Q96412 (SPE1_DIACA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
Short name=ADC
Short name=ARGDC
EC=4.1.1.19

Gene names

Name:

ADC

Organism

Dianthus caryophyllus (Carnation) (Clove pink)

Taxonomic identifier

3570 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › Caryophyllales › Caryophyllaceae › Dianthus

Protein attributes

Sequence length	725 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate. Magnesium.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 725	725	Arginine decarboxylase		PRO_0000149950
Regions
	Region	340 – 350	11	Substrate-binding By similarity
Amino acid modifications
	Modified residue	156	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96412 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6B1C8BA09DE19355	FASTA	725	77,676
	10 20 30 40 50 60 MPAVACYVDT SAAVYGGAGA LSLPASEINF SGVPPTTTST TVNQPPPPQQ WSPSLSAELY 70 80 90 100 110 120 RIDRWGPPYF AVNSSGNVTV KPFGDATLPH QEIDLLKVVK KVSDSKSSSG LGLHLPVIIR 130 140 150 160 170 180 FPDVLKHRLE SLQSAFDFAV RTHGYGSHYQ GVYPVKCNQD RYIVEDIVEF GSGFRFGLEA 190 200 210 220 230 240 GSKPELLMAM SSLCKGSPDS LLVCNGFKDA EYISLAIIGR KLGLNTVIVI EQEEEVDMAI 250 260 270 280 290 300 ELSRKMGIRP VVGVRAKLRT KHSGHFGSTS GEKGKFGLTT TQILRVVRKL ENFGMLDCLQ 310 320 330 340 350 360 LLHFHIGSQI PTTTLLSDGV AEASQVYCEL TRLGAHMRVI DIGGGLGIDY DGSKSGDSDL 370 380 390 400 410 420 SVGYTLEEYA SAVVGTVMSV CDRKGVKSPV ICSESVRAIV SHHSILVFEA VSSSSSASPP 430 440 450 460 470 480 MPGSTLALDY LVDGLTDEVK GEYRSLTAAA MRGEYESCLM YSGMLKQRCV ELFKDGCLGM 490 500 510 520 530 540 EQLAAVDGLC ELVSKALGVA DGVCTYNVNL SVFTSIPDFW GIGQLFPIMP IHRLDQQPKA 550 560 570 580 590 600 RGILSDLTCD SDGKIDKFIG DESSLPLHEL SGGEGYYLGM FLGGAYEEAL GGVHNLFGGP 610 620 630 640 650 660 SVVRVQQSDG PQSYAVTRAV PGPSSSDVLR VMHHEPELMF QTLKHRAEEC DNDYTAGPLA 670 680 690 700 710 720 DMLAQSFNST PYLVPGHATG SCGFSNGSGL VNGCREYFYG VDDGCNAAAV DAAAGEEEQW SYVCA

References

[1]	"Nucleotide sequence of cDNA encoding arginine decarboxylase from carnation flowers." Chang K.S., Nam K.H., Lee M.M., Lee S.H., Park K.Y. Plant Gene Register PGR96-092 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. White Sim.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63832 mRNA. Translation: AAB67887.1.
PIR	T10721.
3D structure databases
ProteinModelPortal	Q96412.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009006. Ala_racemase/Decarboxylase_C. IPR002985. Arg_decrbxlase. IPR022643. De-COase2_C. IPR022657. De-COase2_CS. IPR022644. De-COase2_N. IPR022653. De-COase2_pyr-phos_BS. IPR000183. Orn/DAP/Arg_de-COase. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 2 hits.
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. SpeA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPE1_DIACA

Accession

Primary (citable) accession number: Q96412

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 31, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program