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Q95XX1

- PNCB_CAEEL

UniProt

Q95XX1 - PNCB_CAEEL

Protein

Nicotinate phosphoribosyltransferase

Gene

Y54G2A.17

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (25 Jan 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro
    3. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Gene namesi
    ORF Names:Y54G2A.17
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiY54G2A.17a; CE46116; WBGene00021882.
    Y54G2A.17b; CE46281; WBGene00021882.
    Y54G2A.17c; CE33887; WBGene00021882.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Nicotinate phosphoribosyltransferasePRO_0000315685Add
    BLAST

    Proteomic databases

    PaxDbiQ95XX1.
    PRIDEiQ95XX1.

    Interactioni

    Protein-protein interaction databases

    BioGridi42215. 1 interaction.
    DIPiDIP-59878N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ95XX1.
    SMRiQ95XX1. Positions 109-520.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    GeneTreeiENSGT00390000002664.
    HOGENOMiHOG000001111.
    InParanoidiQ95XX1.
    KOiK00763.
    OMAiVNPDLYP.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: Q95XX1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH    50
    NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP 100
    ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE 150
    TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY 200
    CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL KVRLLNHKIT 250
    NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL 300
    ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC 350
    FVKVSTLKGE YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV 400
    TCQKQPALGC VYKLVAQSAQ PKIKLSQDVT KITIPGKKKC YRIFGKNGYA 450
    ILDLMMLEDE PEPQPNQQIL CRHPFEESKR ALVNANKIIK LHNVYWKDGE 500
    MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV SERLYQFLHT 550
    LWLQNAPIGQ LE 562

    Note: No experimental confirmation available.

    Length:562
    Mass (Da):63,347
    Last modified:January 25, 2012 - v3
    Checksum:iC37B5385BC9EE745
    GO
    Isoform a (identifier: Q95XX1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:542
    Mass (Da):61,209
    Checksum:iF598BA246D6E6113
    GO
    Isoform c (identifier: Q95XX1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.
         240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
         259-562: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:238
    Mass (Da):26,512
    Checksum:i12F03D8AFC08D90D
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform a and isoform c. CuratedVSP_030613Add
    BLAST
    Alternative sequencei240 – 25819LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c. CuratedVSP_042230Add
    BLAST
    Alternative sequencei259 – 562304Missing in isoform c. CuratedVSP_042231Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081809 Genomic DNA. Translation: CCD83505.1.
    FO081809 Genomic DNA. Translation: CCD83544.1.
    FO081809 Genomic DNA. Translation: CCD83545.1.
    RefSeqiNP_001023490.1. NM_001028319.3. [Q95XX1-3]
    NP_500264.4. NM_067863.5. [Q95XX1-2]
    NP_500265.3. NM_067864.4. [Q95XX1-1]
    UniGeneiCel.38853.
    Cel.38975.

    Genome annotation databases

    EnsemblMetazoaiY54G2A.17b; Y54G2A.17b; WBGene00021882. [Q95XX1-1]
    GeneIDi177070.
    KEGGicel:CELE_Y54G2A.17.
    UCSCiY54G2A.17a.1. c. elegans. [Q95XX1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081809 Genomic DNA. Translation: CCD83505.1 .
    FO081809 Genomic DNA. Translation: CCD83544.1 .
    FO081809 Genomic DNA. Translation: CCD83545.1 .
    RefSeqi NP_001023490.1. NM_001028319.3. [Q95XX1-3 ]
    NP_500264.4. NM_067863.5. [Q95XX1-2 ]
    NP_500265.3. NM_067864.4. [Q95XX1-1 ]
    UniGenei Cel.38853.
    Cel.38975.

    3D structure databases

    ProteinModelPortali Q95XX1.
    SMRi Q95XX1. Positions 109-520.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 42215. 1 interaction.
    DIPi DIP-59878N.

    Proteomic databases

    PaxDbi Q95XX1.
    PRIDEi Q95XX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y54G2A.17b ; Y54G2A.17b ; WBGene00021882 . [Q95XX1-1 ]
    GeneIDi 177070.
    KEGGi cel:CELE_Y54G2A.17.
    UCSCi Y54G2A.17a.1. c. elegans. [Q95XX1-1 ]

    Organism-specific databases

    CTDi 177070.
    WormBasei Y54G2A.17a ; CE46116 ; WBGene00021882 .
    Y54G2A.17b ; CE46281 ; WBGene00021882 .
    Y54G2A.17c ; CE33887 ; WBGene00021882 .

    Phylogenomic databases

    eggNOGi COG1488.
    GeneTreei ENSGT00390000002664.
    HOGENOMi HOG000001111.
    InParanoidi Q95XX1.
    KOi K00763.
    OMAi VNPDLYP.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    NextBioi 895208.
    PROi Q95XX1.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPNCB_CAEEL
    AccessioniPrimary (citable) accession number: Q95XX1
    Secondary accession number(s): Q8WTL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 25, 2012
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3