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Q95WL3

- Q95WL3_TRYCR

UniProt

Q95WL3 - Q95WL3_TRYCR

Protein
Submitted name:

Farnesyl pyrophosphate synthase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911Sulfate 4
    Metal bindingi176 – 1761SodiumImported
    Metal bindingi190 – 1901SodiumImported
    Metal bindingi191 – 1911Sodium; via amide nitrogenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Farnesyl pyrophosphate synthaseImported
    OrganismiTrypanosoma cruziImported
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IBAX-ray2.40A1-362[»]
    3ICKX-ray2.40A1-362[»]
    3ICMX-ray2.20A1-362[»]
    3ICNX-ray2.40A1-362[»]
    3ICZX-ray2.15A1-362[»]
    4DWBX-ray2.10A1-362[»]
    4DWGX-ray2.01A1-362[»]
    4DXJX-ray2.35A/B/C1-362[»]
    4DZWX-ray3.05A1-362[»]
    4E1EX-ray2.65A2-362[»]
    ProteinModelPortaliQ95WL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni48 – 514Sulfate 4 binding

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q95WL3-1 [UniParc]FASTAAdd to Basket

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    MASMERFLSV YDEVQAFLLD QLQSKYEIDP NRARYLRIMM DTTCLGGKYF    50
    RGMTVVNVAE GFLAVTQHDE ATKERILHDA CVGGWMIEFL QAHYLVEDDI 100
    MDGSVMRRGK PCWYRFPGVT TQCAINDGII LKSWTQIMAW HYFADRPFLK 150
    DLLCLFQKVD YATAVGQMYD VTSMCDSNKL DPEVAQPMTT DFAEFTPAIY 200
    KRIVKYKTTF YTYLLPLVMG LFVSEAAASV EMNLVERVAH LIGEYFQVQD 250
    DVMDCFTPPE QLGKVGTDIE DAKCSWLAVT FLGKANAAQV AEFKANYGDK 300
    DPAKVAVVKR LYSEANLQAD FAAYEAEVVR EVESLIEQLK VKSPTFAESV 350
    AVVWEKTHKR KK 362
    Length:362
    Mass (Da):41,180
    Last modified:December 1, 2001 - v1
    Checksum:iCF2CB54BA03B3DB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei362 – 3621Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312690 Genomic DNA. Translation: AAK71861.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312690 Genomic DNA. Translation: AAK71861.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IBA X-ray 2.40 A 1-362 [» ]
    3ICK X-ray 2.40 A 1-362 [» ]
    3ICM X-ray 2.20 A 1-362 [» ]
    3ICN X-ray 2.40 A 1-362 [» ]
    3ICZ X-ray 2.15 A 1-362 [» ]
    4DWB X-ray 2.10 A 1-362 [» ]
    4DWG X-ray 2.01 A 1-362 [» ]
    4DXJ X-ray 2.35 A/B/C 1-362 [» ]
    4DZW X-ray 3.05 A 1-362 [» ]
    4E1E X-ray 2.65 A 2-362 [» ]
    ProteinModelPortali Q95WL3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase."
      Montalvetti A., Bailey B.N., Martin M.B., Severin G.W., Oldfield E., Docampo R.
      J. Biol. Chem. 276:33930-33937(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer."
      Huang C.H., Gabelli S.B., Oldfield E., Amzel L.M.
      Proteins 78:888-899(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS).
    3. "Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase."
      Aripirala S., Szajnman S.H., Jakoncic J., Rodriguez J.B., Docampo R., Gabelli S.B., Amzel L.M.
      J. Med. Chem. 55:6445-6454(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS).

    Entry informationi

    Entry nameiQ95WL3_TRYCR
    AccessioniPrimary (citable) accession number: Q95WL3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3