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Protein

Actin-2

Gene

ACT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins.

Miscellaneous

There are 8 actin genes in A.thaliana.

Enzyme regulationi

Subject to negative translational control in pollen.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  • response to cytokinin Source: TAIR
  • response to far red light Source: TAIR
  • response to high light intensity Source: TAIR
  • response to red light Source: TAIR
  • root epidermal cell differentiation Source: TAIR
  • root hair cell tip growth Source: TAIR
  • root hair elongation Source: TAIR

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-2029482 Regulation of actin dynamics for phagocytic cup formation
R-ATH-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-2
Gene namesi
Name:ACT2
Ordered Locus Names:At3g18780
ORF Names:MVE11.16
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G18780
TAIRilocus:2093954 AT3G18780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000888892 – 377Actin-2Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ96292
PRIDEiQ96292

PTM databases

iPTMnetiQ96292

Expressioni

Tissue specificityi

Strongly expressed in nearly all vegetative tissues, and remains high in older tissues. Little or no expression is detected in mature pollen sacs, ovules, embryos or seeds.

Gene expression databases

ExpressionAtlasiQ96292 baseline and differential
GenevisibleiQ96292 AT

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. The binding of profilin to monomeric G-actin cause the sequestration of actin into profilactin complexes, and prevents the polymerization.

Binary interactionsi

WithEntry#Exp.IntActNotes
HXK1Q425252EBI-1644538,EBI-1644489

Protein-protein interaction databases

BioGridi6744, 15 interactors
IntActiQ96292, 9 interactors
STRINGi3702.AT3G18780.2

Structurei

3D structure databases

ProteinModelPortaliQ96292
SMRiQ96292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
HOGENOMiHOG000233340
InParanoidiQ96292
KOiK10355
OMAiWISIDEY
OrthoDBiEOG09360BTG
PhylomeDBiQ96292

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q96292-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEADDIQPI VCDNGTGMVK AGFAGDDAPR AVFPSVVGRP RHHGVMVGMN
60 70 80 90 100
QKDAYVGDEA QSKRGILTLK YPIEHGVVSN WDDMEKIWHH TFYNELRIAP
110 120 130 140 150
EEHPVLLTEA PLNPKANREK MTQIMFETFN SPAMYVAIQA VLSLYASGRT
160 170 180 190 200
TGIVLDSGDG VSHTVPIYEG FSLPHAILRL DLAGRDLTDY LMKILTERGY
210 220 230 240 250
MFTTTAEREI VRDIKEKLSF VAVDYEQEME TSKTSSSIEK NYELPDGQVI
260 270 280 290 300
TIGAERFRCP EVLFQPSFVG MEAAGIHETT YNSIMKCDVD IRKDLYGNIV
310 320 330 340 350
LSGGTTMFSG IADRMSKEIT ALAPSSMKIK VVAPPERKYS VWIGGSILAS
360 370
LSTFQQMWIS KAEYDEAGPG IVHRKCF
Length:377
Mass (Da):41,877
Last modified:February 1, 1997 - v1
Checksum:iF9E53D17F333D786
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41998 Genomic DNA Translation: AAB37098.1
AB026654 Genomic DNA Translation: BAB01806.1
CP002686 Genomic DNA Translation: AEE76148.1
CP002686 Genomic DNA Translation: ANM65915.1
AF428330 mRNA Translation: AAL16260.1
AY064043 mRNA Translation: AAL36399.1
AY096381 mRNA Translation: AAM20022.1
AY087751 mRNA Translation: AAM65287.1
Z25952 mRNA Translation: CAA81112.1
RefSeqiNP_001327851.1, NM_001338359.1 [Q96292-1]
NP_188508.1, NM_112764.4 [Q96292-1]
UniGeneiAt.23604
At.24689
At.67767

Genome annotation databases

EnsemblPlantsiAT3G18780.2; AT3G18780.2; AT3G18780 [Q96292-1]
AT3G18780.3; AT3G18780.3; AT3G18780 [Q96292-1]
GeneIDi821411
GrameneiAT3G18780.2; AT3G18780.2; AT3G18780 [Q96292-1]
AT3G18780.3; AT3G18780.3; AT3G18780 [Q96292-1]
KEGGiath:AT3G18780

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiACT2_ARATH
AccessioniPrimary (citable) accession number: Q96292
Secondary accession number(s): Q42056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: February 1, 1997
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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