ID   Q95TD4_ENTHI            Unreviewed;       212 AA.
AC   Q95TD4;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Rho-like small GTPase {ECO:0000313|EMBL:AAL23699.1};
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759 {ECO:0000313|EMBL:AAL23699.1};
RN   [1] {ECO:0000313|EMBL:AAL23699.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HM1:IMSS {ECO:0000313|EMBL:AAL23699.1};
RX   PubMed=12427464; DOI=10.1016/S0014-4894(02)00101-7;
RA   Godbold G.D., Corbett K.D., Mann B.J.;
RT   "A Rho-like small GTPase of Entamoeba histolytica contains an unusual amino
RT   acid residue in a conserved GDP-stabilization region and is not a substrate
RT   for C3 exoenzyme.";
RL   Exp. Parasitol. 101:107-110(2002).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   EMBL; AY059622; AAL23699.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95TD4; -.
DR   VEuPathDB; AmoebaDB:EHI5A_260040; -.
DR   VEuPathDB; AmoebaDB:EHI7A_081570; -.
DR   VEuPathDB; AmoebaDB:EHI8A_083020; -.
DR   VEuPathDB; AmoebaDB:EHI_015440; -.
DR   VEuPathDB; AmoebaDB:KM1_150520; -.
DR   HOGENOM; CLU_041217_21_3_1; -.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00157; Rho; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR24072:SF168; RAS-LIKE GTP-BINDING PROTEIN RHO1; 1.
DR   PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
SQ   SEQUENCE   212 AA;  23447 MW;  6C18AAF567C50CF4 CRC64;
     MLAFSDMNTG AGKIENGKKA LKIVVVGDGA VGKTCLLLAF SKGEIPTAYV PTVFENFSHV
     MKYKNEEFIL HLWDTAGQEE YDRLRPLSYA DSDVVLLCFA VNNRTSFDNI STKWEPEIKH
     YIDTAKTVLV GLKVDLRKDG SDDVTKQEGD DLCQKLGCVA YIEASSVAKI GLNEVFEKSV
     DCIFSNKPVP KASVTTQAKS QEVCFFIFLL VV
//