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Q96253

- ATP5E_ARATH

UniProt

Q96253 - ATP5E_ARATH

Protein

ATP synthase subunit epsilon, mitochondrial

Gene

At1g51650

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

    GO - Molecular functioni

    1. proton-transporting ATPase activity, rotational mechanism Source: InterPro
    2. proton-transporting ATP synthase activity, rotational mechanism Source: InterPro

    GO - Biological processi

    1. ATP synthesis coupled proton transport Source: InterPro

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit epsilon, mitochondrial
    Short name:
    ATPase subunit epsilon
    Gene namesi
    Ordered Locus Names:At1g51650
    ORF Names:F19C24.25
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G51650.

    Subcellular locationi

    Mitochondrion 1 Publication. Mitochondrion inner membrane 1 Publication

    GO - Cellular componenti

    1. mitochondrial proton-transporting ATP synthase complex Source: TAIR
    2. mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) Source: InterPro
    3. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7069ATP synthase subunit epsilon, mitochondrialPRO_0000071668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ96253.
    PRIDEiQ96253.

    Expressioni

    Gene expression databases

    GenevestigatoriQ96253.

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

    Protein-protein interaction databases

    BioGridi26815. 5 interactions.
    IntActiQ96253. 6 interactions.
    STRINGi3702.AT1G51650.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96253.
    SMRiQ96253. Positions 7-52.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic ATPase epsilon family.Curated

    Phylogenomic databases

    eggNOGiNOG328846.
    HOGENOMiHOG000214506.
    InParanoidiQ96253.
    KOiK02135.
    OMAiTREKVHF.
    PhylomeDBiQ96253.

    Family and domain databases

    Gene3Di1.10.1620.20. 1 hit.
    InterProiIPR006721. ATPase_F1-cplx_esu_mt.
    [Graphical view]
    PfamiPF04627. ATP-synt_Eps. 1 hit.
    [Graphical view]
    SUPFAMiSSF48690. SSF48690. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96253-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNAAVPFW RAAGMTYISY SNICANIVRN CLKEPHKAEA LTREKVHFSL   50
    SKWADGKPQK PVLRSDTPEV 70
    Length:70
    Mass (Da):7,832
    Last modified:January 23, 2007 - v3
    Checksum:i13CA2441550ED5A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88377 mRNA. Translation: BAA13602.1.
    AC025294 Genomic DNA. Translation: AAG50890.1.
    CP002684 Genomic DNA. Translation: AEE32695.1.
    AY072309 mRNA. Translation: AAL61916.1.
    AY114540 mRNA. Translation: AAM47859.1.
    PIRiC96555.
    RefSeqiNP_175576.1. NM_104043.2.
    UniGeneiAt.25226.

    Genome annotation databases

    EnsemblPlantsiAT1G51650.1; AT1G51650.1; AT1G51650.
    GeneIDi841590.
    KEGGiath:AT1G51650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D88377 mRNA. Translation: BAA13602.1 .
    AC025294 Genomic DNA. Translation: AAG50890.1 .
    CP002684 Genomic DNA. Translation: AEE32695.1 .
    AY072309 mRNA. Translation: AAL61916.1 .
    AY114540 mRNA. Translation: AAM47859.1 .
    PIRi C96555.
    RefSeqi NP_175576.1. NM_104043.2.
    UniGenei At.25226.

    3D structure databases

    ProteinModelPortali Q96253.
    SMRi Q96253. Positions 7-52.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 26815. 5 interactions.
    IntActi Q96253. 6 interactions.
    STRINGi 3702.AT1G51650.1-P.

    Proteomic databases

    PaxDbi Q96253.
    PRIDEi Q96253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G51650.1 ; AT1G51650.1 ; AT1G51650 .
    GeneIDi 841590.
    KEGGi ath:AT1G51650.

    Organism-specific databases

    GeneFarmi 3311.
    TAIRi AT1G51650.

    Phylogenomic databases

    eggNOGi NOG328846.
    HOGENOMi HOG000214506.
    InParanoidi Q96253.
    KOi K02135.
    OMAi TREKVHF.
    PhylomeDBi Q96253.

    Gene expression databases

    Genevestigatori Q96253.

    Family and domain databases

    Gene3Di 1.10.1620.20. 1 hit.
    InterProi IPR006721. ATPase_F1-cplx_esu_mt.
    [Graphical view ]
    Pfami PF04627. ATP-synt_Eps. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48690. SSF48690. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cDNAs encoding gamma, delta, delta-prime, and epsilon subunits of mitochondrial F1-ATPase in Arabidopsis thaliana."
      Sakamoto W., Wintz H.
      Plant Gene Register PGR96-125
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATP5E_ARATH
    AccessioniPrimary (citable) accession number: Q96253
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3