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Q964T1

- CP4CU_BLAGE

UniProt

Q964T1 - CP4CU_BLAGE

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Protein
Cytochrome P450 4c21
Gene
CYP4C21
Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Heme (covalent; via 1 link) By similarity
Metal bindingi447 – 4471Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4c21 (EC:1.14.14.1)
Alternative name(s):
CYPIVC21
Gene namesi
Name:CYP4C21
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 4c21
PRO_0000051824Add
BLAST

Expressioni

Inductioni

Expressed at all life stages.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ964T1.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q964T1-1 [UniParc]FASTAAdd to Basket

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MDITVFLSLT VVVFLAVIIF YGRNEERKRM LQKIPGAPSL PLIGTALPIL    50
YRRKEDRMTW IEEILEKYKP LILWYFGNRP FVNISSPELI EVVLRNTQLI 100
DKAFLYDLFH SWLGTGLLTS SGAKWHQHRK IITPTFHFSI LEGFITIFAE 150
KSEILVRKLQ KEVGRGPFFI RQYVSNCALD IICETAMGTS VNAQDEGFSE 200
YVTAINKMTD VLSDRMANPL LYPEFIFKLT PYYWTHKKCL KVLNGFVNKI 250
IQERKEERKK SKVTQTSEDA DIGKKKRVPF LDTLLDASED DNKLTDTDIL 300
EEVHTFMFEG HDTVSAAMTW LLFELGHHPE IQEEAYKEVQ DIFQGSDRVP 350
TMADLNNMNY LERVIKESLR LHPSVIYFVR EAHQDFELGG YTIPAGTNID 400
FSVPFIHRNP EIFPNPRCFN PDNFLPDRVV NRHPYAYIPF SAGPRNCIGQ 450
RFALLEEKVV LSYLLRHYRF RTVNKREDSK FKLEMINTPV KPIQLIIEAR 500
N 501
Length:501
Mass (Da):58,297
Last modified:December 1, 2001 - v1
Checksum:i825F90FAA12AB22B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF275641 mRNA. Translation: AAK69411.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF275641 mRNA. Translation: AAK69411.1 .

3D structure databases

ProteinModelPortali Q964T1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s."
    Wen Z., Horak C.E., Scott J.G.
    Gene 272:257-266(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

Entry informationi

Entry nameiCP4CU_BLAGE
AccessioniPrimary (citable) accession number: Q964T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: December 11, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3