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Q95XX1 (PNCB_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
ORF Names:Y54G2A.17
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Sequence similarities

Belongs to the NAPRTase family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: Q95XX1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: Q95XX1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
Note: No experimental confirmation available.
Isoform c (identifier: Q95XX1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
     259-562: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Nicotinate phosphoribosyltransferase
PRO_0000315685

Natural variations

Alternative sequence1 – 2020Missing in isoform a and isoform c.
VSP_030613
Alternative sequence240 – 25819LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c.
VSP_042230
Alternative sequence259 – 562304Missing in isoform c.
VSP_042231

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified January 25, 2012. Version 3.
Checksum: C37B5385BC9EE745

FASTA56263,347
        10         20         30         40         50         60 
MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH NEPAVFDVFF 

        70         80         90        100        110        120 
RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP ENAEPEFYEY LETLNGSHLT 

       130        140        150        160        170        180 
IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE TSILNLVNYA SLVATNAARF RQASGWKIQL 

       190        200        210        220        230        240 
LEFGLRRAQG PNGGLTASKY CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL 

       250        260        270        280        290        300 
KVRLLNHKIT NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL 

       310        320        330        340        350        360 
ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC FVKVSTLKGE 

       370        380        390        400        410        420 
YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV TCQKQPALGC VYKLVAQSAQ 

       430        440        450        460        470        480 
PKIKLSQDVT KITIPGKKKC YRIFGKNGYA ILDLMMLEDE PEPQPNQQIL CRHPFEESKR 

       490        500        510        520        530        540 
ALVNANKIIK LHNVYWKDGE MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV 

       550        560 
SERLYQFLHT LWLQNAPIGQ LE 

« Hide

Isoform a [UniParc].

Checksum: F598BA246D6E6113
Show »

FASTA54261,209
Isoform c [UniParc].

Checksum: 12F03D8AFC08D90D
Show »

FASTA23826,512

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081809 Genomic DNA. Translation: CCD83505.1.
FO081809 Genomic DNA. Translation: CCD83544.1.
FO081809 Genomic DNA. Translation: CCD83545.1.
RefSeqNP_001023490.1. NM_001028319.3.
NP_500264.4. NM_067863.5.
NP_500265.3. NM_067864.4.
UniGeneCel.38853.
Cel.38975.

3D structure databases

ProteinModelPortalQ95XX1.
SMRQ95XX1. Positions 29-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid42215. 1 interaction.
DIPDIP-59878N.

Proteomic databases

PaxDbQ95XX1.
PRIDEQ95XX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY54G2A.17b; Y54G2A.17b; Y54G2A.17. [Q95XX1-1]
GeneID177070.
KEGGcel:CELE_Y54G2A.17.
UCSCY54G2A.17a.1. c. elegans. [Q95XX1-1]

Organism-specific databases

CTD177070.
WormBaseY54G2A.17a; CE46116; WBGene00021882.
Y54G2A.17b; CE46281; WBGene00021882.
Y54G2A.17c; CE33887; WBGene00021882.

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000001111.
InParanoidQ95XX1.
KOK00763.
OMAVFPREPL.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

InterProIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01513. NAPRTase_put. 1 hit.
ProtoNetSearch...

Other

NextBio895208.
PROQ95XX1.

Entry information

Entry namePNCB_CAEEL
AccessionPrimary (citable) accession number: Q95XX1
Secondary accession number(s): Q8WTL1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 25, 2012
Last modified: April 16, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase