Reviewed, UniProtKB/Swiss-Prot Q95ZE3 (CDS1_ENCCU)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	CDS1
Ordered Locus Names:	ECU05_1250

Organism

Encephalitozoon cuniculi (Microsporidian parasite) [Complete proteome]

Taxonomic identifier

6035 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Phosphatidate cytidylyltransferase		PRO_0000090721
Regions
	Transmembrane	49 – 69	21	Potential
	Transmembrane	73 – 93	21	Potential
	Transmembrane	108 – 128	21	Potential
	Transmembrane	141 – 161	21	Potential
	Transmembrane	171 – 191	21	Potential
	Transmembrane	198 – 218	21	Potential
	Transmembrane	237 – 257	21	Potential
	Transmembrane	290 – 310	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q95ZE3-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 34794E225A5D3CFC	FASTA	393	44,467
	10 20 30 40 50 60 MAEERKDSEE SPGTYSCSKT LRRRGEITPN GKVRYETTQN KAAGITKTNF FRRLVLSIVM 70 80 90 100 110 120 ISGFCWISVN DKIYSFGLII FLTISIIREI IGITRKSDGR PFHLRTSIIL GLAVPIYSYL 130 140 150 160 170 180 VFPSIMMMYF SRVSKCFLRR LSFVCFYSYV AAFMCFVASL RKGRLKPQLG LFALIHLSTY 190 200 210 220 230 240 TMAIAAKCAI FNLNKGRFWF VFPALLVISN DISAYVVGKS IGKRPLYRLS PKKTLEGFIG 250 260 270 280 290 300 AFIFTTAVGF ALGHLHVNSG FLRDADSEQF QKFMKFTVFG ANVRVQSIYI HIIPFIFVAS 310 320 330 340 350 360 FVAPFSGFLA SALKRAYKKK DFGEAISGHG GIADRMDCQV LIAIFASTYI SSFIYTEERS 370 380 390 VGSVFSLICR NFSHDEIMIL IEMLNRRVES IRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Encephalitozoon cuniculi (Microspora): characterization of phospholipid metabolic pathway potentially linked to therapeutics." El Alaoui H., Bata J., Peyret P., Vivares C.P. Exp. Parasitol. 98:171-179(2001) [PubMed: 11560410] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed: 11719806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ310088 Genomic DNA. Translation: CAC51023.1. AL590445 Genomic DNA. Translation: CAD26645.1.
RefSeq	NP_597468.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q95ZE3.
Genome annotation databases
GeneID	859134.
GenomeReviews	Gene locus ECU05_1250 in contig AL590445_GR.
KEGG	ecu:ECU05_1250.
NMPDR	fig|6035.1.peg.615.
Enzyme and pathway databases
BRENDA	2.7.7.41. 276319.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDS1_ENCCU

Accession

Primary (citable) accession number: Q95ZE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	December 1, 2001
Last modified:	October 13, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)