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Protein

Peroxidase 16

Gene

PER16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei61 – 611Transition state stabilizerPROSITE-ProRule annotation
Active sitei65 – 651Proton acceptorPROSITE-ProRule annotation
Metal bindingi66 – 661Calcium 1PROSITE-ProRule annotation
Metal bindingi69 – 691Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi71 – 711Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi73 – 731Calcium 1PROSITE-ProRule annotation
Metal bindingi75 – 751Calcium 1PROSITE-ProRule annotation
Binding sitei161 – 1611Substrate; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi191 – 1911Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi192 – 1921Calcium 2PROSITE-ProRule annotation
Metal bindingi243 – 2431Calcium 2PROSITE-ProRule annotation
Metal bindingi246 – 2461Calcium 2PROSITE-ProRule annotation
Metal bindingi251 – 2511Calcium 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G18980-MONOMER.

Protein family/group databases

PeroxiBasei97. AtPrx16.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 16 (EC:1.11.1.7)
Short name:
Atperox P16
Alternative name(s):
ATP22a
Gene namesi
Name:PER16
Synonyms:P16
Ordered Locus Names:At2g18980
ORF Names:F19F24.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G18980.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 323300Peroxidase 16PRO_0000023682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 113PROSITE-ProRule annotation
Disulfide bondi67 ↔ 72PROSITE-ProRule annotation
Disulfide bondi119 ↔ 319PROSITE-ProRule annotation
Disulfide bondi198 ↔ 230PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ96518.
PRIDEiQ96518.

Expressioni

Tissue specificityi

Expressed in the whole plant, but preferentially in roots and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ96518. baseline and differential.
GenevisibleiQ96518. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G18980.1.

Structurei

3D structure databases

ProteinModelPortaliQ96518.
SMRiQ96518. Positions 24-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJYG. Eukaryota.
ENOG4111S7R. LUCA.
HOGENOMiHOG000237556.
InParanoidiQ96518.
KOiK00430.
OMAiDRDPNCR.
OrthoDBiEOG09360FB9.
PhylomeDBiQ96518.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQSSFSIV ALLLIFFSSS VFAQLQTNFY RKSCPNVETI VRNAVRQKFQ
60 70 80 90 100
QTFVTAPATL RLFFHDCFVR GCDASILLAS PSEKDHPDDK SLAGDGFDTV
110 120 130 140 150
AKAKQALDRD PNCRNKVSCA DILALATRDV VVLTGGPNYP VELGRRDGRL
160 170 180 190 200
STVASVQHSL PQPSFKLDQL NTMFARHGLS QTDMIALSGA HTIGFAHCGK
210 220 230 240 250
FSKRIYNFSP KRPIDPTLNI RYALQLRQMC PIRVDLRIAI NMDPTSPNTF
260 270 280 290 300
DNAYFKNLQK GMGLFTSDQV LFSDERSRST VNSFASSEAT FRQAFISAIT
310 320
KLGRVGVKTG NAGEIRRDCS RVN
Length:323
Mass (Da):35,832
Last modified:November 1, 1998 - v2
Checksum:i43880AD393482989
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003673 Genomic DNA. Translation: AAC09031.1.
CP002685 Genomic DNA. Translation: AEC06835.1.
BT003082 mRNA. Translation: AAO23647.1.
Y08781 mRNA. Translation: CAA70034.1.
PIRiT01626.
RefSeqiNP_179488.1. NM_127455.3.
UniGeneiAt.86.

Genome annotation databases

EnsemblPlantsiAT2G18980.1; AT2G18980.1; AT2G18980.
GeneIDi816415.
GrameneiAT2G18980.1; AT2G18980.1; AT2G18980.
KEGGiath:AT2G18980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003673 Genomic DNA. Translation: AAC09031.1.
CP002685 Genomic DNA. Translation: AEC06835.1.
BT003082 mRNA. Translation: AAO23647.1.
Y08781 mRNA. Translation: CAA70034.1.
PIRiT01626.
RefSeqiNP_179488.1. NM_127455.3.
UniGeneiAt.86.

3D structure databases

ProteinModelPortaliQ96518.
SMRiQ96518. Positions 24-323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G18980.1.

Protein family/group databases

PeroxiBasei97. AtPrx16.

Proteomic databases

PaxDbiQ96518.
PRIDEiQ96518.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18980.1; AT2G18980.1; AT2G18980.
GeneIDi816415.
GrameneiAT2G18980.1; AT2G18980.1; AT2G18980.
KEGGiath:AT2G18980.

Organism-specific databases

TAIRiAT2G18980.

Phylogenomic databases

eggNOGiENOG410IJYG. Eukaryota.
ENOG4111S7R. LUCA.
HOGENOMiHOG000237556.
InParanoidiQ96518.
KOiK00430.
OMAiDRDPNCR.
OrthoDBiEOG09360FB9.
PhylomeDBiQ96518.

Enzyme and pathway databases

BioCyciARA:AT2G18980-MONOMER.

Miscellaneous databases

PROiQ96518.

Gene expression databases

ExpressionAtlasiQ96518. baseline and differential.
GenevisibleiQ96518. AT.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER16_ARATH
AccessioniPrimary (citable) accession number: Q96518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.