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Protein

Zinc finger protein ZAT10

Gene

ZAT10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in abiotic stress responses. Can repress the stress responsive genes DREB1A and LTI78. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade.6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri80 – 10223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri136 – 15823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: TAIR
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • multicellular organism growth Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • photoprotection Source: TAIR
  • photosynthesis Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to chitin Source: TAIR
  • response to cold Source: TAIR
  • response to high light intensity Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to salt stress Source: TAIR
  • response to water deprivation Source: TAIR
  • response to wounding Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZAT10
Alternative name(s):
Salt-tolerance zinc finger
Gene namesi
Name:ZAT10
Synonyms:STZ
Ordered Locus Names:At1g27730
ORF Names:T22C5.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G27730.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 227227Zinc finger protein ZAT10PRO_0000409719Add
BLAST

Proteomic databases

PaxDbiQ96289.

Expressioni

Tissue specificityi

Expressed in roots, stems and leaves.4 Publications

Inductioni

By salt, cold and drought stresses. Down-regulated by gibberellin.6 Publications

Gene expression databases

GenevisibleiQ96289. AT.

Interactioni

Protein-protein interaction databases

BioGridi24901. 6 interactions.
STRINGi3702.AT1G27730.1.

Structurei

3D structure databases

ProteinModelPortaliQ96289.
SMRiQ96289. Positions 72-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri80 – 10223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri136 – 15823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000240166.
InParanoidiQ96289.
OMAiSSLRYKC.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEALTSPR LASPIPPLFE DSSVFHGVEH WTKGKRSKRS RSDFHHQNLT
60 70 80 90 100
EEEYLAFCLM LLARDNRQPP PPPAVEKLSY KCSVCDKTFS SYQALGGHKA
110 120 130 140 150
SHRKNLSQTL SGGGDDHSTS SATTTSAVTT GSGKSHVCTI CNKSFPSGQA
160 170 180 190 200
LGGHKRCHYE GNNNINTSSV SNSEGAGSTS HVSSSHRGFD LNIPPIPEFS
210 220
MVNGDDEVMS PMPAKKPRFD FPVKLQL
Length:227
Mass (Da):24,614
Last modified:February 1, 1997 - v1
Checksum:iF3B70CCF695A6F54
GO

Sequence cautioni

The sequence AAF24959.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581C → W in CAA67228 (PubMed:9132053).Curated
Sequence conflicti58 – 581C → W in CAA67229 (PubMed:9132053).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95573 mRNA. Translation: CAA64820.1.
X98670 mRNA. Translation: CAA67228.1.
X98671 Genomic DNA. Translation: CAA67229.1.
AF250336 mRNA. Translation: AAG10142.1.
AC012375 Genomic DNA. Translation: AAF24959.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30870.1.
AY034998 mRNA. Translation: AAK59503.1.
AY063006 mRNA. Translation: AAL34180.1.
RefSeqiNP_174094.1. NM_102538.2.
UniGeneiAt.24624.

Genome annotation databases

EnsemblPlantsiAT1G27730.1; AT1G27730.1; AT1G27730.
GeneIDi839666.
GrameneiAT1G27730.1; AT1G27730.1; AT1G27730.
KEGGiath:AT1G27730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95573 mRNA. Translation: CAA64820.1.
X98670 mRNA. Translation: CAA67228.1.
X98671 Genomic DNA. Translation: CAA67229.1.
AF250336 mRNA. Translation: AAG10142.1.
AC012375 Genomic DNA. Translation: AAF24959.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE30870.1.
AY034998 mRNA. Translation: AAK59503.1.
AY063006 mRNA. Translation: AAL34180.1.
RefSeqiNP_174094.1. NM_102538.2.
UniGeneiAt.24624.

3D structure databases

ProteinModelPortaliQ96289.
SMRiQ96289. Positions 72-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24901. 6 interactions.
STRINGi3702.AT1G27730.1.

Proteomic databases

PaxDbiQ96289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G27730.1; AT1G27730.1; AT1G27730.
GeneIDi839666.
GrameneiAT1G27730.1; AT1G27730.1; AT1G27730.
KEGGiath:AT1G27730.

Organism-specific databases

TAIRiAT1G27730.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000240166.
InParanoidiQ96289.
OMAiSSLRYKC.

Miscellaneous databases

PROiQ96289.

Gene expression databases

GenevisibleiQ96289. AT.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast."
    Lippuner V., Cyert M.S., Gasser C.S.
    J. Biol. Chem. 271:12859-12866(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION BY SALT.
  2. "Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered protein genes and cDNA's."
    Meissner R., Michael A.J.
    Plant Mol. Biol. 33:615-624(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  3. "Functional identification of an Arabidopsis Snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast."
    Kleinow T., Bhalerao R., Breuer F., Umeda M., Salchert K., Koncz C.
    Plant J. 23:115-122(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  4. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  5. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Expression of a subset of the Arabidopsis Cys(2)/His(2)-type zinc-finger protein gene family under water stress."
    Sakamoto H., Araki T., Meshi T., Iwabuchi M.
    Gene 248:23-32(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.
  8. Cited for: INDUCTION.
  9. "LOS2, a genetic locus required for cold-responsive gene transcription encodes a bi-functional enolase."
    Lee H., Guo Y., Ohta M., Xiong L., Stevenson B., Zhu J.K.
    EMBO J. 21:2692-2702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Arabidopsis Cys2/His2-type zinc-finger proteins function as transcription repressors under drought, cold, and high-salinity stress conditions."
    Sakamoto H., Maruyama K., Sakuma Y., Meshi T., Iwabuchi M., Shinozaki K., Yamaguchi-Shinozaki K.
    Plant Physiol. 136:2734-2746(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  11. "Gibberellin biosynthesis and response during Arabidopsis seed germination."
    Ogawa M., Hanada A., Yamauchi Y., Kuwahara A., Kamiya Y., Yamaguchi S.
    Plant Cell 15:1591-1604(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  12. "Gain- and loss-of-function mutations in Zat10 enhance the tolerance of plants to abiotic stress."
    Mittler R., Kim Y., Song L., Coutu J., Coutu A., Ciftci-Yilmaz S., Lee H., Stevenson B., Zhu J.K.
    FEBS Lett. 580:6537-6542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  13. "Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells."
    Pauwels L., Morreel K., De Witte E., Lammertyn F., Van Montagu M., Boerjan W., Inze D., Goossens A.
    Proc. Natl. Acad. Sci. U.S.A. 105:1380-1385(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Fine-tuning of early events in the jasmonate response."
    Pauwels L., Goossens A.
    Plant Signal. Behav. 3:846-847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiZAT10_ARATH
AccessioniPrimary (citable) accession number: Q96289
Secondary accession number(s): Q42423, Q9SFY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: February 1, 1997
Last modified: February 17, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing ZAT10 show growth retardation and enhanced tolerance to drought, salt, heat and osmotic stresses. Plants silencing ZAT10 show enhanced tolerance to salt and osmotic stresses.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.