Cryptochrome-2 - Arabidopsis thaliana (Mouse-ear cress)

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Reviewed, UniProtKB/Swiss-Prot Q96524 (CRY2_ARATH)

Last modified June 16, 2009. Version 84. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Cryptochrome-2
Alternative name(s):
Blue light photoreceptor

Gene names

Name:	CRY2
Synonyms:	PHH1
Ordered Locus Names:	At1g04400
ORF Names:	F19P19.14

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	612 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Mediates blue light-induced gene expression. Involved in blue light-dependent stomatal opening and inhibition of stem and root growth. Regulates the timing of flowering by promoting the expression of 'FLOWERING LOCUS T' (FT) in vascular bundles. Negatively regulated by 'FLOWERING LOCUS C' (FLC). Involved in triggering chromatin decondensation. Ref.9 Ref.11 Ref.16 Ref.18 Ref.19 Ref.21 Ref.24
Cofactor	Binds 1 FAD per subunit. Ref.20 Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit By similarity.
Subunit structure	Homodimer. Interacts with COP1 and PHYB. Ref.13 Ref.14 Ref.22
Subcellular location	Nucleus. Ref.22 Ref.12 Ref.23
Induction	Daily oscillation of protein abundance in plants grown in short days (SD) but not in long days (LD). Ref.17
Domain	The NC80 domain (486-565) contains a major active site responsible for the signal transduction processes regulating both hypocotyl inhibition and floral promotion. The C-terminal tail (564-612) is not required for physiological activity of the protein.
Post-translational modification	Phosphorylated; in response to blue light. Required for degradation. Ref.22 Ref.23 Ref.10 Ref.15 Ubiquitinated. Ref.23
Disruption phenotype	Plants show increased root elongation in blue light. Ref.19
Miscellaneous	Phosphorylation of the C-terminal tail and resulting derepression of NC80 domain may both depend on homodimerization.
Sequence similarities	Belongs to the DNA photolyase class-1 family. Contains 1 DNA photolyase domain.
Caution	Was originally (Ref.1) thought to be a DNA photolyase.

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Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Nucleus
Ligand	ATP-binding Chromophore FAD Flavoprotein Nucleotide-binding
Molecular function	Photoreceptor protein Receptor
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: InterPro chromatin remodeling Ref.21 Inferred from mutant phenotype. Source: TAIR circadian regulation of calcium ion oscillation Inferred from mutant phenotype. Source: TAIR phototropism Ref.9 Inferred from genetic interaction. Source: TAIR positive regulation of flower development Ref.24 Inferred from mutant phenotype. Source: TAIR protein-chromophore linkage Inferred from electronic annotation. Source: UniProtKB-KW regulation of meristem growth Inferred from genetic interaction. Source: TAIR response to water deprivation Ref.18 Inferred from genetic interaction. Source: TAIR stomatal movement Ref.18 Inferred from genetic interaction. Source: TAIR
Cellular component	nucleus Ref.12 Inferred from direct assay. Source: TAIR vacuole Inferred from direct assay. Source: TAIR
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA photolyase activity Inferred from electronic annotation. Source: InterPro photoreceptor activity Inferred from electronic annotation. Source: UniProtKB-KW protein homodimerization activity Inferred from physical interaction. Source: TAIR
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct
itself		1	EBI-531555,EBI-531555
COP1	P43254	1	EBI-531555,EBI-301649
PHYB	P14713	2	EBI-531555,EBI-300727

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 612

612

Cryptochrome-2

PRO_0000085122

Regions

Domain

5 – 175

171

DNA photolyase

Nucleotide binding

244 – 248

FAD By similarity

Compositional bias

22 – 27

Poly-Ala

Compositional bias

546 – 550

Poly-Glu

Compositional bias

566 – 587

Ser-rich

Sites

Binding site

232

FAD By similarity

Binding site

357

ATP By similarity

Binding site

387

FAD; via carbonyl oxygen By similarity

Binding site

389

FAD; via amide nitrogen By similarity

Binding site

406

ATP By similarity

Natural variations

Natural variant

I → V in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

127

Q → S in strain: cv. Bu-0, cv. Da(1)-12, cv. Di-G, cv. Landsberg erecta, cv. Le-0, cv. Lip-0, cv. Mrk-0, cv. Stw-0 and cv. Ta-0.

Natural variant

326

D → E in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

367

V → M in strain: cv. Cvi-0.

Natural variant

476

T → I in strain: cv. Cvi-0.

Natural variant

482

A → G in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

498

A → S in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

507

F → L in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

511

G → E in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

543

V → L in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Natural variant

611

C → Y in strain: cv. Chi-1, cv. Co-1, cv. Kon, cv. PHW-1 and cv. Sha.

Experimental info

Mutagenesis

337

G → E: Loss of activity. Ref.9

Sequence conflict

K → Q in AAB04996. Ref.1

Sequence conflict

K → Q in AAB04997. Ref.1

Sequence conflict

A → P in AAB04996. Ref.1

Sequence conflict

A → P in AAB04997. Ref.1

Sequence conflict

188

S → L in AAL16379. Ref.3

Sequence conflict

366

A → G in AAB04996. Ref.1

Sequence conflict

534

A → V in AAB04996. Ref.1

Sequence conflict

534

A → V in AAB04997. Ref.1

Sequence conflict

590

K → E in CAA67508. Ref.1

Sequence conflict

612

K → Q in CAA67508. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q96524-1 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 082E311301465904
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FASTA

612

69,457

        10         20         30         40         50         60 
MKMDKKTIVW FRRDLRIEDN PALAAAAHEG SVFPVFIWCP EEEGQFYPGR ASRWWMKQSL 

        70         80         90        100        110        120 
AHLSQSLKAL GSDLTLIKTH NTISAILDCI RVTGATKVVF NHLYDPVSLV RDHTVKEKLV 

       130        140        150        160        170        180 
ERGISVQSYN GDLLYEPWEI YCEKGKPFTS FNSYWKKCLD MSIESVMLPP PWRLMPITAA 

       190        200        210        220        230        240 
AEAIWACSIE ELGLENEAEK PSNALLTRAW SPGWSNADKL LNEFIEKQLI DYAKNSKKVV 

       250        260        270        280        290        300 
GNSTSLLSPY LHFGEISVRH VFQCARMKQI IWARDKNSEG EESADLFLRG IGLREYSRYI 

       310        320        330        340        350        360 
CFNFPFTHEQ SLLSHLRFFP WDADVDKFKA WRQGRTGYPL VDAGMRELWA TGWMHNRIRV 

       370        380        390        400        410        420 
IVSSFAVKFL LLPWKWGMKY FWDTLLDADL ECDILGWQYI SGSIPDGHEL DRLDNPALQG 

       430        440        450        460        470        480 
AKYDPEGEYI RQWLPELARL PTEWIHHPWD APLTVLKASG VELGTNYAKP IVDIDTAREL 

       490        500        510        520        530        540 
LAKAISRTRE AQIMIGAAPD EIVADSFEAL GANTIKEPGL CPSVSSNDQQ VPSAVRYNGS 

       550        560        570        580        590        600 
KRVKPEEEEE RDMKKSRGFD ERELFSTAES SSSSSVFFVS QSCSLASEGK NLEGIQDSSD 

       610 
QITTSLGKNG CK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PHH1, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial photolyases." Hoffman P.D., Batschauer A., Hays J.B. Mol. Gen. Genet. 253:259-265(1996) [PubMed: 9003312] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: cv. Columbia.
[2]	"CRY2: a second member of the Arabidopsis cryptochrome gene family." Lin C., Ahmad M., Chan J., Cashmore A.R. Plant Gene Register PGR96-001 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[3]	"A QTL for flowering time in Arabidopsis reveals a novel allele of CRY2." El-Din El-Assal S., Alonso-Blanco C., Peeters A.J.M., Raz V., Koornneef M. Nat. Genet. 29:435-440(2001) [PubMed: 11726930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: cv. Cvi-0 and cv. Landsberg erecta.
[4]	"Local patterns of nucleotide polymorphism are highly variable in the selfing species Arabidopsis thaliana." Moore R.C., Stevens M.H.H. J. Mol. Evol. 66:116-129(2008) [PubMed: 18273534] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Bla-10, cv. Bsch-0, cv. Bu-0, cv. Bu-2, cv. Chi-1, cv. Co-1, cv. Columbia, cv. Cvi-0, cv. Da(1)-12, cv. Di-G, cv. El-0, cv. Fe-1, cv. Gr-3, cv. Hn-0, cv. Kon, cv. Kr-0, cv. Landsberg erecta, cv. Le-0, cv. Li-3, cv. Lip-0, cv. Lz-0, cv. Mrk-0, cv. Mt-0, cv. Mz-0, cv. Ove-0, cv. PHW-1, cv. PHW-32, cv. PHW-36, cv. Sha, cv. Stw-0, cv. Ta-0 and cv. Wassilewskija-3.
[5]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[6]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[7]	"Linkage disequilibrium mapping of Arabidopsis CRY2 flowering time alleles." Olsen K.M., Halldorsdottir S.S., Stinchcombe J.R., Weinig C., Schmitt J., Purugganan M.D. Genetics 167:1361-1369(2004) [PubMed: 15280248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-612. Strain: cv. Bla-10, cv. Bsch-0, cv. Bu-0, cv. Bu-2, cv. Chi-1, cv. Co-1, cv. Cvi-0, cv. Da(1)-12, cv. Di-G, cv. El-0, cv. Fe-1, cv. Gr-3, cv. Hn-0, cv. Kon, cv. Kr-0, cv. Landsberg erecta, cv. Le-0, cv. Li-3, cv. Lip-0, cv. Lz-0, cv. Mrk-0, cv. Mt-0, cv. Mz-0, cv. Ove-0, cv. Oy-1, cv. PHW-1, cv. PHW-33, cv. PHW-36, cv. Sha, cv. Stw-0 and cv. Ta-0.
[8]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 485-612. Strain: cv. Columbia.
[9]	"Cryptochrome blue-light photoreceptors of Arabidopsis implicated in phototropism." Ahmad M., Jarillo J.A., Smirnova O., Cashmore A.R. Nature 392:720-723(1998) [PubMed: 9565033] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF GLY-337.
[10]	"The CRY1 blue light photoreceptor of Arabidopsis interacts with phytochrome A in vitro." Ahmad M., Jarillo J.A., Smirnova O., Cashmore A.R. Mol. Cell 1:939-948(1998) [PubMed: 9651577] [Abstract] Cited for: PHOSPHORYLATION.
[11]	"Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2." Lin C., Yang H., Guo H., Mockler T., Chen J., Cashmore A.R. Proc. Natl. Acad. Sci. U.S.A. 95:2686-2690(1998) [PubMed: 9482948] [Abstract] Cited for: FUNCTION.
[12]	"Nuclear localization of the Arabidopsis blue light receptor cryptochrome 2." Kleiner O., Kircher S., Harter K., Batschauer A. Plant J. 19:289-296(1999) [PubMed: 10476076] [Abstract] Cited for: SUBCELLULAR LOCATION.
[13]	"Functional interaction of phytochrome B and cryptochrome 2." Mas P., Devlin P.F., Panda S., Kay S.A. Nature 408:207-211(2000) [PubMed: 11089975] [Abstract] Cited for: INTERACTION WITH PHYB.
[14]	"Direct interaction of Arabidopsis cryptochromes with COP1 in light control development." Wang H., Ma L.-G., Li J.-M., Zhao H.-Y., Deng X.W. Science 294:154-158(2001) [PubMed: 11509693] [Abstract] Cited for: INTERACTION WITH COP1.
[15]	"Regulation of Arabidopsis cryptochrome 2 by blue-light-dependent phosphorylation." Shalitin D., Yang H., Mockler T.C., Maymon M., Guo H., Whitelam G.C., Lin C. Nature 417:763-767(2002) [PubMed: 12066190] [Abstract] Cited for: PHOSPHORYLATION.
[16]	"The role of cryptochrome 2 in flowering in Arabidopsis." El-Din El-Assal S., Alonso-Blanco C., Peeters A.J., Wagemaker C., Weller J.L., Koornneef M. Plant Physiol. 133:1504-1516(2003) [PubMed: 14605222] [Abstract] Cited for: FUNCTION.
[17]	"Regulation of photoperiodic flowering by Arabidopsis photoreceptors." Mockler T., Yang H., Yu X., Parikh D., Cheng Y.C., Dolan S., Lin C. Proc. Natl. Acad. Sci. U.S.A. 100:2140-2145(2003) [PubMed: 12578985] [Abstract] Cited for: INDUCTION.
[18]	"A role for Arabidopsis cryptochromes and COP1 in the regulation of stomatal opening." Mao J., Zhang Y.C., Sang Y., Li Q.H., Yang H.Q. Proc. Natl. Acad. Sci. U.S.A. 102:12270-12275(2005) [PubMed: 16093319] [Abstract] Cited for: FUNCTION.
[19]	"Cryptochrome photoreceptors cry1 and cry2 antagonistically regulate primary root elongation in Arabidopsis thaliana." Canamero R.C., Bakrim N., Bouly J.-P., Garay A., Dudkin E.E., Habricot Y., Ahmad M. Planta 224:995-1003(2006) [PubMed: 16703358] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[20]	"The signaling state of Arabidopsis cryptochrome 2 contains flavin semiquinone." Banerjee R., Schleicher E., Meier S., Viana R.M., Pokorny R., Ahmad M., Bittl R., Batschauer A. J. Biol. Chem. 282:14916-14922(2007) [PubMed: 17355959] [Abstract] Cited for: COFACTOR.
[21]	"Light-regulated large-scale reorganization of chromatin during the floral transition in Arabidopsis." Tessadori F., Schulkes R.K., van Driel R., Fransz P. Plant J. 50:848-857(2007) [PubMed: 17470059] [Abstract] Cited for: FUNCTION.
[22]	"Derepression of the NC80 motif is critical for the photoactivation of Arabidopsis CRY2." Yu X., Shalitin D., Liu X., Maymon M., Klejnot J., Yang H., Lopez J., Zhao X., Bendehakkalu K.T., Lin C. Proc. Natl. Acad. Sci. U.S.A. 104:7289-7294(2007) [PubMed: 17438275] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT, PHOSPHORYLATION.
[23]	"Arabidopsis cryptochrome 2 completes its posttranslational life cycle in the nucleus." Yu X., Klejnot J., Zhao X., Shalitin D., Maymon M., Yang H., Lee J., Liu X., Lopez J., Lin C. Plant Cell 19:3146-3156(2007) [PubMed: 17965271] [Abstract] Cited for: SUBCELLULAR LOCATION, UBIQUITINATION, PHOSPHORYLATION.
[24]	"CRYPTOCHROME2 in vascular bundles regulates flowering in Arabidopsis." Endo M., Mochizuki N., Suzuki T., Nagatani A. Plant Cell 19:84-93(2007) [PubMed: 17259260] [Abstract] Cited for: FUNCTION.

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Cross-references

Sequence databases
	U62549 mRNA. Translation: AAB04996.1. U62550 mRNA. Translation: AAB04997.1. X99061 Genomic DNA. Translation: CAA67508.1. U43397 mRNA. Translation: AAD09837.1. AY057440 mRNA. Translation: AAL16377.1. AY057441 Genomic DNA. Translation: AAL16378.1. AY057442 Genomic DNA. Translation: AAL16379.1. EU351967 Genomic DNA. Translation: ABY77601.1. EU351968 Genomic DNA. Translation: ABY77602.1. EU351969 Genomic DNA. Translation: ABY77603.1. EU351970 Genomic DNA. Translation: ABY77604.1. EU351971 Genomic DNA. Translation: ABY77605.1. EU351972 Genomic DNA. Translation: ABY77606.1. EU351973 Genomic DNA. Translation: ABY77607.1. EU351974 Genomic DNA. Translation: ABY77608.1. EU351975 Genomic DNA. Translation: ABY77609.1. EU351976 Genomic DNA. Translation: ABY77610.1. EU351977 Genomic DNA. Translation: ABY77611.1. EU351978 Genomic DNA. Translation: ABY77612.1. EU351979 Genomic DNA. Translation: ABY77613.1. EU351980 Genomic DNA. Translation: ABY77614.1. EU351981 Genomic DNA. Translation: ABY77615.1. EU351982 Genomic DNA. Translation: ABY77616.1. EU351983 Genomic DNA. Translation: ABY77617.1. EU351984 Genomic DNA. Translation: ABY77618.1. EU351985 Genomic DNA. Translation: ABY77619.1. EU351986 Genomic DNA. Translation: ABY77620.1. EU351987 Genomic DNA. Translation: ABY77621.1. EU351988 Genomic DNA. Translation: ABY77622.1. EU351989 Genomic DNA. Translation: ABY77623.1. EU351990 Genomic DNA. Translation: ABY77624.1. EU351991 Genomic DNA. Translation: ABY77625.1. EU351993 Genomic DNA. Translation: ABY77627.1. EU351992 Genomic DNA. Translation: ABY77626.1. EU351994 Genomic DNA. Translation: ABY77628.1. EU351995 Genomic DNA. Translation: ABY77629.1. EU351996 Genomic DNA. Translation: ABY77630.1. EU351997 Genomic DNA. Translation: ABY77631.1. EU351998 Genomic DNA. Translation: ABY77632.1. AC000104 Genomic DNA. Translation: AAB70435.1. BT008576 mRNA. Translation: AAP40403.1. BT008648 mRNA. Translation: AAP40463.1. AY576241 Genomic DNA. Translation: AAT80593.1. Different initiation. AY576242 Genomic DNA. Translation: AAT80594.1. Different initiation. AY576243 Genomic DNA. Translation: AAT80595.1. Different initiation. AY576244 Genomic DNA. Translation: AAT80596.1. Different initiation. AY576245 Genomic DNA. Translation: AAT80597.1. Different initiation. AY576246 Genomic DNA. Translation: AAT80598.1. Different initiation. AY576247 Genomic DNA. Translation: AAT80599.1. Different initiation. AY576248 Genomic DNA. Translation: AAT80600.1. Different initiation. AY576249 Genomic DNA. Translation: AAT80601.1. Different initiation. AY576250 Genomic DNA. Translation: AAT80602.1. Different initiation. AY576251 Genomic DNA. Translation: AAT80603.1. Different initiation. AY576252 Genomic DNA. Translation: AAT80604.1. Different initiation. AY576253 Genomic DNA. Translation: AAT80605.1. Different initiation. AY576254 Genomic DNA. Translation: AAT80606.1. Different initiation. AY576255 Genomic DNA. Translation: AAT80607.1. Different initiation. AY576256 Genomic DNA. Translation: AAT80608.1. Different initiation. AY576257 Genomic DNA. Translation: AAT80609.1. Different initiation. AY576258 Genomic DNA. Translation: AAT80610.1. Different initiation. AY576259 Genomic DNA. Translation: AAT80611.1. Different initiation. AY576260 Genomic DNA. Translation: AAT80612.1. Different initiation. AY576261 Genomic DNA. Translation: AAT80613.1. Different initiation. AY576262 Genomic DNA. Translation: AAT80614.1. Different initiation. AY576263 Genomic DNA. Translation: AAT80615.1. Different initiation. AY576264 Genomic DNA. Translation: AAT80616.1. Different initiation. AY576265 Genomic DNA. Translation: AAT80617.1. Different initiation. AY576266 Genomic DNA. Translation: AAT80618.1. Different initiation. AY576267 Genomic DNA. Translation: AAT80619.1. Different initiation. AY576268 Genomic DNA. Translation: AAT80620.1. Different initiation. AY576269 Genomic DNA. Translation: AAT80621.1. Different initiation. AY576270 Genomic DNA. Translation: AAT80622.1. Different initiation. AY576271 Genomic DNA. Translation: AAT80623.1. Different initiation. AK220946 mRNA. Translation: BAD94467.1. Different initiation.
IPI	IPI00528436.
PIR	A86176. S71221.
RefSeq	NP_171935.1. NP_849588.1.
UniGene	At.21976
3D structure databases
HSSP	HSSP built from PDB template 1IQR based on UniProtKB P37250.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96524. 2 interactions.
Proteomic databases
PRIDE	Q96524.
Genome annotation databases
GeneID	839529.
GenomeReviews	Gene locus AT1G04400 in contig CT485782_GR.
KEGG	ath:AT1G04400.
NMPDR	fig\|3702.1.peg.585.
Organism-specific databases
TAIR	At1g04400.
Phylogenomic databases
OMA	Q96524. ASFLIAY.
Gene expression databases
ArrayExpress	Q96524.
GermOnline	AT1G04400. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002081. Cryptochrome/DNA_photolyase_1. IPR014134. Cryptochrome_pln. IPR018394. DNA_photolyase_1_CS_C. IPR006050. DNA_photolyase_N. IPR005101. Photolyase_FAD-bd/Cryptochr_C. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF00875. DNA_photolyase. 1 hit. PF03441. FAD_binding_7. 1 hit. [Graphical view]
PRINTS	PR00147. DNAPHOTLYASE.
ProDom	PD004390. FAD_binding_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02766. crypt_chrom_pln. 1 hit.
PROSITE	PS00394. DNA_PHOTOLYASES_1_1. 1 hit. PS00691. DNA_PHOTOLYASES_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CRY2_ARATH

Accession

Primary (citable) accession number: Q96524
Secondary accession number(s): B0LQ23

Q8VZY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	December 15, 1998
Last modified:	June 16, 2009
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents