Q95VY4 (Q95VY4_AEDAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Kynurenine aminotransferase EMBL AAK97625.1

Gene names

Name:

KAT EMBL AAK97625.1

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) EMBL AAK97625.1

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Aminotransferase EMBL AAK97625.1 Transferase
Technical term	3D-structure PDB 1YIY PDB 2R5E PDB 1YIZ PDB 2R5C
Gene Ontology (GO)
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q95VY4 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: D71BFC22649D6D11	FASTA	477	53,505
	10 20 30 40 50 60 MMFLRNHNSV GGAIRTAVVL QDLQFIVSNK SSALTGAVSS VHRQQIRTMS STSNETMHNK 70 80 90 100 110 120 FDLPKRYQGS TKSVWVEYIQ LAAQYKPLNL GQGFPDYHAP KYALNALAAA ANSPDPLANQ 130 140 150 160 170 180 YTRGFGHPRL VQALSKLYSQ LVDRTINPMT EVLVTVGAYE ALYATIQGHV DEGDEVIIIE 190 200 210 220 230 240 PFFDCYEPMV KAAGGIPRFI PLKPNKTGGT ISSADWVLDN NELEALFNEK TKMIIINTPH 250 260 270 280 290 300 NPLGKVMDRA ELEVVANLCK KWNVLCVSDE VYEHMVFEPF EHIRICTLPG MWERTITIGS 310 320 330 340 350 360 AGKTFSLTGW KIGWAYGPEA LLKNLQMVHQ NCVYTCATPI QEAIAVGFET ELKRLKSPEC 370 380 390 400 410 420 YFNSISGELM AKRDYMASFL AEVGMNPTVP QGGYFMVADW SSLDSKVDLT QETDARKDYR 430 440 450 460 470 FTKWMTKSVG LQGIPPSAFY SEPNKHLGED FVRYCFFKKD ENLQKAAEIL RKWKGSS

References

[1]	"3-Hydroxykynurenine transaminase identity with alanine glyoxylate transaminase. A probable detoxification protein in Aedes aegypti." Han Q., Fang J., Li J. J. Biol. Chem. 277:15781-15787(2002) [PubMed: 11880382] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti(1)." Fang J., Han Q., Li J. Insect Biochem. Mol. Biol. 32:943-950(2002) [PubMed: 12110301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Crystal structures of Aedes aegypti kynurenine aminotransferase." Han Q., Gao Y.G., Robinson H., Ding H., Wilson S., Li J. FEBS J. 272:2198-2206(2005) [PubMed: 15853804] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 49-477.
[4]	"Structural insight into the mechanism of substrate specificity of aedes kynurenine aminotransferase." Han Q., Gao Y.G., Robinson H., Li J. Biochemistry 47:1622-1630(2008) [PubMed: 18186649] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 49-477.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF395204 mRNA. Translation: AAK97625.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YIY	X-ray	1.90	A/B	49-477	[»]
1YIZ	X-ray	1.55	A/B	49-477	[»]
2R5C	X-ray	1.96	A/B	49-477	[»]
2R5E	X-ray	1.84	A/B	49-477	[»]

ProteinModelPortal

Q95VY4.

SMR

Q95VY4. Positions 59-477.

ModBase

Search...

Protein-protein interaction databases

STRING

Q95VY4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

eggNOG

inNOG08766.

GeneTree

EMGT00050000012632.

InParanoid

Q95VY4.

Enzyme and pathway databases

BRENDA

2.6.1.7. 1026.

Family and domain databases

InterPro

IPR001176. ACC_synthase.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

Gene3D

G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.

Pfam

PF00155. Aminotran_1_2. 1 hit.
[Graphical view]

PRINTS

PR00753. ACCSYNTHASE.

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q95VY4_AEDAE

Accession

Primary (citable) accession number: Q95VY4

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)