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Protein

Heat stress transcription factor B-1

Gene

HSFB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 106By similarityAdd BLAST95

GO - Molecular functioni

  • DNA binding transcription factor activity Source: TAIR
  • sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to heat Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processStress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response
R-ATH-3371511 HSF1 activation
R-ATH-3371568 Attenuation phase
R-ATH-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor B-1
Short name:
AtHsfB1
Alternative name(s):
AtHsf-16
Heat shock factor protein 4
Short name:
HSF 4
Heat shock transcription factor 4
Short name:
HSTF 4
Gene namesi
Name:HSFB1
Synonyms:HSF16, HSF4
Ordered Locus Names:At4g36990
ORF Names:C7A10.370
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G36990
TAIRilocus:2115015 AT4G36990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245851 – 284Heat stress transcription factor B-1Add BLAST284

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96320

PTM databases

iPTMnetiQ96320

Expressioni

Inductioni

By heat stress.1 Publication

Gene expression databases

GenevisibleiQ96320 AT

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi15134, 7 interactors
IntActiQ96320, 3 interactors
STRINGi3702.AT4G36990.1

Structurei

3D structure databases

ProteinModelPortaliQ96320
SMRiQ96320
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 192Hydrophobic repeat HR-A/BAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi247 – 252Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 227Poly-Gly4

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.

Sequence similaritiesi

Belongs to the HSF family. Class B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0627 Eukaryota
COG5169 LUCA
HOGENOMiHOG000242480
InParanoidiQ96320
KOiK09419
OMAiEMKTVDF
OrthoDBiEOG09360JWU
PhylomeDBiQ96320

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000232 HSF_DNA-bd
IPR027725 HSF_fam
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10015 PTHR10015, 1 hit
PfamiView protein in Pfam
PF00447 HSF_DNA-bind, 1 hit
PRINTSiPR00056 HSFDOMAIN
SMARTiView protein in SMART
SM00415 HSF, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Q96320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVTAAQRS VPAPFLSKTY QLVDDHSTDD VVSWNEEGTA FVVWKTAEFA
60 70 80 90 100
KDLLPQYFKH NNFSSFIRQL NTYGFRKTVP DKWEFANDYF RRGGEDLLTD
110 120 130 140 150
IRRRKSVIAS TAGKCVVVGS PSESNSGGGD DHGSSSTSSP GSSKNPGSVE
160 170 180 190 200
NMVADLSGEN EKLKRENNNL SSELAAAKKQ RDELVTFLTG HLKVRPEQID
210 220 230 240 250
KMIKGGKFKP VESDEESECE GCDGGGGAEE GVGEGLKLFG VWLKGERKKR
260 270 280
DRDEKNYVVS GSRMTEIKNV DFHAPLWKSS KVCN
Length:284
Mass (Da):31,328
Last modified:December 1, 2000 - v2
Checksum:i0785022F667D9655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → R in AAC31756 (PubMed:9222607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68017 mRNA Translation: AAC31756.1
Y14069 mRNA Translation: CAA74398.1
Z99707 Genomic DNA Translation: CAB16764.1
AL161590 Genomic DNA Translation: CAB80365.1
CP002687 Genomic DNA Translation: AEE86732.1
AY120760 mRNA Translation: AAM53318.1
BT003369 mRNA Translation: AAO30002.1
PIRiH85436
S71851
RefSeqiNP_195416.1, NM_119862.3
UniGeneiAt.5365

Genome annotation databases

EnsemblPlantsiAT4G36990.1; AT4G36990.1; AT4G36990
GeneIDi829853
GrameneiAT4G36990.1; AT4G36990.1; AT4G36990
KEGGiath:AT4G36990

Similar proteinsi

Entry informationi

Entry nameiHSFB1_ARATH
AccessioniPrimary (citable) accession number: Q96320
Secondary accession number(s): O23186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 25, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health