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Protein

Putative galactocerebrosidase

Gene

C29E4.10

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride.By similarity

Catalytic activityi

D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87SubstrateBy similarity1
Binding sitei128SubstrateBy similarity1
Binding sitei171SubstrateBy similarity1
Active sitei172Proton donor/acceptorBy similarity1
Active sitei248NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processLipid degradation, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1660662 Glycosphingolipid metabolism

Protein family/group databases

CAZyiGH59 Glycoside Hydrolase Family 59

Names & Taxonomyi

Protein namesi
Recommended name:
Putative galactocerebrosidase (EC:3.2.1.46)
Short name:
GALCERase
Alternative name(s):
Galactocerebroside beta-galactosidase
Galactosylceramidase
Galactosylceramide beta-galactosidase
Gene namesi
ORF Names:C29E4.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC29E4.10 ; CE47094 ; WBGene00016207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001223317 – 645Putative galactocerebrosidaseAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi261 ↔ 365By similarity
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi411N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi532N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi638N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ95QT2
PaxDbiQ95QT2
PeptideAtlasiQ95QT2
PRIDEiQ95QT2

Expressioni

Gene expression databases

BgeeiWBGene00016207

Structurei

3D structure databases

ProteinModelPortaliQ95QT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 59 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITE Eukaryota
ENOG410XTIS LUCA
GeneTreeiENSGT00390000003303
InParanoidiQ95QT2
KOiK01202
OMAiWHLMSAF
OrthoDBiEOG091G04GY

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001286 Glyco_hydro_59
IPR035394 Glyco_hydro_59_dom
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR15172 PTHR15172, 1 hit
PfamiView protein in Pfam
PF02057 Glyco_hydro_59, 1 hit
PF17387 Glyco_hydro_59M, 1 hit
PRINTSiPR00850 GLHYDRLASE59
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q95QT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSIFIKIIL ILPSIATKTN NIDIKSWRSA QTFDGFGAVS GGGATSKLLF
60 70 80 90 100
TYFSEKSDRK QVLESLFNKD NGLQLLKVEM GGDDQSTEGT ESSHESEKGK
110 120 130 140 150
ISKNNYEFQL ISEVREINPT IPICVLPWAF PGWIGNTPYD NVTETAEYVV
160 170 180 190 200
NWLKIGRDTW NFDTFCVGVW NERNFSESYV KELRKILNLN GFNETLIVAG
210 220 230 240 250
EGFRMDDSYS RLLDKRFINE YDIIGVHYPG GRIPENVQKS GKVIWASEDY
260 270 280 290 300
STDNRDTGEG CMARTMNWNF INGNITGMIS WHLMSAFYPQ LPWYRCGLAR
310 320 330 340 350
IDENKFQTEK AFHVLKYITS HVKRGWKILR ESSGRFDGGG TYVTYTNGKD
360 370 380 390 400
STIFVETMSY KKSLCEYSSP RPYHVKPSQL IRFKFSEIPS FQGLNMSLNF
410 420 430 440 450
GPSKFFSKSV NSTITILLPV NSFGILTTLP VSTPKRVTIK TPLVPLNYHD
460 470 480 490 500
DFENYEFDEE PKFWMPQKGS WVVRNGRAVQ KVTRPSISWC TSHIRTPYAV
510 520 530 540 550
MAYRKKNSIL NAEVNIPKHS TAKSIILGIR SNCSGCDIEV INCRGIFVEI
560 570 580 590 600
EFSNKKVTIF SDFVDRSIIA EFKARRKVEF GKFYKFSIHL LDSHLFIKFG
610 620 630 640
NHHVMTSVEI PEEQLNKTNN DTLFVIGTGN FGISEWDNIS TDYFH
Length:645
Mass (Da):73,805
Last modified:October 3, 2012 - v3
Checksum:iBE060A32F3A33304
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080706 Genomic DNA Translation: CCD66013.2
RefSeqiNP_498726.3, NM_066325.3
UniGeneiCel.36779

Genome annotation databases

EnsemblMetazoaiC29E4.10; C29E4.10; WBGene00016207
GeneIDi183002
KEGGicel:CELE_C29E4.10
UCSCiC29E4.10 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGALC_CAEEL
AccessioniPrimary (citable) accession number: Q95QT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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