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Q95Y12

- SET23_CAEEL

UniProt

Q95Y12 - SET23_CAEEL

Protein

Probable histone-lysine N-methyltransferase set-23

Gene

set-23

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Probable histone methyltransferase By similarity. Required for embryonic development.By similarity1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Zinc 1By similarity
    Metal bindingi27 – 271Zinc 2By similarity
    Metal bindingi29 – 291Zinc 1By similarity
    Metal bindingi33 – 331Zinc 1By similarity
    Metal bindingi33 – 331Zinc 3By similarity
    Metal bindingi39 – 391Zinc 1By similarity
    Metal bindingi41 – 411Zinc 2By similarity
    Metal bindingi65 – 651Zinc 2By similarity
    Metal bindingi65 – 651Zinc 3By similarity
    Metal bindingi69 – 691Zinc 2By similarity
    Metal bindingi71 – 711Zinc 3By similarity
    Metal bindingi78 – 781Zinc 3By similarity
    Binding sitei141 – 1411S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei143 – 1431S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei170 – 1701S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi176 – 1761Zinc 4By similarity
    Metal bindingi225 – 2251Zinc 4By similarity
    Metal bindingi227 – 2271Zinc 4By similarity
    Metal bindingi232 – 2321Zinc 4By similarity

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable histone-lysine N-methyltransferase set-23 (EC:2.1.1.43)
    Alternative name(s):
    SET-domain containing protein 23
    Gene namesi
    Name:set-23
    ORF Names:Y41D4B.12
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY41D4B.12a; CE27623; WBGene00021515; set-23.
    Y41D4B.12b; CE31647; WBGene00021515; set-23.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethal.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Probable histone-lysine N-methyltransferase set-23PRO_0000287565Add
    BLAST

    Proteomic databases

    PRIDEiQ95Y12.

    Interactioni

    Protein-protein interaction databases

    IntActiQ95Y12. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95Y12.
    SMRiQ95Y12. Positions 10-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 8662Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini89 – 213125SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini221 – 23717Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 1033S-adenosyl-L-methionine bindingBy similarity
    Regioni173 – 1742S-adenosyl-L-methionine bindingBy similarity

    Domaini

    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00740000114921.
    InParanoidiQ95Y12.
    KOiK11433.
    OMAiITFPGCA.
    OrthoDBiEOG744T8D.
    PhylomeDBiQ95Y12.

    Family and domain databases

    InterProiIPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: Q95Y12-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNYEKIDSTI PGPGISETDW NDVFEGCNCE AECSSAAGCS CLINKIDNYT    50
    VDGKINKSSE LLIECSDQCA CILLPTSCRN RVVQCGPQKK LEIFSTCEMA 100
    KGFGVRAGEQ IAAGEFVCEY AGECIGEQEV ERRCREFRGD DNYTLTLKEF 150
    FGGKPVKTFV DPRLRGNIGR FLNHSCEPNC EIILARLGRM IPAAGIFAKR 200
    DIVRGEELCY DYGHSAIEGE NRKLCLCKSE KCRKYLPMSA TPIE 244
    Length:244
    Mass (Da):27,108
    Last modified:December 1, 2001 - v1
    Checksum:iAB291915D129C2A3
    GO
    Isoform b (identifier: Q95Y12-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: Missing.
         86-95: GPQKKLEIFS → MCLHTAPNFI

    Note: No experimental confirmation available.

    Show »
    Length:159
    Mass (Da):17,895
    Checksum:iAF09BB931CC5CA44
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585Missing in isoform b. CuratedVSP_025564Add
    BLAST
    Alternative sequencei86 – 9510GPQKKLEIFS → MCLHTAPNFI in isoform b. CuratedVSP_025565

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080782 Genomic DNA. Translation: CCD66712.1.
    FO080782 Genomic DNA. Translation: CCD66713.1.
    RefSeqiNP_741320.1. NM_171270.1. [Q95Y12-1]
    NP_741321.1. NM_171271.3. [Q95Y12-2]
    UniGeneiCel.32662.

    Genome annotation databases

    EnsemblMetazoaiY41D4B.12a; Y41D4B.12a; WBGene00021515. [Q95Y12-1]
    GeneIDi176969.
    KEGGicel:CELE_Y41D4B.12.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080782 Genomic DNA. Translation: CCD66712.1 .
    FO080782 Genomic DNA. Translation: CCD66713.1 .
    RefSeqi NP_741320.1. NM_171270.1. [Q95Y12-1 ]
    NP_741321.1. NM_171271.3. [Q95Y12-2 ]
    UniGenei Cel.32662.

    3D structure databases

    ProteinModelPortali Q95Y12.
    SMRi Q95Y12. Positions 10-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q95Y12. 1 interaction.

    Proteomic databases

    PRIDEi Q95Y12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y41D4B.12a ; Y41D4B.12a ; WBGene00021515 . [Q95Y12-1 ]
    GeneIDi 176969.
    KEGGi cel:CELE_Y41D4B.12.

    Organism-specific databases

    CTDi 176969.
    WormBasei Y41D4B.12a ; CE27623 ; WBGene00021515 ; set-23.
    Y41D4B.12b ; CE31647 ; WBGene00021515 ; set-23.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00740000114921.
    InParanoidi Q95Y12.
    KOi K11433.
    OMAi ITFPGCA.
    OrthoDBi EOG744T8D.
    PhylomeDBi Q95Y12.

    Miscellaneous databases

    NextBioi 894788.
    PROi Q95Y12.

    Family and domain databases

    InterProi IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.
    2. "Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development."
      Andersen E.C., Horvitz H.R.
      Development 134:2991-2999(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSET23_CAEEL
    AccessioniPrimary (citable) accession number: Q95Y12
    Secondary accession number(s): Q8MXT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3