Reviewed, UniProtKB/Swiss-Prot Q961C9 (TNG11_DROME)

Names and origin

Protein names

Recommended name:
    Transport and Golgi organization protein 11
      Short name=Tango-11

Gene names

Name:	Tango11
ORF Names:	CG30404

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Ref.4
Sequence similarities	Belongs to the tango11 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Coiled coil Transmembrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Ref.4 Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VFG3	1	EBI-95452,EBI-192116

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Transport and Golgi organization protein 11		PRO_0000289192
Regions
	Topological domain	1 – 256	256	Cytoplasmic Potential
	Transmembrane	257 – 274	18	Anchor for type IV membrane protein Potential
	Topological domain	275 – 277	3	Lumenal Potential
	Coiled coil	225 – 253	29	Potential
Amino acid modifications
	Modified residue	127	1	Phosphoserine Ref.5
	Modified residue	129	1	Phosphoserine Ref.5
	Modified residue	132	1	Phosphoserine Ref.5
	Modified residue	133	1	Phosphoserine Ref.5
	Modified residue	177	1	Phosphothreonine Ref.5
	Modified residue	179	1	Phosphoserine Ref.5
	Modified residue	182	1	Phosphoserine Ref.5
	Modified residue	190	1	Phosphoserine Ref.5
	Modified residue	216	1	Phosphothreonine Ref.5
	Modified residue	222	1	Phosphothreonine Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q961C9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 73589873005CAC92	FASTA	277	31,541
	10 20 30 40 50 60 MVTPQSPTPM FNGLDDDLYS DAKYAHEIND KMRVPKRIKA TGEYSNEDLL LSNQNGMISS 70 80 90 100 110 120 WNYHDKIDMN VPDRIVVLGH NQHLETRSAP REIQLENSIL PKNPSVGLVR VQTPPRIITL 130 140 150 160 170 180 TDQHFPSASE ESSPIRANGH HLYGNDLDED ADDEEVHATQ YVRANGVARM GFQGNDTNSV 190 200 210 220 230 240 ESDSQLTTGS ASKRSQLNQQ QHNNLDASML AHREGTPMGE LTPHEEILYL RRQLAKLNRR 250 260 270 VLNIEINNEQ RTQREKIVYC LGLAYFVLKT IFWLNRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[4]	"Functional genomics reveals genes involved in protein secretion and Golgi organization." Bard F., Casano L., Mallabiabarrena A., Wallace E., Saito K., Kitayama H., Guizzunti G., Hu Y., Wendler F., Dasgupta R., Perrimon N., Malhotra V. Nature 439:604-607(2006) [PubMed: 16452979] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127; SER-129; SER-132; SER-133; THR-177; SER-179; SER-182; SER-190; THR-216 AND THR-222, MASS SPECTROMETRY. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE013599 Genomic DNA. Translation: AAM71012.1. AY051672 mRNA. Translation: AAK93096.1.
RefSeq	NP_726111.1. NP_726112.1.
UniGene	Dm.20857
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q961C9. 9 interactions.
Proteomic databases
PRIDE	Q961C9.
Genome annotation databases
Ensembl	FBgn0050404. Drosophila melanogaster. [Contig view]
GeneID	246596.
KEGG	dme:Dmel_CG30404.
Organism-specific databases
FlyBase	FBgn0050404. Tango11.
Phylogenomic databases
HOGENOM	Q961C9.
OMA	Q961C9. WNYHDKI.
Gene expression databases
ArrayExpress	Q961C9.
Family and domain databases
InterPro	IPR008518. DUF800. [Graphical view]
PANTHER	PTHR16501. DUF800. 1 hit.
Pfam	PF05644. DUF800. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	843148.

Entry information

Entry name

TNG11_DROME

Accession

Primary (citable) accession number: Q961C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project