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Q95Q98 (JHD1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
JmjC domain-containing histone demethylation protein 1
EC=1.14.11.27
Alternative name(s):
[Histone-H3]-lysine-36 demethylase 1
Gene names
Name:jhd-1
ORF Names:T26A5.5
OrganismCaenorhabditis elegans
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length1076 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.

Catalytic activity

Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2.

Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Subcellular location

Nucleus By similarity.

Domain

The JmjC domain mediates the demethylation activity By similarity.

Sequence similarities

Belongs to the JHDM1 histone demethylase family.

Contains 1 JmjC domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: Q95Q98-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform b (identifier: Q95Q98-2)

The sequence of this isoform differs from the canonical sequence as follows:
     504-505: TG → PN
     506-1076: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10761076JmjC domain-containing histone demethylation protein 1
PRO_0000226789

Regions

Domain93 – 265173JmjC
Compositional bias586 – 705120Glu-rich
Compositional bias664 – 73067Lys-rich

Sites

Metal binding1621Iron; catalytic By similarity
Metal binding1641Iron; catalytic By similarity
Metal binding2331Iron; catalytic By similarity
Binding site1591Substrate By similarity
Binding site1791Substrate By similarity

Natural variations

Alternative sequence504 – 5052TG → PN in isoform b.
VSP_017481
Alternative sequence506 – 1076571Missing in isoform b.
VSP_017482

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified March 1, 2003. Version 2.
Checksum: C050485361154151

FASTA1,076123,434
        10         20         30         40         50         60 
MDPEALNLEF YDKNGLDNPI HFRCDPKRIG MTLPSPDFSV DDVLELVGGN RMIEVVQVQN 

        70         80         90        100        110        120 
QGSVKMSLQE FINFYKTPQE KREVLYNVLS LEFSQTPLED LVKSPELVRQ IDWVGNQWPD 

       130        140        150        160        170        180 
ALRQRWISFN GRDKKFYNPH HTFPKVQNYC LMSVANCYTD FHIDFSGTSV WYHVLKGRKV 

       190        200        210        220        230        240 
FWLIPPTETN FFIYQEFIKT VNDNAFFGKS VEKCHVAILE PGDTMLIPSG WIHAVYTPDD 

       250        260        270        280        290        300 
SLVFGGNFLH SQSCKTQLRV YQVENKLNIT RKFRLPYNEE LIFYVIADYV KQWTGREYVR 

       310        320        330        340        350        360 
PLRIEDAKYD YVGDKWKTAG GHHKKIEYSD YETGVELTND MIKGDEESTK DEVKVIAMHA 

       370        380        390        400        410        420 
ENSLFGYPMV SKATFSADTG LEEEADEDEV KYQETKEEMD ARRDAEIDEL ANSNSLIFYK 

       430        440        450        460        470        480 
NRTHDFVRNK CVPDHKLPIG HEPPIYFNDD EISRISPRLL DELETLGTYI RRKARVEVAE 

       490        500        510        520        530        540 
GICQPASLIN TFQTVLKKRR SELTGKKFEF NQIMPRRYTR STMETGEYDF QPTQEVPQES 

       550        560        570        580        590        600 
ARRSTRFKVD NFPDELLESE VTDKPIILPQ QPSSGPLEYL PAPKDEIKED INGFEEEFEE 

       610        620        630        640        650        660 
EYEGIGQRDD QEEEEYDAEE PEDQEEEEED EYQAEEYTPT PVTRRSSSRR SGAKNDESEE 

       670        680        690        700        710        720 
VSVKKDKKEK MEKVEKDEKR RNSKSKKDKI SKEKKKKERE RIELESQLDA ELRAAHGGGS 

       730        740        750        760        770        780 
SKSKKKKPEK PAFVGGLPTS SIQIDPVVSN PYNYDPRMEM MKLGTGQLKS AYRKTKNNVE 

       790        800        810        820        830        840 
LHIEKNLYKI EPKRGSEEGS QSREQSMEPE HSTPVFTTFD DINEANNDHY DGQKPPTKRA 

       850        860        870        880        890        900 
KYEAISVDTY ETPSSSRNKE HKEYRPSPNA APTPSPSHHQ KPKLSSPAMV SSTNEYQLRK 

       910        920        930        940        950        960 
HMSSERRSSD AGSAMKKGVY MPAMSRQDKM IAEGASAPSS RHSSISSERR PSFIPDFNSS 

       970        980        990       1000       1010       1020 
RNSSIDTPYT PTTVTPSRSS WLPNTSSINR HSIEDDSPID VVNDSLSPIN IASSPTYPTA 

      1030       1040       1050       1060       1070 
ITPPPVTLSD LKKDMSNGRK SHSQHHDDGH KHKIPSKEAI AELKLLVGKL KAINDS

« Hide

Isoform b [UniParc].

Checksum: 600AD0CB9F78A410
Show »

FASTA50558,746

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FO080366 Genomic DNA. Translation: CCD63210.1.
FO080366 Genomic DNA. Translation: CCD63211.1.
RefSeqNP_498418.2. NM_066017.4.
NP_498419.2. NM_066018.7.
UniGeneCel.5081.

3D structure databases

ProteinModelPortalQ95Q98.
SMRQ95Q98. Positions 1-306.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ95Q98.

Proteomic databases

PRIDEQ95Q98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaT26A5.5a; T26A5.5a; T26A5.5.
GeneID175919.
KEGGcel:T26A5.5.
NMPDRfig|6239.3.peg.10209.
UCSCT26A5.5b. c. elegans.

Organism-specific databases

CTD175919.
WormBaseT26A5.5a; CE32733; WBGene00020821.
T26A5.5b; CE32734; WBGene00020821.

Phylogenomic databases

eggNOGmeNOG29365.
GeneTreeEMGT00050000003730.
HOGENOMHBG384294.
InParanoidQ95Q98.
OMADPRMEMM.
PhylomeDBQ95Q98.

Gene expression databases

ArrayExpressQ95Q98.

Family and domain databases

InterProIPR013129. TF_JmjC.
IPR003347. TF_JmjC_AAH.
[Graphical view]
KOK10276.
PfamPF02373. JmjC. 1 hit.
[Graphical view]
SMARTSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio890308.

Entry information

Entry nameJHD1_CAEEL
AccessionPrimary (citable) accession number: Q95Q98
Secondary accession number(s): Q95Q99
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2003
Last modified: December 14, 2011
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormPep

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents