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Q95WL3 (Q95WL3_TRYCR) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismTrypanosoma cruzi EMBL AAK71861.1
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length362 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FPP/GGPP synthase family. RuleBase RU004466

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region48 – 514Sulfate 4 binding
Region48 – 492Sulfate 5 binding PDB 3ICM

Sites

Metal binding1761Sodium PDB 4DWG
Metal binding1901Sodium PDB 4DWG
Metal binding1911Sodium; via amide nitrogen PDB 4DWG
Binding site211Sulfate 3 PDB 4DWB
Binding site481Sulfate 6; via amide nitrogen PDB 4DWG
Binding site911Sulfate 4
Binding site991Sulfate 7 PDB 4DZW
Binding site1081Sulfate 5 PDB 3ICM
Binding site1081Sulfate 6 PDB 4DWG
Binding site1131Sulfate 7; via amide nitrogen PDB 4DZW
Binding site1411Acetate 1 PDB 4DWB
Binding site1411Sulfate 1 PDB 3ICK PDB 4DWG
Binding site1411Sulfate 2 PDB 4DXJ
Binding site1411Sulfate 3 PDB 4DWB
Binding site1411Sulfate 8 PDB 3ICN
Binding site2371Sulfate 9 PDB 4DWB PDB 4DWG
Binding site3341Sulfate 9 PDB 4DWG

Experimental info

Non-terminal residue3621 EMBL AAK71861.1

Sequences

Sequence LengthMass (Da)Tools
Q95WL3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: CF2CB54BA03B3DB0

FASTA36241,180
        10         20         30         40         50         60 
MASMERFLSV YDEVQAFLLD QLQSKYEIDP NRARYLRIMM DTTCLGGKYF RGMTVVNVAE 

        70         80         90        100        110        120 
GFLAVTQHDE ATKERILHDA CVGGWMIEFL QAHYLVEDDI MDGSVMRRGK PCWYRFPGVT 

       130        140        150        160        170        180 
TQCAINDGII LKSWTQIMAW HYFADRPFLK DLLCLFQKVD YATAVGQMYD VTSMCDSNKL 

       190        200        210        220        230        240 
DPEVAQPMTT DFAEFTPAIY KRIVKYKTTF YTYLLPLVMG LFVSEAAASV EMNLVERVAH 

       250        260        270        280        290        300 
LIGEYFQVQD DVMDCFTPPE QLGKVGTDIE DAKCSWLAVT FLGKANAAQV AEFKANYGDK 

       310        320        330        340        350        360 
DPAKVAVVKR LYSEANLQAD FAAYEAEVVR EVESLIEQLK VKSPTFAESV AVVWEKTHKR 


KK 

« Hide

References

[1]"Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase."
Montalvetti A., Bailey B.N., Martin M.B., Severin G.W., Oldfield E., Docampo R.
J. Biol. Chem. 276:33930-33937(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer."
Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M.
Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH SULFATE.
[3]"Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase."
Aripirala S., Szajnman S.H., Jakoncic J., Rodriguez J.B., Docampo R., Gabelli S.B., Amzel L.M.
J. Med. Chem. 55:6445-6454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) IN COMPLEX WITH ACETATE; SODIUM AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF312690 Genomic DNA. Translation: AAK71861.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3IBAX-ray2.40A1-362[»]
3ICKX-ray2.40A1-362[»]
3ICMX-ray2.20A1-362[»]
3ICNX-ray2.40A1-362[»]
3ICZX-ray2.15A1-362[»]
4DWBX-ray2.10A1-362[»]
4DWGX-ray2.01A1-362[»]
4DXJX-ray2.35A/B/C1-362[»]
4DZWX-ray3.05A1-362[»]
4E1EX-ray2.65A2-362[»]
ProteinModelPortalQ95WL3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ95WL3_TRYCR
AccessionPrimary (citable) accession number: Q95WL3
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)