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Protein

Cation diffusion facilitator family protein 1

Gene

cdf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: WormBase
  • zinc ion transmembrane transporter activity Source: WormBase

GO - Biological processi

  • cellular response to zinc ion Source: WormBase
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of Ras protein signal transduction Source: WormBase
  • positive regulation of vulval development Source: WormBase
  • zinc II ion transmembrane transport Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

SignaLinkiQ95QW4.

Protein family/group databases

TCDBi2.A.4.2.4. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation diffusion facilitator family protein 1
Gene namesi
Name:cdf-1
ORF Names:C15B12.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC15B12.7a; CE27065; WBGene00000393; cdf-1.
C15B12.7b; CE29581; WBGene00000393; cdf-1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 112112CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 1363ExtracellularSequence analysis
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 17619CytoplasmicSequence analysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence analysisAdd
BLAST
Topological domaini198 – 21518ExtracellularSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Topological domaini237 – 391155CytoplasmicSequence analysisAdd
BLAST
Transmembranei392 – 41221HelicalSequence analysisAdd
BLAST
Topological domaini413 – 4208ExtracellularSequence analysis
Transmembranei421 – 44121HelicalSequence analysisAdd
BLAST
Topological domaini442 – 561120CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basolateral plasma membrane Source: WormBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 561561Cation diffusion facilitator family protein 1PRO_0000294932Add
BLAST

Proteomic databases

EPDiQ95QW4.
PaxDbiQ95QW4.
PRIDEiQ95QW4.

PTM databases

iPTMnetiQ95QW4.

Expressioni

Tissue specificityi

Expressed in intestine and vulva.1 Publication

Interactioni

Subunit structurei

Interacts with lin-45 in a zinc-dependent manner.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: WormBase

Protein-protein interaction databases

BioGridi45853. 1 interaction.
STRINGi6239.C15B12.7b.

Structurei

3D structure databases

ProteinModelPortaliQ95QW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni246 – 270256 X 2 AA approximate repeats of H-GSequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000017668.
InParanoidiQ95QW4.
KOiK14688.
OMAiVNICHPA.
OrthoDBiEOG741Z28.
PhylomeDBiQ95QW4.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b1 Publication (identifier: Q95QW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVTMEDRSV KADKADRDDN NTTSTELLGK MRQTKVISTN QNNNHLIDRM
60 70 80 90 100
VSIYEMEMIK SQSTETISDV SDVLEFTVID NCSHGTHTLE HDLRLKGEPI
110 120 130 140 150
GKSESVKGVS RSLIIQIGMT VIFCALEFIT GVVCSSIAML ADSYHMAADV
160 170 180 190 200
MALIVAFTCI KIATRPSTRL GYGWVRAETL GGFFNGIFMC TVCVLVFQEA
210 220 230 240 250
VGRIINVHMI THPLQVLVIG FIGLLINLFG MFNLSGHGHS HGGGSHGHSH
260 270 280 290 300
GGSHGHSHNN KKTKKNDGHG HSHANGHGHS HDGKSDCNGE EEPDHTRLNG
310 320 330 340 350
KFRSASAMAN SDANVRLLDN DDNSNDIIER RLSGVNSQNT IIATVDRQMT
360 370 380 390 400
PYGTHMASEV LNVSSNNLDK SAQKTEQKKD KNVNIHGVWL HLLSDAFGSV
410 420 430 440 450
IVMISAGFVY FLPTWKIAAY LDPILSISLA SIMGFTAVVL VKTSGEKLLK
460 470 480 490 500
QTPEGLDLEK VKKDLCSIVG VSKVEKLSVW TLCGQRIIAA AHVNICHPAV
510 520 530 540 550
FPEAAYKIKN YFHDLGVHST TIEPTFEDTC MQSMRIMVKK VVDGKSIEEP
560
VSVSTENEIT E
Note: No experimental confirmation available.Curated
Length:561
Mass (Da):61,434
Last modified:December 1, 2001 - v1
Checksum:i519038EE332B253A
GO
Isoform a1 Publication (identifier: Q95QW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-79: Missing.

Show »
Length:519
Mass (Da):56,619
Checksum:iF7B850664172ED37
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 7942Missing in isoform a. 1 PublicationVSP_052484Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080547 Genomic DNA. Translation: CCD64570.1.
FO080547 Genomic DNA. Translation: CCD64571.1.
RefSeqiNP_509095.1. NM_076694.4. [Q95QW4-2]
NP_509096.1. NM_076695.3. [Q95QW4-1]
UniGeneiCel.7204.

Genome annotation databases

EnsemblMetazoaiC15B12.7b; C15B12.7b; WBGene00000393. [Q95QW4-1]
GeneIDi180923.
KEGGicel:CELE_C15B12.7.
UCSCiC15B12.7b. c. elegans. [Q95QW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080547 Genomic DNA. Translation: CCD64570.1.
FO080547 Genomic DNA. Translation: CCD64571.1.
RefSeqiNP_509095.1. NM_076694.4. [Q95QW4-2]
NP_509096.1. NM_076695.3. [Q95QW4-1]
UniGeneiCel.7204.

3D structure databases

ProteinModelPortaliQ95QW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45853. 1 interaction.
STRINGi6239.C15B12.7b.

Protein family/group databases

TCDBi2.A.4.2.4. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ95QW4.

Proteomic databases

EPDiQ95QW4.
PaxDbiQ95QW4.
PRIDEiQ95QW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC15B12.7b; C15B12.7b; WBGene00000393. [Q95QW4-1]
GeneIDi180923.
KEGGicel:CELE_C15B12.7.
UCSCiC15B12.7b. c. elegans. [Q95QW4-1]

Organism-specific databases

CTDi180923.
WormBaseiC15B12.7a; CE27065; WBGene00000393; cdf-1.
C15B12.7b; CE29581; WBGene00000393; cdf-1.

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000017668.
InParanoidiQ95QW4.
KOiK14688.
OMAiVNICHPA.
OrthoDBiEOG741Z28.
PhylomeDBiQ95QW4.

Enzyme and pathway databases

SignaLinkiQ95QW4.

Miscellaneous databases

NextBioi911568.
PROiQ95QW4.

Family and domain databases

Gene3Di1.20.1510.10. 2 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 2 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling."
    Bruinsma J.J., Jirakulaporn T., Muslin A.J., Kornfeld K.
    Dev. Cell 2:567-578(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  3. "Cation diffusion facilitator proteins modulate Raf-1 activity."
    Jirakulaporn T., Muslin A.J.
    J. Biol. Chem. 279:27807-27815(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LIN-45.

Entry informationi

Entry nameiCDF1_CAEEL
AccessioniPrimary (citable) accession number: Q95QW4
Secondary accession number(s): Q18009
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.