G-protein regulator 1 - Caenorhabditis elegans

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Q95QJ7 (GPR1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
G-protein regulator 1

Gene names

Name:	gpr-1
ORF Names:	F22B7.13

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement. Ref.3
Subunit structure	Interacts with gpr-1, lin-5 and GDP-bound goa-1. Ref.3
Subcellular location	Cytoplasm › cell cortex. Cytoplasm › cytoskeleton › spindle. Note: Located to the spindle and cell cortex when in complex with lin-5 and gpr-1. Ref.3
Sequence similarities	Contains 1 GoLoco domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytokinesis Inferred from mutant phenotype. Source: WormBase embryo development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase meiotic chromosome segregation Inferred from mutant phenotype. Source: WormBase mitosis Inferred from electronic annotation. Source: UniProtKB-KW mitotic spindle organization Inferred from mutant phenotype. Source: WormBase negative regulation of GTP catabolic process Inferred from direct assay. Source: WormBase nematode larval development Inferred from mutant phenotype Ref.3. Source: WormBase receptor-mediated endocytosis Inferred from mutant phenotype. Source: WormBase signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	aster Inferred from direct assay. Source: WormBase cell cortex Inferred from direct assay. Source: WormBase
Molecular function	GDP-dissociation inhibitor activity Inferred from direct assay. Source: WormBase GTPase activator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
C13F10.2	O01488	5	EBI-316069,EBI-320537
gpa-16	Q9N2V6	2	EBI-316069,EBI-1005005

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 525

525

G-protein regulator 1

PRO_0000087562

Regions

Domain

424 – 445

GoLoco

Sequences

Sequence

Length

Mass (Da)

Tools

Q95QJ7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: EC68F930E3622AB5
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FASTA

525

60,128

        10         20         30         40         50         60 
MDVSYYDGPK DEVAEAMLKS AVTAMRLGQY EDGKGRLEEI MEFGTSNFQL LGTIYMYYGR 

        70         80         90        100        110        120 
VCRHLNHDAK ALEFFEHELN MFKLIFNYPE ACDSTRRIVE QALKMGKFPK ARRFAEDLID 

       130        140        150        160        170        180 
YTSNKKNGEK YIGQARILFA SVCLEGCERD VESNQDEKKK LLSICAEQIA AVKLFNENNT 

       190        200        210        220        230        240 
EGAVSETKIM LLEAKCLSLD EKYEESRRKY QECIDFAIKT DQFEAVHIAY YDKALYAETD 

       250        260        270        280        290        300 
LLFFIIRDLR SALFYATKFG KERDVVKYKS KLSEEMLRNG EFHEAYLYGL EALVSIRKLG 

       310        320        330        340        350        360 
LNEYIGDVLL TIAKCLIALG KRRQAAYFII LGSVLTINQN SFKLFYEQID VAMNQERSET 

       370        380        390        400        410        420 
ATDQDVCLAI DSSPDPTSSN DMINKFVVEL EHATNVETWE MIVNGIIDDQ KKPVAIEKKE 

       430        440        450        460        470        480 
NEEPVDMMDL IFSMSSRMDD QRTELPAARF IPPRPVSSAS KKTTKSHRIL PGLRANWTKV 

       490        500        510        520 
QSMKFDGHTM NRILKRSKKS KSSLDSTNSM QGDDTRSDDV TMTSK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans." Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L. Wohldman P. Nature 368:32-38(1994) [PubMed: 7906398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[3]	"A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans." Srinivasan D.G., Fisk R.M., Xu H., van den Heuvel S. Genes Dev. 17:1225-1239(2003) [PubMed: 12730122] [Abstract] Cited for: FUNCTION, INTERACTION WITH GPR-1; LIN-5 AND GOA-1, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080222 Genomic DNA. Translation: CCD62140.1.
PIR	S44636.
RefSeq	NP_498900.1. NM_066499.2.
UniGene	Cel.8150.
3D structure databases
ProteinModelPortal	Q95QJ7.
SMR	Q95QJ7. Positions 13-82, 92-120, 192-329.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26900N.
IntAct	Q95QJ7. 7 interactions.
MINT	MINT-1068490.
STRING	Q95QJ7.
Proteomic databases
PRIDE	Q95QJ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F22B7.13; F22B7.13; F22B7.13.
GeneID	176210.
KEGG	cel:F22B7.13.
NMPDR	fig\|6239.3.peg.10902.
UCSC	F22B7.13. c. elegans.
Organism-specific databases
CTD	176210.
WormBase	F22B7.13; CE24910; WBGene00001688; gpr-1.
Phylogenomic databases
GeneTree	EMGT00050000011628.
HOGENOM	HBG381403.
InParanoid	Q95QJ7.
OMA	MNSRMDD.
Gene expression databases
ArrayExpress	Q95QJ7.
Family and domain databases
InterPro	IPR003109. GoLoco_motif. IPR011990. TPR-like_helical. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
Pfam	PF02188. GoLoco. 1 hit. [Graphical view]
SMART	SM00390. GoLoco. 1 hit. [Graphical view]
PROSITE	PS50877. GOLOCO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	891594.

Entry information

Entry name

GPR1_CAEEL

Accession

Primary (citable) accession number: Q95QJ7
Secondary accession number(s): P34408

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents