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Q95ZE3

- CDS1_ENCCU

UniProt

Q95ZE3 - CDS1_ENCCU

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Protein

Phosphatidate cytidylyltransferase

Gene
CDS1, ECU05_1250
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:CDS1
Ordered Locus Names:ECU05_1250
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_1250.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei49 – 6921Helical; Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Transmembranei108 – 12821Helical; Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Transmembranei290 – 31021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Phosphatidate cytidylyltransferasePRO_0000090721Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU05_1250.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000111503.
KOiK00981.
OMAiKKDVKFQ.
OrthoDBiEOG7XDBQH.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q95ZE3-1 [UniParc]FASTAAdd to Basket

« Hide

MAEERKDSEE SPGTYSCSKT LRRRGEITPN GKVRYETTQN KAAGITKTNF    50
FRRLVLSIVM ISGFCWISVN DKIYSFGLII FLTISIIREI IGITRKSDGR 100
PFHLRTSIIL GLAVPIYSYL VFPSIMMMYF SRVSKCFLRR LSFVCFYSYV 150
AAFMCFVASL RKGRLKPQLG LFALIHLSTY TMAIAAKCAI FNLNKGRFWF 200
VFPALLVISN DISAYVVGKS IGKRPLYRLS PKKTLEGFIG AFIFTTAVGF 250
ALGHLHVNSG FLRDADSEQF QKFMKFTVFG ANVRVQSIYI HIIPFIFVAS 300
FVAPFSGFLA SALKRAYKKK DFGEAISGHG GIADRMDCQV LIAIFASTYI 350
SSFIYTEERS VGSVFSLICR NFSHDEIMIL IEMLNRRVES IRK 393
Length:393
Mass (Da):44,467
Last modified:December 1, 2001 - v1
Checksum:i34794E225A5D3CFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310088 Genomic DNA. Translation: CAC51023.1.
AL590445 Genomic DNA. Translation: CAD26645.1.
RefSeqiNP_597468.1. NM_001041334.1.

Genome annotation databases

GeneIDi859134.
KEGGiecu:ECU05_1250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310088 Genomic DNA. Translation: CAC51023.1 .
AL590445 Genomic DNA. Translation: CAD26645.1 .
RefSeqi NP_597468.1. NM_001041334.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU05_1250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859134.
KEGGi ecu:ECU05_1250.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU05_1250.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000111503.
KOi K00981.
OMAi KKDVKFQ.
OrthoDBi EOG7XDBQH.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Encephalitozoon cuniculi (Microspora): characterization of phospholipid metabolic pathway potentially linked to therapeutics."
    El Alaoui H., Bata J., Peyret P., Vivares C.P.
    Exp. Parasitol. 98:171-179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiCDS1_ENCCU
AccessioniPrimary (citable) accession number: Q95ZE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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