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Protein

Nicotinate phosphoribosyltransferase

Gene

nprt-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN).By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.By similarity

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (nprt-1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

ReactomeiR-CEL-197264 Nicotinamide salvaging
R-CEL-6798695 Neutrophil degranulation
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseBy similarity (EC:6.3.4.21By similarity)
Short name:
NAPRTaseBy similarity
Gene namesi
Name:nprt-1Imported
ORF Names:Y54G2A.17Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY54G2A.17a ; CE46116 ; WBGene00021882 ; nprt-1
Y54G2A.17b ; CE46281 ; WBGene00021882 ; nprt-1
Y54G2A.17c ; CE33887 ; WBGene00021882 ; nprt-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156851 – 562Nicotinate phosphoribosyltransferaseAdd BLAST562

Proteomic databases

EPDiQ95XX1
PaxDbiQ95XX1
PeptideAtlasiQ95XX1
PRIDEiQ95XX1

Expressioni

Gene expression databases

BgeeiWBGene00021882

Interactioni

Protein-protein interaction databases

BioGridi42215, 1 interactor
DIPiDIP-59878N
IntActiQ95XX1, 1 interactor
STRINGi6239.Y54G2A.17b

Structurei

3D structure databases

ProteinModelPortaliQ95XX1
SMRiQ95XX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiKOG2511 Eukaryota
COG1488 LUCA
GeneTreeiENSGT00390000002664
HOGENOMiHOG000001111
InParanoidiQ95XX1
KOiK00763
OMAiNPHIYKV
OrthoDBiEOG091G088G

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR007229 Nic_PRibTrfase-Fam
IPR006405 Nic_PRibTrfase_pncB
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 2 hits
TIGRFAMsiTIGR01513 NAPRTase_put, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform bImported (identifier: Q95XX1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFILPSESI DGTHPCNGLH MNGQDSLVQP LLTDFYQITM CYAYWKTGTH
60 70 80 90 100
NEPAVFDVFF RKNPFQGEFT VFAGLEDCLR FVENFKFSQS DIDYVKKILP
110 120 130 140 150
ENAEPEFYEY LETLNGSHLT IEAVAEGSVV FPKVPLLTIN GPLAMCQLIE
160 170 180 190 200
TSILNLVNYA SLVATNAARF RQASGWKIQL LEFGLRRAQG PNGGLTASKY
210 220 230 240 250
CYIGGFDATS NVLAGKLYGI PVKGTQAHSF ICSFSSPAEL KVRLLNHKIT
260 270 280 290 300
NEKADLFQIS MEKRAWLLDQ FSWKAALSEV SDGELSAFVA YAIAFPDTFL
310 320 330 340 350
ALIDTYDVIR SGVVNFVAVS LALHDLGYRS MGCRIDSGDL SYLSKELREC
360 370 380 390 400
FVKVSTLKGE YKFFEKMSIV ASNDINEETI MSLNDQQHEI NAFGVGTHLV
410 420 430 440 450
TCQKQPALGC VYKLVAQSAQ PKIKLSQDVT KITIPGKKKC YRIFGKNGYA
460 470 480 490 500
ILDLMMLEDE PEPQPNQQIL CRHPFEESKR ALVNANKIIK LHNVYWKDGE
510 520 530 540 550
MITPLPTLNE IKEHVNESIR STLRQDHRRY LNPTPYKVSV SERLYQFLHT
560
LWLQNAPIGQ LE
Note: No experimental confirmation available.
Length:562
Mass (Da):63,347
Last modified:January 25, 2012 - v3
Checksum:iC37B5385BC9EE745
GO
Isoform aImported (identifier: Q95XX1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):61,209
Checksum:iF598BA246D6E6113
GO
Isoform cImported (identifier: Q95XX1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     240-258: LKVRLLNHKITNEKADLFQ → VEHYLSIMGDFALNSSLWF
     259-562: Missing.

Note: No experimental confirmation available.
Show »
Length:238
Mass (Da):26,512
Checksum:i12F03D8AFC08D90D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0306131 – 20Missing in isoform a and isoform c. CuratedAdd BLAST20
Alternative sequenceiVSP_042230240 – 258LKVRL…ADLFQ → VEHYLSIMGDFALNSSLWF in isoform c. CuratedAdd BLAST19
Alternative sequenceiVSP_042231259 – 562Missing in isoform c. CuratedAdd BLAST304

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081809 Genomic DNA Translation: CCD83505.1
FO081809 Genomic DNA Translation: CCD83544.1
FO081809 Genomic DNA Translation: CCD83545.1
RefSeqiNP_001023490.1, NM_001028319.3 [Q95XX1-3]
NP_500264.4, NM_067863.5 [Q95XX1-2]
NP_500265.3, NM_067864.4 [Q95XX1-1]
UniGeneiCel.38853
Cel.38975

Genome annotation databases

EnsemblMetazoaiY54G2A.17b.1; Y54G2A.17b.1; WBGene00021882 [Q95XX1-1]
Y54G2A.17b.2; Y54G2A.17b.2; WBGene00021882 [Q95XX1-1]
GeneIDi177070
KEGGicel:CELE_Y54G2A.17
UCSCiY54G2A.17a.1 c. elegans [Q95XX1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPNCB_CAEEL
AccessioniPrimary (citable) accession number: Q95XX1
Secondary accession number(s): Q8WTL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 25, 2012
Last modified: March 28, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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