Q95XX1 (PNCB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

ORF Names:

Y54G2A.17

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Coding sequence diversity	Alternative splicing
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway nicotinate nucleotide salvage Inferred from electronic annotation. Source: InterPro response to oxidative stress Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: Q95XX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: Q95XX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Isoform c (identifier: Q95XX1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
     259-562: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 562	562	Nicotinate phosphoribosyltransferase		PRO_0000315685
Natural variations
	Alternative sequence	1 – 20	20	Missing in isoform a and isoform c.		VSP_030613
	Alternative sequence	240 – 258	19	LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c.		VSP_042230
	Alternative sequence	259 – 562	304	Missing in isoform c.		VSP_042231

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified January 25, 2012. Version 3. Checksum: C37B5385BC9EE745	FASTA	562	63,347
	10 20 30 40 50 60 MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH NEPAVFDVFF 70 80 90 100 110 120 RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP ENAEPEFYEY LETLNGSHLT 130 140 150 160 170 180 IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE TSILNLVNYA SLVATNAARF RQASGWKIQL 190 200 210 220 230 240 LEFGLRRAQG PNGGLTASKY CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL 250 260 270 280 290 300 KVRLLNHKIT NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL 310 320 330 340 350 360 ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC FVKVSTLKGE 370 380 390 400 410 420 YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV TCQKQPALGC VYKLVAQSAQ 430 440 450 460 470 480 PKIKLSQDVT KITIPGKKKC YRIFGKNGYA ILDLMMLEDE PEPQPNQQIL CRHPFEESKR 490 500 510 520 530 540 ALVNANKIIK LHNVYWKDGE MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV 550 560 SERLYQFLHT LWLQNAPIGQ LE
	Isoform a [UniParc]. Checksum: F598BA246D6E6113	FASTA	542	61,209
	10 20 30 40 50 60 MNGQDSLVQP LLTDFYQITM CYAYWKTGTH NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR 70 80 90 100 110 120 FVENFKFSQS DIDYVKKILP ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN 130 140 150 160 170 180 GPLAMCQLIE TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY 190 200 210 220 230 240 CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL KVRLLNHKIT NEKADLFQIS 250 260 270 280 290 300 MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL ALIDTYDVIR SGVVNFVAVS 310 320 330 340 350 360 LALHDLGYRS MGCRIDSGDL SYLSKELREC FVKVSTLKGE YKFFEKMSIV ASNDINEETI 370 380 390 400 410 420 MSLNDQQHEI NAFGVGTHLV TCQKQPALGC VYKLVAQSAQ PKIKLSQDVT KITIPGKKKC 430 440 450 460 470 480 YRIFGKNGYA ILDLMMLEDE PEPQPNQQIL CRHPFEESKR ALVNANKIIK LHNVYWKDGE 490 500 510 520 530 540 MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV SERLYQFLHT LWLQNAPIGQ LE
	Isoform c [UniParc]. Checksum: 12F03D8AFC08D90D	FASTA	238	26,512
	10 20 30 40 50 60 MNGQDSLVQP LLTDFYQITM CYAYWKTGTH NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR 70 80 90 100 110 120 FVENFKFSQS DIDYVKKILP ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN 130 140 150 160 170 180 GPLAMCQLIE TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY 190 200 210 220 230 CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEV EHYLSIMGDF ALNSSLWF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081809 Genomic DNA. Translation: CCD83505.1. FO081809 Genomic DNA. Translation: CCD83544.1. FO081809 Genomic DNA. Translation: CCD83545.1.
RefSeq	NP_001023490.1. NM_001028319.3. NP_500264.4. NM_067863.5. NP_500265.3. NM_067864.4.
3D structure databases
HSSP	HSSP built from PDB template 2F7F based on UniProtKB Q830Y8.
ProteinModelPortal	Q95XX1.
SMR	Q95XX1. Positions 109-520.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59878N.
Proteomic databases
PaxDb	Q95XX1.
PRIDE	Q95XX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y54G2A.17b; Y54G2A.17b; Y54G2A.17.
GeneID	177070.
KEGG	cel:CELE_Y54G2A.17.
UCSC	Y54G2A.17a.1. c. elegans.
Organism-specific databases
CTD	177070.
WormBase	Y54G2A.17a; CE46116; WBGene00021882. Y54G2A.17b; CE46281; WBGene00021882. Y54G2A.17c; CE33887; WBGene00021882.
Phylogenomic databases
eggNOG	COG1488.
GeneTree	ENSGT00390000002664.
HOGENOM	HOG000001111.
InParanoid	Q95XX1.
OMA	AVYKLVS.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
InterPro	IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR006405. Nic_PRibTrfase_put. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 2 hits. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01513. NAPRTase_put. 1 hit.
ProtoNet	Search...
Other
NextBio	895208.

Entry information

Entry name

PNCB_CAEEL

Accession

Primary (citable) accession number: Q95XX1
Secondary accession number(s): Q8WTL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 25, 2012
Last modified:	May 1, 2013
This is version 80 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project