Q96133 (COX3_CARAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:	mt-co3
Synonyms:	coiii, coxiii, mtco3

Encoded on

Mitochondrion

Organism

Carassius auratus (Goldfish)

Taxonomic identifier

7957 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Carassius

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Cytochrome c oxidase subunit 3		PRO_0000183754
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	31 – 51	21	Helical; Potential
	Transmembrane	81 – 101	21	Helical; Potential
	Transmembrane	127 – 147	21	Helical; Potential
	Transmembrane	159 – 179	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
Experimental info
	Sequence conflict	171	1	F → L in AAA99828. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96133 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: C8BD83AD5BE184FF	FASTA	261	29,674
	10 20 30 40 50 60 MAHQAHAYHM VDPSPWPLTG AIAALLMTSG LAIWFHFHST TLMTLGLILL LLTMYQWWRD 70 80 90 100 110 120 IIREGTFQGH HTPPVQKGLR YGMILFITSE VFFFLGFFWA FYHSSLAPTP ELGGCWPPTG 130 140 150 160 170 180 ITPLDPFEVP LLNTAVLLAS GVTVTWAHHS IMEGERKQAI QSLALTILLG FYFTALQAME 190 200 210 220 230 240 YYEAPFTIAD GVYGSTFFVA TGFHGLHVII GSTFLAVCLL RQIQYHFTSE HHFGFEAAAW 250 260 YWHFVDVVWL FLYVSIYWWG S

References

[1]	"The complete sequence of mitochondrial genome from a gynogenetic triploid 'ginbuna' (Carassius auratus langsdorfi)." Murakami M., Yamashita Y., Fujitani H. Zool. Sci. 15:335-337(1998) Cited for: NUCLEOTIDE SEQUENCE. Strain: AZ3 / Langsdorfi. Tissue: Oocyte.
[2]	Lin X.-W. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-261.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB006953 Genomic DNA. Translation: BAA31244.1. U57388 mRNA. Translation: AAA99828.1.
RefSeq	NP_008594.1. NC_002079.1.
3D structure databases
ProteinModelPortal	Q96133.
SMR	Q96133. Positions 1-261.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	808427.
Organism-specific databases
CTD	4514.
Phylogenomic databases
HOVERGEN	HBG016686.
ProtClustDB	MTH00130.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_CARAU

Accession

Primary (citable) accession number: Q96133
Secondary accession number(s): O78685

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 30, 2000
Last modified:	March 6, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program