

        70         80         90        100        110        120 
CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA ADLTYWESAA RMIADVSKSD 

       130        140        150        160        170        180 
KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF QILSNPEFLA EGTAIKDLFN PDRVLIGGRE 

       190        200        210        220        230        240 
TPEGQKAIQT LKDVYAQWVP EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT 

       250        260        270        280        290        300 
GANVQQVSYS VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI 

       310        320        330        340        350        360 
KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC QGLLGDKANL 

       370        380        390        400        410        420 
SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV SVVWDAYEAT KDAHGLCILT 

       430        440        450        460        470        480 
EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV DADKLREIGF IVYSIGKPLD PWLKDMPAVA

« Hide

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References

[1]"Cloning of an enzyme that synthesizes a key nucleotide-sugar precursor of hemicellulose biosynthesis from soybean: UDP-glucose dehydrogenase."
Tenhaken R., Thulke O.
Plant Physiol. 112:1127-1134(1996) [PubMed: 8938413] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Williams 82.

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Cross-references

Sequence databases

U53418 mRNA. Translation: AAB58398.1.
PIRT08818.
UniGeneGma.31239

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.22. 299.

Family and domain databases

InterProIPR016040. NAD(P)-bd_dom.
IPR017476. Nucleotide_sugar_DH.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd.
IPR001732. UDP-Glc/GDP-Man_DH_N.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit.
PANTHERPTHR11374. UDPG_MGDP_DH_Creg. 1 hit.
PfamPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR03026. NDP-sugDHase. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameUGDH_SOYBN
AccessionPrimary (citable) accession number: Q96558
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents