SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q95XX1

- PNCB_CAEEL

UniProt

Q95XX1 - PNCB_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Nicotinate phosphoribosyltransferase
Gene
Y54G2A.17
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) By similarity.
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: UniProtKB
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
  3. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
ORF Names:Y54G2A.17
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiY54G2A.17a; CE46116; WBGene00021882.
Y54G2A.17b; CE46281; WBGene00021882.
Y54G2A.17c; CE33887; WBGene00021882.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Nicotinate phosphoribosyltransferase
PRO_0000315685Add
BLAST

Proteomic databases

PaxDbiQ95XX1.
PRIDEiQ95XX1.

Interactioni

Protein-protein interaction databases

BioGridi42215. 1 interaction.
DIPiDIP-59878N.

Structurei

3D structure databases

ProteinModelPortaliQ95XX1.
SMRiQ95XX1. Positions 109-520.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
GeneTreeiENSGT00390000002664.
HOGENOMiHOG000001111.
InParanoidiQ95XX1.
KOiK00763.
OMAiVNPDLYP.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform b (identifier: Q95XX1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH    50
NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP 100
ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE 150
TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY 200
CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL KVRLLNHKIT 250
NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL 300
ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC 350
FVKVSTLKGE YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV 400
TCQKQPALGC VYKLVAQSAQ PKIKLSQDVT KITIPGKKKC YRIFGKNGYA 450
ILDLMMLEDE PEPQPNQQIL CRHPFEESKR ALVNANKIIK LHNVYWKDGE 500
MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV SERLYQFLHT 550
LWLQNAPIGQ LE 562

Note: No experimental confirmation available.

Length:562
Mass (Da):63,347
Last modified:January 25, 2012 - v3
Checksum:iC37B5385BC9EE745
GO
Isoform a (identifier: Q95XX1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Show »
Length:542
Mass (Da):61,209
Checksum:iF598BA246D6E6113
GO
Isoform c (identifier: Q95XX1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
     259-562: Missing.

Note: No experimental confirmation available.

Show »
Length:238
Mass (Da):26,512
Checksum:i12F03D8AFC08D90D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform a and isoform c.
VSP_030613Add
BLAST
Alternative sequencei240 – 25819LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c.
VSP_042230Add
BLAST
Alternative sequencei259 – 562304Missing in isoform c.
VSP_042231Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081809 Genomic DNA. Translation: CCD83505.1.
FO081809 Genomic DNA. Translation: CCD83544.1.
FO081809 Genomic DNA. Translation: CCD83545.1.
RefSeqiNP_001023490.1. NM_001028319.3. [Q95XX1-3]
NP_500264.4. NM_067863.5. [Q95XX1-2]
NP_500265.3. NM_067864.4. [Q95XX1-1]
UniGeneiCel.38853.
Cel.38975.

Genome annotation databases

EnsemblMetazoaiY54G2A.17b; Y54G2A.17b; WBGene00021882. [Q95XX1-1]
GeneIDi177070.
KEGGicel:CELE_Y54G2A.17.
UCSCiY54G2A.17a.1. c. elegans. [Q95XX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081809 Genomic DNA. Translation: CCD83505.1 .
FO081809 Genomic DNA. Translation: CCD83544.1 .
FO081809 Genomic DNA. Translation: CCD83545.1 .
RefSeqi NP_001023490.1. NM_001028319.3. [Q95XX1-3 ]
NP_500264.4. NM_067863.5. [Q95XX1-2 ]
NP_500265.3. NM_067864.4. [Q95XX1-1 ]
UniGenei Cel.38853.
Cel.38975.

3D structure databases

ProteinModelPortali Q95XX1.
SMRi Q95XX1. Positions 109-520.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 42215. 1 interaction.
DIPi DIP-59878N.

Proteomic databases

PaxDbi Q95XX1.
PRIDEi Q95XX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y54G2A.17b ; Y54G2A.17b ; WBGene00021882 . [Q95XX1-1 ]
GeneIDi 177070.
KEGGi cel:CELE_Y54G2A.17.
UCSCi Y54G2A.17a.1. c. elegans. [Q95XX1-1 ]

Organism-specific databases

CTDi 177070.
WormBasei Y54G2A.17a ; CE46116 ; WBGene00021882 .
Y54G2A.17b ; CE46281 ; WBGene00021882 .
Y54G2A.17c ; CE33887 ; WBGene00021882 .

Phylogenomic databases

eggNOGi COG1488.
GeneTreei ENSGT00390000002664.
HOGENOMi HOG000001111.
InParanoidi Q95XX1.
KOi K00763.
OMAi VNPDLYP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

NextBioi 895208.
PROi Q95XX1.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 2 hits.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPNCB_CAEEL
AccessioniPrimary (citable) accession number: Q95XX1
Secondary accession number(s): Q8WTL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 25, 2012
Last modified: September 3, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi