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Protein

Catalase-1

Gene

CAT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65PROSITE-ProRule annotation1
Active sitei138PROSITE-ProRule annotation1
Metal bindingi348Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • catalase activity Source: TAIR
  • cobalt ion binding Source: TAIR
  • heme binding Source: GO_Central

GO - Biological processi

  • cellular response to nitrogen starvation Source: TAIR
  • cellular response to phosphate starvation Source: TAIR
  • cellular response to sulfate starvation Source: TAIR
  • hydrogen peroxide catabolic process Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to hydrogen peroxide Source: TAIR
  • response to light stimulus Source: TAIR

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species
R-ATH-6798695 Neutrophil degranulation

Protein family/group databases

PeroxiBasei5142 AtKat01

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-1 (EC:1.11.1.6)
Gene namesi
Name:CAT1
Ordered Locus Names:At1g20630
ORF Names:F2D10.11, F5M15.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G20630
TAIRilocus:2034428 AT1G20630

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849301 – 492Catalase-1Add BLAST492

Proteomic databases

PaxDbiQ96528
PRIDEiQ96528

PTM databases

iPTMnetiQ96528

Expressioni

Inductioni

By hydrogen peroxide. By abscisic acid (ABA), drought, and salt stress through the MKK1-MPK6 mediation.2 Publications

Gene expression databases

ExpressionAtlasiQ96528 baseline and differential
GenevisibleiQ96528 AT

Interactioni

Subunit structurei

Homotetramer and heterotetramer. At least six or seven isozymes are produced from a mixture of 3 gene products. Interacts with NCA1 (PubMed:25700484). Interacts with LSD1 (PubMed:23958864).2 Publications

Protein-protein interaction databases

BioGridi23891, 7 interactors
IntActiQ96528, 2 interactors
STRINGi3702.AT1G20630.1

Structurei

3D structure databases

ProteinModelPortaliQ96528
SMRiQ96528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiKOG0047 Eukaryota
COG0753 LUCA
HOGENOMiHOG000087852
KOiK03781
OMAiPLLQFRM
OrthoDBiEOG093606DL
PhylomeDBiQ96528

Family and domain databases

Gene3Di2.40.180.10, 1 hit
InterProiView protein in InterPro
IPR018028 Catalase
IPR024708 Catalase_AS
IPR024711 Catalase_clade1/3
IPR011614 Catalase_core
IPR037060 Catalase_core_sf
IPR002226 Catalase_haem_BS
IPR010582 Catalase_immune_responsive
IPR020835 Catalase_sf
PANTHERiPTHR11465 PTHR11465, 1 hit
PfamiView protein in Pfam
PF00199 Catalase, 1 hit
PF06628 Catalase-rel, 1 hit
PIRSFiPIRSF038928 Catalase_clade1-3, 1 hit
PRINTSiPR00067 CATALASE
SMARTiView protein in SMART
SM01060 Catalase, 1 hit
SUPFAMiSSF56634 SSF56634, 1 hit
PROSITEiView protein in PROSITE
PS00437 CATALASE_1, 1 hit
PS00438 CATALASE_2, 1 hit
PS51402 CATALASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q96528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPYRVRPSS AHDSPFFTTN SGAPVWNNNS SLTVGTRGPI LLEDYHLLEK
60 70 80 90 100
LANFDRERIP ERVVHARGAS AKGFFEVTHD ITQLTSADFL RGPGVQTPVI
110 120 130 140 150
VRFSTVIHER GSPETLRDPR GFAVKFYTRE GNFDLVGNNF PVFFVRDGMK
160 170 180 190 200
FPDMVHALKP NPKSHIQENW RILDFFSHHP ESLHMFSFLF DDLGIPQDYR
210 220 230 240 250
HMEGAGVNTY MLINKAGKAH YVKFHWKPTC GIKCLSDEEA IRVGGANHSH
260 270 280 290 300
ATKDLYDSIA AGNYPQWNLF VQVMDPAHED KFDFDPLDVT KIWPEDILPL
310 320 330 340 350
QPVGRLVLNK NIDNFFNENE QIAFCPALVV PGIHYSDDKL LQTRIFSYAD
360 370 380 390 400
SQRHRLGPNY LQLPVNAPKC AHHNNHHDGF MNFMHRDEEV NYFPSRLDPV
410 420 430 440 450
RHAEKYPTTP IVCSGNREKC FIGKENNFKQ PGERYRSWDS DRQERFVKRF
460 470 480 490
VEALSEPRVT HEIRSIWISY WSQADKSLGQ KLATRLNVRP NF
Length:492
Mass (Da):56,762
Last modified:July 11, 2002 - v3
Checksum:i271E55FF7D6910EB
GO

Sequence cautioni

The sequence AAF79625 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF80611 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103F → L in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti332G → F in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti339 – 340KL → NV in AAB07026 (PubMed:8819328).Curated2
Sequence conflicti423G → R in AAB07026 (PubMed:8819328).Curated1
Sequence conflicti423G → R in AAC17731 (PubMed:9584109).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43340 mRNA Translation: AAB07026.1
AF021937 Genomic DNA Translation: AAC17731.1
AC027665 Genomic DNA Translation: AAF79625.1 Sequence problems.
AC069251 Genomic DNA Translation: AAF80611.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29998.1
AY136424 mRNA Translation: AAM97090.1
BT010373 mRNA Translation: AAQ56816.1
RefSeqiNP_564121.1, NM_101914.4
UniGeneiAt.26213

Genome annotation databases

EnsemblPlantsiAT1G20630.1; AT1G20630.1; AT1G20630
GeneIDi838652
GrameneiAT1G20630.1; AT1G20630.1; AT1G20630
KEGGiath:AT1G20630

Similar proteinsi

Entry informationi

Entry nameiCATA1_ARATH
AccessioniPrimary (citable) accession number: Q96528
Secondary accession number(s): O22529, Q9LDS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 11, 2002
Last modified: April 25, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health