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Protein

Protein cueball

Gene

cue

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in spermatogenesis and oogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • oogenesis Source: UniProtKB
  • primary spermatocyte growth Source: FlyBase
  • sleep Source: FlyBase
  • spermatogenesis Source: UniProtKB
  • triglyceride homeostasis Source: FlyBase

Keywordsi

Biological processDifferentiation, Oogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cueball1 Publication
Gene namesi
Name:cueImported
ORF Names:CG12086
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011204. cue.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 531ExtracellularSequence analysisAdd BLAST505
Transmembranei532 – 552HelicalSequence analysisAdd BLAST21
Topological domaini553 – 644CytoplasmicSequence analysisAdd BLAST92

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Accumulation of spermatocytes with cytoplasmic abnormalities. Early spermatocytes are filled with small, refractile cytoplasmic inclusions, late spermatocytes often contain up to three hook-shaped structures in the cytoplasm. Testes are short with incomplete coiling. The sheath of pigment cells that covers the muscle layer surrounding the testis frequently peels away, particularly from the region near the tip. Female fertility is also reduced, ovaries are small and misshapen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000038657227 – 644Protein cueballSequence analysisAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi402 ↔ 411PROSITE-ProRule annotation
Disulfide bondi406 ↔ 421PROSITE-ProRule annotation
Disulfide bondi437 ↔ 447PROSITE-ProRule annotation
Disulfide bondi441 ↔ 459PROSITE-ProRule annotation
Disulfide bondi461 ↔ 470PROSITE-ProRule annotation
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi508N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95RU0.
PRIDEiQ95RU0.

Expressioni

Gene expression databases

BgeeiFBgn0011204.
GenevisibleiQ95RU0. DM.

Structurei

3D structure databases

ProteinModelPortaliQ95RU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati121 – 166LDL-receptor class B 1Sequence analysisAdd BLAST46
Repeati167 – 211LDL-receptor class B 2Sequence analysisAdd BLAST45
Repeati212 – 257LDL-receptor class B 3Sequence analysisAdd BLAST46
Domaini398 – 430EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini433 – 471EGF-like 2PROSITE-ProRule annotationAdd BLAST39

Sequence similaritiesi

Belongs to the cueball family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPSX. Eukaryota.
ENOG410XPMR. LUCA.
GeneTreeiENSGT00880000137921.
InParanoidiQ95RU0.
OMAiETPCFDP.
OrthoDBiEOG091G0PM5.
PhylomeDBiQ95RU0.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000033. LDLR_classB_rpt.
PfamiView protein in Pfam
PF00058. Ldl_recept_b. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00135. LY. 4 hits.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS51120. LDLRB. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95RU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRIRFGMDV LLVLLLATCL LTPAHGTPLE WDFAVTLRTK IQFMDSSWQT
60 70 80 90 100
IATAAHEFDE LSALTFDESE ELIYFNDLKH RNGSIFSLKR DLIAANHVAE
110 120 130 140 150
QTIARTGNES VGGLAYDPLN MNLFWSDTEQ RKIFFAPIHG SATPQVLVDL
160 170 180 190 200
SAEGGRPDGV AVDVCRRKLY WTNSNVTHPT VERINLDGSN RTVIISSNID
210 220 230 240 250
MPRGIVVDQL SDRLFWIDDL KGVFFSVESS KLDGSDRQVV LKDKHHEPLN
260 270 280 290 300
LAVTNDAIYW TDRTTRAVWS HPKVPVIKVT TTSKPDEEDS TDSTDFKDPE
310 320 330 340 350
PVAEDCPLVR VANLSEEARG IVARTGFYQR LQKDHHCASI VRKVKERVDE
360 370 380 390 400
QSRKFEIRSL LDQKIKVLED ERCMNDGEYR AATDLCICPT GFKGSRCEIR
410 420 430 440 450
ECHNYCVHGT CQMSELAYPK CYCQPGFKGE RCELSVCSGL CLNGGHCRVS
460 470 480 490 500
KDENEAPSCE CPAKFGGARC EQNSTEICSL FCRLLKHEPE MYVPFGCHSI
510 520 530 540 550
CEELAQDNST NIAIPQYQHL EVCLTPRVWT SSVIIILVVG IVSSLLLVAV
560 570 580 590 600
IVQGIRRLYK PKRPRIRKTF VVRKQARTNS AGDTPLTNRP LATEQCEITI
610 620 630 640
ENCCNMNICE TPCFDPKLVE QTLSKSSCKE DKKILIHNME DDLY
Length:644
Mass (Da):72,623
Last modified:December 1, 2001 - v1
Checksum:i1FF14BFD962E95EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47503.2.
AY061139 mRNA. Translation: AAL28687.1.
RefSeqiNP_612113.2. NM_138269.3.
UniGeneiDm.18864.

Genome annotation databases

EnsemblMetazoaiFBtr0072706; FBpp0072590; FBgn0011204.
GeneIDi38174.
KEGGidme:Dmel_CG12086.
UCSCiCG12086-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiCUE_DROME
AccessioniPrimary (citable) accession number: Q95RU0
Secondary accession number(s): Q9W0E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families