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Q95ZE3

- CDS1_ENCCU

UniProt

Q95ZE3 - CDS1_ENCCU

Protein

Phosphatidate cytidylyltransferase

Gene

CDS1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:CDS1
    Ordered Locus Names:ECU05_1250
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome V

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU05_1250.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Phosphatidate cytidylyltransferasePRO_0000090721Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU05_1250.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    HOGENOMiHOG000111503.
    KOiK00981.
    OMAiKKDVKFQ.
    OrthoDBiEOG7XDBQH.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q95ZE3-1 [UniParc]FASTAAdd to Basket

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    MAEERKDSEE SPGTYSCSKT LRRRGEITPN GKVRYETTQN KAAGITKTNF    50
    FRRLVLSIVM ISGFCWISVN DKIYSFGLII FLTISIIREI IGITRKSDGR 100
    PFHLRTSIIL GLAVPIYSYL VFPSIMMMYF SRVSKCFLRR LSFVCFYSYV 150
    AAFMCFVASL RKGRLKPQLG LFALIHLSTY TMAIAAKCAI FNLNKGRFWF 200
    VFPALLVISN DISAYVVGKS IGKRPLYRLS PKKTLEGFIG AFIFTTAVGF 250
    ALGHLHVNSG FLRDADSEQF QKFMKFTVFG ANVRVQSIYI HIIPFIFVAS 300
    FVAPFSGFLA SALKRAYKKK DFGEAISGHG GIADRMDCQV LIAIFASTYI 350
    SSFIYTEERS VGSVFSLICR NFSHDEIMIL IEMLNRRVES IRK 393
    Length:393
    Mass (Da):44,467
    Last modified:December 1, 2001 - v1
    Checksum:i34794E225A5D3CFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310088 Genomic DNA. Translation: CAC51023.1.
    AL590445 Genomic DNA. Translation: CAD26645.1.
    RefSeqiNP_597468.1. NM_001041334.1.

    Genome annotation databases

    GeneIDi859134.
    KEGGiecu:ECU05_1250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310088 Genomic DNA. Translation: CAC51023.1 .
    AL590445 Genomic DNA. Translation: CAD26645.1 .
    RefSeqi NP_597468.1. NM_001041334.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU05_1250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859134.
    KEGGi ecu:ECU05_1250.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU05_1250.

    Phylogenomic databases

    eggNOGi COG0575.
    HOGENOMi HOG000111503.
    KOi K00981.
    OMAi KKDVKFQ.
    OrthoDBi EOG7XDBQH.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Encephalitozoon cuniculi (Microspora): characterization of phospholipid metabolic pathway potentially linked to therapeutics."
      El Alaoui H., Bata J., Peyret P., Vivares C.P.
      Exp. Parasitol. 98:171-179(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiCDS1_ENCCU
    AccessioniPrimary (citable) accession number: Q95ZE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3