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Protein

Arginine decarboxylase

Gene

ADC

Organism
Dianthus caryophyllus (Carnation) (Clove pink)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-KW
  3. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Short name:
ARGDC
Gene namesi
Name:ADC
OrganismiDianthus caryophyllus (Carnation) (Clove pink)
Taxonomic identifieri3570 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeDianthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Arginine decarboxylasePRO_0000149950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei156 – 1561N6-(pyridoxal phosphate)lysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ96412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 35011Substrate-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVACYVDT SAAVYGGAGA LSLPASEINF SGVPPTTTST TVNQPPPPQQ
60 70 80 90 100
WSPSLSAELY RIDRWGPPYF AVNSSGNVTV KPFGDATLPH QEIDLLKVVK
110 120 130 140 150
KVSDSKSSSG LGLHLPVIIR FPDVLKHRLE SLQSAFDFAV RTHGYGSHYQ
160 170 180 190 200
GVYPVKCNQD RYIVEDIVEF GSGFRFGLEA GSKPELLMAM SSLCKGSPDS
210 220 230 240 250
LLVCNGFKDA EYISLAIIGR KLGLNTVIVI EQEEEVDMAI ELSRKMGIRP
260 270 280 290 300
VVGVRAKLRT KHSGHFGSTS GEKGKFGLTT TQILRVVRKL ENFGMLDCLQ
310 320 330 340 350
LLHFHIGSQI PTTTLLSDGV AEASQVYCEL TRLGAHMRVI DIGGGLGIDY
360 370 380 390 400
DGSKSGDSDL SVGYTLEEYA SAVVGTVMSV CDRKGVKSPV ICSESVRAIV
410 420 430 440 450
SHHSILVFEA VSSSSSASPP MPGSTLALDY LVDGLTDEVK GEYRSLTAAA
460 470 480 490 500
MRGEYESCLM YSGMLKQRCV ELFKDGCLGM EQLAAVDGLC ELVSKALGVA
510 520 530 540 550
DGVCTYNVNL SVFTSIPDFW GIGQLFPIMP IHRLDQQPKA RGILSDLTCD
560 570 580 590 600
SDGKIDKFIG DESSLPLHEL SGGEGYYLGM FLGGAYEEAL GGVHNLFGGP
610 620 630 640 650
SVVRVQQSDG PQSYAVTRAV PGPSSSDVLR VMHHEPELMF QTLKHRAEEC
660 670 680 690 700
DNDYTAGPLA DMLAQSFNST PYLVPGHATG SCGFSNGSGL VNGCREYFYG
710 720
VDDGCNAAAV DAAAGEEEQW SYVCA
Length:725
Mass (Da):77,676
Last modified:February 1, 1997 - v1
Checksum:i6B1C8BA09DE19355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63832 mRNA. Translation: AAB67887.1.
PIRiT10721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U63832 mRNA. Translation: AAB67887.1.
PIRiT10721.

3D structure databases

ProteinModelPortaliQ96412.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of cDNA encoding arginine decarboxylase from carnation flowers."
    Chang K.S., Nam K.H., Lee M.M., Lee S.H., Park K.Y.
    Plant Gene Register PGR96-092
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. White Sim.

Entry informationi

Entry nameiSPE1_DIACA
AccessioniPrimary (citable) accession number: Q96412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.