Reviewed,
UniProtKB/Swiss-Prot Q960X4 (TIP60_DROME)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histone acetyltransferase Tip60 EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 541 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalytic subunit of the Tip60 chromatin-remodeling complex which is involved in DNA repair. Upon induction of DNA double-strand breaks, acetylates phosphorylated histone H2AV in nucleosomes on 'Lys-4' and exchanges it with unmodified H2AV. Ref.5 |
| Catalytic activity | Acetyl-CoA + histone = CoA + acetylhistone. |
| Subunit structure | Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1. |
| Subcellular location | Nucleus Probable. |
| Sequence similarities | Belongs to the MYST (SAS/MOZ) family. |
| Sequence caution | The sequence CAA21829.1 differs from that shown. Reason: Erroneous gene model prediction. |
Ontologies
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AE014298 Genomic DNA. Translation: AAF45923.3. AL033125 Genomic DNA. Translation: CAA21829.1. Sequence problems. AY051795 mRNA. Translation: AAK93219.1. | |
| RefSeq | NP_572151.1. |
| UniGene | Dm.75 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FY7 based on UniProtKB Q08649. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q960X4. 8 interactions. |
Proteomic databases | |
| PRIDE | Q960X4. |
Genome annotation databases | |
| Ensembl | FBgn0026080. Drosophila melanogaster. [Contig view] |
| GeneID | 31362. |
| KEGG | dme:Dmel_CG6121. |
| NMPDR | fig|7227.3.peg.16445. |
Organism-specific databases | |
| FlyBase | FBgn0026080. Tip60. |
Phylogenomic databases | |
| HOGENOM | Q960X4. |
| OMA | Q960X4. VASICES. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.48. 48. |
Gene expression databases | |
| ArrayExpress | Q960X4. |
| GermOnline | CG6121. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR000953. Chromodomain. IPR002717. MOZ_SAS. IPR011991. Wing_hlx_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. |
| Pfam | PF01853. MOZ_SAS. 1 hit. [Graphical view] |
| SMART | SM00298. CHROMO. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 773249. |
Entry information
| Entry name | TIP60_DROME | ||||||||
| Accession | Primary (citable) accession number: Q960X4 Secondary accession number(s): O97425 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


