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Protein

UDP-glucose 6-dehydrogenase 1

Gene

UGD1

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers.1 Publication

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi: UDP-alpha-D-glucuronate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-glucose 6-dehydrogenase 1 (UGD1)
This subpathway is part of the pathway UDP-alpha-D-glucuronate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-alpha-D-glucuronate from UDP-alpha-D-glucose, the pathway UDP-alpha-D-glucuronate biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33NADBy similarity1
Binding sitei38NADBy similarity1
Binding sitei161NADBy similarity1
Active sitei272NucleophileBy similarity1
Binding sitei342NADBy similarity1
Binding sitei447SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADBy similarity6
Nucleotide bindingi86 – 90NADBy similarity5
Nucleotide bindingi127 – 128NADBy similarity2
Nucleotide bindingi272 – 275NADBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase 1 (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase 1
Short name:
UDP-GlcDH 1
Short name:
UDPGDH 1
Alternative name(s):
Gm-UGD1
Gene namesi
Name:UGD1
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Chromosome 8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740651 – 480UDP-glucose 6-dehydrogenase 1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei393PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ96558
ProMEXiQ96558

Expressioni

Gene expression databases

GenevisibleiQ96558 GM

Interactioni

Protein-protein interaction databases

STRINGi3847.GLYMA08G26520.1

Structurei

3D structure databases

ProteinModelPortaliQ96558
SMRiQ96558
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 161Substrate bindingBy similarity5
Regioni216 – 223Substrate bindingBy similarity8
Regioni256 – 269Substrate bindingBy similarityAdd BLAST14
Regioni334 – 335Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2666 Eukaryota
COG1004 LUCA
InParanoidiQ96558
KOiK00012
OMAiLCTEWDE
OrthoDBiEOG093607HD

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

Q96558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKICCIGAG YVGGPTMAVI ALKCPSIEVA VVDISKSRIA AWNSDQLPIY
60 70 80 90 100
EPGLDGVVKQ CRGKNLFFST DVEKHVFEAD IVFVSVNTPT KTQGLGAGKA
110 120 130 140 150
ADLTYWESAA RMIADVSKSD KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF
160 170 180 190 200
QILSNPEFLA EGTAIKDLFN PDRVLIGGRE TPEGQKAIQT LKDVYAQWVP
210 220 230 240 250
EERILTTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT GANVQQVSYS
260 270 280 290 300
VGTDSRIGPK FLNASVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI
310 320 330 340 350
KINDYQKSRF VNRVVASMFN TVSNKKIAIL GFAFKKDTGD TRETPAIDVC
360 370 380 390 400
QGLLGDKANL SIYDPQVTED QIQRDLSMNK FDWDHPIHLQ PTSPTTVKKV
410 420 430 440 450
SVVWDAYEAT KDAHGLCILT EWDEFKTLDY QKIFDNMQKP AFVFDGRNIV
460 470 480
DADKLREIGF IVYSIGKPLD PWLKDMPAVA
Length:480
Mass (Da):52,942
Last modified:February 1, 1997 - v1
Checksum:iAFCADA0F5951FD11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53418 mRNA Translation: AAB58398.1
PIRiT08818
RefSeqiNP_001238410.1, NM_001251481.1
XP_006584641.1, XM_006584578.2
UniGeneiGma.6350

Genome annotation databases

EnsemblPlantsiKRH44990; KRH44990; GLYMA_08G243000
GeneIDi548074
GrameneiKRH44990; KRH44990; GLYMA_08G243000
KEGGigmx:548074

Similar proteinsi

Entry informationi

Entry nameiUGDH1_SOYBN
AccessioniPrimary (citable) accession number: Q96558
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health