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Protein

Cytochrome P450 4c21

Gene

CYP4C21

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Heme (covalent; via 1 link)By similarity
Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4c21 (EC:1.14.14.1)
Alternative name(s):
CYPIVC21
Gene namesi
Name:CYP4C21
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Cytochrome P450 4c21PRO_0000051824Add
BLAST

Expressioni

Inductioni

Expressed at all life stages.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ964T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q964T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITVFLSLT VVVFLAVIIF YGRNEERKRM LQKIPGAPSL PLIGTALPIL
60 70 80 90 100
YRRKEDRMTW IEEILEKYKP LILWYFGNRP FVNISSPELI EVVLRNTQLI
110 120 130 140 150
DKAFLYDLFH SWLGTGLLTS SGAKWHQHRK IITPTFHFSI LEGFITIFAE
160 170 180 190 200
KSEILVRKLQ KEVGRGPFFI RQYVSNCALD IICETAMGTS VNAQDEGFSE
210 220 230 240 250
YVTAINKMTD VLSDRMANPL LYPEFIFKLT PYYWTHKKCL KVLNGFVNKI
260 270 280 290 300
IQERKEERKK SKVTQTSEDA DIGKKKRVPF LDTLLDASED DNKLTDTDIL
310 320 330 340 350
EEVHTFMFEG HDTVSAAMTW LLFELGHHPE IQEEAYKEVQ DIFQGSDRVP
360 370 380 390 400
TMADLNNMNY LERVIKESLR LHPSVIYFVR EAHQDFELGG YTIPAGTNID
410 420 430 440 450
FSVPFIHRNP EIFPNPRCFN PDNFLPDRVV NRHPYAYIPF SAGPRNCIGQ
460 470 480 490 500
RFALLEEKVV LSYLLRHYRF RTVNKREDSK FKLEMINTPV KPIQLIIEAR

N
Length:501
Mass (Da):58,297
Last modified:December 1, 2001 - v1
Checksum:i825F90FAA12AB22B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275641 mRNA. Translation: AAK69411.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275641 mRNA. Translation: AAK69411.1.

3D structure databases

ProteinModelPortaliQ964T1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s."
    Wen Z., Horak C.E., Scott J.G.
    Gene 272:257-266(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

Entry informationi

Entry nameiCP4CU_BLAGE
AccessioniPrimary (citable) accession number: Q964T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.