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Q96528

- CATA1_ARATH

UniProt

Q96528 - CATA1_ARATH

Protein

Catalase-1

Gene

CAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651PROSITE-ProRule annotation
    Active sitei138 – 1381PROSITE-ProRule annotation
    Metal bindingi348 – 3481Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: TAIR
    2. cobalt ion binding Source: TAIR
    3. heme binding Source: InterPro
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to nitrogen starvation Source: TAIR
    2. cellular response to phosphate starvation Source: TAIR
    3. cellular response to sulfate starvation Source: TAIR
    4. hydrogen peroxide catabolic process Source: TAIR
    5. response to abscisic acid Source: TAIR
    6. response to cadmium ion Source: TAIR
    7. response to hydrogen peroxide Source: TAIR
    8. response to light stimulus Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Protein family/group databases

    PeroxiBasei5142. AtKat01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase-1 (EC:1.11.1.6)
    Gene namesi
    Name:CAT1
    Ordered Locus Names:At1g20630
    ORF Names:F2D10.11, F5M15.31
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G20630.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. chloroplast envelope Source: TAIR
    3. cytosolic ribosome Source: TAIR
    4. mitochondrion Source: TAIR
    5. peroxisome Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Catalase-1PRO_0000084930Add
    BLAST

    Proteomic databases

    PaxDbiQ96528.
    PRIDEiQ96528.

    Expressioni

    Inductioni

    By hydrogen peroxide. By abscisic acid (ABA), drought, and salt stress through the MKK1-MPK6 mediation.2 Publications

    Gene expression databases

    ArrayExpressiQ96528.
    GenevestigatoriQ96528.

    Interactioni

    Subunit structurei

    Homotetramer and heterotetramer. At least six or seven isozymes are produced from a mixture of 3 gene products.

    Protein-protein interaction databases

    BioGridi23891. 6 interactions.
    IntActiQ96528. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96528.
    SMRiQ96528. Positions 10-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    HOGENOMiHOG000087852.
    InParanoidiQ96528.
    KOiK03781.
    OMAiLIHAQKR.
    PhylomeDBiQ96528.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96528-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPYRVRPSS AHDSPFFTTN SGAPVWNNNS SLTVGTRGPI LLEDYHLLEK    50
    LANFDRERIP ERVVHARGAS AKGFFEVTHD ITQLTSADFL RGPGVQTPVI 100
    VRFSTVIHER GSPETLRDPR GFAVKFYTRE GNFDLVGNNF PVFFVRDGMK 150
    FPDMVHALKP NPKSHIQENW RILDFFSHHP ESLHMFSFLF DDLGIPQDYR 200
    HMEGAGVNTY MLINKAGKAH YVKFHWKPTC GIKCLSDEEA IRVGGANHSH 250
    ATKDLYDSIA AGNYPQWNLF VQVMDPAHED KFDFDPLDVT KIWPEDILPL 300
    QPVGRLVLNK NIDNFFNENE QIAFCPALVV PGIHYSDDKL LQTRIFSYAD 350
    SQRHRLGPNY LQLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRLDPV 400
    RHAEKYPTTP IVCSGNREKC FIGKENNFKQ PGERYRSWDS DRQERFVKRF 450
    VEALSEPRVT HEIRSIWISY WSQADKSLGQ KLATRLNVRP NF 492
    Length:492
    Mass (Da):56,762
    Last modified:July 11, 2002 - v3
    Checksum:i271E55FF7D6910EB
    GO

    Sequence cautioni

    The sequence AAF79625.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAF80611.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031F → L in AAB07026. (PubMed:8819328)Curated
    Sequence conflicti332 – 3321G → F in AAB07026. (PubMed:8819328)Curated
    Sequence conflicti339 – 3402KL → NV in AAB07026. (PubMed:8819328)Curated
    Sequence conflicti423 – 4231G → R in AAB07026. (PubMed:8819328)Curated
    Sequence conflicti423 – 4231G → R in AAC17731. (PubMed:9584109)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43340 mRNA. Translation: AAB07026.1.
    AF021937 Genomic DNA. Translation: AAC17731.1.
    AC027665 Genomic DNA. Translation: AAF79625.1. Sequence problems.
    AC069251 Genomic DNA. Translation: AAF80611.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29998.1.
    AY136424 mRNA. Translation: AAM97090.1.
    BT010373 mRNA. Translation: AAQ56816.1.
    RefSeqiNP_564121.1. NM_101914.3.
    UniGeneiAt.26213.

    Genome annotation databases

    EnsemblPlantsiAT1G20630.1; AT1G20630.1; AT1G20630.
    GeneIDi838652.
    KEGGiath:AT1G20630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43340 mRNA. Translation: AAB07026.1 .
    AF021937 Genomic DNA. Translation: AAC17731.1 .
    AC027665 Genomic DNA. Translation: AAF79625.1 . Sequence problems.
    AC069251 Genomic DNA. Translation: AAF80611.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29998.1 .
    AY136424 mRNA. Translation: AAM97090.1 .
    BT010373 mRNA. Translation: AAQ56816.1 .
    RefSeqi NP_564121.1. NM_101914.3.
    UniGenei At.26213.

    3D structure databases

    ProteinModelPortali Q96528.
    SMRi Q96528. Positions 10-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 23891. 6 interactions.
    IntActi Q96528. 2 interactions.

    Protein family/group databases

    PeroxiBasei 5142. AtKat01.

    Proteomic databases

    PaxDbi Q96528.
    PRIDEi Q96528.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G20630.1 ; AT1G20630.1 ; AT1G20630 .
    GeneIDi 838652.
    KEGGi ath:AT1G20630.

    Organism-specific databases

    TAIRi AT1G20630.

    Phylogenomic databases

    eggNOGi COG0753.
    HOGENOMi HOG000087852.
    InParanoidi Q96528.
    KOi K03781.
    OMAi LIHAQKR.
    PhylomeDBi Q96528.

    Gene expression databases

    ArrayExpressi Q96528.
    Genevestigatori Q96528.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Catalase is encoded by a multigene family in Arabidopsis thaliana (L.) Heynh."
      Frugoli J.A., Zhong H.H., Nuccio M.L., McCourt P., McPeek M.A., Thomas T.L., McClung C.R.
      Plant Physiol. 112:327-336(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Landsberg erecta.
    2. "Intron loss and gain during evolution of the catalase gene family in angiosperms."
      Frugoli J.A., McPeek M.A., Thomas T.L., McClung C.R.
      Genetics 149:355-365(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis."
      Xing Y., Jia W., Zhang J.
      J. Exp. Bot. 58:2969-2981(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "AtMKK1 mediates ABA-induced CAT1 expression and H2O2 production via AtMPK6-coupled signaling in Arabidopsis."
      Xing Y., Jia W., Zhang J.
      Plant J. 54:440-451(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCATA1_ARATH
    AccessioniPrimary (citable) accession number: Q96528
    Secondary accession number(s): O22529, Q9LDS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3