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Protein

Heat stress transcription factor B-1

Gene

HSFB1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi12 – 106By similarityAdd BLAST95

GO - Molecular functioni

  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to heat Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat stress transcription factor B-1
Short name:
AtHsfB1
Alternative name(s):
AtHsf-16
Heat shock factor protein 4
Short name:
HSF 4
Heat shock transcription factor 4
Short name:
HSTF 4
Gene namesi
Name:HSFB1
Synonyms:HSF16, HSF4
Ordered Locus Names:At4g36990
ORF Names:C7A10.370
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G36990.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001245851 – 284Heat stress transcription factor B-1Add BLAST284

Post-translational modificationi

Exhibits temperature-dependent phosphorylation.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96320.

PTM databases

iPTMnetiQ96320.

Expressioni

Inductioni

By heat stress.1 Publication

Gene expression databases

GenevisibleiQ96320. AT.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi15134. 7 interactors.
STRINGi3702.AT4G36990.1.

Structurei

3D structure databases

ProteinModelPortaliQ96320.
SMRiQ96320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 192Hydrophobic repeat HR-A/BAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi247 – 252Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 227Poly-Gly4

Domaini

The hydrophobic-rich region (HR-A/B) corresponds to the oligomerization domain.

Sequence similaritiesi

Belongs to the HSF family. Class B subfamily.Curated

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000242480.
InParanoidiQ96320.
KOiK09419.
OMAiESECEGC.
OrthoDBiEOG09360JWU.
PhylomeDBiQ96320.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96320-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVTAAQRS VPAPFLSKTY QLVDDHSTDD VVSWNEEGTA FVVWKTAEFA
60 70 80 90 100
KDLLPQYFKH NNFSSFIRQL NTYGFRKTVP DKWEFANDYF RRGGEDLLTD
110 120 130 140 150
IRRRKSVIAS TAGKCVVVGS PSESNSGGGD DHGSSSTSSP GSSKNPGSVE
160 170 180 190 200
NMVADLSGEN EKLKRENNNL SSELAAAKKQ RDELVTFLTG HLKVRPEQID
210 220 230 240 250
KMIKGGKFKP VESDEESECE GCDGGGGAEE GVGEGLKLFG VWLKGERKKR
260 270 280
DRDEKNYVVS GSRMTEIKNV DFHAPLWKSS KVCN
Length:284
Mass (Da):31,328
Last modified:December 1, 2000 - v2
Checksum:i0785022F667D9655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → R in AAC31756 (PubMed:9222607).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68017 mRNA. Translation: AAC31756.1.
Y14069 mRNA. Translation: CAA74398.1.
Z99707 Genomic DNA. Translation: CAB16764.1.
AL161590 Genomic DNA. Translation: CAB80365.1.
CP002687 Genomic DNA. Translation: AEE86732.1.
AY120760 mRNA. Translation: AAM53318.1.
BT003369 mRNA. Translation: AAO30002.1.
PIRiH85436.
S71851.
RefSeqiNP_195416.1. NM_119862.3.
UniGeneiAt.5365.

Genome annotation databases

EnsemblPlantsiAT4G36990.1; AT4G36990.1; AT4G36990.
GeneIDi829853.
GrameneiAT4G36990.1; AT4G36990.1; AT4G36990.
KEGGiath:AT4G36990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68017 mRNA. Translation: AAC31756.1.
Y14069 mRNA. Translation: CAA74398.1.
Z99707 Genomic DNA. Translation: CAB16764.1.
AL161590 Genomic DNA. Translation: CAB80365.1.
CP002687 Genomic DNA. Translation: AEE86732.1.
AY120760 mRNA. Translation: AAM53318.1.
BT003369 mRNA. Translation: AAO30002.1.
PIRiH85436.
S71851.
RefSeqiNP_195416.1. NM_119862.3.
UniGeneiAt.5365.

3D structure databases

ProteinModelPortaliQ96320.
SMRiQ96320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi15134. 7 interactors.
STRINGi3702.AT4G36990.1.

PTM databases

iPTMnetiQ96320.

Proteomic databases

PaxDbiQ96320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36990.1; AT4G36990.1; AT4G36990.
GeneIDi829853.
GrameneiAT4G36990.1; AT4G36990.1; AT4G36990.
KEGGiath:AT4G36990.

Organism-specific databases

TAIRiAT4G36990.

Phylogenomic databases

eggNOGiKOG0627. Eukaryota.
COG5169. LUCA.
HOGENOMiHOG000242480.
InParanoidiQ96320.
KOiK09419.
OMAiESECEGC.
OrthoDBiEOG09360JWU.
PhylomeDBiQ96320.

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.
R-ATH-3371568. Attenuation phase.
R-ATH-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ96320.

Gene expression databases

GenevisibleiQ96320. AT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSFB1_ARATH
AccessioniPrimary (citable) accession number: Q96320
Secondary accession number(s): O23186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.