Q964D8 (BUP1_DICDI) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 51.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Beta-ureidopropionase EC=3.5.1.6 Alternative name(s): Beta-alanine synthase N-carbamoyl-beta-alanine amidohydrolase | ||||||
| Gene names |
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| Organism | Dictyostelium discoideum (Slime mold) | ||||||
| Taxonomic identifier | 44689 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 391 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Converts N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to, respectively, beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide. |
| Catalytic activity | N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. Ref.1 |
| Pathway | |
| Sequence similarities | Belongs to the CN hydrolase family. BUP subfamily. Contains 1 CN hydrolase domain. |
| Caution | Lacks the zinc-binding sites found in mammalian orthologs. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | phagocytic vesicle Inferred from direct assay. Source: dictyBase |
| Molecular function | beta-ureidopropionase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Eukaryotic beta-alanine synthases are functionally related but have a high degree of structural diversity." Gojkovic Z., Sandrini M.P., Piskur J. Genetics 158:999-1011(2001) [PubMed: 11454750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY. |
| [2] | "Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [3] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [4] | Bienvenut W.V., Ura S., Insall R.H. Submitted (JUL-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-14; 62-70; 277-291 AND 371-391, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Strain: AX2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF333186 mRNA. Translation: AAK60519.1. AAFI02000012 Genomic DNA. Translation: EAL69954.1. |
| RefSeq | XP_644181.1. XM_639089.1. |
3D structure databases | |
| ProteinModelPortal | Q964D8. |
| SMR | Q964D8. Positions 5-387. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q964D8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblProtists | DDB0185221; DDB0185221; DDB_G0274123. |
| GeneID | 8619610. |
| GenomeReviews | Gene locus pyd3 in contig CM000151_GR. |
| KEGG | ddi:DDB_G0274123. |
Organism-specific databases | |
| dictyBase | DDB_G0274123. pyd3. |
Phylogenomic databases | |
| eggNOG | KOG0808. |
| GeneTree | EPrGT00050000005425. |
| HOGENOM | HBG742418. |
| OMA | VGTEVFP. |
| PhylomeDB | Q964D8. |
| ProtClustDB | CLSZ2729211. |
Family and domain databases | |
| InterPro | IPR003010. Ntlse/CNhydtse. [Graphical view] |
| Gene3D | G3DSA:3.60.110.10. Ntlse/CNhydtse. 1 hit. |
| KO | K01431. |
| Pfam | PF00795. CN_hydrolase. 1 hit. [Graphical view] |
| SUPFAM | SSF56317. Ntlse/CNhydtse. 1 hit. |
| PROSITE | PS50263. CN_HYDROLASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | BUP1_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q964D8 Secondary accession number(s): Q554Z2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with