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Protein

Protein cueball

Gene

cue

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in spermatogenesis and oogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • oogenesis Source: UniProtKB
  • primary spermatocyte growth Source: FlyBase
  • sleep Source: FlyBase
  • spermatogenesis Source: UniProtKB
  • triglyceride homeostasis Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Differentiation, Oogenesis, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-DME-2160916. Hyaluronan uptake and degradation.
R-DME-3000497. Scavenging by Class H Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cueball1 Publication
Gene namesi
Name:cueImported
ORF Names:CG12086
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0011204. cue.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 531505ExtracellularSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Topological domaini553 – 64492CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Accumulation of spermatocytes with cytoplasmic abnormalities. Early spermatocytes are filled with small, refractile cytoplasmic inclusions, late spermatocytes often contain up to three hook-shaped structures in the cytoplasm. Testes are short with incomplete coiling. The sheath of pigment cells that covers the muscle layer surrounding the testis frequently peels away, particularly from the region near the tip. Female fertility is also reduced, ovaries are small and misshapen.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 644618Protein cueballSequence analysisPRO_0000386572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Glycosylationi313 – 3131N-linked (GlcNAc...)1 Publication
Disulfide bondi402 ↔ 411PROSITE-ProRule annotation
Disulfide bondi406 ↔ 421PROSITE-ProRule annotation
Disulfide bondi437 ↔ 447PROSITE-ProRule annotation
Disulfide bondi441 ↔ 459PROSITE-ProRule annotation
Disulfide bondi461 ↔ 470PROSITE-ProRule annotation
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence analysis
Glycosylationi508 – 5081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ95RU0.
PRIDEiQ95RU0.

Expressioni

Gene expression databases

BgeeiFBgn0011204.
GenevisibleiQ95RU0. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0072590.

Structurei

3D structure databases

ProteinModelPortaliQ95RU0.
SMRiQ95RU0. Positions 63-273, 373-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati121 – 16646LDL-receptor class B 1Sequence analysisAdd
BLAST
Repeati167 – 21145LDL-receptor class B 2Sequence analysisAdd
BLAST
Repeati212 – 25746LDL-receptor class B 3Sequence analysisAdd
BLAST
Domaini398 – 43033EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 47139EGF-like 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cueball family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 3 LDL-receptor class B repeats.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPSX. Eukaryota.
ENOG410XPMR. LUCA.
GeneTreeiENSGT00840000131967.
InParanoidiQ95RU0.
OMAiCETPCFD.
OrthoDBiEOG091G0PM5.
PhylomeDBiQ95RU0.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00135. LY. 4 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS51120. LDLRB. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95RU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRIRFGMDV LLVLLLATCL LTPAHGTPLE WDFAVTLRTK IQFMDSSWQT
60 70 80 90 100
IATAAHEFDE LSALTFDESE ELIYFNDLKH RNGSIFSLKR DLIAANHVAE
110 120 130 140 150
QTIARTGNES VGGLAYDPLN MNLFWSDTEQ RKIFFAPIHG SATPQVLVDL
160 170 180 190 200
SAEGGRPDGV AVDVCRRKLY WTNSNVTHPT VERINLDGSN RTVIISSNID
210 220 230 240 250
MPRGIVVDQL SDRLFWIDDL KGVFFSVESS KLDGSDRQVV LKDKHHEPLN
260 270 280 290 300
LAVTNDAIYW TDRTTRAVWS HPKVPVIKVT TTSKPDEEDS TDSTDFKDPE
310 320 330 340 350
PVAEDCPLVR VANLSEEARG IVARTGFYQR LQKDHHCASI VRKVKERVDE
360 370 380 390 400
QSRKFEIRSL LDQKIKVLED ERCMNDGEYR AATDLCICPT GFKGSRCEIR
410 420 430 440 450
ECHNYCVHGT CQMSELAYPK CYCQPGFKGE RCELSVCSGL CLNGGHCRVS
460 470 480 490 500
KDENEAPSCE CPAKFGGARC EQNSTEICSL FCRLLKHEPE MYVPFGCHSI
510 520 530 540 550
CEELAQDNST NIAIPQYQHL EVCLTPRVWT SSVIIILVVG IVSSLLLVAV
560 570 580 590 600
IVQGIRRLYK PKRPRIRKTF VVRKQARTNS AGDTPLTNRP LATEQCEITI
610 620 630 640
ENCCNMNICE TPCFDPKLVE QTLSKSSCKE DKKILIHNME DDLY
Length:644
Mass (Da):72,623
Last modified:December 1, 2001 - v1
Checksum:i1FF14BFD962E95EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47503.2.
AY061139 mRNA. Translation: AAL28687.1.
RefSeqiNP_612113.2. NM_138269.3.
UniGeneiDm.18864.

Genome annotation databases

EnsemblMetazoaiFBtr0072706; FBpp0072590; FBgn0011204.
GeneIDi38174.
KEGGidme:Dmel_CG12086.
UCSCiCG12086-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF47503.2.
AY061139 mRNA. Translation: AAL28687.1.
RefSeqiNP_612113.2. NM_138269.3.
UniGeneiDm.18864.

3D structure databases

ProteinModelPortaliQ95RU0.
SMRiQ95RU0. Positions 63-273, 373-472.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072590.

Proteomic databases

PaxDbiQ95RU0.
PRIDEiQ95RU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072706; FBpp0072590; FBgn0011204.
GeneIDi38174.
KEGGidme:Dmel_CG12086.
UCSCiCG12086-RA. d. melanogaster.

Organism-specific databases

CTDi38174.
FlyBaseiFBgn0011204. cue.

Phylogenomic databases

eggNOGiENOG410IPSX. Eukaryota.
ENOG410XPMR. LUCA.
GeneTreeiENSGT00840000131967.
InParanoidiQ95RU0.
OMAiCETPCFD.
OrthoDBiEOG091G0PM5.
PhylomeDBiQ95RU0.

Enzyme and pathway databases

ReactomeiR-DME-2160916. Hyaluronan uptake and degradation.
R-DME-3000497. Scavenging by Class H Receptors.

Miscellaneous databases

GenomeRNAii38174.
PROiQ95RU0.

Gene expression databases

BgeeiFBgn0011204.
GenevisibleiQ95RU0. DM.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000033. LDLR_classB_rpt.
[Graphical view]
PfamiPF00058. Ldl_recept_b. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 1 hit.
SM00135. LY. 4 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 3 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS51120. LDLRB. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCUE_DROME
AccessioniPrimary (citable) accession number: Q95RU0
Secondary accession number(s): Q9W0E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.