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Q960T2

- SAP47_DROME

UniProt

Q960T2 - SAP47_DROME

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Protein

Synapse-associated protein of 47 kDa

Gene
Sap47, CG8884
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. associative learning Source: FlyBase
  2. regulation of short-term neuronal synaptic plasticity Source: FlyBase
  3. synaptic transmission Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein of 47 kDa
Gene namesi
Name:Sap47
ORF Names:CG8884
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013334. Sap47.

Subcellular locationi

GO - Cellular componenti

  1. synapse Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Synapse-associated protein of 47 kDaPRO_0000097584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei186 – 1861Phosphothreonine1 Publication
Modified residuei433 – 4331Phosphoserine1 Publication
Modified residuei530 – 5301Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ960T2.
PRIDEiQ960T2.

Expressioni

Tissue specificityi

Expressed specifically in neurons and transported to synaptic terminals.1 Publication

Gene expression databases

BgeeiQ960T2.

Interactioni

Protein-protein interaction databases

BioGridi66992. 13 interactions.
DIPiDIP-18495N.
IntActiQ960T2. 1 interaction.
STRINGi7227.FBpp0082661.

Structurei

3D structure databases

ProteinModelPortaliQ960T2.
SMRiQ960T2. Positions 260-359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini295 – 34753BSDAdd
BLAST

Sequence similaritiesi

Contains 1 BSD domain.

Phylogenomic databases

eggNOGiNOG283411.
GeneTreeiENSGT00390000007662.
InParanoidiQ960T2.
OMAiNASIPSM.
OrthoDBiEOG7WDN49.
PhylomeDBiQ960T2.

Family and domain databases

InterProiIPR005607. BSD.
[Graphical view]
PfamiPF03909. BSD. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 1 hit.
[Graphical view]
PROSITEiPS50858. BSD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q960T2-1) [UniParc]FASTAAdd to Basket

Also known as: C, D, E, H

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFSGLTNQFT SLVGAVKGGA GDEDVPAPTG DAPAAAPAAS TSVEATASSA    50
VDPEAAAAAG GEGLEGEEAG KRLPKSASLV DSLVSEATGW LGSAKGWLGN 100
ASIPSMPAMP SMPSMPAMPA MPSIPSIPGL RKGAGADGAE GAEGAVAGEG 150
GAAASGAVSG GEDDDKSRYI SATEGADSHP ASGGGTPTGD EGQIGQGKGD 200
EVKITTKVTQ QAKHFGSFLS SAISKAGSKI KETVKDNTIL DSFNKEQEAF 250
IKGQGGVGNG AAPWIGHANE AKIKEEILGL SQDRRNFVRA PPAGVDFEFS 300
YDTAYPTAIA IMAEDKALET MRFELVPKII TEENFWRNYF YRVSLIIQAA 350
ELGTLGADGV GQASSGEDAN EVATKEKKSK TAEPAKGDSS VKAIAEQPKA 400
VIEPEAQECD VQAAKSKAKA KAQAGKELGQ KISESEFVSD DFQASSESDL 450
AEIQDGMRKL GIDSMTQQAL AATDEEQWEK DLEAELKDYE VVDEGGTGGD 500
GGGGRRKGRK AGEDDTEADE DEPTISNLRT RSTNNDWEEY ADLIEDTDDL 550
K 551

Note: No experimental confirmation available.

Length:551
Mass (Da):56,980
Last modified:December 1, 2001 - v1
Checksum:i430392D0EAD5916E
GO
Isoform B (identifier: Q960T2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-374: NEVAT → LAFNY
     375-551: Missing.

Note: No experimental confirmation available.

Show »
Length:374
Mass (Da):37,891
Checksum:i42AF0887B9A2961F
GO
Isoform F (identifier: Q960T2-4) [UniParc]FASTAAdd to Basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S
     197-204: GKGDEVKI → V
     370-374: NEVAT → LAFNY
     375-551: Missing.

Show »
Length:351
Mass (Da):35,495
Checksum:i5D82A5B308551B40
GO
Isoform G (identifier: Q960T2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S

Note: No experimental confirmation available.

Show »
Length:535
Mass (Da):55,313
Checksum:iDC70FD0FCF9CF667
GO
Isoform I (identifier: Q960T2-3) [UniParc]FASTAAdd to Basket

Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S
     197-204: GKGDEVKI → V
     369-370: AN → ED
     371-551: Missing.

Show »
Length:347
Mass (Da):35,060
Checksum:iA5D3DB403CFBCE67
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei72 – 8817RLPKS…VSEAT → S in isoform F, isoform G and isoform I. VSP_007389Add
BLAST
Alternative sequencei197 – 2048GKGDEVKI → V in isoform F and isoform I. VSP_007390
Alternative sequencei369 – 3702AN → ED in isoform I. VSP_007391
Alternative sequencei370 – 3745NEVAT → LAFNY in isoform B and isoform F. VSP_007393
Alternative sequencei371 – 551181Missing in isoform I. VSP_007392Add
BLAST
Alternative sequencei375 – 551177Missing in isoform B and isoform F. VSP_007394Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80110 mRNA. Translation: CAA56415.1.
X80111 mRNA. Translation: CAA56416.1.
AE014297 Genomic DNA. Translation: AAF55255.2.
AE014297 Genomic DNA. Translation: AAN13682.1.
AE014297 Genomic DNA. Translation: AAN13683.1.
AE014297 Genomic DNA. Translation: AAN13684.1.
AE014297 Genomic DNA. Translation: AAN13685.1.
AE014297 Genomic DNA. Translation: AAN13686.2.
AE014297 Genomic DNA. Translation: AAN13687.1.
AE014297 Genomic DNA. Translation: AAN13688.1.
AY051871 mRNA. Translation: AAK93295.1.
PIRiS60653.
RefSeqiNP_524371.1. NM_079647.4. [Q960T2-4]
NP_732088.1. NM_169684.3. [Q960T2-1]
NP_732089.1. NM_169685.3. [Q960T2-1]
NP_732090.1. NM_169686.3. [Q960T2-1]
NP_732091.1. NM_169687.3. [Q960T2-1]
NP_732092.2. NM_169688.3. [Q960T2-3]
NP_732093.1. NM_169689.3. [Q960T2-5]
NP_732094.1. NM_169690.3. [Q960T2-2]
UniGeneiDm.4457.

Genome annotation databases

EnsemblMetazoaiFBtr0083204; FBpp0082658; FBgn0013334. [Q960T2-1]
FBtr0083206; FBpp0082660; FBgn0013334. [Q960T2-1]
FBtr0083207; FBpp0082661; FBgn0013334. [Q960T2-1]
FBtr0083208; FBpp0082662; FBgn0013334. [Q960T2-1]
GeneIDi41938.
KEGGidme:Dmel_CG8884.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80110 mRNA. Translation: CAA56415.1 .
X80111 mRNA. Translation: CAA56416.1 .
AE014297 Genomic DNA. Translation: AAF55255.2 .
AE014297 Genomic DNA. Translation: AAN13682.1 .
AE014297 Genomic DNA. Translation: AAN13683.1 .
AE014297 Genomic DNA. Translation: AAN13684.1 .
AE014297 Genomic DNA. Translation: AAN13685.1 .
AE014297 Genomic DNA. Translation: AAN13686.2 .
AE014297 Genomic DNA. Translation: AAN13687.1 .
AE014297 Genomic DNA. Translation: AAN13688.1 .
AY051871 mRNA. Translation: AAK93295.1 .
PIRi S60653.
RefSeqi NP_524371.1. NM_079647.4. [Q960T2-4 ]
NP_732088.1. NM_169684.3. [Q960T2-1 ]
NP_732089.1. NM_169685.3. [Q960T2-1 ]
NP_732090.1. NM_169686.3. [Q960T2-1 ]
NP_732091.1. NM_169687.3. [Q960T2-1 ]
NP_732092.2. NM_169688.3. [Q960T2-3 ]
NP_732093.1. NM_169689.3. [Q960T2-5 ]
NP_732094.1. NM_169690.3. [Q960T2-2 ]
UniGenei Dm.4457.

3D structure databases

ProteinModelPortali Q960T2.
SMRi Q960T2. Positions 260-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66992. 13 interactions.
DIPi DIP-18495N.
IntActi Q960T2. 1 interaction.
STRINGi 7227.FBpp0082661.

Proteomic databases

PaxDbi Q960T2.
PRIDEi Q960T2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0083204 ; FBpp0082658 ; FBgn0013334 . [Q960T2-1 ]
FBtr0083206 ; FBpp0082660 ; FBgn0013334 . [Q960T2-1 ]
FBtr0083207 ; FBpp0082661 ; FBgn0013334 . [Q960T2-1 ]
FBtr0083208 ; FBpp0082662 ; FBgn0013334 . [Q960T2-1 ]
GeneIDi 41938.
KEGGi dme:Dmel_CG8884.

Organism-specific databases

CTDi 41938.
FlyBasei FBgn0013334. Sap47.

Phylogenomic databases

eggNOGi NOG283411.
GeneTreei ENSGT00390000007662.
InParanoidi Q960T2.
OMAi NASIPSM.
OrthoDBi EOG7WDN49.
PhylomeDBi Q960T2.

Miscellaneous databases

ChiTaRSi Sap47. drosophila.
GenomeRNAii 41938.
NextBioi 826353.
PROi Q960T2.

Gene expression databases

Bgeei Q960T2.

Family and domain databases

InterProi IPR005607. BSD.
[Graphical view ]
Pfami PF03909. BSD. 1 hit.
[Graphical view ]
SMARTi SM00751. BSD. 1 hit.
[Graphical view ]
PROSITEi PS50858. BSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals."
    Reichmuth C., Becker S., Benz M., Debel K., Reisch D., Heimbeck G., Hofbauer A., Klagges B., Pflugfelder G.O., Buchner E.
    Brain Res. Mol. Brain Res. 32:45-54(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS F AND I), TISSUE SPECIFICITY.
    Strain: Berlin.
    Tissue: Head.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-182; THR-186; SER-433 AND THR-530, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSAP47_DROME
AccessioniPrimary (citable) accession number: Q960T2
Secondary accession number(s): A4V2Z5
, Q24502, Q24503, Q8INC9, Q9VF07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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