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Protein

Synapse-associated protein of 47 kDa

Gene

Sap47

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • associative learning Source: FlyBase
  • chemical synaptic transmission Source: UniProtKB
  • regulation of short-term neuronal synaptic plasticity Source: FlyBase

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein of 47 kDa
Gene namesi
Name:Sap47
ORF Names:CG8884
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0013334. Sap47.

Subcellular locationi

GO - Cellular componenti

  • synapse Source: UniProtKB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975841 – 551Synapse-associated protein of 47 kDaAdd BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178Phosphoserine1 Publication1
Modified residuei182Phosphoserine1 Publication1
Modified residuei186Phosphothreonine1 Publication1
Modified residuei433Phosphoserine1 Publication1
Modified residuei530Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ960T2.
PRIDEiQ960T2.

PTM databases

iPTMnetiQ960T2.

Expressioni

Tissue specificityi

Expressed specifically in neurons and transported to synaptic terminals.1 Publication

Gene expression databases

BgeeiFBgn0013334.
ExpressionAtlasiQ960T2. differential.
GenevisibleiQ960T2. DM.

Interactioni

Protein-protein interaction databases

BioGridi66992. 14 interactors.
DIPiDIP-18495N.
IntActiQ960T2. 3 interactors.
STRINGi7227.FBpp0082658.

Structurei

3D structure databases

ProteinModelPortaliQ960T2.
SMRiQ960T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini295 – 347BSDPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4310. Eukaryota.
ENOG410ZPSV. LUCA.
GeneTreeiENSGT00390000007662.
InParanoidiQ960T2.
OMAiVTQQAKH.
OrthoDBiEOG091G0HAT.
PhylomeDBiQ960T2.

Family and domain databases

Gene3Di1.10.3970.10. 1 hit.
InterProiView protein in InterPro
IPR005607. BSD_dom.
PfamiView protein in Pfam
PF03909. BSD. 1 hit.
SMARTiView protein in SMART
SM00751. BSD. 1 hit.
SUPFAMiSSF140383. SSF140383. 1 hit.
PROSITEiView protein in PROSITE
PS50858. BSD. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q960T2-1) [UniParc]FASTAAdd to basket
Also known as: C, D, E, H

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSGLTNQFT SLVGAVKGGA GDEDVPAPTG DAPAAAPAAS TSVEATASSA
60 70 80 90 100
VDPEAAAAAG GEGLEGEEAG KRLPKSASLV DSLVSEATGW LGSAKGWLGN
110 120 130 140 150
ASIPSMPAMP SMPSMPAMPA MPSIPSIPGL RKGAGADGAE GAEGAVAGEG
160 170 180 190 200
GAAASGAVSG GEDDDKSRYI SATEGADSHP ASGGGTPTGD EGQIGQGKGD
210 220 230 240 250
EVKITTKVTQ QAKHFGSFLS SAISKAGSKI KETVKDNTIL DSFNKEQEAF
260 270 280 290 300
IKGQGGVGNG AAPWIGHANE AKIKEEILGL SQDRRNFVRA PPAGVDFEFS
310 320 330 340 350
YDTAYPTAIA IMAEDKALET MRFELVPKII TEENFWRNYF YRVSLIIQAA
360 370 380 390 400
ELGTLGADGV GQASSGEDAN EVATKEKKSK TAEPAKGDSS VKAIAEQPKA
410 420 430 440 450
VIEPEAQECD VQAAKSKAKA KAQAGKELGQ KISESEFVSD DFQASSESDL
460 470 480 490 500
AEIQDGMRKL GIDSMTQQAL AATDEEQWEK DLEAELKDYE VVDEGGTGGD
510 520 530 540 550
GGGGRRKGRK AGEDDTEADE DEPTISNLRT RSTNNDWEEY ADLIEDTDDL

K
Note: No experimental confirmation available.
Length:551
Mass (Da):56,980
Last modified:December 1, 2001 - v1
Checksum:i430392D0EAD5916E
GO
Isoform B (identifier: Q960T2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-374: NEVAT → LAFNY
     375-551: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):37,891
Checksum:i42AF0887B9A2961F
GO
Isoform F (identifier: Q960T2-4) [UniParc]FASTAAdd to basket
Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S
     197-204: GKGDEVKI → V
     370-374: NEVAT → LAFNY
     375-551: Missing.

Show »
Length:351
Mass (Da):35,495
Checksum:i5D82A5B308551B40
GO
Isoform G (identifier: Q960T2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S

Note: No experimental confirmation available.
Show »
Length:535
Mass (Da):55,313
Checksum:iDC70FD0FCF9CF667
GO
Isoform I (identifier: Q960T2-3) [UniParc]FASTAAdd to basket
Also known as: 2

The sequence of this isoform differs from the canonical sequence as follows:
     72-88: RLPKSASLVDSLVSEAT → S
     197-204: GKGDEVKI → V
     369-370: AN → ED
     371-551: Missing.

Show »
Length:347
Mass (Da):35,060
Checksum:iA5D3DB403CFBCE67
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00738972 – 88RLPKS…VSEAT → S in isoform F, isoform G and isoform I. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_007390197 – 204GKGDEVKI → V in isoform F and isoform I. 1 Publication8
Alternative sequenceiVSP_007391369 – 370AN → ED in isoform I. 1 Publication2
Alternative sequenceiVSP_007393370 – 374NEVAT → LAFNY in isoform B and isoform F. 1 Publication5
Alternative sequenceiVSP_007392371 – 551Missing in isoform I. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_007394375 – 551Missing in isoform B and isoform F. 1 PublicationAdd BLAST177

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80110 mRNA. Translation: CAA56415.1.
X80111 mRNA. Translation: CAA56416.1.
AE014297 Genomic DNA. Translation: AAF55255.2.
AE014297 Genomic DNA. Translation: AAN13682.1.
AE014297 Genomic DNA. Translation: AAN13683.1.
AE014297 Genomic DNA. Translation: AAN13684.1.
AE014297 Genomic DNA. Translation: AAN13685.1.
AE014297 Genomic DNA. Translation: AAN13686.2.
AE014297 Genomic DNA. Translation: AAN13687.1.
AE014297 Genomic DNA. Translation: AAN13688.1.
AY051871 mRNA. Translation: AAK93295.1.
PIRiS60653.
RefSeqiNP_001287350.1. NM_001300421.1. [Q960T2-3]
NP_524371.1. NM_079647.4. [Q960T2-4]
NP_732088.1. NM_169684.3. [Q960T2-1]
NP_732089.1. NM_169685.3. [Q960T2-1]
NP_732090.1. NM_169686.3. [Q960T2-1]
NP_732091.1. NM_169687.3. [Q960T2-1]
NP_732092.2. NM_169688.3. [Q960T2-3]
NP_732093.1. NM_169689.3. [Q960T2-5]
NP_732094.1. NM_169690.3. [Q960T2-2]
UniGeneiDm.4457.

Genome annotation databases

EnsemblMetazoaiFBtr0083204; FBpp0082658; FBgn0013334. [Q960T2-1]
FBtr0083205; FBpp0082659; FBgn0013334. [Q960T2-2]
FBtr0083206; FBpp0082660; FBgn0013334. [Q960T2-1]
FBtr0083207; FBpp0082661; FBgn0013334. [Q960T2-1]
FBtr0083208; FBpp0082662; FBgn0013334. [Q960T2-1]
FBtr0083209; FBpp0082663; FBgn0013334. [Q960T2-4]
FBtr0083210; FBpp0082664; FBgn0013334. [Q960T2-5]
FBtr0301655; FBpp0290869; FBgn0013334. [Q960T2-3]
FBtr0344384; FBpp0310757; FBgn0013334. [Q960T2-3]
GeneIDi41938.
KEGGidme:Dmel_CG8884.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSAP47_DROME
AccessioniPrimary (citable) accession number: Q960T2
Secondary accession number(s): A4V2Z5
, Q24502, Q24503, Q8INC9, Q9VF07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase