Reviewed,
UniProtKB/Swiss-Prot Q95Q98 (JHD1_CAEEL)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: JmjC domain-containing histone demethylation protein 1 EC=1.14.11.27 Alternative name(s): [Histone-H3]-lysine-36 demethylase 1 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 1076 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity. |
| Catalytic activity | Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2. |
| Cofactor | Binds 1 Fe2+ ion per subunit By similarity. |
| Subcellular location | Nucleus By similarity. |
| Domain | The JmjC domain mediates the demethylation activity By similarity. |
| Sequence similarities | Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform a (identifier: Q95Q98-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform b (identifier: Q95Q98-2) The sequence of this isoform differs from the canonical sequence as follows: 504-505: TG → PN 506-1076: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1076 | 1076 | JmjC domain-containing histone demethylation protein 1 | PRO_0000226789 | |||||
Regions | |||||||||
| Domain | 93 – 265 | 173 | JmjC | ||||||
| Compositional bias | 586 – 705 | 120 | Glu-rich | ||||||
| Compositional bias | 664 – 730 | 67 | Lys-rich | ||||||
Sites | |||||||||
| Metal binding | 162 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 164 | 1 | Iron; catalytic By similarity | ||||||
| Metal binding | 233 | 1 | Iron; catalytic By similarity | ||||||
| Binding site | 159 | 1 | Substrate By similarity | ||||||
| Binding site | 179 | 1 | Substrate By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 504 – 505 | 2 | TG → PN in isoform b. | VSP_017481 | |||||
| Alternative sequence | 506 – 1076 | 571 | Missing in isoform b. | VSP_017482 | |||||
Sequences
| ||||||||||||||||||||||||
References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U00043 Genomic DNA. Translation: AAN65291.1. U00043 Genomic DNA. Translation: AAN65292.1. |
| RefSeq | NP_498418.2. NP_498419.2. |
| UniGene | Cel.5081 |
3D structure databases | |
| SMR | Q95Q98. Positions 1-302. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q95Q98. |
Genome annotation databases | |
| Ensembl | T26A5.5a; T26A5.5a; T26A5.5; Caenorhabditis elegans. [Genome view] |
| GeneID | 175919. |
| KEGG | cel:T26A5.5. |
| NMPDR | fig|6239.3.peg.10209. |
| UCSC | T26A5.5b. c. elegans. |
Organism-specific databases | |
| CTD | 175919. |
| WormBase | WBGene00020821. T26A5.5. |
| WormPep | T26A5.5a. CE32733. [WorfDB] T26A5.5b. CE32734. [WorfDB] |
Phylogenomic databases | |
| eggNOG | meNOG29365. |
| HOGENOM | HBG384294. |
| InParanoid | Q95Q98. |
| OMA | DPRMEMM. |
| PhylomeDB | Q95Q98. |
Enzyme and pathway databases | |
| BRENDA | 1.14.11.27. 672. |
Gene expression databases | |
| ArrayExpress | Q95Q98. |
Family and domain databases | |
| InterPro | IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. [Graphical view] |
| Pfam | PF02373. JmjC. 1 hit. [Graphical view] |
| SMART | SM00558. JmjC. 1 hit. [Graphical view] |
| PROSITE | PS51184. JMJC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 890308. |
Entry information
| Entry name | JHD1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q95Q98 Secondary accession number(s): Q95Q99 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |
