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Q964T1 (CP4CU_BLAGE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4c21

EC=1.14.14.1
Alternative name(s):
CYPIVC21
Gene names
Name:CYP4C21
OrganismBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifier6973 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein Potential. Microsome membrane; Peripheral membrane protein Potential.

Induction

Expressed at all life stages. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Cytochrome P450 4c21
PRO_0000051824

Sites

Metal binding4471Iron (heme axial ligand) By similarity
Binding site3091Heme (covalent; via 1 link) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q964T1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 825F90FAA12AB22B

FASTA50158,297
        10         20         30         40         50         60 
MDITVFLSLT VVVFLAVIIF YGRNEERKRM LQKIPGAPSL PLIGTALPIL YRRKEDRMTW 

        70         80         90        100        110        120 
IEEILEKYKP LILWYFGNRP FVNISSPELI EVVLRNTQLI DKAFLYDLFH SWLGTGLLTS 

       130        140        150        160        170        180 
SGAKWHQHRK IITPTFHFSI LEGFITIFAE KSEILVRKLQ KEVGRGPFFI RQYVSNCALD 

       190        200        210        220        230        240 
IICETAMGTS VNAQDEGFSE YVTAINKMTD VLSDRMANPL LYPEFIFKLT PYYWTHKKCL 

       250        260        270        280        290        300 
KVLNGFVNKI IQERKEERKK SKVTQTSEDA DIGKKKRVPF LDTLLDASED DNKLTDTDIL 

       310        320        330        340        350        360 
EEVHTFMFEG HDTVSAAMTW LLFELGHHPE IQEEAYKEVQ DIFQGSDRVP TMADLNNMNY 

       370        380        390        400        410        420 
LERVIKESLR LHPSVIYFVR EAHQDFELGG YTIPAGTNID FSVPFIHRNP EIFPNPRCFN 

       430        440        450        460        470        480 
PDNFLPDRVV NRHPYAYIPF SAGPRNCIGQ RFALLEEKVV LSYLLRHYRF RTVNKREDSK 

       490        500 
FKLEMINTPV KPIQLIIEAR N 

« Hide

References

[1]"CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s."
Wen Z., Horak C.E., Scott J.G.
Gene 272:257-266(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF275641 mRNA. Translation: AAK69411.1.

3D structure databases

ProteinModelPortalQ964T1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP4CU_BLAGE
AccessionPrimary (citable) accession number: Q964T1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: December 1, 2001
Last modified: December 11, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families