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Protein

Catalase-1

Gene

CAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65PROSITE-ProRule annotation1
Active sitei138PROSITE-ProRule annotation1
Metal bindingi348Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: TAIR
  • cobalt ion binding Source: TAIR
  • heme binding Source: InterPro

GO - Biological processi

  • cellular response to nitrogen starvation Source: TAIR
  • cellular response to phosphate starvation Source: TAIR
  • cellular response to sulfate starvation Source: TAIR
  • hydrogen peroxide catabolic process Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to light stimulus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-74259. Purine catabolism.

Protein family/group databases

PeroxiBasei5142. AtKat01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-1 (EC:1.11.1.6)
Gene namesi
Name:CAT1
Ordered Locus Names:At1g20630
ORF Names:F2D10.11, F5M15.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G20630.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • chloroplast envelope Source: TAIR
  • cytosolic ribosome Source: TAIR
  • mitochondrion Source: TAIR
  • peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849301 – 492Catalase-1Add BLAST492

Proteomic databases

PaxDbiQ96528.
PRIDEiQ96528.

PTM databases

iPTMnetiQ96528.

Expressioni

Inductioni

By hydrogen peroxide. By abscisic acid (ABA), drought, and salt stress through the MKK1-MPK6 mediation.2 Publications

Gene expression databases

ExpressionAtlasiQ96528. baseline and differential.
GenevisibleiQ96528. AT.

Interactioni

Subunit structurei

Homotetramer and heterotetramer. At least six or seven isozymes are produced from a mixture of 3 gene products.

Protein-protein interaction databases

BioGridi23891. 7 interactors.
IntActiQ96528. 2 interactors.
STRINGi3702.AT1G20630.1.

Structurei

3D structure databases

ProteinModelPortaliQ96528.
SMRiQ96528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.
OMAiDNYFQDI.
OrthoDBiEOG093606DL.
PhylomeDBiQ96528.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPYRVRPSS AHDSPFFTTN SGAPVWNNNS SLTVGTRGPI LLEDYHLLEK
60 70 80 90 100
LANFDRERIP ERVVHARGAS AKGFFEVTHD ITQLTSADFL RGPGVQTPVI
110 120 130 140 150
VRFSTVIHER GSPETLRDPR GFAVKFYTRE GNFDLVGNNF PVFFVRDGMK
160 170 180 190 200
FPDMVHALKP NPKSHIQENW RILDFFSHHP ESLHMFSFLF DDLGIPQDYR
210 220 230 240 250
HMEGAGVNTY MLINKAGKAH YVKFHWKPTC GIKCLSDEEA IRVGGANHSH
260 270 280 290 300
ATKDLYDSIA AGNYPQWNLF VQVMDPAHED KFDFDPLDVT KIWPEDILPL
310 320 330 340 350
QPVGRLVLNK NIDNFFNENE QIAFCPALVV PGIHYSDDKL LQTRIFSYAD
360 370 380 390 400
SQRHRLGPNY LQLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRLDPV
410 420 430 440 450
RHAEKYPTTP IVCSGNREKC FIGKENNFKQ PGERYRSWDS DRQERFVKRF
460 470 480 490
VEALSEPRVT HEIRSIWISY WSQADKSLGQ KLATRLNVRP NF
Length:492
Mass (Da):56,762
Last modified:July 11, 2002 - v3
Checksum:i271E55FF7D6910EB
GO

Sequence cautioni

The sequence AAF79625 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF80611 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103F → L in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti332G → F in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti339 – 340KL → NV in AAB07026 (PubMed:8819328).Curated2
Sequence conflicti423G → R in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti423G → R in AAC17731 (PubMed:9584109).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43340 mRNA. Translation: AAB07026.1.
AF021937 Genomic DNA. Translation: AAC17731.1.
AC027665 Genomic DNA. Translation: AAF79625.1. Sequence problems.
AC069251 Genomic DNA. Translation: AAF80611.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29998.1.
AY136424 mRNA. Translation: AAM97090.1.
BT010373 mRNA. Translation: AAQ56816.1.
RefSeqiNP_564121.1. NM_101914.4.
UniGeneiAt.26213.

Genome annotation databases

EnsemblPlantsiAT1G20630.1; AT1G20630.1; AT1G20630.
GeneIDi838652.
GrameneiAT1G20630.1; AT1G20630.1; AT1G20630.
KEGGiath:AT1G20630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43340 mRNA. Translation: AAB07026.1.
AF021937 Genomic DNA. Translation: AAC17731.1.
AC027665 Genomic DNA. Translation: AAF79625.1. Sequence problems.
AC069251 Genomic DNA. Translation: AAF80611.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29998.1.
AY136424 mRNA. Translation: AAM97090.1.
BT010373 mRNA. Translation: AAQ56816.1.
RefSeqiNP_564121.1. NM_101914.4.
UniGeneiAt.26213.

3D structure databases

ProteinModelPortaliQ96528.
SMRiQ96528.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23891. 7 interactors.
IntActiQ96528. 2 interactors.
STRINGi3702.AT1G20630.1.

Protein family/group databases

PeroxiBasei5142. AtKat01.

PTM databases

iPTMnetiQ96528.

Proteomic databases

PaxDbiQ96528.
PRIDEiQ96528.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G20630.1; AT1G20630.1; AT1G20630.
GeneIDi838652.
GrameneiAT1G20630.1; AT1G20630.1; AT1G20630.
KEGGiath:AT1G20630.

Organism-specific databases

TAIRiAT1G20630.

Phylogenomic databases

eggNOGiKOG0047. Eukaryota.
COG0753. LUCA.
HOGENOMiHOG000087852.
KOiK03781.
OMAiDNYFQDI.
OrthoDBiEOG093606DL.
PhylomeDBiQ96528.

Enzyme and pathway databases

ReactomeiR-ATH-3299685. Detoxification of Reactive Oxygen Species.
R-ATH-6798695. Neutrophil degranulation.
R-ATH-74259. Purine catabolism.

Miscellaneous databases

PROiQ96528.

Gene expression databases

ExpressionAtlasiQ96528. baseline and differential.
GenevisibleiQ96528. AT.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA1_ARATH
AccessioniPrimary (citable) accession number: Q96528
Secondary accession number(s): O22529, Q9LDS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: November 30, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.