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Q96000

- COX1_PECMA

UniProt

Q96000 - COX1_PECMA

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Protein
Cytochrome c oxidase subunit 1
Gene
COI
Organism
Pecten maximus (King scallop) (Pilgrim's clam)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Iron (heme A axial ligand) Inferred
Metal bindingi242 – 2421Copper B Inferred
Metal bindingi246 – 2461Copper B Inferred
Metal bindingi292 – 2921Copper B Inferred
Metal bindingi293 – 2931Copper B Inferred
Metal bindingi378 – 3781Iron (heme A3 axial ligand) Inferred
Metal bindingi380 – 3801Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiPecten maximus (King scallop) (Pilgrim's clam)
Taxonomic identifieri6579 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaPectinoidaPectinoideaPectinidaePecten

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Reviewed prediction
Add
BLAST
Transmembranei149 – 17123Helical; Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Reviewed prediction
Add
BLAST
Transmembranei309 – 32921Helical; Reviewed prediction
Add
BLAST
Transmembranei340 – 36021Helical; Reviewed prediction
Add
BLAST
Transmembranei382 – 40221Helical; Reviewed prediction
Add
BLAST
Transmembranei416 – 43621Helical; Reviewed prediction
Add
BLAST
Transmembranei455 – 47521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›477›477Cytochrome c oxidase subunit 1
PRO_0000183385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki242 ↔ 2461'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliQ96000.
SMRiQ96000. Positions 3-473.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q96000-1 [UniParc]FASTAAdd to Basket

« Hide

MVRWSRWFMA NSHKDVGTMY LMLGMWSGFG GLNLSWMMRL ELSRPGMWLP    50
SSEVYNGIVT LHAIMMIFSF VMPVLIGGFG NWLLPMMLGS IDMSFPRLNT 100
FSFWVLPPAL YLVIVSCFID YGSGTGWTMY PVPLSSTPYS GGISTDLMIL 150
GLHLAGISSS AESINYLVTF LNVRSKSFKA EFSPLFVWAL AVTSFLLLVS 200
LPVLAGGLTM LIMDRDFNCS FFDPSGGGDP VLFQHLFWFF GHPEVYVLIL 250
PGFGLVSHVL VFYTKKLRVF GSVAMMYAMI SIGVLGFIVW GHHMYTVGLD 300
VDTRFYFTAV TMLIAVPTGV KVFSWIATIY GSYLSFEAPT LWVLGFIMKF 350
TMGGITGVIL SNACLDVALH DTYYVVAHFH YVLSMGAVFT IFAGYIHYFP 400
FFTSKLFSPV LARGHFFLTF VGVNLTFFPQ HFLGLGGMPR RIPDYPIFYY 450
YWNQWSTIGC AMVMVSVSLF IHMQWEA 477
Length:477
Mass (Da):53,692
Last modified:February 1, 1997 - v1
Checksum:i4A6DA9D830CABAEE
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei477 – 4771

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92688 Genomic DNA. Translation: CAA63370.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92688 Genomic DNA. Translation: CAA63370.1 .

3D structure databases

ProteinModelPortali Q96000.
SMRi Q96000. Positions 3-473.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and complete nucleotide sequence of the repeated unit and flanking gene of the scallop Pecten maximus mitochondrial DNA: putative replication origin features."
    Rigaa A., Monnerot M., Sellos D.
    J. Mol. Evol. 41:189-195(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.

Entry informationi

Entry nameiCOX1_PECMA
AccessioniPrimary (citable) accession number: Q96000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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