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Protein
Submitted name:

CG33791, isoform B

Gene

CG18170

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: GO_Central
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
CG33791, isoform BImported (EC:1.2.4.2Imported)
Submitted name:
CG33791, isoform DImported (EC:1.2.4.2Imported)
Submitted name:
GH27234pImported
Gene namesi
ORF Names:CG18170Imported, CG33791Imported, Dmel_CG33791Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035240. CG33791.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: GO_Central
  2. oxoglutarate dehydrogenase complex Source: GO_Central
Complete GO annotation...

Interactioni

Protein-protein interaction databases

IntActiQ95T35. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ95T35.
SMRiQ95T35. Positions 139-1052.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063092.
KOiK00164.
OMAiNWIVTNL.
PhylomeDBiQ95T35.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q95T35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQCRLRSLA RIRRSLTLGL RGTDQHVLAR QALRTIQTTS QRRGVHDLDS
60 70 80 90 100
FANGCSAAYI EGLYNKWKRN PSSVDESWNE LFSSNDWSSP KRSPLQVSHS
110 120 130 140 150
RKYRRPPVER IAVKARSGER TASGGASAAP AAPPSDWKNI DDHHVIQAII
160 170 180 190 200
RAYQSRGHLA ADLDPLGIVG PKKRTSVDGT QRHAAREVLR QHFSYIFNDL
210 220 230 240 250
NTVFKLPSST MIGGDQEFLS LKEILDRLER IYCGHIGVEY MQITSLTKTN
260 270 280 290 300
WLRDRFEKPG GLDLTKEEKK LILERLTRST GFENFLAKKF SSEKRFGLEG
310 320 330 340 350
CDIMIPAIKE VVDRATDHGV ESILIGMAHR GRLNVLANIC RKPISDILSQ
360 370 380 390 400
FHGLQATDSG SGDVKYHLGV FQERLNRQTN RMVRITVVAN PSHLEHVNPV
410 420 430 440 450
LLGKARAEMF QRGDTCGSTV MPIIIHGDAS FSGQGVVYES MHLSDLPNYT
460 470 480 490 500
TYGTIHIVSN NQVGFTTDPR FSRSSRYCTD VAKVVNAPIL HVNADDPEAC
510 520 530 540 550
IQCARIAIDY RTRFKKDVVI DIVGYRRNGH NEADEPMFTQ PLMYQRIKKL
560 570 580 590 600
KPCLQLYADK LIKEGVVTDS EFKAMVSSYE KICEDAWAKS KTIKTIKYSS
610 620 630 640 650
WIDSPWPGFF EGRDRLKLCP TGISTDTLKT IGNMFSTPPP PEHKFETHKG
660 670 680 690 700
ILRILAQRTQ MVQDKVADWS LGEAFAFGSL LKEGIHVRLS GQDVERGTFS
710 720 730 740 750
HRHHVLHHQS EDKVVYNSLD HLYPDQAPYS VSNSSLSECA VLGFEHGYSM
760 770 780 790 800
ASPNALVMWE GQFGDFCNTA QCIIDTFIAS GETKWVRQSG VVMLLPHSME
810 820 830 840 850
GMGPEHSSGR IERFLQMSDD DPDVYPDTCD ADFVARQLMN VNWIVTNLST
860 870 880 890 900
PANLFHCLRR QVKMGFRKPL INFSPKSLLR HPLARSPFKD FNECSCFQRI
910 920 930 940 950
IPDKGPAGKQ PDCVQKLVFC SGKVYYDLVK ERDDHEQVET VALVRVEQVR
960 970 980 990 1000
RLPTRHLFLF MITMIGRILQ LCPFPYDLIS QQLELYPKAE LLWAQEEHKN
1010 1020 1030 1040 1050
MGAWSYVQPR FDTALLKNEN ESRCVSYHGR PPSASPATGN KVQHYNEYKA
1060 1070 1080 1090 1100
LITSIFGELT PENKKRIEDR IKKQQAKAKA DAQSKPSTKP PAAPPKGGSS
1110 1120 1130 1140 1150
PPPGKGESGG KKRSDSSPSA SIAPTGPAPR KPLISLPSRP PRGGKQRSGS
1160 1170 1180 1190 1200
APAPNLVDED SAARNREPDA SAYDGASPSA WKRSGSAPAP SVVPRASASR
1210 1220 1230 1240 1250
SPSRKSPSPS HDGISPSTRQ ESLSKKKSGS APAPTPTSRG PFRTAPSNTE
1260 1270 1280
FIKRRPAKDY GSRNETQSTP GESELDPTKP QP
Length:1,282
Mass (Da):143,010
Last modified:December 1, 2001 - v1
Checksum:i1B9C474E68C3A6C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47519.2.
AE014296 Genomic DNA. Translation: AAF47520.2.
AY060348 mRNA. Translation: AAL25387.1.
RefSeqiNP_001027100.1. NM_001031929.2.
NP_001027102.1. NM_001031931.2.
UniGeneiDm.4028.

Genome annotation databases

EnsemblMetazoaiFBtr0091793; FBpp0072631; FBgn0035240.
FBtr0091795; FBpp0072636; FBgn0035240.
GeneIDi317974.
KEGGidme:Dmel_CG33791.
UCSCiCG33791-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47519.2.
AE014296 Genomic DNA. Translation: AAF47520.2.
AY060348 mRNA. Translation: AAL25387.1.
RefSeqiNP_001027100.1. NM_001031929.2.
NP_001027102.1. NM_001031931.2.
UniGeneiDm.4028.

3D structure databases

ProteinModelPortaliQ95T35.
SMRiQ95T35. Positions 139-1052.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ95T35. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0091793; FBpp0072631; FBgn0035240.
FBtr0091795; FBpp0072636; FBgn0035240.
GeneIDi317974.
KEGGidme:Dmel_CG33791.
UCSCiCG33791-RB. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0035240. CG33791.

Phylogenomic databases

GeneTreeiENSGT00530000063092.
KOiK00164.
OMAiNWIVTNL.
PhylomeDBiQ95T35.

Miscellaneous databases

GenomeRNAii317974.
NextBioi844397.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ95T35_DROME
AccessioniPrimary (citable) accession number: Q95T35
Secondary accession number(s): Q9W0D1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.