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Protein

Nicotinate phosphoribosyltransferase

Gene

Y54G2A.17

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathway: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (Y54G2A.17)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiREACT_337721. Nicotinamide salvaging.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
ORF Names:Y54G2A.17
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY54G2A.17a; CE46116; WBGene00021882.
Y54G2A.17b; CE46281; WBGene00021882.
Y54G2A.17c; CE33887; WBGene00021882.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Nicotinate phosphoribosyltransferasePRO_0000315685Add
BLAST

Proteomic databases

PaxDbiQ95XX1.
PRIDEiQ95XX1.

Interactioni

Protein-protein interaction databases

BioGridi42215. 1 interaction.
DIPiDIP-59878N.
STRINGi6239.Y54G2A.17b.

Structurei

3D structure databases

ProteinModelPortaliQ95XX1.
SMRiQ95XX1. Positions 109-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
GeneTreeiENSGT00390000002664.
HOGENOMiHOG000001111.
InParanoidiQ95XX1.
KOiK00763.
OMAiTYDIAQG.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q95XX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH
60 70 80 90 100
NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP
110 120 130 140 150
ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE
160 170 180 190 200
TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY
210 220 230 240 250
CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL KVRLLNHKIT
260 270 280 290 300
NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL
310 320 330 340 350
ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC
360 370 380 390 400
FVKVSTLKGE YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV
410 420 430 440 450
TCQKQPALGC VYKLVAQSAQ PKIKLSQDVT KITIPGKKKC YRIFGKNGYA
460 470 480 490 500
ILDLMMLEDE PEPQPNQQIL CRHPFEESKR ALVNANKIIK LHNVYWKDGE
510 520 530 540 550
MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV SERLYQFLHT
560
LWLQNAPIGQ LE
Note: No experimental confirmation available.
Length:562
Mass (Da):63,347
Last modified:January 25, 2012 - v3
Checksum:iC37B5385BC9EE745
GO
Isoform a (identifier: Q95XX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):61,209
Checksum:iF598BA246D6E6113
GO
Isoform c (identifier: Q95XX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
     259-562: Missing.

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):26,512
Checksum:i12F03D8AFC08D90D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform a and isoform c. CuratedVSP_030613Add
BLAST
Alternative sequencei240 – 25819LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c. CuratedVSP_042230Add
BLAST
Alternative sequencei259 – 562304Missing in isoform c. CuratedVSP_042231Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081809 Genomic DNA. Translation: CCD83505.1.
FO081809 Genomic DNA. Translation: CCD83544.1.
FO081809 Genomic DNA. Translation: CCD83545.1.
RefSeqiNP_001023490.1. NM_001028319.3. [Q95XX1-3]
NP_500264.4. NM_067863.5. [Q95XX1-2]
NP_500265.3. NM_067864.4. [Q95XX1-1]
UniGeneiCel.38853.
Cel.38975.

Genome annotation databases

EnsemblMetazoaiY54G2A.17b; Y54G2A.17b; WBGene00021882. [Q95XX1-1]
GeneIDi177070.
KEGGicel:CELE_Y54G2A.17.
UCSCiY54G2A.17a.1. c. elegans. [Q95XX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081809 Genomic DNA. Translation: CCD83505.1.
FO081809 Genomic DNA. Translation: CCD83544.1.
FO081809 Genomic DNA. Translation: CCD83545.1.
RefSeqiNP_001023490.1. NM_001028319.3. [Q95XX1-3]
NP_500264.4. NM_067863.5. [Q95XX1-2]
NP_500265.3. NM_067864.4. [Q95XX1-1]
UniGeneiCel.38853.
Cel.38975.

3D structure databases

ProteinModelPortaliQ95XX1.
SMRiQ95XX1. Positions 109-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi42215. 1 interaction.
DIPiDIP-59878N.
STRINGi6239.Y54G2A.17b.

Proteomic databases

PaxDbiQ95XX1.
PRIDEiQ95XX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY54G2A.17b; Y54G2A.17b; WBGene00021882. [Q95XX1-1]
GeneIDi177070.
KEGGicel:CELE_Y54G2A.17.
UCSCiY54G2A.17a.1. c. elegans. [Q95XX1-1]

Organism-specific databases

CTDi177070.
WormBaseiY54G2A.17a; CE46116; WBGene00021882.
Y54G2A.17b; CE46281; WBGene00021882.
Y54G2A.17c; CE33887; WBGene00021882.

Phylogenomic databases

eggNOGiCOG1488.
GeneTreeiENSGT00390000002664.
HOGENOMiHOG000001111.
InParanoidiQ95XX1.
KOiK00763.
OMAiTYDIAQG.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.
ReactomeiREACT_337721. Nicotinamide salvaging.

Miscellaneous databases

NextBioi895208.
PROiQ95XX1.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPNCB_CAEEL
AccessioniPrimary (citable) accession number: Q95XX1
Secondary accession number(s): Q8WTL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 25, 2012
Last modified: June 24, 2015
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.