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Protein

Peroxidase 11

Gene

PER11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Transition state stabilizerPROSITE-ProRule annotation1
Active sitei70Proton acceptorPROSITE-ProRule annotation1
Metal bindingi71Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi76Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi80Calcium 1PROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi197Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi198Calcium 2PROSITE-ProRule annotation1
Metal bindingi251Calcium 2PROSITE-ProRule annotation1
Metal bindingi254Calcium 2PROSITE-ProRule annotation1
Metal bindingi259Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processBiological rhythms, Hydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G68850-MONOMER

Protein family/group databases

PeroxiBasei92 AtPrx11

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 11 (EC:1.11.1.7)
Short name:
Atperox P11
Alternative name(s):
ATP23a/ATP23b
Gene namesi
Name:PER11
Synonyms:P11
Ordered Locus Names:At1g68850
ORF Names:F14K14.4, T6L1.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G68850
TAIRilocus:2012428 AT1G68850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002367721 – 336Peroxidase 11Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 119PROSITE-ProRule annotation
Disulfide bondi72 ↔ 77PROSITE-ProRule annotation
Disulfide bondi125 ↔ 331PROSITE-ProRule annotation
Disulfide bondi204 ↔ 236PROSITE-ProRule annotation
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96519

Expressioni

Tissue specificityi

Expressed in roots and stems.

Inductioni

Expressed under a diurnal rhythm.1 Publication

Gene expression databases

ExpressionAtlasiQ96519 baseline and differential
GenevisibleiQ96519 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G68850.1

Structurei

3D structure databases

ProteinModelPortaliQ96519
SMRiQ96519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHG7 Eukaryota
ENOG410YA9R LUCA
HOGENOMiHOG000237557
InParanoidiQ96519
KOiK00430
OMAiEMYSSLF
OrthoDBiEOG09360F1F
PhylomeDBiQ96519

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRLLFVFFM VHTIFIPCFS FDTPGKDLPL TLDYYKSTCP TVFDVIKKEM
60 70 80 90 100
ECIVKEDPRN AAIIIRLHFH DCFVQGCDGS VLLDETETLQ GEKKASPNIN
110 120 130 140 150
SLKGYKIVDR IKNIIESECP GVVSCADLLT IGARDATILV GGPYWDVPVG
160 170 180 190 200
RKDSKTASYE LATTNLPTPE EGLISIIAKF YSQGLSVEDM VALIGAHTIG
210 220 230 240 250
KAQCRNFRSR IYGDFQVTSA LNPVSETYLA SLREICPASS GEGDSNVTAI
260 270 280 290 300
DNVTPNLFDN SIYHTLLRGE GLLNSDQEMY TSLFGIQTRR IVSKYAEDPV
310 320 330
AFFEQFSKSM VKMGNILNSE SLADGEVRRN CRFVNT
Length:336
Mass (Da):37,313
Last modified:February 1, 1997 - v1
Checksum:i846D69A84530900B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192 – 194ALI → YLL in CAA72485 (Ref. 1) Curated3
Sequence conflicti218T → M in CAA72485 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08782 mRNA Translation: CAA70035.1
Y11789 mRNA Translation: CAA72485.1
AC011665 Genomic DNA Translation: AAG51588.1
AC011914 Genomic DNA Translation: AAG52033.1
CP002684 Genomic DNA Translation: AEE34850.1
PIRiC96713
RefSeqiNP_564948.1, NM_105559.4
UniGeneiAt.87

Genome annotation databases

EnsemblPlantsiAT1G68850.1; AT1G68850.1; AT1G68850
GeneIDi843218
GrameneiAT1G68850.1; AT1G68850.1; AT1G68850
KEGGiath:AT1G68850

Similar proteinsi

Entry informationi

Entry nameiPER11_ARATH
AccessioniPrimary (citable) accession number: Q96519
Secondary accession number(s): P93723
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health