Q960X4 (TIP60_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 104.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Histone acetyltransferase Tip60 EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Reference proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › ![]() |
Protein attributes
| Sequence length | 541 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV. Ref.5 |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subunit structure | Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1. Ref.5 |
| Subcellular location | Nucleus Probable. |
| Post-translational modification | Autoacetylation at Lys-355 is required for proper function By similarity. |
| Sequence similarities | Belongs to the MYST (SAS/MOZ) family. |
| Sequence caution | The sequence CAA21829.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 541 | 541 | Histone acetyltransferase Tip60 | PRO_0000051583 | |||||
Regions | |||||||||
| Region | 405 – 411 | 7 | Acetyl-CoA binding By similarity | ||||||
Sites | |||||||||
| Active site | 355 | 1 | By similarity | ||||||
| Active site | 397 | 1 | Nucleophile By similarity | ||||||
| Binding site | 400 | 1 | Acetyl-CoA By similarity | ||||||
| Binding site | 435 | 1 | Acetyl-CoA By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 355 | 1 | N6-acetyllysine; by autocatalysis By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014298 Genomic DNA. Translation: AAF45923.3. AL033125 Genomic DNA. Translation: CAA21829.1. Sequence problems. AY051795 mRNA. Translation: AAK93219.1. |
| RefSeq | NP_001259234.1. NM_001272305.1. NP_572151.1. NM_131923.4. |
| UniGene | Dm.75. |
3D structure databases | |
| ProteinModelPortal | Q960X4. |
| SMR | Q960X4. Positions 27-96, 258-533. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q960X4. 4 interactions. |
| MINT | MINT-785367. |
Proteomic databases | |
| PRIDE | Q960X4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0070668; FBpp0070636; FBgn0026080. FBtr0333186; FBpp0305388; FBgn0026080. |
| GeneID | 31362. |
| KEGG | dme:Dmel_CG6121. |
Organism-specific databases | |
| CTD | 31362. |
| FlyBase | FBgn0026080. Tip60. |
Phylogenomic databases | |
| eggNOG | COG5027. |
| GeneTree | ENSGT00550000074503. |
| InParanoid | Q960X4. |
| KO | K11304. |
| OMA | CMCTRDE. |
| OrthoDB | EOG4TQJR4. |
| PhylomeDB | Q960X4. |
Gene expression databases | |
| Bgee | Q960X4. |
| GermOnline | CG6121. Drosophila melanogaster. |
Family and domain databases | |
| Gene3D | 3.40.630.30. 1 hit. |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR002717. MOZ_SAS. IPR025995. Tudor-knot. [Graphical view] |
| Pfam | PF01853. MOZ_SAS. 1 hit. PF11717. Tudor-knot. 1 hit. [Graphical view] |
| SMART | SM00298. CHROMO. 1 hit. [Graphical view] |
| SUPFAM | SSF55729. Acyl_CoA_acyltransferase. 1 hit. SSF54160. Chromodomain-like. 1 hit. |
| ProtoNet | Search... |
Other | |
| ChiTaRS | KAT5. drosophila. |
| GenomeRNAi | 31362. |
| NextBio | 773249. |
Entry information
| Entry name | TIP60_DROME | ||||||||
| Accession | Primary (citable) accession number: Q960X4 Secondary accession number(s): O97425 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with
