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Protein

Chloride channel protein CLC-c

Gene

CLC-C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated chloride channel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-ATH-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel protein CLC-c
Short name:
AtCLC-c
Alternative name(s):
CBS domain-containing protein CBSCLC4
Gene namesi
Name:CLC-C
Synonyms:CBSCLC4
Ordered Locus Names:At5g49890
ORF Names:K9P8.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G49890.
TAIRilocus:2158809. AT5G49890.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei92 – 112Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei190 – 210Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei257 – 277Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei287 – 307Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei341 – 361Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei380 – 400Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei466 – 486Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei488 – 508Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei520 – 540Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei541 – 561Helical; Name=12Sequence analysisAdd BLAST21
Transmembranei741 – 761Helical; Name=13Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944671 – 779Chloride channel protein CLC-cAdd BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei672PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ96282.

PTM databases

iPTMnetiQ96282.

Expressioni

Tissue specificityi

Broadly expressed in the plant.

Gene expression databases

ExpressionAtlasiQ96282. baseline and differential.
GenevisibleiQ96282. AT.

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with PP2A5 (PubMed:27676158).By similarity1 Publication

Protein-protein interaction databases

BioGridi20298. 8 interactors.
STRINGi3702.AT5G49890.1.

Structurei

3D structure databases

ProteinModelPortaliQ96282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini601 – 659CBS 1PROSITE-ProRule annotationAdd BLAST59
Domaini713 – 777CBS 2PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0474. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000231081.
InParanoidiQ96282.
KOiK05016.
OMAiKYHSASM.
OrthoDBiEOG093602TR.
PhylomeDBiQ96282.

Family and domain databases

Gene3Di1.10.3080.10. 1 hit.
InterProiView protein in InterPro
IPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002251. Cl_channel_pln.
PfamiView protein in Pfam
PF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
PRINTSiPR00762. CLCHANNEL.
PR01120. CLCHANNELPLT.
SMARTiView protein in SMART
SM00116. CBS. 2 hits.
SUPFAMiSSF81340. SSF81340. 2 hits.
PROSITEiView protein in PROSITE
PS51371. CBS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDRHEGDHH DIEVEGGALH GFERKISGIL DDGSVGFRQP LLARNRKNTT
60 70 80 90 100
SQIAIVGANT CPIESLDYEI FENDFFKQDW RSRKKIEILQ YTFLKWALAF
110 120 130 140 150
LIGLATGLVG FLNNLGVENI AGFKLLLIGN LMLKEKYFQA FFAFAGCNLI
160 170 180 190 200
LATAAASLCA FIAPAAAGSG IPEVKAYLNG IDAYSILAPS TLFVKIFGSI
210 220 230 240 250
FGVAAGFVVG KEGPMVHTGA CIANLLGQGG SKKYRLTWKW LRFFKNDRDR
260 270 280 290 300
RDLITCGAAA GVAAAFRAPV GGVLFALEEA ASWWRNALLW RTFFTTAVVA
310 320 330 340 350
VVLRSLIEFC RSGRCGLFGK GGLIMFDVNS GPVLYSTPDL LAIVFLGVIG
360 370 380 390 400
GVLGSLYNYL VDKVLRTYSI INEKGPRFKI MLVMAVSILS SCCAFGLPWL
410 420 430 440 450
SQCTPCPIGI EEGKCPSVGR SSIYKSFQCP PNHYNDLSSL LLNTNDDAIR
460 470 480 490 500
NLFTSRSENE FHISTLAIFF VAVYCLGIIT YGIAIPSGLF IPVILAGASY
510 520 530 540 550
GRLVGRLLGP VSQLDVGLFS LLGAASFLGG TMRMTVSLCV ILLELTNNLL
560 570 580 590 600
MLPLVMLVLL ISKTVADCFN RGVYDQIVTM KGLPYMEDHA EPYMRNLVAK
610 620 630 640 650
DVVSGALISF SRVEKVGVIW QALKMTRHNG FPVIDEPPFT EASELCGIAL
660 670 680 690 700
RSHLLVLLQG KKFSKQRTTF GSQILRSCKA RDFGKAGLGK GLKIEDLDLS
710 720 730 740 750
EEEMEMYVDL HPITNTSPYT VLETLSLAKA AILFRQLGLR HLCVVPKTPG
760 770
RPPIVGILTR HDFMPEHVLG LYPHIDPLK
Length:779
Mass (Da):85,232
Last modified:February 1, 1997 - v1
Checksum:i1717716DB1EE5867
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71447 mRNA. Translation: CAA96059.1.
Y09095 mRNA. Translation: CAA70310.1.
AB024032 Genomic DNA. Translation: BAA97010.1.
CP002688 Genomic DNA. Translation: AED95868.1.
AY120754 mRNA. Translation: AAM53312.1.
BT001211 mRNA. Translation: AAN65098.1.
RefSeqiNP_199800.1. NM_124367.4.
UniGeneiAt.16.

Genome annotation databases

EnsemblPlantsiAT5G49890.1; AT5G49890.1; AT5G49890.
GeneIDi835052.
GrameneiAT5G49890.1; AT5G49890.1; AT5G49890.
KEGGiath:AT5G49890.

Similar proteinsi

Entry informationi

Entry nameiCLCC_ARATH
AccessioniPrimary (citable) accession number: Q96282
Secondary accession number(s): O04753, O04837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 1, 1997
Last modified: December 20, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families