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Q964T1

- CP4CU_BLAGE

UniProt

Q964T1 - CP4CU_BLAGE

Protein

Cytochrome P450 4c21

Gene

CYP4C21

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei309 – 3091Heme (covalent; via 1 link)By similarity
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4c21 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVC21
    Gene namesi
    Name:CYP4C21
    OrganismiBlattella germanica (German cockroach) (Blatta germanica)
    Taxonomic identifieri6973 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Cytochrome P450 4c21PRO_0000051824Add
    BLAST

    Expressioni

    Inductioni

    Expressed at all life stages.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ964T1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q964T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDITVFLSLT VVVFLAVIIF YGRNEERKRM LQKIPGAPSL PLIGTALPIL    50
    YRRKEDRMTW IEEILEKYKP LILWYFGNRP FVNISSPELI EVVLRNTQLI 100
    DKAFLYDLFH SWLGTGLLTS SGAKWHQHRK IITPTFHFSI LEGFITIFAE 150
    KSEILVRKLQ KEVGRGPFFI RQYVSNCALD IICETAMGTS VNAQDEGFSE 200
    YVTAINKMTD VLSDRMANPL LYPEFIFKLT PYYWTHKKCL KVLNGFVNKI 250
    IQERKEERKK SKVTQTSEDA DIGKKKRVPF LDTLLDASED DNKLTDTDIL 300
    EEVHTFMFEG HDTVSAAMTW LLFELGHHPE IQEEAYKEVQ DIFQGSDRVP 350
    TMADLNNMNY LERVIKESLR LHPSVIYFVR EAHQDFELGG YTIPAGTNID 400
    FSVPFIHRNP EIFPNPRCFN PDNFLPDRVV NRHPYAYIPF SAGPRNCIGQ 450
    RFALLEEKVV LSYLLRHYRF RTVNKREDSK FKLEMINTPV KPIQLIIEAR 500
    N 501
    Length:501
    Mass (Da):58,297
    Last modified:December 1, 2001 - v1
    Checksum:i825F90FAA12AB22B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF275641 mRNA. Translation: AAK69411.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF275641 mRNA. Translation: AAK69411.1 .

    3D structure databases

    ProteinModelPortali Q964T1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s."
      Wen Z., Horak C.E., Scott J.G.
      Gene 272:257-266(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

    Entry informationi

    Entry nameiCP4CU_BLAGE
    AccessioniPrimary (citable) accession number: Q964T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3